Basic Information:

  VIRBase ID:  

VHID00471295

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.2202

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-12-5p:  MIMAT0003712          CDK4:  NM_000075     

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Interactor Information:

	Interactor1	Interactor2
Symbol	kshv-miR-K12-12-5p	CDK4
miRBase Accession/Entrez ID	MIMAT0003712	1019
Organism	Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	CMM3//PSK-J3

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	CDK4	chr12:58144306(-) A-I      intronic chr12:58144164(-) A-I      intronic chr12:58142707(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	CDK4	chr12:58142491(-) G-A intron -    22484847 chr12:58143571(-) T-C intron -    22484847 chr12:58143593(-) T-C intron -    22484847 chr12:58144164(-) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	CDK4	chr12:58141854-58141855(-) m6A 3'UTR       27773535 chr12:58142034-58142035(-) m6A 3'UTR       24284625 chr12:58142039-58142040(-) m6A 3'UTR       24284625 chr12:58142255-58142256(-) m6A 3'UTR//exon       24284625//24981863//26404942//27773535 chr12:58142987-58142988(-) Gm 3'UTR//CDS//exon       - chr12:58145029-58145030(-) m6A CDS//exon//intron       27773535//22575960 chr12:58145039-58145040(-) m6A CDS//exon//intron       27773535//22575960 chr12:58145047-58145048(-) m6A CDS//exon//intron       27773535//22575960 chr12:58145053-58145054(-) m6A CDS//exon//intron       27773535//22575960 chr12:58145096-58145097(-) m6A CDS//exon//intron       27773535//22575960 chr12:58145194-58145195(-) m6A exon//intron       27773535 chr12:58145236-58145237(-) m6A exon//intron       27773535 chr12:58145445-58145446(-) m6A 5'UTR//CDS//exon//intron       22575960 chr12:58146013-58146014(-) m6A 5'UTR//exon//intron       24284625//25456834//24981863//22575960 chr12:58146042-58146043(-) m6A 5'UTR//exon//intron       24284625//25456834//24981863//22575960

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	kshv-miR-K12-12-5p	Exosome Primary dendritic cells     21505438
	CDK4	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)     - Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: kshv-miR-K12-12-5p
Interactor2: CDK4

Evidence Support:

Prediction-Evidence	miRanda//RNAHybrid
Support Database	VmiReg