Basic Information:

  VIRBase ID:  

VHID00493851

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-8-5p:  MIMAT0015216          UBN2:  NM_173569     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	kshv-miR-K12-8-5p	UBN2
miRBase Accession/Entrez ID	MIMAT0015216	254048
Organism	Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	-

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	UBN2	chr7:138970921(+) A-I      intronic chr7:138970982(+) A-I      intronic chr7:138920233(+) A-I      intronic chr7:138920232(+) A-I      intronic chr7:138920221(+) A-I      intronic chr7:138976070(+) A-I      intronic chr7:138935646(+) A-I      intronic chr7:138970993(+) A-I      intronic chr7:138934583(+) A-I      intronic chr7:138971030(+) A-I      intronic chr7:138935595(+) A-I      intronic chr7:138970000(+) A-I      intronic chr7:138971045(+) A-I      intronic chr7:138935651(+) A-I      intronic chr7:138926642(+) A-I      intronic chr7:138956244(+) A-I      intronic chr7:138974769(+) A-I      intronic chr7:138956243(+) A-I      intronic chr7:138975868(+) A-I      intronic chr7:138971010(+) A-I      intronic chr7:138956217(+) A-I      intronic chr7:138935667(+) A-I      intronic chr7:138956155(+) A-I      intronic chr7:138955762(+) A-I      intronic chr7:138955132(+) A-I      intronic chr7:138955118(+) A-I      intronic chr7:138955084(+) A-I      intronic chr7:138934569(+) A-I      intronic chr7:138973577(+) A-I      intronic chr7:138935652(+) A-I      intronic chr7:138935645(+) A-I      intronic chr7:138935002(+) A-I      intronic chr7:138920270(+) A-I      intronic chr7:138975860(+) A-I      intronic chr7:138920253(+) A-I      intronic chr7:138975878(+) A-I      intronic chr7:138920252(+) A-I      intronic chr7:138973586(+) A-I      intronic chr7:138973587(+) A-I      intronic chr7:138974776(+) A-I      intronic chr7:138973609(+) A-I      intronic chr7:138973650(+) A-I      intronic chr7:138974238(+) A-I      intronic chr7:138974305(+) A-I      intronic chr7:138974358(+) A-I      intronic chr7:138974418(+) A-I      intronic chr7:138975895(+) A-I      intronic chr7:138975923(+) A-I      intronic chr7:138946790(+) A-I      intronic chr7:138975930(+) A-I      intronic chr7:138975945(+) A-I      intronic chr7:138975948(+) A-I      intronic chr7:138975986(+) A-I      intronic chr7:138976032(+) A-I      intronic chr7:138946898(+) A-I      intronic chr7:138922136(+) A-I      intronic chr7:138976579(+) A-I      intronic chr7:138973538(+) A-I      intronic chr7:138976787(+) A-I      intronic chr7:138976064(+) A-I      intronic chr7:138976056(+) A-I      intronic chr7:138946946(+) A-I      intronic chr7:138920427(+) A-I      intronic chr7:138947026(+) A-I      intronic chr7:138948329(+) A-I      intronic chr7:138976869(+) A-I      intronic chr7:138948432(+) A-I      intronic chr7:138974956(+) A-I      intronic chr7:138970883(+) A-I      intronic chr7:138948441(+) A-I      intronic chr7:138922063(+) A-I      intronic chr7:138922143(+) A-I      intronic chr7:138926669(+) A-I      intronic chr7:138920429(+) A-I      intronic chr7:138949980(+) A-I      intronic chr7:138949987(+) A-I      intronic chr7:138970815(+) A-I      intronic chr7:138974701(+) A-I      intronic chr7:138974733(+) A-I      intronic chr7:138920415(+) A-I      intronic chr7:138974739(+) A-I      intronic chr7:138920400(+) A-I      intronic chr7:138926579(+) A-I      intronic chr7:138974740(+) A-I      intronic chr7:138970033(+) A-I      intronic chr7:138974665(+) A-I      intronic chr7:138970069(+) A-I      intronic chr7:138934939(+) A-I      intronic chr7:138974233(+) A-I      intronic chr7:138974927(+) A-I      intronic chr7:138974856(+) A-I      intronic chr7:138950067(+) A-I      intronic chr7:138956174(+) A-I      intronic chr7:138935096(+) A-I      intronic chr7:138926591(+) A-I      intronic chr7:138976920(+) A-I      intronic chr7:138973693(+) A-I      intronic chr7:138974853(+) A-I      intronic chr7:138970694(+) A-I      intronic chr7:138976889(+) A-I      intronic chr7:138974420(+) A-I      intronic chr7:138975852(+) A-I      intronic chr7:138971031(+) A-I      intronic chr7:138973522(+) A-I      intronic chr7:138970813(+) A-I      intronic chr7:138955193(+) A-I      intronic chr7:138973627(+) A-I      intronic chr7:138974431(+) A-I      intronic chr7:138956281(+) A-I      intronic chr7:138949576(+) A-I      intronic chr7:138976515(+) A-I      intronic chr7:138976972(+) A-I      intronic chr7:138949435(+) A-I      intronic chr7:138960487(+) A-I      intronic chr7:138947201(+) A-I      intronic chr7:138973583(+) A-I      intronic chr7:138976959(+) A-I      intronic chr7:138974259(+) A-I      intronic chr7:138974919(+) A-I      intronic chr7:138935254(+) A-I      intronic chr7:138974410(+) A-I      intronic chr7:138970630(+) A-I      intronic chr7:138970839(+) A-I      intronic chr7:138976342(+) A-I      intronic chr7:138956211(+) A-I      intronic chr7:138974338(+) A-I      intronic chr7:138974954(+) A-I      intronic chr7:138970810(+) A-I      intronic chr7:138970835(+) A-I      intronic chr7:138949434(+) A-I      intronic chr7:138973597(+) A-I      intronic chr7:138949439(+) A-I      intronic chr7:138974323(+) A-I      intronic chr7:138976502(+) A-I      intronic chr7:138970854(+) A-I      intronic chr7:138973533(+) A-I      intronic chr7:138924397(+) A-I      intronic chr7:138976915(+) A-I      intronic chr7:138971038(+) A-I      intronic chr7:138934661(+) A-I      intronic chr7:138976879(+) A-I      intronic chr7:138950073(+) A-I      intronic chr7:138971032(+) A-I      intronic chr7:138974785(+) A-I      intronic chr7:138970020(+) A-I      intronic chr7:138970606(+) A-I      intronic chr7:138935079(+) A-I      intronic chr7:138976347(+) A-I      intronic chr7:138974916(+) A-I      intronic chr7:138973705(+) A-I      intronic chr7:138975897(+) A-I      intronic chr7:138935591(+) A-I      intronic chr7:138974432(+) A-I      intronic chr7:138950139(+) A-I      intronic chr7:138934853(+) A-I      intronic chr7:138974276(+) A-I      intronic chr7:138974688(+) A-I      intronic chr7:138973689(+) A-I      intronic chr7:138974779(+) A-I      intronic chr7:138970863(+) A-I      intronic chr7:138976796(+) A-I      intronic chr7:138969979(+) A-I      intronic chr7:138976863(+) A-I      intronic chr7:138976790(+) A-I      intronic chr7:138974303(+) A-I      intronic chr7:138970024(+) A-I      intronic chr7:138973668(+) A-I      intronic chr7:138926676(+) A-I      intronic chr7:138947281(+) A-I      intronic chr7:138947081(+) A-I      intronic chr7:138976738(+) A-I      intronic chr7:138956176(+) A-I      intronic chr7:138976479(+) A-I      intronic chr7:138974434(+) A-I      intronic chr7:138955197(+) A-I      intronic chr7:138959903(+) A-I      intronic chr7:138949387(+) A-I      intronic chr7:138974262(+) A-I      intronic chr7:138976341(+) A-I      intronic chr7:138973541(+) A-I      intronic chr7:138970057(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	UBN2	chr7:138934866(+) A-I intron -    15545495 chr7:138931014(+) G-T intron -    22484847 chr7:138935079(+) A-G intron -    22484847 chr7:138946791(+) A-G intron -    22484847 chr7:138949387(+) A-G intron -    22484847 chr7:138949434(+) A-G intron -    22484847 chr7:138949435(+) A-G intron -    22484847 chr7:138949439(+) A-G intron -    22484847 chr7:138949536(+) A-G intron -    22484847 chr7:138969979(+) A-G intron -    22484847 chr7:138970024(+) A-G intron -    22484847 chr7:138970694(+) A-G intron -    22484847 chr7:138973522(+) A-G intron -    22484847 chr7:138973693(+) A-G intron -    22484847 chr7:138973705(+) A-G intron -    22484847 chr7:138974223(+) A-G intron -    22484847 chr7:138974259(+) A-G intron -    22484847 chr7:138974262(+) A-G intron -    22484847 chr7:138974276(+) A-G intron -    22484847 chr7:138974297(+) A-G intron -    22484847 chr7:138974341(+) A-G intron -    22484847 chr7:138974410(+) A-G intron -    22484847 chr7:138974779(+) A-G intron -    22484847 chr7:138974856(+) A-G intron -    22484847 chr7:138974916(+) A-G intron -    22484847 chr7:138974919(+) A-G intron -    22484847 chr7:138974954(+) A-G intron -    22484847 chr7:138976515(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	UBN2	chr7:138915187-138915188(+) m6A 5'UTR       - chr7:138916633-138916634(+) m6A CDS//intron       24284625 chr7:138943345-138943346(+) m6A CDS       24981863//27773535 chr7:138944107-138944108(+) m6A CDS       24981863//27773535//22608085 chr7:138946162-138946163(+) m6A CDS       24284625//24981863//22608085 chr7:138946203-138946204(+) m6A CDS       24284625//24981863//22608085 chr7:138946230-138946231(+) m6A CDS       24284625//24981863//22608085 chr7:138946258-138946259(+) m6A CDS       24284625//24981863//22608085 chr7:138958049-138958050(+) m6A CDS       24981863 chr7:138958099-138958100(+) m6A CDS       24981863 chr7:138958120-138958121(+) m6A CDS       24981863 chr7:138967926-138967927(+) m6A CDS       24284625//24981863//22608085 chr7:138967992-138967993(+) m6A CDS       24284625//24209618//25456834//24981863//22608085 chr7:138968050-138968051(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr7:138968110-138968111(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr7:138968126-138968127(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr7:138968179-138968180(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr7:138968241-138968242(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr7:138968260-138968261(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr7:138968290-138968291(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr7:138968333-138968334(+) m6A CDS       24284625//24209618//25456834//24981863//22608085 chr7:138968390-138968391(+) m6A CDS       24284625//24209618//25456834//24981863//22608085 chr7:138968463-138968464(+) m6A CDS       24284625//24209618//24981863//27773535//22608085 chr7:138968504-138968505(+) m6A CDS       24284625//24209618//24981863//27773535//22608085 chr7:138968567-138968568(+) m6A CDS       24284625//24209618//24981863//22608085 chr7:138968657-138968658(+) m6A CDS       24284625//24209618//24981863//22608085 chr7:138968764-138968765(+) m6A CDS       24284625//24981863//22608085 chr7:138968800-138968801(+) m6A CDS       24284625//24981863//22608085 chr7:138968872-138968873(+) m6A CDS       24284625//24981863//22608085 chr7:138968986-138968987(+) m6A CDS       24284625//24981863//22608085 chr7:138969003-138969004(+) m6A CDS       24284625//24981863//22608085 chr7:138969013-138969014(+) m6A CDS       24284625//24981863//22608085 chr7:138969102-138969103(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr7:138969119-138969120(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr7:138969132-138969133(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr7:138969206-138969207(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr7:138969224-138969225(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr7:138969236-138969237(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr7:138969253-138969254(+) m6A CDS       24284625//25456834//24981863//22575960//22608085 chr7:138969274-138969275(+) m6A CDS       24284625//25456834//24981863//22608085 chr7:138978143-138978144(+) m6A CDS       24284625//24981863 chr7:138982553-138982554(+) m6A CDS//exon       24284625//24209618//25456834//24981863//22608085 chr7:138982733-138982734(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773535//22608085 chr7:138982836-138982837(+) m6A 3'UTR//exon       24284625//24981863//27773535//22608085 chr7:138982847-138982848(+) m6A 3'UTR//exon       24284625//24981863//27773535//22608085 chr7:138982860-138982861(+) m6A 3'UTR//exon       24284625//24981863//27773535//22608085 chr7:138982926-138982927(+) m6A 3'UTR//exon       24284625//24981863//27773535//22608085 chr7:138982955-138982956(+) m6A 3'UTR//exon       24284625//24981863//27773535//22608085 chr7:138982965-138982966(+) m6A 3'UTR//exon       24284625//24981863//27773535//22608085 chr7:138982993-138982994(+) m6A 3'UTR//exon       24284625//24981863//27773535//22608085 chr7:138983044-138983045(+) m6A 3'UTR//exon       24284625//24981863//27773535//22608085 chr7:138983098-138983099(+) m6A 3'UTR//exon       24981863//22608085 chr7:138983133-138983134(+) m6A 3'UTR//exon       22608085 chr7:138983181-138983182(+) m6A 3'UTR//exon       22608085 chr7:138987351-138987352(+) m6A 3'UTR       24981863 chr7:138987420-138987421(+) m6A 3'UTR       24981863 chr7:138992330-138992331(+) m6A 3'UTR       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	UBN2	Chromatin K562 cells     - Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     - Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: kshv-miR-K12-8-5p
Interactor2: UBN2

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	PARalyzer
Support Database	ViRBase//VIRmiRNA

References:

PMID	22100165	Target region	3'UTR
Source	ViRBase//VIRmiRNA	Interactor1 expression	None
Tissue or cell line	BC-1 cells//BC-3 cells	Interactor2 expression	None
Description	Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.