Basic Information:

  VIRBase ID:  

VHID00485855

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-1-3p:  MIMAT0015214          ZNF701:  NM_001172655     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	kshv-miR-K12-1-3p	ZNF701
miRBase Accession/Entrez ID	MIMAT0015214	55762
Organism	Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	-

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	ZNF701	chr19:53087650(+) A-I      3'UTR chr19:53087636(+) A-I      3'UTR chr19:53087620(+) A-I      3'UTR chr19:53082547(+) A-I      intronic chr19:53082150(+) A-I      intronic chr19:53081392(+) A-I      intronic chr19:53080575(+) A-I      intronic chr19:53080573(+) A-I      intronic chr19:53080533(+) A-I      intronic chr19:53080514(+) A-I      intronic chr19:53080489(+) A-I      intronic chr19:53079532(+) A-I      intronic chr19:53079635(+) A-I      intronic chr19:53080432(+) A-I      intronic chr19:53080482(+) A-I      intronic chr19:53078773(+) A-I      intronic chr19:53089380(+) A-I      3'UTR chr19:53089556(+) A-I      3'UTR chr19:53080446(+) A-I      intronic chr19:53080371(+) A-I      intronic chr19:53083084(+) A-I      intronic chr19:53083214(+) A-I      intronic chr19:53080429(+) A-I      intronic chr19:53082032(+) A-I      intronic chr19:53084504(+) A-I      intronic chr19:53083059(+) A-I      intronic chr19:53081275(+) A-I      intronic chr19:53089769(+) A-I      3'UTR chr19:53082661(+) A-I      intronic chr19:53089770(+) A-I      3'UTR chr19:53083663(+) A-I      intronic chr19:53079647(+) A-I      intronic chr19:53079746(+) A-I      intronic chr19:53089555(+) A-I      3'UTR chr19:53079629(+) A-I      intronic chr19:53087633(+) A-I      3'UTR chr19:53079748(+) A-I      intronic chr19:53089557(+) A-I      3'UTR chr19:53081266(+) A-I      intronic chr19:53079555(+) A-I      intronic chr19:53080536(+) A-I      intronic chr19:53082629(+) A-I      intronic chr19:53081253(+) A-I      intronic chr19:53080414(+) A-I      intronic chr19:53079592(+) A-I      intronic chr19:53083016(+) A-I      intronic chr19:53084870(+) A-I      intronic chr19:53084550(+) A-I      intronic chr19:53079727(+) A-I      intronic chr19:53076460(+) A-I      intronic chr19:53080454(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	ZNF701	chr19:53083059(+) A-G intron -    22484847 chr19:53087633(+) A-G intron -    22484847 chr19:53089557(+) A-G intron -    22484847 chr19:53089776(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	ZNF701	chr19:53059096-53059097(+) m6A exon       24284625 chr19:53059121-53059122(+) m6A exon       24284625//24981863 chr19:53059178-53059179(+) m6A exon       24284625//24981863 chr19:53059199-53059200(+) m6A exon       24284625//24981863 chr19:53059262-53059263(+) m6A exon       24284625//24981863 chr19:53059316-53059317(+) m6A intron       24284625 chr19:53059475-53059476(+) m6A intron       - chr19:53066846-53066847(+) m6A intron       24284625 chr19:53066879-53066880(+) m6A intron       24284625 chr19:53066919-53066920(+) m6A intron       - chr19:53066954-53066955(+) m6A intron       - chr19:53067013-53067014(+) m6A intron       - chr19:53067020-53067021(+) m6A intron       - chr19:53067029-53067030(+) m6A intron       - chr19:53067238-53067239(+) m6A intron       24284625//25456834 chr19:53067251-53067252(+) m6A intron       24284625//25456834 chr19:53067259-53067260(+) m6A intron       24284625//25456834 chr19:53067343-53067344(+) m6A intron       24284625 chr19:53067418-53067419(+) m6A intron       24284625//24981863 chr19:53067453-53067454(+) m6A intron       24284625//25456834//24981863 chr19:53067466-53067467(+) m6A intron       24284625//25456834//24981863 chr19:53067573-53067574(+) m6A intron       24981863 chr19:53067579-53067580(+) m6A intron       24981863 chr19:53077344-53077345(+) m6A 5'UTR//CDS//exon       25456834 chr19:53077364-53077365(+) m6A 5'UTR//CDS//exon       25456834 chr19:53085497-53085498(+) m6A CDS       22608085 chr19:53085528-53085529(+) m6A CDS       22608085 chr19:53085627-53085628(+) m6A CDS       22608085 chr19:53085657-53085658(+) m6A CDS       22608085 chr19:53086007-53086008(+) m6A CDS       24981863//22608085 chr19:53086030-53086031(+) m6A CDS       24981863//22608085 chr19:53086063-53086064(+) m6A CDS       24981863//22608085 chr19:53086666-53086667(+) m6A CDS       22608085 chr19:53086685-53086686(+) m6A CDS       22608085 chr19:53086746-53086747(+) m6A 3'UTR       22608085 chr19:53086765-53086766(+) m6A 3'UTR       22608085 chr19:53086783-53086784(+) m6A 3'UTR       22608085 chr19:53086868-53086869(+) m6A 3'UTR       22608085 chr19:53086952-53086953(+) m6A 3'UTR       25456834//24981863//22608085 chr19:53087036-53087037(+) m6A 3'UTR       24981863//22608085 chr19:53087093-53087094(+) m6A 3'UTR       22608085 chr19:53087155-53087156(+) m6A 3'UTR       22608085 chr19:53087364-53087365(+) m6A 3'UTR       - chr19:53087481-53087482(+) m6A 3'UTR       24981863//22608085 chr19:53087541-53087542(+) m6A 3'UTR       24284625//24981863//22608085 chr19:53088453-53088454(+) m6A 3'UTR       - chr19:53089985-53089986(+) m6A 3'UTR       25456834 chr19:53090061-53090062(+) m6A 3'UTR       25456834 chr19:53090088-53090089(+) m6A 3'UTR       25456834

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	ZNF701	Exosome Blood     - Nucleolus K562 cells     - Nucleus HeLa-S3 cells     -

Interaction Network (The top 100 interactions):

Interactor1: kshv-miR-K12-1-3p
Interactor2: ZNF701

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	miRanda//PARalyzer//Targetscan
Support Database	ViRBase//VmiReg

References:

PMID	22100165	Target region	3'UTR
Source	ViRBase//VmiReg	Interactor1 expression	None
Tissue or cell line	BC-1 cells	Interactor2 expression	None
Description	Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.