Basic Information:

  VIRBase ID:  

VHID00493005

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-8-5p:  MIMAT0015216          ZNF419:  NM_001098491     

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Interactor Information:

	Interactor1	Interactor2
Symbol	kshv-miR-K12-8-5p	ZNF419
miRBase Accession/Entrez ID	MIMAT0015216	79744
Organism	Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	ZAPHIR//ZNF419A

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	ZNF419	chr19:58000987(+) A-I      intronic chr19:58000997(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	ZNF419	chr19:58004471(+) A-I exon CDS    15258596 chr19:58004569(+) A-I exon CDS    15258596 chr19:58005559(+) A-I exon 3'UTR    15258596

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	ZNF419	chr19:57999099-57999100(+) m6A 5'UTR//exon       24981863 chr19:57999143-57999144(+) m6A 5'UTR//exon       24981863 chr19:58004278-58004279(+) m6A CDS//exon       25456834//24981863//22608085 chr19:58004292-58004293(+) m6A CDS//exon       25456834//24981863//22608085 chr19:58004329-58004330(+) m6A CDS//exon       25456834//24981863//22608085 chr19:58004341-58004342(+) m6A CDS//exon       25456834//24981863//22608085 chr19:58004593-58004594(+) m6A CDS//exon       24284625//24981863//22608085 chr19:58004752-58004753(+) m6A CDS//exon       24284625//22608085 chr19:58005004-58005005(+) m6A CDS//exon       24981863 chr19:58005582-58005583(+) m6A 3'UTR//exon       24284625//24981863//27773535//22608085 chr19:58005598-58005599(+) m6A 3'UTR//exon       24284625//24981863//27773535//22608085 chr19:58005731-58005732(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773535//22608085 chr19:58005737-58005738(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773535//22608085 chr19:58005775-58005776(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773535//22608085 chr19:58005845-58005846(+) m6A 3'UTR//exon       24284625//24981863//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	ZNF419	Exosome Blood     -

Interaction Network (The top 100 interactions):

Interactor1: kshv-miR-K12-8-5p
Interactor2: ZNF419

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	miRanda//PARalyzer//Targetscan
Support Database	ViRBase//VIRmiRNA//VmiReg

References:

PMID	22100165	Target region	3'UTR
Source	ViRBase//VIRmiRNA//VmiReg	Interactor1 expression	None
Tissue or cell line	BC-1 cells	Interactor2 expression	None
Description	Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.