Detail Information

Basic Information:


  VIRBase ID:  

VHID00483795

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-11-5p:           ZFP82:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol kshv-miR-K12-11-5p ZFP82
miRBase
Accession/Entrez ID		 MIMAT0015213 284406
Organism Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV) Homo sapiens
Category miRNA mRNA
Alias - ZNF545

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR ZFP82
chr19:36907582(-) A-I      intronic
chr19:36907595(-) A-I      intronic
chr19:36907601(-) A-I      intronic
chr19:36904108(-) A-I      intronic
chr19:36904096(-) A-I      intronic
chr19:36907558(-) A-I      intronic
chr19:36907619(-) A-I      intronic
chr19:36907575(-) A-I      intronic
chr19:36909051(-) A-I      intronic
chr19:36904110(-) A-I      intronic
chr19:36889377(-) A-I      intronic
chr19:36877595(-) A-I      intronic
chr19:36877622(-) A-I      intronic
chr19:36880116(-) A-I      intronic
chr19:36880159(-) A-I      intronic
chr19:36889339(-) A-I      intronic
chr19:36887360(-) A-I      intronic
chr19:36887482(-) A-I      intronic
chr19:36888132(-) A-I      intronic
chr19:36905333(-) A-I      intronic
chr19:36893623(-) A-I      intronic
chr19:36909033(-) A-I      intronic
chr19:36905884(-) A-I      intronic
chr19:36905355(-) A-I      intronic
chr19:36905351(-) A-I      intronic
chr19:36905342(-) A-I      intronic
chr19:36880109(-) A-I      intronic
chr19:36888669(-) A-I      intronic
chr19:36904941(-) A-I      intronic
chr19:36877676(-) A-I      intronic
chr19:36887648(-) A-I      intronic
chr19:36901587(-) A-I      intronic
chr19:36905814(-) A-I      intronic
chr19:36888654(-) A-I      intronic
chr19:36904230(-) A-I      intronic
chr19:36877756(-) A-I      intronic
chr19:36880158(-) A-I      intronic
chr19:36886938(-) A-I      intronic
chr19:36888760(-) A-I      intronic
chr19:36880133(-) A-I      intronic
chr19:36877634(-) A-I      intronic
chr19:36904237(-) A-I      intronic
chr19:36901526(-) A-I      intronic
chr19:36901451(-) A-I      intronic
chr19:36907730(-) A-I      intronic
chr19:36893716(-) A-I      intronic
chr19:36880235(-) A-I      intronic
chr19:36877755(-) A-I      intronic
chr19:36886922(-) A-I      intronic
chr19:36886858(-) A-I      intronic
chr19:36877774(-) A-I      intronic
chr19:36880118(-) A-I      intronic
chr19:36886935(-) A-I      intronic
chr19:36880117(-) A-I      intronic
chr19:36893873(-) A-I      intronic
chr19:36904299(-) A-I      intronic
chr19:36886860(-) A-I      intronic
chr19:36908941(-) A-I      intronic
chr19:36887174(-) A-I      intronic
chr19:36880049(-) A-I      intronic
chr19:36878592(-) A-I      intronic
chr19:36888628(-) A-I      intronic
chr19:36907718(-) A-I      intronic
chr19:36904116(-) A-I      intronic
chr19:36877682(-) A-I      intronic
chr19:36880122(-) A-I      intronic
chr19:36878655(-) A-I      intronic
chr19:36880213(-) A-I      intronic
chr19:36901533(-) A-I      intronic
chr19:36877798(-) A-I      intronic
chr19:36888178(-) A-I      intronic
chr19:36888660(-) A-I      intronic
chr19:36904261(-) A-I      intronic
chr19:36889344(-) A-I      intronic
chr19:36878654(-) A-I      intronic
chr19:36893181(-) A-I      intronic
chr19:36894400(-) A-I      intronic
chr19:36882465(-) A-I      intronic
chr19:36882521(-) A-I      intronic
chr19:36880080(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED ZFP82
chr19:36886858(-) A-I intron -    15342557
chr19:36886860(-) A-I intron -    15342557
chr19:36886909(-) A-I intron -    15342557
chr19:36886922(-) A-I intron -    15342557
chr19:36886935(-) A-I intron -    15342557
chr19:36886938(-) A-I intron -    15342557
chr19:36886964(-) A-T intron -    22484847
chr19:36887006(-) G-A intron -    22484847
chr19:36887013(-) C-A intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase ZFP82
chr19:36881317-36881318(-) m6A exon//intron       27773535
chr19:36881342-36881343(-) m6A exon//intron       27773535
chr19:36881359-36881360(-) m6A exon//intron       27773535
chr19:36881382-36881383(-) m6A exon//intron       24981863//27773535
chr19:36881408-36881409(-) m6A exon//intron       24981863//27773535
chr19:36881439-36881440(-) m6A exon//intron       24981863//27773535
chr19:36881471-36881472(-) m6A exon//intron       24981863//27773535
chr19:36881515-36881516(-) m6A exon//intron       24981863//27773535
chr19:36881570-36881571(-) m6A exon//intron       24981863//27773535
chr19:36881630-36881631(-) m6A exon//intron       24981863//27773535//27371828
chr19:36881661-36881662(-) m6A exon//intron       27773535//27371828
chr19:36881666-36881667(-) m6A exon//intron       27773535//27371828
chr19:36881671-36881672(-) m6A exon//intron       27371828
chr19:36881678-36881679(-) m6A exon//intron       27371828
chr19:36881685-36881686(-) m6A exon//intron       27371828
chr19:36881697-36881698(-) m6A exon//intron       27371828
chr19:36881703-36881704(-) m6A exon//intron       27371828
chr19:36881766-36881767(-) m6A exon//intron       27371828
chr19:36882542-36882543(-) m6A exon//intron       25456834//24981863
chr19:36882561-36882562(-) m6A exon//intron       25456834//24981863
chr19:36882584-36882585(-) m6A exon//intron       25456834//24981863
chr19:36882666-36882667(-) m6A exon//intron       25456834//24981863
chr19:36882679-36882680(-) m6A exon//intron       25456834//24981863
chr19:36882856-36882857(-) m6A exon//intron       27773535
chr19:36882897-36882898(-) m6A 3'UTR//exon//intron       24981863//27773535
chr19:36882964-36882965(-) m6A 3'UTR//exon//intron       24981863//27773535
chr19:36883007-36883008(-) m6A 3'UTR//exon//intron       24981863//27773535
chr19:36883036-36883037(-) m6A 3'UTR//exon//intron       24981863//27773535
chr19:36883069-36883070(-) m6A 3'UTR//exon//intron       24981863//27773535
chr19:36883099-36883100(-) m6A 3'UTR//exon//intron       24981863//27773535
chr19:36883120-36883121(-) m6A 3'UTR//exon//intron       24981863//27773535
chr19:36883158-36883159(-) m6A 3'UTR//exon//intron       24981863//27773535
chr19:36883198-36883199(-) m6A 3'UTR//exon//intron       24981863//27773535
chr19:36883395-36883396(-) m6A 3'UTR//exon//intron       24981863//27773535
chr19:36883438-36883439(-) m6A 3'UTR//exon//intron       24981863//27773535
chr19:36883465-36883466(-) m6A 3'UTR//exon//intron       24981863//27773535
chr19:36883488-36883489(-) m6A 3'UTR//exon//intron       24981863//27773535
chr19:36883495-36883496(-) m6A 3'UTR//exon//intron       27773535
chr19:36883777-36883778(-) m6A CDS//exon//intron       24981863//27773535
chr19:36883813-36883814(-) m6A CDS//exon//intron       24981863//27773535
chr19:36883849-36883850(-) m6A CDS//exon//intron       24981863//27773535
chr19:36883897-36883898(-) m6A CDS//exon//intron       24981863//27773535
chr19:36883945-36883946(-) m6A CDS//exon//intron       24981863//27773535
chr19:36884065-36884066(-) m6A CDS//exon//intron       27773535
chr19:36884121-36884122(-) m6A CDS//exon//intron       27773535
chr19:36884149-36884150(-) m6A CDS//exon//intron       27773535
chr19:36884233-36884234(-) m6A CDS//exon//intron       27773535
chr19:36884251-36884252(-) m6A CDS//exon//intron       27773535
chr19:36884365-36884366(-) m6A CDS//exon//intron       24981863//27773535
chr19:36884401-36884402(-) m6A CDS//exon//intron       24981863//27773535
chr19:36884440-36884441(-) m6A CDS//exon//intron       25456834//24981863//27773535//27371828
chr19:36884569-36884570(-) m6A CDS//exon//intron       25456834//24981863//27773535//27371828
chr19:36884587-36884588(-) m6A CDS//exon//intron       25456834//24981863//27773535//27371828
chr19:36884617-36884618(-) m6A CDS//exon//intron       25456834//24981863//27773535//27371828
chr19:36884653-36884654(-) m6A CDS//exon//intron       25456834//24981863//27773535//27371828
chr19:36884737-36884738(-) m6A CDS//exon//intron       25456834//24981863//27773535//27371828
chr19:36884755-36884756(-) m6A CDS//exon//intron       25456834//24981863//27773535//27371828
chr19:36884845-36884846(-) m6A CDS//exon//intron       25456834//24981863//27773535//27371828
chr19:36884854-36884855(-) m6A CDS//exon//intron       25456834//24981863//27773535//27371828
chr19:36884915-36884916(-) m6A CDS//exon//intron       27773535

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate ZFP82
Cytosol HCC cell line (HepG2)     -
Exosome Blood     -

Interaction Network (The top 100 interactions):


Interactor1: kshv-miR-K12-11-5p
Interactor2: ZFP82

Evidence Support:


Weak-Evidence PAR-CLIP
Prediction-Evidence cRep//miRanda//PARalyzer
Support Database RepTar//ViRBase//VIRmiRNA//VmiReg

References:


PMID 22100165 Target region 3'UTR
Source RepTar//ViRBase//VIRmiRNA//VmiReg Interactor1 expression None
Tissue or cell line BC-1 cells Interactor2 expression None
Description Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.

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