Detail Information

Basic Information:


  VIRBase ID:  

VHID00493495

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-8-5p:           CANT1:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol kshv-miR-K12-8-5p CANT1
miRBase
Accession/Entrez ID		 MIMAT0015216 124583
Organism Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV) Homo sapiens
Category miRNA mRNA
Alias - DBQD//DBQD1//EDM7//SCAN-1//SCAN1//SHAPY

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR CANT1
chr17:76995864(-) A-I      intronic
chr17:76999254(-) A-I      intronic
chr17:76999255(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED CANT1
chr17:76999254(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase CANT1
chr17:76988000-76988001(-) m6A 3'UTR       24284625//25456834//24981863//26404942//27371828//22575960//22608085
chr17:76988017-76988018(-) m6A 3'UTR       24284625//25456834//24981863//26404942//27371828//22575960//22608085
chr17:76988024-76988025(-) m6A 3'UTR       24284625//25456834//24981863//26404942//27371828//22575960//22608085
chr17:76988181-76988182(-) Cm 3'UTR       -
chr17:76988263-76988264(-) m6A 3'UTR//intron       24284625//25456834//24981863//26404942//27371828//27773536
chr17:76988299-76988300(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//26404942//27371828//27773536
chr17:76988316-76988317(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//26404942//27371828//27773536
chr17:76988496-76988497(-) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr17:76988568-76988569(-) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085
chr17:76988704-76988705(-) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr17:76988732-76988733(-) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr17:76989025-76989026(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr17:76989093-76989094(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr17:76989223-76989224(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr17:76989238-76989239(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr17:76989441-76989442(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr17:76989472-76989473(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr17:76989515-76989516(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr17:76989539-76989540(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr17:76989580-76989581(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr17:76989597-76989598(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr17:76989618-76989619(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr17:76989675-76989676(-) m6A CDS//intron       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr17:76989740-76989741(-) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//27773535//27371828//27773536//22575960//22608085
chr17:76991152-76991153(-) m6A CDS//exon//intron       24284625//24209618//27773536
chr17:76991161-76991162(-) m6A CDS//exon//intron       24284625//24209618//27773536
chr17:76991203-76991204(-) m6A CDS//exon//intron       24284625//24209618//27773535//27371828//27773536
chr17:76991319-76991320(-) m6A exon//intron       24284625//24209618//27773535//27371828//27773536//22575960//22608085
chr17:76993064-76993065(-) m6A CDS//intron       24284625//24209618//27773535//27371828//27773536//22575960//22608085
chr17:76993139-76993140(-) Cm CDS       -
chr17:76993176-76993177(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr17:76993255-76993256(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr17:76993261-76993262(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr17:76993282-76993283(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr17:76993291-76993292(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr17:76993336-76993337(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr17:76993363-76993364(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr17:76993369-76993370(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr17:76993409-76993410(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//27371828//27773536//22575960//22608085
chr17:76993597-76993598(-) m6A CDS       24284625//24209618//27773536//22575960
chr17:76993786-76993787(-) m6A 5'UTR//exon//intron       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085
chr17:76993943-76993944(-) m6A 5'UTR//exon//intron       24284625//24209618//25456834//24981863//27371828//27773536//22608085
chr17:76993976-76993977(-) m6A 5'UTR//exon//intron       24284625//24209618//25456834//24981863//27371828//27773536//22608085
chr17:76994015-76994016(-) m6A 5'UTR//exon//intron       24284625//24209618//25456834//24981863//27371828//27773536//22608085
chr17:76994040-76994041(-) m6A 5'UTR//exon//intron       24284625//24209618//25456834//24981863//27371828//27773536//22608085
chr17:76994260-76994261(-) m6A 5'UTR//exon//intron       24284625//24209618//25456834//24981863//27371828//27773536//22608085
chr17:76994264-76994265(-) m6A 5'UTR//exon//intron       -
chr17:76994268-76994269(-) m6A 5'UTR//exon//intron       24284625//25456834//24981863//27371828//27773536//22608085
chr17:76994274-76994275(-) m6A 5'UTR//exon//intron       24284625//25456834//24981863//27371828//27773536//22608085
chr17:76994343-76994344(-) m6A 5'UTR//exon//intron       25456834//24981863//27371828//27773536
chr17:76996301-76996302(-) m6A 5'UTR//exon//intron       24284625
chr17:76996311-76996312(-) m6A 5'UTR//exon//intron       24284625
chr17:76996316-76996317(-) m6A 5'UTR//exon//intron       24284625
chr17:77001550-77001551(-) m6A 5'UTR//exon//intron       27371828
chr17:77005946-77005947(-) m6A 5'UTR       27773536

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate CANT1
Chromatin K562 cells     -
Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus Retinoblastoma cell lines (Weri-Rb1|Y79)     32366932
Nucleus HeLa-S3 cells|K562 cells     -
Ribosome HEK-293 cells     22199352
Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):


Interactor1: kshv-miR-K12-8-5p
Interactor2: CANT1

Evidence Support:


Weak-Evidence PAR-CLIP
Prediction-Evidence miRanda//PARalyzer//Targetscan
Support Database ViRBase//VIRmiRNA//VmiReg

References:


PMID 22100165 Target region 3'UTR
Source ViRBase//VIRmiRNA//VmiReg Interactor1 expression None
Tissue or cell line BC-1 cells Interactor2 expression None
Description Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.

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