Basic Information:

  VIRBase ID:  

VHID00481554

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-11-5p:  MIMAT0015213          IL2RB:  NM_000878     

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Interactor Information:

	Interactor1	Interactor2
Symbol	kshv-miR-K12-11-5p	IL2RB
miRBase Accession/Entrez ID	MIMAT0015213	3560
Organism	Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	CD122//IL15RB//IMD63//P70-75

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	IL2RB	chr22:37527914(-) A-I      intronic chr22:37534094(-) A-I      intronic chr22:37528046(-) A-I      intronic chr22:37527915(-) A-I      intronic chr22:37527837(-) A-I      intronic chr22:37526950(-) A-I      intronic chr22:37527144(-) A-I      intronic chr22:37527082(-) A-I      intronic chr22:37527125(-) A-I      intronic chr22:37527955(-) A-I      intronic chr22:37527176(-) A-I      intronic chr22:37527024(-) A-I      intronic chr22:37527954(-) A-I      intronic chr22:37527873(-) A-I      intronic chr22:37527098(-) A-I      intronic chr22:37527095(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	IL2RB	chr22:37527098(-) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	IL2RB	chr22:37522465-37522466(-) m6A 3'UTR       28052920 chr22:37522501-37522502(-) m6A 3'UTR       28052920 chr22:37523654-37523655(-) m6A 3'UTR       28052920 chr22:37523688-37523689(-) m6A 3'UTR       28052920 chr22:37524619-37524620(-) m6A CDS//exon       - chr22:37539596-37539597(-) m6A CDS//exon       27371828 chr22:37545904-37545905(-) m6A 5'UTR//intron       27371828 chr22:37557862-37557863(-) m6A 5'UTR//intron       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	IL2RB	Exosome Blood     -

Interaction Network (The top 100 interactions):

Interactor1: kshv-miR-K12-11-5p
Interactor2: IL2RB

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	PARalyzer
Support Database	ViRBase

References:

PMID	22100165	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	BC-1 cells//BC-3 cells	Interactor2 expression	None
Description	Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.