Basic Information:

  VIRBase ID:  

VHID00485768

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-1-3p:  MIMAT0015214          GID8:  NM_017896     

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Interactor Information:

	Interactor1	Interactor2
Symbol	kshv-miR-K12-1-3p	GID8
miRBase Accession/Entrez ID	MIMAT0015214	54994
Organism	Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	C20orf11//TWA1

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	GID8	chr20:61571854(+) A-I      intronic chr20:61570395(+) A-I      intronic chr20:61573565(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	GID8	chr20:61572871-61572872(+) m6A CDS       24981863 chr20:61572936-61572937(+) m6A CDS       24981863 chr20:61572942-61572943(+) m6A CDS       24981863 chr20:61572957-61572958(+) m6A CDS       24981863 chr20:61574424-61574425(+) Am CDS       - chr20:61574882-61574883(+) m6A CDS       24981863 chr20:61575015-61575016(+) m6A CDS       24284625//24209618//22575960//22608085 chr20:61576149-61576150(+) m6A CDS       24284625//24209618//24981863//27773535//22575960//22608085 chr20:61576167-61576168(+) m6A CDS       24284625//24209618//24981863//27773535//22575960//22608085 chr20:61576196-61576197(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr20:61576229-61576230(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr20:61576310-61576311(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr20:61576359-61576360(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr20:61576436-61576437(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr20:61576659-61576660(+) m6A 3'UTR       24284625//24209618//24981863 chr20:61576908-61576909(+) m6A 3'UTR       24209618 chr20:61576931-61576932(+) m6A 3'UTR       24209618 chr20:61577311-61577312(+) m6A 3'UTR       - chr20:61577380-61577381(+) m6A 3'UTR       - chr20:61577443-61577444(+) m6A 3'UTR       - chr20:61577700-61577701(+) m6A 3'UTR       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	GID8	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Insoluble cytoplasm K562 cells     - Membrane HCC cell line (HepG2)     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: kshv-miR-K12-1-3p
Interactor2: GID8

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	miRanda//PARalyzer//Targetscan
Support Database	ViRBase//VIRmiRNA//VmiReg

References:

PMID	22100165	Target region	3'UTR
Source	ViRBase//VIRmiRNA//VmiReg	Interactor1 expression	None
Tissue or cell line	BC-1 cells	Interactor2 expression	None
Description	Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.