Basic Information:

  VIRBase ID:  

VHID00485981

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-1-3p:  MIMAT0015214          ARRDC3:  NM_001329672     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	kshv-miR-K12-1-3p	ARRDC3
miRBase Accession/Entrez ID	MIMAT0015214	57561
Organism	Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	TLIMP

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	ARRDC3	chr5:90665238-90665239(-) m6A 3'UTR       27773535 chr5:90666204-90666205(-) m6A 3'UTR       - chr5:90666260-90666261(-) m6A 3'UTR       27773535 chr5:90666357-90666358(-) m6A 3'UTR       24284625//24981863//27773535//22608085 chr5:90666486-90666487(-) m6A 3'UTR       24284625//24209618//24981863//27773535//27371828//22575960//22608085 chr5:90666600-90666601(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr5:90666693-90666694(-) m6A 3'UTR//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr5:90666745-90666746(-) m6A 3'UTR//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr5:90666761-90666762(-) m6A 3'UTR//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr5:90666766-90666767(-) m6A 3'UTR//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr5:90666793-90666794(-) m6A 3'UTR//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr5:90666811-90666812(-) m6A 3'UTR//exon       24284625//24209618//24981863//27773535//22575960//22608085 chr5:90666942-90666943(-) m6A 3'UTR//exon       24284625//24981863//26404942//27773535//22575960//22608085 chr5:90666993-90666994(-) m6A 3'UTR//exon       24284625//24981863//26404942//27773535//22575960//22608085 chr5:90667036-90667037(-) m6A 3'UTR//exon       24284625//24981863//27773535//22575960//22608085 chr5:90667080-90667081(-) m6A 3'UTR//exon       24284625//24981863//27773535//22575960//22608085 chr5:90667136-90667137(-) m6A 3'UTR//exon       24284625//24209618//24981863//27773535//22575960//22608085 chr5:90667155-90667156(-) m6A 3'UTR//exon       24284625//24209618//24981863//27773535//22575960//22608085 chr5:90667177-90667178(-) m6A 3'UTR//exon       24284625//24981863//27773535//22575960//22608085 chr5:90667211-90667212(-) m6A 3'UTR//exon       24284625//24981863//22608085 chr5:90667237-90667238(-) m6A CDS//exon       24981863 chr5:90669609-90669610(-) m6A CDS//exon       - chr5:90669620-90669621(-) m6A CDS//exon       - chr5:90669937-90669938(-) m6A CDS       - chr5:90669965-90669966(-) m6A CDS       - chr5:90670002-90670003(-) m6A CDS       - chr5:90679119-90679120(-) m6A 5'UTR       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	ARRDC3	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol K562 cells     - Exosome Blood     - Nucleoplasm K562 cells     - Nucleus K562 cells     - Ribosome HEK-293 cells     22199352

Interaction Network (The top 100 interactions):

Interactor1: kshv-miR-K12-1-3p
Interactor2: ARRDC3

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	miRanda//PARalyzer//Targetscan
Support Database	ViRBase//VIRmiRNA//VmiReg

References:

PMID	22100165	Target region	3'UTR
Source	ViRBase//VIRmiRNA//VmiReg	Interactor1 expression	None
Tissue or cell line	BC-1 cells	Interactor2 expression	None
Description	Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.