Basic Information:

  VIRBase ID:  

VHID00479568

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-10a-5p:  MIMAT0015212          CBX6:  NM_014292     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	kshv-miR-K12-10a-5p	CBX6
miRBase Accession/Entrez ID	MIMAT0015212	23466
Organism	Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	-

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	CBX6	chr22:39258645-39258646(-) m6A 3'UTR       27371828 chr22:39258655-39258656(-) m6A 3'UTR       27371828//27773536 chr22:39258684-39258685(-) m6A 3'UTR       27371828//27773536 chr22:39258795-39258796(-) m6A 3'UTR       27371828//27773536 chr22:39258872-39258873(-) m6A 3'UTR       24981863//26404942//27773535//27371828 chr22:39258958-39258959(-) m6A 3'UTR       27773535//27371828 chr22:39259559-39259560(-) m6A 3'UTR       24284625 chr22:39259821-39259822(-) m6A 3'UTR       - chr22:39260011-39260012(-) m6A 3'UTR       24209618//27773536 chr22:39260049-39260050(-) m6A 3'UTR       24209618//24981863//27773535//27773536 chr22:39260250-39260251(-) m6A 3'UTR       24981863//27773535 chr22:39260256-39260257(-) m6A 3'UTR       24981863//27773535 chr22:39260835-39260836(-) m6A 3'UTR       24284625 chr22:39261161-39261162(-) m6A 3'UTR       24284625 chr22:39261179-39261180(-) m6A 3'UTR       24284625//24981863 chr22:39261204-39261205(-) m6A 3'UTR       24284625//24981863 chr22:39261329-39261330(-) m6A 3'UTR       24284625//24981863 chr22:39261357-39261358(-) m6A 3'UTR       24284625//24981863 chr22:39261378-39261379(-) m6A 3'UTR       24284625//24981863 chr22:39261486-39261487(-) m6A 3'UTR       24284625//22575960 chr22:39261499-39261500(-) m6A 3'UTR       24284625//22575960 chr22:39261577-39261578(-) m6A 3'UTR       24284625//24981863//22575960 chr22:39261635-39261636(-) m6A 3'UTR       24284625//24981863//22575960 chr22:39261951-39261952(-) m6A 3'UTR       24284625 chr22:39262382-39262383(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27371828//27773536//22575960//22608085 chr22:39262557-39262558(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27371828//27773536//22575960//22608085 chr22:39262835-39262836(-) m6A CDS       24284625//24209618//24981863//27371828//27773536//22575960//22608085 chr22:39262922-39262923(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27371828//27773536//22575960//22608085 chr22:39262937-39262938(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27371828//27773536//22575960//22608085 chr22:39263017-39263018(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27371828//27773536//22575960//22608085 chr22:39263039-39263040(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27371828//27773536//22575960//22608085 chr22:39263087-39263088(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27371828//27773536//22575960//22608085 chr22:39265582-39265583(-) m6A exon//intron       24284625//24209618//27371828//27773536 chr22:39265636-39265637(-) m6A exon//intron       24209618//27371828//27773536 chr22:39266820-39266821(-) m6A exon//intron       - chr22:39267406-39267407(-) m6A exon//intron       27773536 chr22:39267498-39267499(-) m6A CDS//exon       24284625//24209618//24981863//27773535//27371828//27773536 chr22:39267505-39267506(-) m6A CDS//exon       24284625//24209618//24981863//27773535//27371828//27773536 chr22:39267511-39267512(-) m6A CDS//exon       24284625//24209618//24981863//27773535//27371828//27773536 chr22:39267523-39267524(-) Y CDS//exon       26075521 chr22:39267701-39267702(-) m6A CDS//exon       24284625//24209618//24981863//27773535//27371828//27773536 chr22:39267726-39267727(-) m6A CDS//exon       24284625//24209618//24981863//27773535//27371828//27773536 chr22:39267735-39267736(-) m6A CDS//exon       24284625//24209618//24981863//27773535//27371828//27773536//22575960

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	CBX6	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleolus K562 cells     - Nucleus Colon cancer cells     24393600 Nucleus K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: kshv-miR-K12-10a-5p
Interactor2: CBX6

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	miRanda//PARalyzer//RNAHybrid
Support Database	ViRBase//VmiReg

References:

PMID	22100165	Target region	3'UTR
Source	ViRBase//VmiReg	Interactor1 expression	None
Tissue or cell line	BC-3 cells	Interactor2 expression	None
Description	Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs.