Basic Information:

  VIRBase ID:  

VHID00483206

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6040

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-11-5p:  MIMAT0015213          PGAP1:  NM_001321099     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	kshv-miR-K12-11-5p	PGAP1
miRBase Accession/Entrez ID	MIMAT0015213	80055
Organism	Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	Bst1//ISPD3024//MRT42//SPG67

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	PGAP1	chr2:197766981(-) A-I      intronic chr2:197766989(-) A-I      intronic chr2:197743913(-) A-I      intronic chr2:197720915(-) A-I      intronic chr2:197743909(-) A-I      intronic chr2:197720922(-) A-I      intronic chr2:197743936(-) A-I      intronic chr2:197720917(-) A-I      intronic chr2:197720919(-) A-I      intronic chr2:197720913(-) A-I      intronic chr2:197743900(-) A-I      intronic chr2:197766961(-) A-I      intronic chr2:197720908(-) A-I      intronic chr2:197720894(-) A-I      intronic chr2:197720870(-) A-I      intronic chr2:197766970(-) A-I      intronic chr2:197727498(-) A-I      intronic chr2:197728387(-) A-I      intronic chr2:197754802(-) A-I      intronic chr2:197727559(-) A-I      intronic chr2:197720041(-) A-I      intronic chr2:197720898(-) A-I      intronic chr2:197720129(-) A-I      intronic chr2:197752045(-) A-I      intronic chr2:197752032(-) A-I      intronic chr2:197752026(-) A-I      intronic chr2:197751996(-) A-I      intronic chr2:197751984(-) A-I      intronic chr2:197751599(-) A-I      intronic chr2:197751590(-) A-I      intronic chr2:197751586(-) A-I      intronic chr2:197743945(-) A-I      intronic chr2:197735117(-) A-I      intronic chr2:197735106(-) A-I      intronic chr2:197729067(-) A-I      intronic chr2:197729032(-) A-I      intronic chr2:197729014(-) A-I      intronic chr2:197728986(-) A-I      intronic chr2:197728897(-) A-I      intronic chr2:197727530(-) A-I      intronic chr2:197728881(-) A-I      intronic chr2:197718888(-) A-I      intronic chr2:197720019(-) A-I      intronic chr2:197728521(-) A-I      intronic chr2:197728482(-) A-I      intronic chr2:197728478(-) A-I      intronic chr2:197728440(-) A-I      intronic chr2:197720857(-) A-I      intronic chr2:197720106(-) A-I      intronic chr2:197720043(-) A-I      intronic chr2:197728439(-) A-I      intronic chr2:197702255(-) A-I      3'UTR chr2:197702232(-) A-I      3'UTR chr2:197751453(-) A-I      intronic chr2:197751944(-) A-I      intronic chr2:197743903(-) A-I      intronic chr2:197767035(-) A-I      intronic chr2:197714126(-) A-I      intronic chr2:197744319(-) A-I      intronic chr2:197725093(-) A-I      intronic chr2:197779724(-) A-I      intronic chr2:197719906(-) A-I      intronic chr2:197729045(-) A-I      intronic chr2:197743912(-) A-I      intronic chr2:197735136(-) A-I      intronic chr2:197751160(-) A-I      intronic chr2:197787533(-) A-I      intronic chr2:197751022(-) A-I      intronic chr2:197714152(-) A-I      intronic chr2:197702328(-) A-I      3'UTR chr2:197702159(-) A-I      3'UTR chr2:197703716(-) A-I      3'UTR chr2:197702104(-) A-I      3'UTR chr2:197702311(-) A-I      3'UTR chr2:197727520(-) A-I      intronic chr2:197751600(-) A-I      intronic chr2:197727603(-) A-I      intronic chr2:197720820(-) A-I      intronic chr2:197754862(-) A-I      intronic chr2:197743883(-) A-I      intronic chr2:197754734(-) A-I      intronic chr2:197728957(-) A-I      intronic chr2:197718880(-) A-I      intronic chr2:197754796(-) A-I      intronic chr2:197727486(-) A-I      intronic chr2:197728466(-) A-I      intronic chr2:197779669(-) A-I      intronic chr2:197720875(-) A-I      intronic chr2:197719928(-) A-I      intronic chr2:197751601(-) A-I      intronic chr2:197767034(-) A-I      intronic chr2:197788457(-) A-I      intronic chr2:197720107(-) A-I      intronic chr2:197767037(-) A-I      intronic chr2:197721014(-) A-I      intronic chr2:197719594(-) A-I      intronic chr2:197743935(-) A-I      intronic chr2:197720987(-) A-I      intronic chr2:197729051(-) A-I      intronic chr2:197787516(-) A-I      intronic chr2:197728410(-) A-I      intronic chr2:197751592(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	PGAP1	chr2:197718693(-) A-G intron -    22484847 chr2:197720107(-) A-G intron -    22484847 chr2:197720820(-) A-G intron -    22484847 chr2:197720987(-) A-G intron -    22484847 chr2:197727520(-) A-G intron -    22484847 chr2:197728462(-) A-G intron -    22484847 chr2:197728466(-) A-G intron -    22484847 chr2:197728575(-) A-G intron -    22484847 chr2:197728931(-) A-G intron -    22484847 chr2:197728957(-) A-G intron -    22484847 chr2:197735136(-) A-G intron -    22484847 chr2:197743894(-) A-G intron -    22484847 chr2:197744319(-) A-G intron -    22484847 chr2:197751600(-) A-G intron -    22484847 chr2:197751601(-) A-G intron -    22484847 chr2:197751604(-) A-G intron -    22484847 chr2:197751663(-) C-G intron -    22484847 chr2:197752094(-) G-A intron -    22484847 chr2:197754796(-) A-G intron -    22484847 chr2:197754805(-) A-G intron -    22484847 chr2:197764694(-) T-C intron -    22484847 chr2:197779669(-) A-G intron -    22484847 chr2:197779724(-) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	PGAP1	chr2:197698364-197698365(-) m6A 3'UTR       27773535 chr2:197698388-197698389(-) m6A 3'UTR       27773535 chr2:197698435-197698436(-) m6A 3'UTR       27773535 chr2:197699190-197699191(-) m6A 3'UTR       27773535 chr2:197699212-197699213(-) m6A 3'UTR       27773535 chr2:197699248-197699249(-) m6A 3'UTR       27773535 chr2:197699253-197699254(-) m6A 3'UTR       27773535 chr2:197700309-197700310(-) m6A 3'UTR       27773535//22608085 chr2:197700318-197700319(-) m6A 3'UTR       27773535//22608085 chr2:197700337-197700338(-) m6A 3'UTR       27773535//22608085 chr2:197700397-197700398(-) m6A 3'UTR       27773535//22608085 chr2:197700431-197700432(-) m6A 3'UTR       27773535//22608085 chr2:197700490-197700491(-) m6A 3'UTR       27773535//22608085 chr2:197700531-197700532(-) m6A 3'UTR       27773535//22608085 chr2:197700565-197700566(-) m6A 3'UTR       27773535//22608085 chr2:197700995-197700996(-) m6A 3'UTR       27773535 chr2:197705748-197705749(-) Y 3'UTR//intron       26075521 chr2:197705853-197705854(-) m6A 3'UTR//intron       24981863//22608085 chr2:197705875-197705876(-) m6A 3'UTR//intron       24981863//22608085 chr2:197705897-197705898(-) m6A 3'UTR//intron       24981863//22608085 chr2:197705950-197705951(-) m6A 3'UTR//intron       22608085 chr2:197707515-197707516(-) m6A 3'UTR//CDS//exon//intron       27773535 chr2:197707536-197707537(-) m6A 3'UTR//CDS//exon//intron       27773535 chr2:197791432-197791433(-) m6A 5'UTR//exon//intron       27773536

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	PGAP1	Chromatin K562 cells     - Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytosol HCC cell line (HepG2)     - Exosome Blood     - Insoluble cytoplasm HCC cell line (HepG2)     - Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus HCC cell line (HepG2)     -

Interaction Network (The top 100 interactions):

Interactor1: kshv-miR-K12-11-5p
Interactor2: PGAP1

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	cRep//miRanda//PARalyzer//Targetscan
Support Database	RepTar//ViRBase//VIRmiRNA//VmiReg

References:

PMID	22100165	Target region	3'UTR
Source	RepTar//ViRBase//VIRmiRNA//VmiReg	Interactor1 expression	None
Tissue or cell line	BC-1 cells	Interactor2 expression	None
Description	Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.