Basic Information:

  VIRBase ID:  

VHID00492823

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-8-5p:  MIMAT0015216          ZNF462:  NM_021224     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	kshv-miR-K12-8-5p	ZNF462
miRBase Accession/Entrez ID	MIMAT0015216	58499
Organism	Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	WSKA//Zfp462//ZFPIP

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	ZNF462	chr9:109686803-109686804(+) m6A CDS//intron       24981863 chr9:109686833-109686834(+) m6A CDS//intron       24981863 chr9:109686846-109686847(+) m6A CDS//intron       24981863 chr9:109686946-109686947(+) m6A CDS//intron       - chr9:109686987-109686988(+) m6A CDS//intron       - chr9:109687023-109687024(+) m6A CDS//intron       - chr9:109687039-109687040(+) m6A CDS//intron       - chr9:109687061-109687062(+) m6A CDS//intron       24981863 chr9:109687327-109687328(+) m6A CDS//intron       24981863//22575960 chr9:109687379-109687380(+) m6A CDS//intron       24981863//22575960 chr9:109687414-109687415(+) m6A CDS//intron       24981863//22575960 chr9:109687471-109687472(+) m6A CDS//intron       24981863 chr9:109687571-109687572(+) m6A CDS//intron       24981863 chr9:109687591-109687592(+) m6A CDS//intron       24981863 chr9:109687644-109687645(+) m6A CDS//intron       24981863 chr9:109687659-109687660(+) m6A CDS//intron       24981863 chr9:109687930-109687931(+) m6A CDS//intron       25456834//24981863 chr9:109688058-109688059(+) m6A CDS//intron       24981863 chr9:109688198-109688199(+) m6A CDS//intron       - chr9:109688272-109688273(+) m6A CDS//intron       24981863 chr9:109688320-109688321(+) m6A CDS//intron       24981863 chr9:109688325-109688326(+) m6A CDS//intron       24981863 chr9:109688378-109688379(+) m6A CDS//intron       24981863 chr9:109688408-109688409(+) m6A CDS//intron       24981863 chr9:109688421-109688422(+) m6A CDS//intron       24981863 chr9:109688430-109688431(+) m6A CDS//intron       24981863 chr9:109688519-109688520(+) m6A CDS//intron       24981863 chr9:109688609-109688610(+) m6A CDS//intron       24981863 chr9:109688656-109688657(+) m6A CDS//intron       24284625//24981863//22575960 chr9:109688671-109688672(+) m6A CDS//intron       24284625//24981863//22575960 chr9:109688690-109688691(+) m6A CDS//intron       24284625//24981863//22575960 chr9:109688696-109688697(+) m6A CDS//intron       24284625//24209618//24981863//26404942//22575960 chr9:109688730-109688731(+) m6A CDS//intron       24284625//24209618//24981863//26404942//22575960 chr9:109688825-109688826(+) m6A CDS//intron       24981863//26404942 chr9:109689212-109689213(+) m6A CDS//exon//intron       24209618 chr9:109689223-109689224(+) m6A CDS//exon//intron       24209618 chr9:109689254-109689255(+) m6A CDS//exon//intron       24209618//24981863 chr9:109689348-109689349(+) m6A CDS//exon//intron       24981863 chr9:109689515-109689516(+) m6A CDS//intron       24209618//24981863 chr9:109689543-109689544(+) m6A CDS//intron       24209618//24981863 chr9:109689600-109689601(+) m6A CDS//intron       24209618//24981863 chr9:109689636-109689637(+) m6A CDS//intron       24209618//24981863 chr9:109689722-109689723(+) m6A CDS//intron       - chr9:109689965-109689966(+) m6A CDS//intron       24981863 chr9:109689975-109689976(+) m6A CDS//intron       24981863 chr9:109690052-109690053(+) m6A CDS//intron       24981863 chr9:109690203-109690204(+) m6A CDS//intron       24981863 chr9:109690236-109690237(+) m6A CDS//intron       24981863 chr9:109690253-109690254(+) m6A CDS//intron       24981863 chr9:109690294-109690295(+) m6A CDS//intron       24981863 chr9:109690310-109690311(+) m6A CDS//intron       24981863 chr9:109690340-109690341(+) m6A CDS//intron       24981863 chr9:109690406-109690407(+) m6A CDS//intron       - chr9:109690484-109690485(+) m6A CDS//intron       - chr9:109690539-109690540(+) m6A CDS//intron       24209618//24981863 chr9:109690709-109690710(+) m6A CDS//intron       24981863 chr9:109690832-109690833(+) m6A CDS//intron       24981863 chr9:109690932-109690933(+) m6A CDS//intron       - chr9:109690965-109690966(+) m6A CDS//intron       - chr9:109691273-109691274(+) m6A CDS//intron       24981863 chr9:109691395-109691396(+) m6A CDS//intron       24981863 chr9:109691810-109691811(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22575960 chr9:109691822-109691823(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22575960 chr9:109691858-109691859(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22575960 chr9:109691892-109691893(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22575960 chr9:109691927-109691928(+) m6A CDS//intron       24209618//25456834//24981863 chr9:109691979-109691980(+) m6A CDS//exon//intron       24209618//25456834//24981863 chr9:109692030-109692031(+) m6A CDS//exon//intron       24981863 chr9:109736786-109736787(+) m6A 3'UTR//intron       25456834 chr9:109736859-109736860(+) m6A 3'UTR//intron       25456834 chr9:109736877-109736878(+) m6A 3'UTR//intron       25456834 chr9:109736884-109736885(+) m6A 3'UTR//intron       25456834 chr9:109765624-109765625(+) m6A CDS       24981863 chr9:109765668-109765669(+) m6A CDS       24981863 chr9:109765686-109765687(+) m6A CDS       24981863 chr9:109771928-109771929(+) m6A CDS//exon       24981863 chr9:109771940-109771941(+) m6A CDS//exon       24981863 chr9:109773165-109773166(+) m6A CDS//exon       24284625//24209618//25456834//24981863 chr9:109773222-109773223(+) m6A CDS//exon       24284625//24209618//25456834//24981863//22575960 chr9:109773242-109773243(+) m6A CDS//exon       24284625//24209618//25456834//24981863//22575960 chr9:109773335-109773336(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960 chr9:109773346-109773347(+) m6A 3'UTR       24209618//25456834//24981863//22575960 chr9:109773393-109773394(+) m6A 3'UTR       24209618//25456834//24981863//22575960 chr9:109773407-109773408(+) m6A 3'UTR       24209618//25456834//24981863//22575960 chr9:109773412-109773413(+) m6A 3'UTR       24209618//25456834//24981863//22575960 chr9:109773430-109773431(+) m6A 3'UTR       24209618//25456834//24981863//22575960 chr9:109773435-109773436(+) m6A 3'UTR       24209618//25456834//24981863//22575960 chr9:109773625-109773626(+) m6A 3'UTR       24209618//24981863 chr9:109773638-109773639(+) m6A 3'UTR       24209618//24981863 chr9:109773662-109773663(+) m6A 3'UTR       24209618//24981863 chr9:109773741-109773742(+) m6A 3'UTR       25456834//24981863 chr9:109773771-109773772(+) m6A 3'UTR       25456834//24981863 chr9:109773778-109773779(+) m6A 3'UTR       25456834//24981863 chr9:109773785-109773786(+) m6A 3'UTR       25456834//24981863 chr9:109773792-109773793(+) m6A 3'UTR       25456834//24981863 chr9:109773806-109773807(+) m6A 3'UTR       25456834//24981863 chr9:109773821-109773822(+) m6A 3'UTR       25456834//24981863 chr9:109773848-109773849(+) m6A 3'UTR       25456834//24981863 chr9:109773862-109773863(+) m6A 3'UTR       25456834//24981863 chr9:109773916-109773917(+) m6A 3'UTR       25456834//24981863 chr9:109773968-109773969(+) m6A 3'UTR       25456834//24981863 chr9:109774046-109774047(+) m6A 3'UTR       24981863 chr9:109774051-109774052(+) m6A 3'UTR       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	ZNF462	Exosome Blood     -

Interaction Network (The top 100 interactions):

Interactor1: kshv-miR-K12-8-5p
Interactor2: ZNF462

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	PARalyzer
Support Database	ViRBase//VIRmiRNA

References:

PMID	22100165	Target region	3'UTR
Source	ViRBase//VIRmiRNA	Interactor1 expression	None
Tissue or cell line	BC-1 cells	Interactor2 expression	None
Description	Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.