Basic Information:

  VIRBase ID:  

VHID00477176

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-12-5p:  MIMAT0003712          CREBRF:  NM_001168394     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	kshv-miR-K12-12-5p	CREBRF
miRBase Accession/Entrez ID	MIMAT0003712	153222
Organism	Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	C5orf41//LRF

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	CREBRF	chr5:172487333(+) A-I      ncRNA chr5:172487431(+) A-I      ncRNA chr5:172487434(+) A-I      ncRNA chr5:172487334(+) A-I      ncRNA chr5:172487367(+) A-I      ncRNA chr5:172487399(+) A-I      ncRNA chr5:172487408(+) A-I      ncRNA chr5:172487423(+) A-I      ncRNA chr5:172487424(+) A-I      ncRNA chr5:172516088(+) A-I      intronic chr5:172516062(+) A-I      intronic chr5:172516061(+) A-I      intronic chr5:172514715(+) A-I      intronic chr5:172514605(+) A-I      intronic chr5:172514468(+) A-I      intronic chr5:172514467(+) A-I      intronic chr5:172514446(+) A-I      intronic chr5:172514349(+) A-I      intronic chr5:172513897(+) A-I      intronic chr5:172512208(+) A-I      intronic chr5:172512135(+) A-I      intronic chr5:172510059(+) A-I      intronic chr5:172510042(+) A-I      intronic chr5:172510027(+) A-I      intronic chr5:172509862(+) A-I      intronic chr5:172509861(+) A-I      intronic chr5:172509724(+) A-I      intronic chr5:172509701(+) A-I      intronic chr5:172509048(+) A-I      intronic chr5:172508808(+) A-I      intronic chr5:172508802(+) A-I      intronic chr5:172504593(+) A-I      intronic chr5:172504579(+) A-I      intronic chr5:172504521(+) A-I      intronic chr5:172504113(+) A-I      intronic chr5:172504112(+) A-I      intronic chr5:172504108(+) A-I      intronic chr5:172504086(+) A-I      intronic chr5:172504077(+) A-I      intronic chr5:172504076(+) A-I      intronic chr5:172504072(+) A-I      intronic chr5:172503997(+) A-I      intronic chr5:172503594(+) A-I      intronic chr5:172503578(+) A-I      intronic chr5:172503570(+) A-I      intronic chr5:172503558(+) A-I      intronic chr5:172502995(+) A-I      intronic chr5:172502974(+) A-I      intronic chr5:172501886(+) A-I      intronic chr5:172501768(+) A-I      intronic chr5:172501096(+) A-I      intronic chr5:172500721(+) A-I      intronic chr5:172499631(+) A-I      intronic chr5:172498803(+) A-I      intronic chr5:172498456(+) A-I      intronic chr5:172497130(+) A-I      intronic chr5:172497096(+) A-I      intronic chr5:172497060(+) A-I      intronic chr5:172497059(+) A-I      intronic chr5:172496444(+) A-I      intronic chr5:172495981(+) A-I      intronic chr5:172495977(+) A-I      intronic chr5:172495968(+) A-I      intronic chr5:172495964(+) A-I      intronic chr5:172495873(+) A-I      intronic chr5:172495862(+) A-I      intronic chr5:172495843(+) A-I      intronic chr5:172494991(+) A-I      intronic chr5:172494882(+) A-I      intronic chr5:172494825(+) A-I      intronic chr5:172491895(+) A-I      intronic chr5:172491490(+) A-I      intronic chr5:172491487(+) A-I      intronic chr5:172487514(+) A-I      intronic chr5:172556968(+) A-I      intronic chr5:172501174(+) A-I      intronic chr5:172501184(+) A-I      intronic chr5:172501185(+) A-I      intronic chr5:172501210(+) A-I      intronic chr5:172501216(+) A-I      intronic chr5:172506346(+) A-I      intronic chr5:172506355(+) A-I      intronic chr5:172506372(+) A-I      intronic chr5:172506378(+) A-I      intronic chr5:172506381(+) A-I      intronic chr5:172506391(+) A-I      intronic chr5:172508812(+) A-I      intronic chr5:172508819(+) A-I      intronic chr5:172508825(+) A-I      intronic chr5:172508827(+) A-I      intronic chr5:172516121(+) A-I      intronic chr5:172516129(+) A-I      intronic chr5:172516130(+) A-I      intronic chr5:172516140(+) A-I      intronic chr5:172552792(+) A-I      intronic chr5:172552817(+) A-I      intronic chr5:172552851(+) A-I      intronic chr5:172557073(+) A-I      intronic chr5:172557048(+) A-I      intronic chr5:172557025(+) A-I      intronic chr5:172557013(+) A-I      intronic chr5:172508721(+) A-I      intronic chr5:172556673(+) A-I      intronic chr5:172556585(+) A-I      intronic chr5:172556571(+) A-I      intronic chr5:172556567(+) A-I      intronic chr5:172556560(+) A-I      intronic chr5:172554713(+) A-I      intronic chr5:172554708(+) A-I      intronic chr5:172554692(+) A-I      intronic chr5:172554691(+) A-I      intronic chr5:172554683(+) A-I      intronic chr5:172554482(+) A-I      intronic chr5:172552806(+) A-I      intronic chr5:172552773(+) A-I      intronic chr5:172552769(+) A-I      intronic chr5:172552639(+) A-I      intronic chr5:172551305(+) A-I      intronic chr5:172544840(+) A-I      intronic chr5:172544831(+) A-I      intronic chr5:172544807(+) A-I      intronic chr5:172544302(+) A-I      intronic chr5:172544200(+) A-I      intronic chr5:172544198(+) A-I      intronic chr5:172538504(+) A-I      intronic chr5:172534935(+) A-I      intronic chr5:172534850(+) A-I      intronic chr5:172534797(+) A-I      intronic chr5:172533882(+) A-I      intronic chr5:172533330(+) A-I      intronic chr5:172533322(+) A-I      intronic chr5:172533312(+) A-I      intronic chr5:172532719(+) A-I      intronic chr5:172532628(+) A-I      intronic chr5:172532499(+) A-I      intronic chr5:172532488(+) A-I      intronic chr5:172531576(+) A-I      intronic chr5:172531415(+) A-I      intronic chr5:172528089(+) A-I      intronic chr5:172520755(+) A-I      intronic chr5:172520741(+) A-I      intronic chr5:172520646(+) A-I      intronic chr5:172520645(+) A-I      intronic chr5:172518886(+) A-I      3'UTR chr5:172518885(+) A-I      3'UTR chr5:172494948(+) A-I      intronic chr5:172544236(+) A-I      intronic chr5:172499418(+) A-I      intronic chr5:172503512(+) A-I      intronic chr5:172557910(+) A-I      intronic chr5:172491901(+) A-I      intronic chr5:172531452(+) A-I      intronic chr5:172554602(+) A-I      intronic chr5:172490765(+) A-I      intronic chr5:172545833(+) A-I      intronic chr5:172544120(+) A-I      intronic chr5:172544126(+) A-I      intronic chr5:172504525(+) A-I      intronic chr5:172511922(+) A-I      intronic chr5:172510046(+) A-I      intronic chr5:172495817(+) A-I      intronic chr5:172495928(+) A-I      intronic chr5:172498993(+) A-I      intronic chr5:172501155(+) A-I      intronic chr5:172504457(+) A-I      intronic chr5:172496366(+) A-I      intronic chr5:172512209(+) A-I      intronic chr5:172534704(+) A-I      intronic chr5:172532588(+) A-I      intronic chr5:172556678(+) A-I      intronic chr5:172556581(+) A-I      intronic chr5:172556929(+) A-I      intronic chr5:172509672(+) A-I      intronic chr5:172497037(+) A-I      intronic chr5:172509991(+) A-I      intronic chr5:172496378(+) A-I      intronic chr5:172544127(+) A-I      intronic chr5:172551430(+) A-I      intronic chr5:172504465(+) A-I      intronic chr5:172508747(+) A-I      intronic chr5:172496957(+) A-I      intronic chr5:172535087(+) A-I      intronic chr5:172504008(+) A-I      intronic chr5:172497105(+) A-I      intronic chr5:172508737(+) A-I      intronic chr5:172498881(+) A-I      intronic chr5:172494745(+) A-I      intronic chr5:172487990(+) A-I      intronic chr5:172532600(+) A-I      intronic chr5:172503609(+) A-I      intronic chr5:172504162(+) A-I      intronic chr5:172503709(+) A-I      intronic chr5:172528265(+) A-I      intronic chr5:172504024(+) A-I      intronic chr5:172503606(+) A-I      intronic chr5:172509829(+) A-I      intronic chr5:172512585(+) A-I      intronic chr5:172519041(+) A-I      3'UTR chr5:172518912(+) A-I      3'UTR chr5:172508654(+) A-I      intronic chr5:172533282(+) A-I      intronic chr5:172531500(+) A-I      intronic chr5:172504150(+) A-I      intronic chr5:172531521(+) A-I      intronic chr5:172551513(+) A-I      intronic chr5:172553409(+) A-I      intronic chr5:172501147(+) A-I      intronic chr5:172532651(+) A-I      intronic chr5:172508761(+) A-I      intronic chr5:172488110(+) A-I      intronic chr5:172499188(+) A-I      intronic chr5:172498872(+) A-I      intronic chr5:172528113(+) A-I      intronic chr5:172544298(+) A-I      intronic chr5:172553406(+) A-I      intronic chr5:172544110(+) A-I      intronic chr5:172504021(+) A-I      intronic chr5:172504216(+) A-I      intronic chr5:172496949(+) A-I      intronic chr5:172499161(+) A-I      intronic chr5:172509769(+) A-I      intronic chr5:172538411(+) A-I      intronic chr5:172556608(+) A-I      intronic chr5:172501904(+) A-I      intronic chr5:172514291(+) A-I      intronic chr5:172551411(+) A-I      intronic chr5:172491480(+) A-I      intronic chr5:172495954(+) A-I      intronic chr5:172557660(+) A-I      intronic chr5:172556677(+) A-I      intronic chr5:172496454(+) A-I      intronic chr5:172501081(+) A-I      intronic chr5:172504475(+) A-I      intronic chr5:172556467(+) A-I      intronic chr5:172503648(+) A-I      intronic chr5:172534852(+) A-I      intronic chr5:172509867(+) A-I      intronic chr5:172547567(+) A-I      intronic chr5:172528121(+) A-I      intronic chr5:172512586(+) A-I      intronic chr5:172509805(+) A-I      intronic chr5:172498825(+) A-I      intronic chr5:172498804(+) A-I      intronic chr5:172502969(+) A-I      intronic chr5:172494016(+) A-I      intronic chr5:172533898(+) A-I      intronic chr5:172556554(+) A-I      intronic chr5:172552972(+) A-I      intronic chr5:172534848(+) A-I      intronic chr5:172497027(+) A-I      intronic chr5:172534898(+) A-I      intronic chr5:172494803(+) A-I      intronic chr5:172504011(+) A-I      intronic chr5:172545964(+) A-I      intronic chr5:172499700(+) A-I      intronic chr5:172487495(+) A-I      intronic chr5:172556653(+) A-I      intronic chr5:172498937(+) A-I      intronic chr5:172501824(+) A-I      intronic chr5:172498954(+) A-I      intronic chr5:172510048(+) A-I      intronic chr5:172514130(+) A-I      intronic chr5:172553324(+) A-I      intronic chr5:172487462(+) A-I      intronic chr5:172551502(+) A-I      intronic chr5:172503704(+) A-I      intronic chr5:172503684(+) A-I      intronic chr5:172497143(+) A-I      intronic chr5:172496439(+) A-I      intronic chr5:172499420(+) A-I      intronic chr5:172509735(+) A-I      intronic chr5:172509725(+) A-I      intronic chr5:172494081(+) A-I      intronic chr5:172544268(+) A-I      intronic chr5:172512111(+) A-I      intronic chr5:172535044(+) A-I      intronic chr5:172553283(+) A-I      intronic chr5:172503592(+) A-I      intronic chr5:172505612(+) A-I      intronic chr5:172556539(+) A-I      intronic chr5:172503544(+) A-I      intronic chr5:172527049(+) A-I      intronic chr5:172556994(+) A-I      intronic chr5:172509791(+) A-I      intronic chr5:172494953(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	CREBRF	chr5:172496431(+) A-I intron -    21960545 chr5:172499641(+) A-I intron -    21960545 chr5:172487462(+) A-G intron -    22484847 chr5:172487495(+) A-G intron -    22484847 chr5:172488069(+) T-C intron -    22484847 chr5:172490495(+) T-C intron -    22484847 chr5:172494016(+) A-G intron -    22484847 chr5:172494745(+) A-G intron -    22484847 chr5:172495928(+) A-G intron -    22484847 chr5:172496366(+) A-G intron -    22484847 chr5:172496378(+) A-G intron -    22484847 chr5:172496431(+) A-G intron -    22484847 chr5:172496439(+) A-G intron -    22484847 chr5:172496957(+) A-G intron -    22484847 chr5:172497015(+) A-G intron -    22484847 chr5:172497027(+) A-G intron -    22484847 chr5:172497037(+) A-G intron -    22484847 chr5:172497039(+) A-G intron -    22484847 chr5:172497131(+) A-G intron -    22484847 chr5:172497143(+) A-G intron -    22484847 chr5:172497158(+) A-G intron -    22484847 chr5:172499161(+) A-G intron -    22484847 chr5:172499188(+) A-G intron -    22484847 chr5:172499244(+) A-G intron -    22484847 chr5:172499632(+) A-G intron -    22484847 chr5:172499646(+) A-G intron -    22484847 chr5:172499652(+) A-G intron -    22484847 chr5:172501824(+) A-G intron -    22484847 chr5:172503544(+) A-G intron -    22484847 chr5:172503593(+) A-G intron -    22484847 chr5:172503609(+) A-G intron -    22484847 chr5:172503638(+) A-G intron -    22484847 chr5:172503648(+) A-G intron -    22484847 chr5:172503652(+) A-G intron -    22484847 chr5:172503704(+) A-G intron -    22484847 chr5:172503709(+) A-G intron -    22484847 chr5:172503716(+) A-G intron -    22484847 chr5:172504008(+) A-G intron -    22484847 chr5:172504011(+) A-G intron -    22484847 chr5:172504021(+) A-G intron -    22484847 chr5:172504024(+) A-G intron -    22484847 chr5:172504150(+) A-G intron -    22484847 chr5:172504162(+) A-G intron -    22484847 chr5:172504216(+) A-G intron -    22484847 chr5:172504475(+) A-G intron -    22484847 chr5:172504631(+) A-G intron -    22484847 chr5:172504648(+) A-G intron -    22484847 chr5:172508776(+) A-G intron -    22484847 chr5:172508803(+) A-G intron -    22484847 chr5:172508891(+) A-G intron -    22484847 chr5:172508894(+) A-G intron -    22484847 chr5:172518906(+) A-G intron -    22484847 chr5:172520772(+) A-G intron -    22484847 chr5:172532588(+) A-G intron -    22484847 chr5:172532654(+) A-G intron -    22484847 chr5:172533282(+) A-G intron -    22484847 chr5:172533892(+) A-G intron -    22484847 chr5:172533898(+) A-G intron -    22484847 chr5:172534704(+) A-G intron -    22484847 chr5:172552925(+) A-G intron -    22484847 chr5:172553934(+) A-G intron -    22484847 chr5:172553935(+) A-G intron -    22484847 chr5:172556929(+) A-G intron -    22484847 chr5:172556994(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	CREBRF	chr5:172483374-172483375(+) m6A 5'UTR       24981863 chr5:172483388-172483389(+) m6A 5'UTR       24981863 chr5:172483394-172483395(+) m6A 5'UTR//exon       24981863 chr5:172483399-172483400(+) m6A 5'UTR//exon       24981863 chr5:172483445-172483446(+) m6A 5'UTR//exon       24981863 chr5:172483450-172483451(+) m6A 5'UTR//exon       24981863 chr5:172484349-172484350(+) m6A exon//intron       24981863 chr5:172484527-172484528(+) m6A 5'UTR//exon//intron       - chr5:172484586-172484587(+) m6A 5'UTR//exon//intron       - chr5:172484599-172484600(+) m6A 5'UTR//exon//intron       - chr5:172513597-172513598(+) m6A CDS//exon       22608085 chr5:172513625-172513626(+) m6A CDS//exon       22608085 chr5:172517330-172517331(+) m6A CDS//exon       22608085 chr5:172517351-172517352(+) m6A CDS//exon       24981863//22608085 chr5:172517372-172517373(+) m6A CDS//exon       24284625//24981863//26404942//27773535//22608085 chr5:172517381-172517382(+) m6A CDS//exon       24284625//24981863//26404942//27773535//22608085 chr5:172517441-172517442(+) m6A CDS//exon       24284625//24981863//26404942//27773535//22608085 chr5:172517448-172517449(+) m6A CDS//exon       24284625//24981863//26404942//27773535//22608085 chr5:172517471-172517472(+) m6A CDS//exon       24284625//24981863//26404942//27773535//22608085 chr5:172517490-172517491(+) m6A CDS//exon       24284625//24981863//26404942//27773535//22608085 chr5:172517515-172517516(+) m6A CDS//exon       24284625//24981863//26404942//27773535//22608085 chr5:172517587-172517588(+) m6A CDS//exon       24284625//24981863//26404942//22608085 chr5:172517618-172517619(+) m6A CDS//exon       24284625//24981863//22608085 chr5:172517673-172517674(+) m6A CDS//exon       24284625//24981863//22608085 chr5:172517749-172517750(+) m6A CDS//exon       24284625//24209618//24981863//27773535//22575960//22608085 chr5:172517777-172517778(+) m6A CDS//exon       24284625//24209618//24981863//27773535//22575960//22608085 chr5:172517799-172517800(+) m6A CDS//exon       24284625//24209618//24981863//27773535//22575960//22608085 chr5:172517830-172517831(+) m6A CDS//exon       24284625//24209618//24981863//27773535//22575960//22608085 chr5:172517858-172517859(+) m6A CDS//exon       24284625//24209618//24981863//27773535//22575960//22608085 chr5:172517879-172517880(+) m6A CDS//exon       24284625//24209618//24981863//27773535//22575960//22608085 chr5:172517969-172517970(+) m6A CDS//exon       24284625//24981863//26404942//27773535//22608085 chr5:172518000-172518001(+) m6A CDS//exon       24284625//24981863//26404942//27773535//22608085 chr5:172518064-172518065(+) m6A CDS//exon       24284625//24981863//27773535//22608085 chr5:172518072-172518073(+) m6A CDS//exon       24284625//24981863//27773535//22608085 chr5:172518222-172518223(+) m6A CDS//exon       24284625//24981863//27773535//22608085 chr5:172518284-172518285(+) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//22608085 chr5:172518315-172518316(+) m6A CDS//exon       24209618//25456834//24981863//26404942//27773535//22608085 chr5:172518341-172518342(+) m1A CDS//exon       26863196 chr5:172518399-172518400(+) m6A CDS//exon       24981863//27773535//22608085 chr5:172518431-172518432(+) m6A CDS//intron       27773535//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	kshv-miR-K12-12-5p	Exosome Primary dendritic cells     21505438
	CREBRF	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HeLa-S3 cells     - Exosome Blood     - Nucleoplasm K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: kshv-miR-K12-12-5p
Interactor2: CREBRF

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	PARalyzer
Support Database	ViRBase//VIRmiRNA

References:

PMID	22100165	Target region	3'UTR
Source	ViRBase//VIRmiRNA	Interactor1 expression	None
Tissue or cell line	BC-1 cells	Interactor2 expression	None
Description	Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.