Basic Information:

  VIRBase ID:  

VHID00479995

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-10a-5p:  MIMAT0015212          EXOC1:  NM_001024924     

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Interactor Information:

	Interactor1	Interactor2
Symbol	kshv-miR-K12-10a-5p	EXOC1
miRBase Accession/Entrez ID	MIMAT0015212	55763
Organism	Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	BM-102//SEC3//SEC3L1//SEC3P

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	EXOC1	chr4:56762544(+) A-I      intronic chr4:56762549(+) A-I      intronic chr4:56763846(+) A-I      intronic chr4:56764002(+) A-I      intronic chr4:56764211(+) A-I      intronic chr4:56764312(+) A-I      intronic chr4:56764343(+) A-I      intronic chr4:56764332(+) A-I      intronic chr4:56729166(+) A-I      intronic chr4:56729540(+) A-I      intronic chr4:56729735(+) A-I      intronic chr4:56757046(+) A-I      intronic chr4:56757081(+) A-I      intronic chr4:56760332(+) A-I      intronic chr4:56760333(+) A-I      intronic chr4:56760335(+) A-I      intronic chr4:56760344(+) A-I      intronic chr4:56760360(+) A-I      intronic chr4:56760368(+) A-I      intronic chr4:56760370(+) A-I      intronic chr4:56760432(+) A-I      intronic chr4:56760491(+) A-I      intronic chr4:56760925(+) A-I      intronic chr4:56761016(+) A-I      intronic chr4:56762390(+) A-I      intronic chr4:56762395(+) A-I      intronic chr4:56762396(+) A-I      intronic chr4:56762445(+) A-I      intronic chr4:56762455(+) A-I      intronic chr4:56764348(+) A-I      intronic chr4:56762457(+) A-I      intronic chr4:56762477(+) A-I      intronic chr4:56763386(+) A-I      intronic chr4:56729167(+) A-I      intronic chr4:56759338(+) A-I      intronic chr4:56760968(+) A-I      intronic chr4:56761065(+) A-I      intronic chr4:56760853(+) A-I      intronic chr4:56760962(+) A-I      intronic chr4:56729548(+) A-I      intronic chr4:56760440(+) A-I      intronic chr4:56759496(+) A-I      intronic chr4:56762337(+) A-I      intronic chr4:56760276(+) A-I      intronic chr4:56761022(+) A-I      intronic chr4:56760954(+) A-I      intronic chr4:56757055(+) A-I      intronic chr4:56760869(+) A-I      intronic chr4:56760241(+) A-I      intronic chr4:56760215(+) A-I      intronic chr4:56760307(+) A-I      intronic chr4:56762380(+) A-I      intronic chr4:56762545(+) A-I      intronic chr4:56760483(+) A-I      intronic chr4:56760281(+) A-I      intronic chr4:56760420(+) A-I      intronic chr4:56729670(+) A-I      intronic chr4:56760448(+) A-I      intronic chr4:56729703(+) A-I      intronic chr4:56752664(+) A-I      intronic chr4:56762339(+) A-I      intronic chr4:56760889(+) A-I      intronic chr4:56760941(+) A-I      intronic chr4:56760213(+) A-I      intronic chr4:56761010(+) A-I      intronic chr4:56760266(+) A-I      intronic chr4:56760330(+) A-I      intronic chr4:56760271(+) A-I      intronic chr4:56760357(+) A-I      intronic chr4:56761064(+) A-I      intronic chr4:56735441(+) A-I      intronic chr4:56759425(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	EXOC1	chr4:56760307(+) A-I intron -    15258596 chr4:56760330(+) A-I intron -    15258596 chr4:56760331(+) A-I intron -    15258596 chr4:56729131(+) A-G intron -    22484847 chr4:56729167(+) A-G intron -    22484847 chr4:56729703(+) A-G intron -    22484847 chr4:56757055(+) A-G intron -    22484847 chr4:56759333(+) A-G intron -    22484847 chr4:56759338(+) A-G intron -    22484847 chr4:56759425(+) A-G intron -    22484847 chr4:56760213(+) A-G intron -    22484847 chr4:56760215(+) A-G intron -    22484847 chr4:56760266(+) A-G intron -    22484847 chr4:56760276(+) A-G intron -    22484847 chr4:56760281(+) A-G intron -    22484847 chr4:56760307(+) A-G intron -    22484847 chr4:56760357(+) A-G intron -    22484847 chr4:56760420(+) A-G intron -    22484847 chr4:56760888(+) A-G intron -    22484847 chr4:56760889(+) A-G intron -    22484847 chr4:56760918(+) A-G intron -    22484847 chr4:56760954(+) A-G intron -    22484847 chr4:56760962(+) A-G intron -    22484847 chr4:56760968(+) A-G intron -    22484847 chr4:56761008(+) A-G intron -    22484847 chr4:56761009(+) A-G intron -    22484847 chr4:56761010(+) A-G intron -    22484847 chr4:56761022(+) A-G intron -    22484847 chr4:56761065(+) A-G intron -    22484847 chr4:56762465(+) A-G intron -    22484847 chr4:56762545(+) A-G intron -    22484847 chr4:56763845(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	EXOC1	chr4:56719925-56719926(+) m6A 5'UTR       24981863 chr4:56770620-56770621(+) m6A CDS//exon       24284625//24209618//24981863//27773535//22608085 chr4:56770661-56770662(+) m6A 3'UTR//exon       24284625//24209618//24981863//27773535//22608085 chr4:56770711-56770712(+) m6A 3'UTR//exon       24284625//24209618//24981863//27773535//22608085 chr4:56770746-56770747(+) m6A 3'UTR//exon       24284625//24209618//24981863//27773535//22608085 chr4:56770752-56770753(+) m6A 3'UTR//exon       24284625//24981863//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	EXOC1	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol K562 cells     - Exosome Blood     - Nucleoplasm K562 cells     - Nucleus HeLa-S3 cells|K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: kshv-miR-K12-10a-5p
Interactor2: EXOC1

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	PARalyzer
Support Database	ViRBase

References:

PMID	22100165	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	BC-3 cells	Interactor2 expression	None
Description	Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs.