Basic Information:

  VIRBase ID:  

VHID00491103

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-8-5p:  MIMAT0015216          CAPN15:  NM_005632     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	kshv-miR-K12-8-5p	CAPN15
miRBase Accession/Entrez ID	MIMAT0015216	6650
Organism	Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	SOLH

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	CAPN15	chr16:592674(+) A-I      intronic chr16:593016(+) A-I      intronic chr16:592924(+) A-I      intronic chr16:592799(+) A-I      intronic chr16:586648(+) A-I      intronic chr16:586615(+) A-I      intronic chr16:586612(+) A-I      intronic chr16:583142(+) A-I      intronic chr16:582487(+) A-I      intronic chr16:582133(+) A-I      intronic chr16:582079(+) A-I      intronic chr16:581324(+) A-I      intronic chr16:581299(+) A-I      intronic chr16:581285(+) A-I      intronic chr16:581268(+) A-I      intronic chr16:581262(+) A-I      intronic chr16:593051(+) A-I      intronic chr16:582557(+) A-I      intronic chr16:592667(+) A-I      intronic chr16:581337(+) A-I      intronic chr16:592657(+) A-I      intronic chr16:582119(+) A-I      intronic chr16:582395(+) A-I      intronic chr16:586640(+) A-I      intronic chr16:592688(+) A-I      intronic chr16:592611(+) A-I      intronic chr16:586698(+) A-I      intronic chr16:592662(+) A-I      intronic chr16:592655(+) A-I      intronic chr16:582056(+) A-I      intronic chr16:592729(+) A-I      intronic chr16:592627(+) A-I      intronic chr16:586606(+) A-I      intronic chr16:586609(+) A-I      intronic chr16:581224(+) A-I      intronic chr16:593001(+) A-I      intronic chr16:582434(+) A-I      intronic chr16:582120(+) A-I      intronic chr16:592904(+) A-I      intronic chr16:581326(+) A-I      intronic chr16:586503(+) A-I      intronic chr16:581298(+) A-I      intronic chr16:593118(+) A-I      intronic chr16:592930(+) A-I      intronic chr16:582160(+) A-I      intronic chr16:592931(+) A-I      intronic chr16:592641(+) A-I      intronic chr16:592692(+) A-I      intronic chr16:592962(+) A-I      intronic chr16:592705(+) A-I      intronic chr16:582215(+) A-I      intronic chr16:582161(+) A-I      intronic chr16:592607(+) A-I      intronic chr16:593095(+) A-I      intronic chr16:586478(+) A-I      intronic chr16:581278(+) A-I      intronic chr16:581284(+) A-I      intronic chr16:581263(+) A-I      intronic chr16:581985(+) A-I      intronic chr16:582055(+) A-I      intronic chr16:592821(+) A-I      intronic chr16:592798(+) A-I      intronic chr16:582435(+) A-I      intronic chr16:592605(+) A-I      intronic chr16:581316(+) A-I      intronic chr16:581738(+) A-I      intronic chr16:592643(+) A-I      intronic chr16:582007(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	CAPN15	chr16:586047-586048(+) m6A 5'UTR//exon//intron       24284625//24209618 chr16:586054-586055(+) m6A 5'UTR//exon//intron       24284625 chr16:588270-588271(+) m6A exon//intron       24981863 chr16:588359-588360(+) m6A exon//intron       24981863//22608085 chr16:588529-588530(+) m6A exon//intron       24284625//24209618//25456834//24981863//22608085 chr16:588580-588581(+) m6A exon//intron       24284625//24209618//24981863//22608085 chr16:588689-588690(+) m6A exon//intron       24209618 chr16:588863-588864(+) m6A exon//intron       24981863 chr16:589084-589085(+) m6A exon//intron       24209618 chr16:589119-589120(+) m6A exon//intron       24209618//24981863 chr16:589218-589219(+) m6A exon//intron       24981863//22608085 chr16:589266-589267(+) m6A exon//intron       25456834//24981863//22608085 chr16:589348-589349(+) m6A exon//intron       25456834//24981863//22608085 chr16:596884-596885(+) m6A CDS//intron       24284625 chr16:597165-597166(+) m6A CDS//intron       24284625//24209618//25456834//24981863//27371828//27773536//22575960//22608085 chr16:597211-597212(+) m6A CDS//intron       24284625//24209618//25456834//24981863//27371828//27773536//22575960//22608085 chr16:597506-597507(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22608085 chr16:597559-597560(+) m6A 5'UTR//CDS       24284625//25456834//24981863//22608085 chr16:597817-597818(+) m6A 5'UTR//CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr16:597895-597896(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr16:597938-597939(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr16:598230-598231(+) m6A CDS       24284625//22575960 chr16:598264-598265(+) m6A CDS       24284625//22575960 chr16:599125-599126(+) m6A CDS       24284625//22575960 chr16:599170-599171(+) m6A CDS       24284625 chr16:599194-599195(+) m6A CDS       24284625 chr16:599325-599326(+) m6A CDS       24284625 chr16:599408-599409(+) m6A CDS       24284625 chr16:602317-602318(+) m6A CDS//exon       24284625 chr16:602332-602333(+) m6A CDS//exon       24284625 chr16:602929-602930(+) m6A CDS//exon       24284625//22575960 chr16:603441-603442(+) m6A CDS//exon//intron       24284625//24981863//22575960 chr16:603456-603457(+) m6A CDS//exon//intron       24284625//24981863//22575960 chr16:603551-603552(+) m6A 3'UTR//exon//intron       24284625//24209618//24981863//22575960 chr16:603584-603585(+) m6A 3'UTR//exon//intron       24284625//24209618//24981863//22575960 chr16:603619-603620(+) m6A 3'UTR//exon//intron       24284625//24209618//24981863//22575960//22608085 chr16:603693-603694(+) m6A 3'UTR//exon//intron       24284625//24209618//24981863 chr16:603745-603746(+) m6A 3'UTR//exon//intron       24284625 chr16:603761-603762(+) m6A 3'UTR//exon//intron       24284625 chr16:603876-603877(+) m6A 3'UTR//exon//intron       24284625//25456834 chr16:603902-603903(+) m6A 3'UTR//exon//intron       24284625//25456834 chr16:603922-603923(+) m6A 3'UTR//exon//intron       24284625//25456834 chr16:604050-604051(+) m1A 3'UTR//exon//intron       26863410 chr16:604200-604201(+) m6A 3'UTR//exon//intron       24284625//25456834//24981863 chr16:604254-604255(+) m6A 3'UTR//exon//intron       24284625 chr16:604446-604447(+) m6A 3'UTR//exon//intron       24284625//24981863 chr16:604533-604534(+) m6A 3'UTR//exon//intron       24284625//24981863//27773535 chr16:604609-604610(+) m6A 3'UTR//exon       24284625

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	CAPN15	Chromatin K562 cells     - Cytosol HeLa-S3 cells|K562 cells     - Exosome Blood     - Nucleolus K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: kshv-miR-K12-8-5p
Interactor2: CAPN15

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	miRanda//PARalyzer//Targetscan
Support Database	ViRBase//VIRmiRNA//VmiReg

References:

PMID	22100165	Target region	3'UTR
Source	ViRBase//VIRmiRNA//VmiReg	Interactor1 expression	None
Tissue or cell line	BC-1 cells//BC-3 cells	Interactor2 expression	None
Description	Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.