Basic Information:

  VIRBase ID:  

VHID00483351

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-11-5p:  MIMAT0015213          TSLP:  NM_138551     

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Interactor Information:

	Interactor1	Interactor2
Symbol	kshv-miR-K12-11-5p	TSLP
miRBase Accession/Entrez ID	MIMAT0015213	85480
Organism	Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	-

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	TSLP	chr5:110411835-110411836(+) m6A 3'UTR       22608085 chr5:110411862-110411863(+) m6A 3'UTR       22608085 chr5:110412072-110412073(+) m6A 3'UTR       24981863//22608085 chr5:110412103-110412104(+) m6A 3'UTR       24981863//22608085 chr5:110412122-110412123(+) m6A 3'UTR       24981863//22608085 chr5:110412137-110412138(+) m6A 3'UTR       24981863//22608085 chr5:110412178-110412179(+) m6A 3'UTR       24981863//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	TSLP	Exosome Blood     -

Interaction Network (The top 100 interactions):

Interactor1: kshv-miR-K12-11-5p
Interactor2: TSLP

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	cRep//miRanda//PARalyzer
Support Database	RepTar//ViRBase//VmiReg

References:

PMID	22100165	Target region	3'UTR
Source	RepTar//ViRBase//VmiReg	Interactor1 expression	None
Tissue or cell line	BC-3 cells	Interactor2 expression	None
Description	Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs.