Basic Information:

  VIRBase ID:  

VHID00495612

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.9526

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

Binding sites in RBPDB, PDB
RBPDB	RRMx1
PDB	2CQ3

Interactor Information:

	Interactor1	Interactor2
Symbol	kshv-miR-K12-7-5p	RBFOX2
miRBase Accession/Entrez ID	MIMAT0015217	23543
Organism	Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)	Homo sapiens
Category	miRNA	protein
Alias	-	dJ106I20.3//Fox-2//FOX2//fxh//HNRBP2//HRNBP2//RBM9//RTA

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	RBFOX2	chr22:36282529(-) A-I      intronic chr22:36282566(-) A-I      intronic chr22:36282562(-) A-I      intronic chr22:36282561(-) A-I      intronic chr22:36282530(-) A-I      intronic chr22:36422202(-) A-I      intronic chr22:36252001(-) A-I      intronic chr22:36285010(-) A-I      intronic chr22:36251953(-) A-I      intronic chr22:36390685(-) A-I      intronic chr22:36285019(-) A-I      intronic chr22:36256669(-) A-I      intronic chr22:36285028(-) A-I      intronic chr22:36390678(-) A-I      intronic chr22:36422096(-) A-I      intronic chr22:36422192(-) A-I      intronic chr22:36252009(-) A-I      intronic chr22:36274544(-) A-I      intronic chr22:36274333(-) A-I      intronic chr22:36274549(-) A-I      intronic chr22:36274562(-) A-I      intronic chr22:36277821(-) A-I      intronic chr22:36280147(-) A-I      intronic chr22:36280271(-) A-I      intronic chr22:36281971(-) A-I      intronic chr22:36281980(-) A-I      intronic chr22:36282032(-) A-I      intronic chr22:36282068(-) A-I      intronic chr22:36282081(-) A-I      intronic chr22:36282083(-) A-I      intronic chr22:36282084(-) A-I      intronic chr22:36282098(-) A-I      intronic chr22:36282106(-) A-I      intronic chr22:36282108(-) A-I      intronic chr22:36287452(-) A-I      intronic chr22:36287453(-) A-I      intronic chr22:36287461(-) A-I      intronic chr22:36287469(-) A-I      intronic chr22:36294559(-) A-I      intronic chr22:36303865(-) A-I      intronic chr22:36303870(-) A-I      intronic chr22:36303872(-) A-I      intronic chr22:36303877(-) A-I      intronic chr22:36303927(-) A-I      intronic chr22:36303951(-) A-I      intronic chr22:36312467(-) A-I      intronic chr22:36312468(-) A-I      intronic chr22:36321470(-) A-I      intronic chr22:36360090(-) A-I      intronic chr22:36363420(-) A-I      intronic chr22:36390582(-) A-I      intronic chr22:36397679(-) A-I      intronic chr22:36398796(-) A-I      intronic chr22:36398820(-) A-I      intronic chr22:36405578(-) A-I      intronic chr22:36421128(-) A-I      intronic chr22:36421847(-) A-I      intronic chr22:36405560(-) A-I      intronic chr22:36159436(-) A-I      intronic chr22:36181189(-) A-I      intronic chr22:36189090(-) A-I      intronic chr22:36197709(-) A-I      intronic chr22:36238068(-) A-I      intronic chr22:36252006(-) A-I      intronic chr22:36252007(-) A-I      intronic chr22:36252887(-) A-I      intronic chr22:36264576(-) A-I      intronic chr22:36265584(-) A-I      intronic chr22:36269888(-) A-I      intronic chr22:36331137(-) A-I      intronic chr22:36295083(-) A-I      intronic chr22:36183203(-) A-I      intronic chr22:36187003(-) A-I      intronic chr22:36302725(-) A-I      intronic chr22:36249264(-) A-I      intronic chr22:36298796(-) A-I      intronic chr22:36266311(-) A-I      intronic chr22:36295000(-) A-I      intronic chr22:36390631(-) A-I      intronic chr22:36312549(-) A-I      intronic chr22:36281941(-) A-I      intronic chr22:36220157(-) A-I      intronic chr22:36389935(-) A-I      intronic chr22:36326207(-) A-I      intronic chr22:36159398(-) A-I      intronic chr22:36390703(-) A-I      intronic chr22:36305303(-) A-I      intronic chr22:36294993(-) A-I      intronic chr22:36325716(-) A-I      intronic chr22:36295158(-) A-I      intronic chr22:36294638(-) A-I      intronic chr22:36250528(-) A-I      intronic chr22:36274728(-) A-I      intronic chr22:36265646(-) A-I      intronic chr22:36408924(-) A-I      intronic chr22:36188341(-) A-I      intronic chr22:36189312(-) A-I      intronic chr22:36420923(-) A-I      intronic chr22:36302697(-) A-I      intronic chr22:36312776(-) A-I      intronic chr22:36274567(-) A-I      intronic chr22:36251545(-) A-I      intronic chr22:36312398(-) A-I      intronic chr22:36188264(-) A-I      intronic chr22:36266391(-) A-I      intronic chr22:36189066(-) A-I      intronic chr22:36274272(-) A-I      intronic chr22:36274252(-) A-I      intronic chr22:36266312(-) A-I      intronic chr22:36189053(-) A-I      intronic chr22:36159573(-) A-I      intronic chr22:36203021(-) A-I      intronic chr22:36420533(-) A-I      intronic chr22:36287361(-) A-I      intronic chr22:36159557(-) A-I      intronic chr22:36319512(-) A-I      intronic chr22:36251984(-) A-I      intronic chr22:36249277(-) A-I      intronic chr22:36200278(-) A-I      intronic chr22:36266296(-) A-I      intronic chr22:36220155(-) A-I      intronic chr22:36274362(-) A-I      intronic chr22:36282176(-) A-I      intronic chr22:36297494(-) A-I      intronic chr22:36326739(-) A-I      intronic chr22:36420952(-) A-I      intronic chr22:36331121(-) A-I      intronic chr22:36277055(-) A-I      intronic chr22:36312512(-) A-I      intronic chr22:36303984(-) A-I      intronic chr22:36302715(-) A-I      intronic chr22:36332177(-) A-I      intronic chr22:36280182(-) A-I      intronic chr22:36274579(-) A-I      intronic chr22:36362976(-) A-I      intronic chr22:36394459(-) A-I      intronic chr22:36422101(-) A-I      intronic chr22:36274687(-) A-I      intronic chr22:36280208(-) A-I      intronic chr22:36297445(-) A-I      intronic chr22:36264592(-) A-I      intronic chr22:36312602(-) A-I      intronic chr22:36282175(-) A-I      intronic chr22:36390636(-) A-I      intronic chr22:36274358(-) A-I      intronic chr22:36285166(-) A-I      intronic chr22:36303871(-) A-I      intronic chr22:36274187(-) A-I      intronic chr22:36264546(-) A-I      intronic chr22:36266406(-) A-I      intronic chr22:36420953(-) A-I      intronic chr22:36285022(-) A-I      intronic chr22:36281956(-) A-I      intronic chr22:36312576(-) A-I      intronic chr22:36422067(-) A-I      intronic chr22:36326795(-) A-I      intronic chr22:36219140(-) A-I      intronic chr22:36390532(-) A-I      intronic chr22:36294722(-) A-I      intronic chr22:36422147(-) A-I      intronic chr22:36159527(-) A-I      intronic chr22:36422281(-) A-I      intronic chr22:36312494(-) A-I      intronic chr22:36274406(-) A-I      intronic chr22:36325819(-) A-I      intronic chr22:36251525(-) A-I      intronic chr22:36312384(-) A-I      intronic chr22:36409084(-) A-I      intronic chr22:36390680(-) A-I      intronic chr22:36390574(-) A-I      intronic chr22:36255899(-) A-I      intronic chr22:36312572(-) A-I      intronic chr22:36390653(-) A-I      intronic chr22:36421129(-) A-I      intronic chr22:36325761(-) A-I      intronic chr22:36312461(-) A-I      intronic chr22:36297967(-) A-I      intronic chr22:36294669(-) A-I      intronic chr22:36274264(-) A-I      intronic chr22:36295127(-) A-I      intronic chr22:36280127(-) A-I      intronic chr22:36265598(-) A-I      intronic chr22:36285158(-) A-I      intronic chr22:36305249(-) A-I      intronic chr22:36298976(-) A-I      intronic chr22:36251728(-) A-I      intronic chr22:36280243(-) A-I      intronic chr22:36303859(-) A-I      intronic chr22:36389831(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	RBFOX2	chr22:36285089(-) A-I intron -    21960545 chr22:36285093(-) A-I intron -    21960545

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	RBFOX2	chr22:36134858-36134859(-) Am 3'UTR       - chr22:36135138-36135139(-) m6A 3'UTR       24284625//27773535 chr22:36135241-36135242(-) m6A 3'UTR       24284625//27773535 chr22:36135296-36135297(-) m6A 3'UTR       24284625//27773535 chr22:36135301-36135302(-) m6A 3'UTR       24284625//27773535 chr22:36135335-36135336(-) m6A 3'UTR       27773535 chr22:36136746-36136747(-) m6A 3'UTR       - chr22:36136763-36136764(-) m6A 3'UTR       - chr22:36136786-36136787(-) m6A 3'UTR       - chr22:36136832-36136833(-) m6A 3'UTR       - chr22:36136839-36136840(-) m6A 3'UTR       - chr22:36137543-36137544(-) m6A 3'UTR       - chr22:36137961-36137962(-) m6A 3'UTR       - chr22:36138030-36138031(-) m6A 3'UTR       - chr22:36138049-36138050(-) m6A 3'UTR       - chr22:36138903-36138904(-) m6A 3'UTR       26404942 chr22:36138931-36138932(-) m6A 3'UTR       26404942 chr22:36138951-36138952(-) m6A 3'UTR       - chr22:36139593-36139594(-) m6A 3'UTR       27773535 chr22:36139810-36139811(-) Cm 3'UTR       - chr22:36139815-36139816(-) m6A 3'UTR       24981863//27773535 chr22:36139856-36139857(-) m6A 3'UTR       24981863//27773535 chr22:36139897-36139898(-) m6A 3'UTR       24981863//27773535 chr22:36139998-36139999(-) m6A 3'UTR       27773535 chr22:36140124-36140125(-) m6A 3'UTR       24284625//24981863//27773535//22608085 chr22:36140138-36140139(-) m6A 3'UTR//exon       24284625//24981863//27773535//22608085 chr22:36140146-36140147(-) m6A 3'UTR//exon       24284625//24981863//27773535//22608085 chr22:36140172-36140173(-) m6A 3'UTR//exon       24284625//24981863//27773535//22608085 chr22:36140224-36140225(-) m6A 3'UTR//exon       24284625//24981863//27773535//22575960//22608085 chr22:36140239-36140240(-) m6A 3'UTR//exon       24284625//24981863//27773535//22575960//22608085 chr22:36164355-36164356(-) m6A CDS       24981863 chr22:36177671-36177672(-) m6A CDS//exon       24981863 chr22:36177750-36177751(-) m6A CDS//exon       24981863//26404942//27773535//22575960 chr22:36177771-36177772(-) m6A CDS//exon       24981863//26404942//27773535//22575960 chr22:36177789-36177790(-) m6A CDS//exon       24981863//26404942//27773535//22575960 chr22:36205918-36205919(-) m6A CDS//exon       24981863//27773535//27371828 chr22:36205932-36205933(-) m6A CDS//exon       24981863//27773535//27371828 chr22:36220399-36220400(-) m1A 5'UTR//intron       26863196 chr22:36232381-36232382(-) m6A 5'UTR//intron       27773536 chr22:36236421-36236422(-) m6A 5'UTR//exon//intron       24209618//24981863//27773535 chr22:36236454-36236455(-) m6A 5'UTR//intron       24209618//25456834//24981863//27773535 chr22:36334901-36334902(-) m6A 5'UTR//CDS       27773536 chr22:36357620-36357621(-) m6A CDS//intron       27773536 chr22:36357632-36357633(-) m6A CDS//intron       24209618//27773536

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	RBFOX2	Chromatin K562 cells     - Cytoplasm Colon cancer tissue     31028247 Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)|K562 cells     - Exosome Blood     - Membrane HCC cell line (HepG2)     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus Normal colon tissue     31028247 Nucleus Cortex     26687839 Nucleus HeLa-S3 cells|K562 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: kshv-miR-K12-7-5p
Interactor2: RBFOX2

Evidence Support:

Strong-Evidence	Dual luciferase reporter assay//RT-PCR//Western blot
Support Database	VIRmiRNA

References:

PMID	21283761	Target region	3'UTR
Source	VIRmiRNA	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	We found that miR-K12-7 targeted the RTA 3'untranslated region (RTA3'UTR) in a seed sequence-dependent manner. miR-K12-7-5p derived from miR-K12-7 mediates the inhibition of RTA expression, and the mutation of the seed match site totally abrogated the inhibitory effect of miR-K12-7 on RTA 3'UTR.