Basic Information:

  VIRBase ID:  

VHID00483671

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6040

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-11-5p:  MIMAT0015213          DCP2:  NM_001242377     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	kshv-miR-K12-11-5p	DCP2
miRBase Accession/Entrez ID	MIMAT0015213	167227
Organism	Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	NUDT20

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	DCP2	chr5:112347926(+) A-I      intronic chr5:112346171(+) A-I      intronic chr5:112346030(+) A-I      intronic chr5:112345816(+) A-I      intronic chr5:112345804(+) A-I      intronic chr5:112343374(+) A-I      intronic chr5:112343356(+) A-I      intronic chr5:112343355(+) A-I      intronic chr5:112343282(+) A-I      intronic chr5:112343273(+) A-I      intronic chr5:112343250(+) A-I      intronic chr5:112343227(+) A-I      intronic chr5:112343184(+) A-I      intronic chr5:112342675(+) A-I      intronic chr5:112341696(+) A-I      intronic chr5:112340776(+) A-I      intronic chr5:112340668(+) A-I      intronic chr5:112340578(+) A-I      intronic chr5:112339238(+) A-I      intronic chr5:112339162(+) A-I      intronic chr5:112338406(+) A-I      intronic chr5:112338402(+) A-I      intronic chr5:112338383(+) A-I      intronic chr5:112338354(+) A-I      intronic chr5:112338287(+) A-I      intronic chr5:112338039(+) A-I      intronic chr5:112338000(+) A-I      intronic chr5:112337973(+) A-I      intronic chr5:112335924(+) A-I      intronic chr5:112335916(+) A-I      intronic chr5:112335894(+) A-I      intronic chr5:112335593(+) A-I      intronic chr5:112335484(+) A-I      intronic chr5:112335208(+) A-I      intronic chr5:112335192(+) A-I      intronic chr5:112333411(+) A-I      intronic chr5:112329235(+) A-I      intronic chr5:112329234(+) A-I      intronic chr5:112329160(+) A-I      intronic chr5:112324139(+) A-I      intronic chr5:112324134(+) A-I      intronic chr5:112324078(+) A-I      intronic chr5:112324074(+) A-I      intronic chr5:112323999(+) A-I      intronic chr5:112323964(+) A-I      intronic chr5:112323946(+) A-I      intronic chr5:112323925(+) A-I      intronic chr5:112323414(+) A-I      intronic chr5:112323410(+) A-I      intronic chr5:112342676(+) A-I      intronic chr5:112335205(+) A-I      intronic chr5:112323393(+) A-I      intronic chr5:112323392(+) A-I      intronic chr5:112323354(+) A-I      intronic chr5:112323351(+) A-I      intronic chr5:112323267(+) A-I      intronic chr5:112322482(+) A-I      intronic chr5:112322099(+) A-I      intronic chr5:112335246(+) A-I      intronic chr5:112344621(+) A-I      intronic chr5:112348420(+) A-I      intronic chr5:112347930(+) A-I      intronic chr5:112342630(+) A-I      intronic chr5:112346109(+) A-I      intronic chr5:112335143(+) A-I      intronic chr5:112335460(+) A-I      intronic chr5:112338472(+) A-I      intronic chr5:112343357(+) A-I      intronic chr5:112347906(+) A-I      intronic chr5:112338285(+) A-I      intronic chr5:112320453(+) A-I      intronic chr5:112322085(+) A-I      intronic chr5:112343237(+) A-I      intronic chr5:112341672(+) A-I      intronic chr5:112323229(+) A-I      intronic chr5:112335500(+) A-I      intronic chr5:112335890(+) A-I      intronic chr5:112342568(+) A-I      intronic chr5:112323371(+) A-I      intronic chr5:112324117(+) A-I      intronic chr5:112343304(+) A-I      intronic chr5:112345634(+) A-I      intronic chr5:112344680(+) A-I      intronic chr5:112335651(+) A-I      intronic chr5:112342556(+) A-I      intronic chr5:112322093(+) A-I      intronic chr5:112322660(+) A-I      intronic chr5:112323996(+) A-I      intronic chr5:112338262(+) A-I      intronic chr5:112352678(+) A-I      3'UTR chr5:112352639(+) A-I      3'UTR chr5:112337958(+) A-I      intronic chr5:112345809(+) A-I      intronic chr5:112348415(+) A-I      intronic chr5:112342684(+) A-I      intronic chr5:112335083(+) A-I      intronic chr5:112335999(+) A-I      intronic chr5:112329112(+) A-I      intronic chr5:112347936(+) A-I      intronic chr5:112322149(+) A-I      intronic chr5:112342741(+) A-I      intronic chr5:112338297(+) A-I      intronic chr5:112342688(+) A-I      intronic chr5:112345829(+) A-I      intronic chr5:112343354(+) A-I      intronic chr5:112322058(+) A-I      intronic chr5:112330104(+) A-I      intronic chr5:112316839(+) A-I      intronic chr5:112345663(+) A-I      intronic chr5:112323224(+) A-I      intronic chr5:112323433(+) A-I      intronic chr5:112342677(+) A-I      intronic chr5:112323250(+) A-I      intronic chr5:112348410(+) A-I      intronic chr5:112348480(+) A-I      intronic chr5:112347998(+) A-I      intronic chr5:112324068(+) A-I      intronic chr5:112348380(+) A-I      intronic chr5:112323279(+) A-I      intronic chr5:112323181(+) A-I      intronic chr5:112342646(+) A-I      intronic chr5:112338455(+) A-I      intronic chr5:112338061(+) A-I      intronic chr5:112342747(+) A-I      intronic chr5:112323992(+) A-I      intronic chr5:112322269(+) A-I      intronic chr5:112340665(+) A-I      intronic chr5:112323941(+) A-I      intronic chr5:112322094(+) A-I      intronic chr5:112337864(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	DCP2	chr5:112342715(+) A-I intron -    22327324 chr5:112340228(+) A-I intron -    21960545 chr5:112322058(+) A-G intron -    22484847 chr5:112322084(+) A-G intron -    22484847 chr5:112322085(+) A-G intron -    22484847 chr5:112322093(+) A-G intron -    22484847 chr5:112322094(+) A-G intron -    22484847 chr5:112322149(+) A-G intron -    22484847 chr5:112323371(+) A-G intron -    22484847 chr5:112323432(+) A-G intron -    22484847 chr5:112323930(+) A-G intron -    22484847 chr5:112323992(+) A-G intron -    22484847 chr5:112324068(+) A-G intron -    22484847 chr5:112324117(+) A-G intron -    22484847 chr5:112335081(+) A-G intron -    22484847 chr5:112335083(+) A-G intron -    22484847 chr5:112335126(+) A-G intron -    22484847 chr5:112335143(+) A-G intron -    22484847 chr5:112335247(+) A-G intron -    22484847 chr5:112335500(+) A-G intron -    22484847 chr5:112335917(+) A-G intron -    22484847 chr5:112335999(+) A-G intron -    22484847 chr5:112336000(+) A-G intron -    22484847 chr5:112337999(+) A-G intron -    22484847 chr5:112338061(+) A-G intron -    22484847 chr5:112338262(+) A-G intron -    22484847 chr5:112338272(+) A-G intron -    22484847 chr5:112338285(+) A-G intron -    22484847 chr5:112338297(+) A-G intron -    22484847 chr5:112340665(+) A-G intron -    22484847 chr5:112342630(+) A-G intron -    22484847 chr5:112342677(+) A-G intron -    22484847 chr5:112342679(+) A-G intron -    22484847 chr5:112342682(+) A-G intron -    22484847 chr5:112342683(+) A-G intron -    22484847 chr5:112342684(+) A-G intron -    22484847 chr5:112342715(+) A-G intron -    22484847 chr5:112342747(+) A-G intron -    22484847 chr5:112343304(+) A-G intron -    22484847 chr5:112343357(+) A-G intron -    22484847 chr5:112347906(+) A-G intron -    22484847 chr5:112347907(+) A-G intron -    22484847 chr5:112347936(+) A-G intron -    22484847 chr5:112348410(+) A-G intron -    22484847 chr5:112352678(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	DCP2	chr5:112319695-112319696(+) m6A exon//intron       27773535 chr5:112319723-112319724(+) m6A exon//intron       27773535 chr5:112319731-112319732(+) m6A exon//intron       27773535 chr5:112319736-112319737(+) m6A exon//intron       27773535 chr5:112319769-112319770(+) m6A exon//intron       24209618//27773535 chr5:112319829-112319830(+) m6A exon//intron       24284625//24209618//24981863//27773535//22608085 chr5:112319842-112319843(+) m6A exon//intron       24284625//24209618//24981863//27773535//22608085 chr5:112319848-112319849(+) m6A exon//intron       24284625//24209618//24981863//27773535//22608085 chr5:112319860-112319861(+) m6A exon//intron       24284625//24209618//24981863//27773535//22608085 chr5:112319881-112319882(+) m6A exon//intron       24284625//24209618//25456834//24981863//27773535//22608085 chr5:112319923-112319924(+) m6A exon//intron       24284625//24209618//25456834//24981863//27773535//22608085 chr5:112320050-112320051(+) m6A exon//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr5:112320068-112320069(+) m6A exon//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr5:112320160-112320161(+) m6A exon//intron       24284625//24209618//25456834//24981863//22608085 chr5:112320197-112320198(+) m6A exon//intron       24284625//24209618//24981863//22608085 chr5:112320208-112320209(+) m6A exon//intron       24284625//24209618//24981863//22608085 chr5:112320293-112320294(+) m6A exon//intron       - chr5:112320324-112320325(+) m6A exon//intron       - chr5:112343792-112343793(+) m6A exon//intron       22608085 chr5:112343996-112343997(+) m6A exon//intron       22608085 chr5:112346466-112346467(+) m6A CDS       24284625//24981863//22608085 chr5:112346481-112346482(+) m6A CDS       24284625//24981863//22608085 chr5:112346500-112346501(+) m6A CDS       24284625//24981863//22608085 chr5:112349050-112349051(+) m6A CDS       24284625//24981863//22608085 chr5:112349063-112349064(+) m6A CDS       24284625//24981863//22608085 chr5:112349075-112349076(+) m6A CDS       24284625//24981863//22608085 chr5:112349096-112349097(+) m6A CDS       24284625//24981863//22608085 chr5:112349173-112349174(+) m6A CDS       24284625//24981863//22608085 chr5:112349218-112349219(+) m6A 3'UTR       24284625//24981863//22608085 chr5:112349303-112349304(+) m6A 3'UTR       22608085 chr5:112356518-112356519(+) m6A 3'UTR       27773535 chr5:112356592-112356593(+) m6A 3'UTR       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	DCP2	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)     - Exosome Blood     - Membrane K562 cells     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)     - Ribosome HEK-293 cells     22199352 Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: kshv-miR-K12-11-5p
Interactor2: DCP2

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	cRep//miRanda//PARalyzer//Targetscan
Support Database	RepTar//ViRBase//VIRmiRNA//VmiReg

References:

PMID	22100165	Target region	3'UTR
Source	RepTar//ViRBase//VIRmiRNA//VmiReg	Interactor1 expression	None
Tissue or cell line	BC-1 cells//BC-3 cells	Interactor2 expression	None
Description	Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.