Basic Information:

  VIRBase ID:  

VHID00485990

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-1-3p:  MIMAT0015214          WDFY1:  NM_020830     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	kshv-miR-K12-1-3p	WDFY1
miRBase Accession/Entrez ID	MIMAT0015214	57590
Organism	Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	FENS-1//FENS1//WDF1//ZFYVE17

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	WDFY1	chr2:224762339(-) A-I      intronic chr2:224764319(-) A-I      intronic chr2:224763305(-) A-I      intronic chr2:224764381(-) A-I      intronic chr2:224764462(-) A-I      intronic chr2:224763293(-) A-I      intronic chr2:224763318(-) A-I      intronic chr2:224763290(-) A-I      intronic chr2:224763294(-) A-I      intronic chr2:224763291(-) A-I      intronic chr2:224763327(-) A-I      intronic chr2:224763369(-) A-I      intronic chr2:224763372(-) A-I      intronic chr2:224767187(-) A-I      intronic chr2:224767230(-) A-I      intronic chr2:224767236(-) A-I      intronic chr2:224798797(-) A-I      intronic chr2:224798818(-) A-I      intronic chr2:224798853(-) A-I      intronic chr2:224798922(-) A-I      intronic chr2:224764464(-) A-I      intronic chr2:224763326(-) A-I      intronic chr2:224763301(-) A-I      intronic chr2:224763302(-) A-I      intronic chr2:224735744(-) A-I      intronic chr2:224807779(-) A-I      intronic chr2:224798944(-) A-I      intronic chr2:224799298(-) A-I      intronic chr2:224805732(-) A-I      intronic chr2:224804960(-) A-I      intronic chr2:224804812(-) A-I      intronic chr2:224803732(-) A-I      intronic chr2:224803710(-) A-I      intronic chr2:224807715(-) A-I      intronic chr2:224807678(-) A-I      intronic chr2:224784126(-) A-I      intronic chr2:224807454(-) A-I      intronic chr2:224807422(-) A-I      intronic chr2:224807381(-) A-I      intronic chr2:224784060(-) A-I      intronic chr2:224777875(-) A-I      intronic chr2:224770192(-) A-I      intronic chr2:224770142(-) A-I      intronic chr2:224768140(-) A-I      intronic chr2:224767993(-) A-I      intronic chr2:224767976(-) A-I      intronic chr2:224764350(-) A-I      intronic chr2:224764341(-) A-I      intronic chr2:224764296(-) A-I      intronic chr2:224764279(-) A-I      intronic chr2:224764227(-) A-I      intronic chr2:224763413(-) A-I      intronic chr2:224763350(-) A-I      intronic chr2:224763339(-) A-I      intronic chr2:224784131(-) A-I      intronic chr2:224763283(-) A-I      intronic chr2:224763279(-) A-I      intronic chr2:224760835(-) A-I      intronic chr2:224760826(-) A-I      intronic chr2:224760804(-) A-I      intronic chr2:224756917(-) A-I      intronic chr2:224756886(-) A-I      intronic chr2:224756824(-) A-I      intronic chr2:224755876(-) A-I      intronic chr2:224754984(-) A-I      intronic chr2:224754971(-) A-I      intronic chr2:224749644(-) A-I      intronic chr2:224748627(-) A-I      intronic chr2:224747542(-) A-I      intronic chr2:224747483(-) A-I      intronic chr2:224739460(-) A-I      intronic chr2:224739371(-) A-I      intronic chr2:224737452(-) A-I      intronic chr2:224737426(-) A-I      intronic chr2:224737414(-) A-I      intronic chr2:224736741(-) A-I      intronic chr2:224736740(-) A-I      intronic chr2:224735862(-) A-I      intronic chr2:224735683(-) A-I      intronic chr2:224735680(-) A-I      intronic chr2:224735679(-) A-I      intronic chr2:224735675(-) A-I      intronic chr2:224734810(-) A-I      intronic chr2:224734804(-) A-I      intronic chr2:224733732(-) A-I      intronic chr2:224731397(-) A-I      intronic chr2:224729184(-) A-I      intronic chr2:224729217(-) A-I      intronic chr2:224784065(-) A-I      intronic chr2:224729256(-) A-I      intronic chr2:224730630(-) A-I      intronic chr2:224731391(-) A-I      intronic chr2:224784066(-) A-I      intronic chr2:224807364(-) A-I      intronic chr2:224807358(-) A-I      intronic chr2:224805862(-) A-I      intronic chr2:224805733(-) A-I      intronic chr2:224801006(-) A-I      intronic chr2:224799426(-) A-I      intronic chr2:224799407(-) A-I      intronic chr2:224788320(-) A-I      intronic chr2:224788356(-) A-I      intronic chr2:224788391(-) A-I      intronic chr2:224788402(-) A-I      intronic chr2:224798557(-) A-I      intronic chr2:224763319(-) A-I      intronic chr2:224798559(-) A-I      intronic chr2:224798584(-) A-I      intronic chr2:224798596(-) A-I      intronic chr2:224798632(-) A-I      intronic chr2:224798635(-) A-I      intronic chr2:224799375(-) A-I      intronic chr2:224729116(-) A-I      intronic chr2:224760790(-) A-I      intronic chr2:224729036(-) A-I      intronic chr2:224727485(-) A-I      intronic chr2:224721847(-) A-I      intronic chr2:224721704(-) A-I      intronic chr2:224798873(-) A-I      intronic chr2:224798917(-) A-I      intronic chr2:224807901(-) A-I      intronic chr2:224807851(-) A-I      intronic chr2:224729218(-) A-I      intronic chr2:224720581(-) A-I      ncRNA chr2:224736558(-) A-I      intronic chr2:224730629(-) A-I      intronic chr2:224807822(-) A-I      intronic chr2:224798303(-) A-I      intronic chr2:224733714(-) A-I      intronic chr2:224793970(-) A-I      intronic chr2:224804973(-) A-I      intronic chr2:224798863(-) A-I      intronic chr2:224733564(-) A-I      intronic chr2:224804896(-) A-I      intronic chr2:224731324(-) A-I      intronic chr2:224798320(-) A-I      intronic chr2:224769093(-) A-I      intronic chr2:224799353(-) A-I      intronic chr2:224798365(-) A-I      intronic chr2:224763202(-) A-I      intronic chr2:224747102(-) A-I      intronic chr2:224764411(-) A-I      intronic chr2:224807640(-) A-I      intronic chr2:224763322(-) A-I      intronic chr2:224756017(-) A-I      intronic chr2:224756832(-) A-I      intronic chr2:224789173(-) A-I      intronic chr2:224763245(-) A-I      intronic chr2:224725195(-) A-I      intronic chr2:224804953(-) A-I      intronic chr2:224756875(-) A-I      intronic chr2:224749737(-) A-I      intronic chr2:224725885(-) A-I      intronic chr2:224749710(-) A-I      intronic chr2:224799376(-) A-I      intronic chr2:224768558(-) A-I      intronic chr2:224799340(-) A-I      intronic chr2:224799526(-) A-I      intronic chr2:224722250(-) A-I      intronic chr2:224730615(-) A-I      intronic chr2:224734644(-) A-I      intronic chr2:224721843(-) A-I      intronic chr2:224735738(-) A-I      intronic chr2:224763219(-) A-I      intronic chr2:224725674(-) A-I      intronic chr2:224798810(-) A-I      intronic chr2:224798327(-) A-I      intronic chr2:224798970(-) A-I      intronic chr2:224763401(-) A-I      intronic chr2:224807854(-) A-I      intronic chr2:224735746(-) A-I      intronic chr2:224784127(-) A-I      intronic chr2:224735650(-) A-I      intronic chr2:224730564(-) A-I      intronic chr2:224756024(-) A-I      intronic chr2:224753758(-) A-I      intronic chr2:224795251(-) A-I      intronic chr2:224749585(-) A-I      intronic chr2:224800943(-) A-I      intronic chr2:224786370(-) A-I      intronic chr2:224749661(-) A-I      intronic chr2:224798418(-) A-I      intronic chr2:224735814(-) A-I      intronic chr2:224807524(-) A-I      intronic chr2:224723975(-) A-I      intronic chr2:224804992(-) A-I      intronic chr2:224760630(-) A-I      intronic chr2:224735656(-) A-I      intronic chr2:224736622(-) A-I      intronic chr2:224760678(-) A-I      intronic chr2:224768073(-) A-I      intronic chr2:224729042(-) A-I      intronic chr2:224735854(-) A-I      intronic chr2:224795079(-) A-I      intronic chr2:224804790(-) A-I      intronic chr2:224731323(-) A-I      intronic chr2:224730652(-) A-I      intronic chr2:224805365(-) A-I      intronic chr2:224798902(-) A-I      intronic chr2:224764380(-) A-I      intronic chr2:224724628(-) A-I      intronic chr2:224756965(-) A-I      intronic chr2:224724207(-) A-I      intronic chr2:224734709(-) A-I      intronic chr2:224781638(-) A-I      intronic chr2:224798513(-) A-I      intronic chr2:224806943(-) A-I      intronic chr2:224755936(-) A-I      intronic chr2:224735817(-) A-I      intronic chr2:224807718(-) A-I      intronic chr2:224768232(-) A-I      intronic chr2:224751347(-) A-I      intronic chr2:224805812(-) A-I      intronic chr2:224763355(-) A-I      intronic chr2:224763292(-) A-I      intronic chr2:224751364(-) A-I      intronic chr2:224768367(-) A-I      intronic chr2:224753880(-) A-I      intronic chr2:224722263(-) A-I      intronic chr2:224763213(-) A-I      intronic chr2:224798360(-) A-I      intronic chr2:224783156(-) A-I      intronic chr2:224735716(-) A-I      intronic chr2:224803723(-) A-I      intronic chr2:224731284(-) A-I      intronic chr2:224798395(-) A-I      intronic chr2:224769065(-) A-I      intronic chr2:224768622(-) A-I      intronic chr2:224748644(-) A-I      intronic chr2:224755023(-) A-I      intronic chr2:224800946(-) A-I      intronic chr2:224768443(-) A-I      intronic chr2:224788440(-) A-I      intronic chr2:224803674(-) A-I      intronic chr2:224749723(-) A-I      intronic chr2:224756870(-) A-I      intronic chr2:224760704(-) A-I      intronic chr2:224768439(-) A-I      intronic chr2:224798290(-) A-I      intronic chr2:224750127(-) A-I      intronic chr2:224746393(-) A-I      intronic chr2:224770179(-) A-I      intronic chr2:224768506(-) A-I      intronic chr2:224798610(-) A-I      intronic chr2:224731326(-) A-I      intronic chr2:224735708(-) A-I      intronic chr2:224728181(-) A-I      intronic chr2:224747869(-) A-I      intronic chr2:224732306(-) A-I      intronic chr2:224805851(-) A-I      intronic chr2:224760787(-) A-I      intronic chr2:224725254(-) A-I      intronic chr2:224789260(-) A-I      intronic chr2:224807101(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	WDFY1	chr2:224753880(-) A-G intron -    22484847 chr2:224755875(-) A-G intron -    22484847 chr2:224755927(-) A-G intron -    22484847 chr2:224755930(-) A-G intron -    22484847 chr2:224756024(-) A-G intron -    22484847 chr2:224756832(-) A-G intron -    22484847 chr2:224756875(-) A-G intron -    22484847 chr2:224758241(-) A-G intron -    22484847 chr2:224760787(-) A-G intron -    22484847 chr2:224763152(-) A-G intron -    22484847 chr2:224763171(-) A-G intron -    22484847 chr2:224764473(-) C-T intron -    22484847 chr2:224767166(-) A-G intron -    22484847 chr2:224768068(-) A-G intron -    22484847 chr2:224768073(-) A-G intron -    22484847 chr2:224768232(-) A-G intron -    22484847 chr2:224768622(-) A-G intron -    22484847 chr2:224769065(-) A-G intron -    22484847 chr2:224769093(-) A-G intron -    22484847 chr2:224769101(-) A-G intron -    22484847 chr2:224770179(-) A-G intron -    22484847 chr2:224777879(-) A-G intron -    22484847 chr2:224784116(-) A-G intron -    22484847 chr2:224784127(-) A-G intron -    22484847 chr2:224789173(-) A-G intron -    22484847 chr2:224798360(-) A-G intron -    22484847 chr2:224798365(-) A-G intron -    22484847 chr2:224798417(-) A-G intron -    22484847 chr2:224798418(-) A-G intron -    22484847 chr2:224798439(-) A-G intron -    22484847 chr2:224798595(-) A-G intron -    22484847 chr2:224799340(-) A-G intron -    22484847 chr2:224799502(-) A-G intron -    22484847 chr2:224799511(-) A-G intron -    22484847 chr2:224804896(-) A-G intron -    22484847 chr2:224807718(-) A-G intron -    22484847 chr2:224807822(-) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	WDFY1	chr2:224720585-224720586(-) m6A exon       24981863 chr2:224720593-224720594(-) m6A exon       24981863 chr2:224741781-224741782(-) m6A 3'UTR//intron       27773535 chr2:224741800-224741801(-) m6A 3'UTR//intron       27773535 chr2:224741806-224741807(-) m6A 3'UTR//intron       27773535 chr2:224741891-224741892(-) m6A 3'UTR//intron       24981863//27773535//22608085 chr2:224741917-224741918(-) m6A 3'UTR//intron       27773535//22608085 chr2:224741950-224741951(-) m6A 3'UTR//intron       24981863//27773535//22608085 chr2:224741958-224741959(-) m6A 3'UTR//intron       24981863//27773535//22608085 chr2:224741984-224741985(-) m6A 3'UTR//intron       24981863//22608085 chr2:224742022-224742023(-) m6A 3'UTR//intron       22608085 chr2:224743025-224743026(-) m6A 3'UTR//intron       27773535 chr2:224743052-224743053(-) m6A 3'UTR//intron       24981863//27773535//22608085 chr2:224743073-224743074(-) m6A 3'UTR//intron       24981863//27773535//22608085 chr2:224743085-224743086(-) m6A 3'UTR//intron       24981863//27773535//22608085 chr2:224743135-224743136(-) m6A 3'UTR//intron       24981863//27773535//22608085 chr2:224743147-224743148(-) m6A 3'UTR//intron       24284625//24209618//24981863//27773535//22608085 chr2:224743167-224743168(-) m6A 3'UTR//intron       24284625//24209618//24981863//27773535//22608085 chr2:224743207-224743208(-) m6A 3'UTR//intron       24284625//24209618//24981863//27773535//22608085 chr2:224743221-224743222(-) m6A 3'UTR//intron       24284625//24209618//24981863//27773535//22608085 chr2:224743277-224743278(-) m6A 3'UTR//exon       24284625//24981863//27371828//22608085 chr2:224743294-224743295(-) m6A 3'UTR//exon       24284625//24981863//27371828 chr2:224743355-224743356(-) m6A 3'UTR//exon       24284625//24981863//27371828 chr2:224743439-224743440(-) m6A CDS       24284625//27773535//27371828 chr2:224744857-224744858(-) m6A CDS       24284625//27773535//27371828 chr2:224744876-224744877(-) m6A CDS       27773535//27371828 chr2:224744889-224744890(-) m6A CDS       27773535//27371828 chr2:224744915-224744916(-) m6A CDS       27773535//27371828 chr2:224744944-224744945(-) m6A CDS       27773535//27371828 chr2:224760265-224760266(-) m6A CDS//exon       27773535 chr2:224760322-224760323(-) m6A CDS//exon       27773535 chr2:224763681-224763682(-) m6A CDS//exon       27773535 chr2:224763712-224763713(-) m6A CDS//exon       27773535 chr2:224763717-224763718(-) m6A CDS//exon       27773535 chr2:224765680-224765681(-) m6A exon//intron       27773535 chr2:224765796-224765797(-) m6A exon//intron       27773535 chr2:224782700-224782701(-) m6A CDS//exon       27371828//27773536 chr2:224809867-224809868(-) m6A CDS//exon       27371828//27773536 chr2:224810002-224810003(-) m6A 5'UTR//exon       24981863//27371828//27773536 chr2:224810078-224810079(-) m6A 5'UTR       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	WDFY1	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Insoluble cytoplasm HCC cell line (HepG2)     - Membrane HCC cell line (HepG2)     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: kshv-miR-K12-1-3p
Interactor2: WDFY1

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	miRanda//PARalyzer//Targetscan
Support Database	ViRBase//VIRmiRNA//VmiReg

References:

PMID	22100165	Target region	3'UTR
Source	ViRBase//VIRmiRNA//VmiReg	Interactor1 expression	None
Tissue or cell line	BC-1 cells	Interactor2 expression	None
Description	Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.