Basic Information:

  VIRBase ID:  

VHID00490167

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6040

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-8-5p:  MIMAT0015216          BST2:  NM_004335     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	kshv-miR-K12-8-5p	BST2
miRBase Accession/Entrez ID	MIMAT0015216	684
Organism	Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	CD317//HM1.24//TETHERIN

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	BST2	chr19:17512145(-) A-I      intronic chr19:17512156(-) A-I      intronic chr19:17510983(-) A-I      intronic chr19:17512758(-) A-I      intronic chr19:17512713(-) A-I      intronic chr19:17512211(-) A-I      intronic chr19:17512164(-) A-I      intronic chr19:17512759(-) A-I      intronic chr19:17510977(-) A-I      intronic chr19:17512939(-) A-I      intronic chr19:17512036(-) A-I      intronic chr19:17510967(-) A-I      intronic chr19:17510965(-) A-I      intronic chr19:17510927(-) A-I      intronic chr19:17509551(-) A-I      intronic chr19:17509524(-) A-I      intronic chr19:17509358(-) A-I      intronic chr19:17507840(-) A-I      intronic chr19:17507805(-) A-I      intronic chr19:17507773(-) A-I      intronic chr19:17507671(-) A-I      intronic chr19:17507546(-) A-I      intronic chr19:17504287(-) A-I      intronic chr19:17504294(-) A-I      intronic chr19:17507777(-) A-I      intronic chr19:17512063(-) A-I      intronic chr19:17507533(-) A-I      intronic chr19:17507526(-) A-I      intronic chr19:17507135(-) A-I      intronic chr19:17506766(-) A-I      intronic chr19:17506750(-) A-I      intronic chr19:17506744(-) A-I      intronic chr19:17506726(-) A-I      intronic chr19:17506676(-) A-I      intronic chr19:17506665(-) A-I      intronic chr19:17506640(-) A-I      intronic chr19:17506572(-) A-I      intronic chr19:17506516(-) A-I      intronic chr19:17506407(-) A-I      intronic chr19:17505720(-) A-I      intronic chr19:17505576(-) A-I      intronic chr19:17505458(-) A-I      intronic chr19:17505426(-) A-I      intronic chr19:17504270(-) A-I      intronic chr19:17503742(-) A-I      intronic chr19:17503683(-) A-I      intronic chr19:17503651(-) A-I      intronic chr19:17503569(-) A-I      intronic chr19:17503556(-) A-I      intronic chr19:17503216(-) A-I      intronic chr19:17503185(-) A-I      intronic chr19:17511174(-) A-I      intronic chr19:17511191(-) A-I      intronic chr19:17511217(-) A-I      intronic chr19:17511218(-) A-I      intronic chr19:17503203(-) A-I      intronic chr19:17511255(-) A-I      intronic chr19:17511311(-) A-I      intronic chr19:17511313(-) A-I      intronic chr19:17511316(-) A-I      intronic chr19:17511326(-) A-I      intronic chr19:17511353(-) A-I      intronic chr19:17511865(-) A-I      intronic chr19:17511866(-) A-I      intronic chr19:17511880(-) A-I      intronic chr19:17511045(-) A-I      intronic chr19:17510951(-) A-I      intronic chr19:17511893(-) A-I      intronic chr19:17511897(-) A-I      intronic chr19:17511933(-) A-I      intronic chr19:17512003(-) A-I      intronic chr19:17512059(-) A-I      intronic chr19:17512105(-) A-I      intronic chr19:17512109(-) A-I      intronic chr19:17512165(-) A-I      intronic chr19:17512245(-) A-I      intronic chr19:17512269(-) A-I      intronic chr19:17512326(-) A-I      intronic chr19:17512357(-) A-I      intronic chr19:17512773(-) A-I      intronic chr19:17512858(-) A-I      intronic chr19:17512865(-) A-I      intronic chr19:17512914(-) A-I      intronic chr19:17512915(-) A-I      intronic chr19:17510874(-) A-I      intronic chr19:17510847(-) A-I      intronic chr19:17510537(-) A-I      intronic chr19:17510468(-) A-I      intronic chr19:17510330(-) A-I      intronic chr19:17509547(-) A-I      intronic chr19:17509518(-) A-I      intronic chr19:17509382(-) A-I      intronic chr19:17509345(-) A-I      intronic chr19:17509154(-) A-I      intronic chr19:17508540(-) A-I      intronic chr19:17512975(-) A-I      intronic chr19:17513231(-) A-I      intronic chr19:17513177(-) A-I      intronic chr19:17506561(-) A-I      intronic chr19:17513153(-) A-I      intronic chr19:17513121(-) A-I      intronic chr19:17513111(-) A-I      intronic chr19:17513095(-) A-I      intronic chr19:17508468(-) A-I      intronic chr19:17508398(-) A-I      intronic chr19:17508397(-) A-I      intronic chr19:17508005(-) A-I      intronic chr19:17507996(-) A-I      intronic chr19:17507985(-) A-I      intronic chr19:17507973(-) A-I      intronic chr19:17507960(-) A-I      intronic chr19:17507919(-) A-I      intronic chr19:17507817(-) A-I      intronic chr19:17507798(-) A-I      intronic chr19:17507764(-) A-I      intronic chr19:17507732(-) A-I      intronic chr19:17507693(-) A-I      intronic chr19:17507669(-) A-I      intronic chr19:17507651(-) A-I      intronic chr19:17507579(-) A-I      intronic chr19:17507573(-) A-I      intronic chr19:17507565(-) A-I      intronic chr19:17507552(-) A-I      intronic chr19:17507537(-) A-I      intronic chr19:17505688(-) A-I      intronic chr19:17507876(-) A-I      intronic chr19:17509741(-) A-I      intronic chr19:17511269(-) A-I      intronic chr19:17507093(-) A-I      intronic chr19:17511831(-) A-I      intronic chr19:17511037(-) A-I      intronic chr19:17512837(-) A-I      intronic chr19:17510410(-) A-I      intronic chr19:17503222(-) A-I      intronic chr19:17508556(-) A-I      intronic chr19:17505485(-) A-I      intronic chr19:17507875(-) A-I      intronic chr19:17510331(-) A-I      intronic chr19:17511190(-) A-I      intronic chr19:17506725(-) A-I      intronic chr19:17505537(-) A-I      intronic chr19:17511861(-) A-I      intronic chr19:17509359(-) A-I      intronic chr19:17505563(-) A-I      intronic chr19:17512028(-) A-I      intronic chr19:17507752(-) A-I      intronic chr19:17506398(-) A-I      intronic chr19:17509548(-) A-I      intronic chr19:17510991(-) A-I      intronic chr19:17507913(-) A-I      intronic chr19:17510963(-) A-I      intronic chr19:17503223(-) A-I      intronic chr19:17506502(-) A-I      intronic chr19:17507589(-) A-I      intronic chr19:17511804(-) A-I      intronic chr19:17505750(-) A-I      intronic chr19:17511421(-) A-I      intronic chr19:17512283(-) A-I      intronic chr19:17509363(-) A-I      intronic chr19:17512202(-) A-I      intronic chr19:17506774(-) A-I      intronic chr19:17503655(-) A-I      intronic chr19:17513033(-) A-I      intronic chr19:17506664(-) A-I      intronic chr19:17507742(-) A-I      intronic chr19:17507066(-) A-I      intronic chr19:17504345(-) A-I      intronic chr19:17503629(-) A-I      intronic chr19:17510476(-) A-I      intronic chr19:17507656(-) A-I      intronic chr19:17505719(-) A-I      intronic chr19:17511836(-) A-I      intronic chr19:17506975(-) A-I      intronic chr19:17511433(-) A-I      intronic chr19:17507786(-) A-I      intronic chr19:17512877(-) A-I      intronic chr19:17512135(-) A-I      intronic chr19:17512895(-) A-I      intronic chr19:17508010(-) A-I      intronic chr19:17509414(-) A-I      intronic chr19:17507479(-) A-I      intronic chr19:17512329(-) A-I      intronic chr19:17510407(-) A-I      intronic chr19:17504314(-) A-I      intronic chr19:17506666(-) A-I      intronic chr19:17511169(-) A-I      intronic chr19:17512110(-) A-I      intronic chr19:17507617(-) A-I      intronic chr19:17512933(-) A-I      intronic chr19:17505593(-) A-I      intronic chr19:17511252(-) A-I      intronic chr19:17510464(-) A-I      intronic chr19:17511278(-) A-I      intronic chr19:17503763(-) A-I      intronic chr19:17509142(-) A-I      intronic chr19:17511352(-) A-I      intronic chr19:17503746(-) A-I      intronic chr19:17505390(-) A-I      intronic chr19:17512055(-) A-I      intronic chr19:17511335(-) A-I      intronic chr19:17507168(-) A-I      intronic chr19:17510940(-) A-I      intronic chr19:17506998(-) A-I      intronic chr19:17503717(-) A-I      intronic chr19:17510574(-) A-I      intronic chr19:17511372(-) A-I      intronic chr19:17509200(-) A-I      intronic chr19:17504435(-) A-I      intronic chr19:17506698(-) A-I      intronic chr19:17512111(-) A-I      intronic chr19:17511345(-) A-I      intronic chr19:17512007(-) A-I      intronic chr19:17503163(-) A-I      intronic chr19:17509674(-) A-I      intronic chr19:17512719(-) A-I      intronic chr19:17512746(-) A-I      intronic chr19:17512294(-) A-I      intronic chr19:17507633(-) A-I      intronic chr19:17510891(-) A-I      intronic chr19:17507524(-) A-I      intronic chr19:17507807(-) A-I      intronic chr19:17507478(-) A-I      intronic chr19:17512732(-) A-I      intronic chr19:17511964(-) A-I      intronic chr19:17503704(-) A-I      intronic chr19:17504411(-) A-I      intronic chr19:17509401(-) A-I      intronic chr19:17507768(-) A-I      intronic chr19:17512203(-) A-I      intronic chr19:17503209(-) A-I      intronic chr19:17505391(-) A-I      intronic chr19:17507772(-) A-I      intronic chr19:17505469(-) A-I      intronic chr19:17507100(-) A-I      intronic chr19:17510996(-) A-I      intronic chr19:17509362(-) A-I      intronic chr19:17512814(-) A-I      intronic chr19:17505539(-) A-I      intronic chr19:17513081(-) A-I      intronic chr19:17509652(-) A-I      intronic chr19:17505453(-) A-I      intronic chr19:17505445(-) A-I      intronic chr19:17507870(-) A-I      intronic chr19:17512820(-) A-I      intronic chr19:17510901(-) A-I      intronic chr19:17510385(-) A-I      intronic chr19:17504335(-) A-I      intronic chr19:17507060(-) A-I      intronic chr19:17510942(-) A-I      intronic chr19:17512284(-) A-I      intronic chr19:17511178(-) A-I      intronic chr19:17513034(-) A-I      intronic chr19:17512069(-) A-I      intronic chr19:17513021(-) A-I      intronic chr19:17511036(-) A-I      intronic chr19:17503270(-) A-I      intronic chr19:17506419(-) A-I      intronic chr19:17511266(-) A-I      intronic chr19:17504336(-) A-I      intronic chr19:17512894(-) A-I      intronic chr19:17505427(-) A-I      intronic chr19:17512308(-) A-I      intronic chr19:17503037(-) A-I      intronic chr19:17510318(-) A-I      intronic chr19:17503085(-) A-I      intronic chr19:17506432(-) A-I      intronic chr19:17509174(-) A-I      intronic chr19:17511969(-) A-I      intronic chr19:17503280(-) A-I      intronic chr19:17512855(-) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	BST2	chr19:17513914-17513915(-) m6A 3'UTR       22575960 chr19:17513963-17513964(-) m6A 3'UTR       22575960 chr19:17514002-17514003(-) Cm 3'UTR       - chr19:17514093-17514094(-) m6A 3'UTR//exon       27773536//22575960 chr19:17515269-17515270(-) m6A exon//intron       27371828//22575960 chr19:17515284-17515285(-) m6A exon//intron       27371828//22575960 chr19:17515323-17515324(-) m6A exon//intron       27371828//22575960 chr19:17516403-17516404(-) m6A 5'UTR       24284625//27371828

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	BST2	Chromatin K562 cells     - Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleus HeLa-S3 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: kshv-miR-K12-8-5p
Interactor2: BST2

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	miRanda//PARalyzer//RNAHybrid//Targetscan
Support Database	ViRBase//VmiReg

References:

PMID	22100165	Target region	3'UTR
Source	ViRBase//VmiReg	Interactor1 expression	None
Tissue or cell line	BC-3 cells	Interactor2 expression	None
Description	Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs.