Detail Information

Basic Information:


  VIRBase ID:  

VHID00473090

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-12-5p:           ZFAND5:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol kshv-miR-K12-12-5p ZFAND5
miRBase
Accession/Entrez ID		 MIMAT0003712 7763
Organism Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV) Homo sapiens
Category miRNA mRNA
Alias - ZA20D2//ZFAND5A//ZNF216

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR ZFAND5
chr9:74968543(-) A-I      3'UTR
chr9:74967193(-) A-I      3'UTR
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED ZFAND5
chr9:74971252(-) A-I intron -    19478186
chr9:74966576(-) A-I exon 3'UTR    22327324

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase ZFAND5
chr9:74969373-74969374(-) m6A 3'UTR//exon       27773535
chr9:74969818-74969819(-) m6A 3'UTR//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr9:74969883-74969884(-) m6A 3'UTR//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr9:74969948-74969949(-) m6A 3'UTR//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr9:74970094-74970095(-) m6A 3'UTR//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr9:74970133-74970134(-) m6A 3'UTR//exon       24284625//24209618//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr9:74970239-74970240(-) m6A 3'UTR//exon       24284625//24209618//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr9:74970255-74970256(-) m6A 3'UTR//exon       24284625//24209618//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr9:74970263-74970264(-) m6A 3'UTR//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr9:74970281-74970282(-) m6A 3'UTR//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr9:74970342-74970343(-) m6A 3'UTR//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr9:74970359-74970360(-) m6A 3'UTR//exon       24284625//24209618//24981863//26404942//27773535//22608085
chr9:74970427-74970428(-) m6A 3'UTR//exon       24284625//24209618//24981863//26404942//27773535//22608085
chr9:74970455-74970456(-) m6A 3'UTR//exon       24284625//24209618//24981863//26404942//27773535//22608085
chr9:74970576-74970577(-) m6A 3'UTR//exon       24284625//24981863//26404942//27773535
chr9:74970601-74970602(-) m6A 3'UTR//exon       24981863//26404942//27773535
chr9:74970618-74970619(-) m6A 3'UTR//exon       24981863//26404942//27773535
chr9:74970811-74970812(-) m6A 3'UTR//exon       24981863//27773535//22608085
chr9:74970843-74970844(-) m6A 3'UTR//exon       24981863//27773535//22608085
chr9:74970849-74970850(-) m6A 3'UTR//exon       24981863//27773535//22608085
chr9:74974351-74974352(-) m6A CDS//exon       -
chr9:74974371-74974372(-) m6A CDS//exon       -
chr9:74975067-74975068(-) m6A CDS//exon       -
chr9:74975079-74975080(-) m6A CDS//exon       -
chr9:74975444-74975445(-) m6A exon//intron       24981863//27371828
chr9:74975486-74975487(-) m6A exon//intron       24981863//27371828
chr9:74975499-74975500(-) m6A exon//intron       24981863//27371828
chr9:74975507-74975508(-) m6A exon//intron       24981863
chr9:74975521-74975522(-) m6A exon//intron       24981863
chr9:74975672-74975673(-) m6A CDS//exon       -
chr9:74975681-74975682(-) m6A CDS//exon       -
chr9:74978404-74978405(-) m6A 5'UTR//exon//intron       -
chr9:74978410-74978411(-) m6A 5'UTR//exon//intron       -
chr9:74978417-74978418(-) m6A 5'UTR//exon//intron       -
chr9:74978447-74978448(-) m6A 5'UTR//exon//intron       -
chr9:74978468-74978469(-) m6A 5'UTR//exon//intron       -
chr9:74979414-74979415(-) m6A 5'UTR//CDS//intron       27773536
chr9:74979542-74979543(-) m6A 5'UTR//intron       24209618//27773536
chr9:74979620-74979621(-) m6A 5'UTR//exon       24209618//27773536
chr9:74979640-74979641(-) m6A 5'UTR//exon       24209618//27773536
chr9:74979775-74979776(-) m6A 5'UTR//exon       24284625//27371828//27773536//22575960
chr9:74979785-74979786(-) m6A 5'UTR//exon       24284625//27371828//27773536//22575960

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate kshv-miR-K12-12-5p
Exosome Primary dendritic cells     21505438
ZFAND5
Chromatin K562 cells     -
Cytoplasm Nasopharyngeal carcinoma cells     20498841
Cytoplasm Nasopharyngeal carcinoma cells     20498841
Cytoplasm Nasopharyngeal carcinoma cells     20498841
Exosome Blood     -
Nucleus Nasopharyngeal carcinoma cells     20498841
Nucleus Nasopharyngeal carcinoma cells     20498841
Nucleus Nasopharyngeal carcinoma cells     20498841
Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -
Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):


Interactor1: kshv-miR-K12-12-5p
Interactor2: ZFAND5

Evidence Support:


Weak-Evidence PAR-CLIP
Prediction-Evidence PARalyzer
Support Database ViRBase

References:


PMID 22100165 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line BC-3 cells Interactor2 expression None
Description Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs.

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