Basic Information:

  VIRBase ID:  

VHID00471007

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.2381

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-12-5p:  MIMAT0003712          ACTB:  NM_001101     

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Interactor Information:

	Interactor1	Interactor2
Symbol	kshv-miR-K12-12-5p	ACTB
miRBase Accession/Entrez ID	MIMAT0003712	60
Organism	Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	BRWS1//PS1TP5BP1

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	ACTB	chr7:5567017(-) A-I      3'UTR

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	ACTB	chr7:5567291(-) A-I exon 3'UTR    22327324

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	ACTB	chr7:5566811-5566812(-) m6A 3'UTR//exon       22575960 chr7:5567163-5567164(-) m6A 3'UTR//exon       24284625//25456834//24981863//28052920//26404942//27773535 chr7:5567232-5567233(-) m6A 3'UTR//exon       24284625//25456834//24981863//28052920//27773535//22608085 chr7:5567318-5567319(-) m6A 3'UTR//exon//intron       24284625//25456834//24981863//28052920//27773535//22575960//22608085 chr7:5567336-5567337(-) m6A 3'UTR//exon//intron       24284625//25456834//24981863//28052920//27773535//22575960//22608085 chr7:5567373-5567374(-) m6A 3'UTR//exon       24284625//25456834//24981863//28052920//27773535//22575960//22608085 chr7:5567743-5567744(-) m6A 3'UTR//CDS//exon       24284625//27773535//22575960 chr7:5567755-5567756(-) m6A 3'UTR//CDS//exon       24284625//27773535//22575960 chr7:5567789-5567790(-) m6A 3'UTR//CDS//exon       24284625//27773535//22575960 chr7:5567900-5567901(-) m6A exon//intron       24284625//27773535//22575960 chr7:5568048-5568049(-) m6A 3'UTR//CDS//exon       24284625//26404942//27773535//22575960 chr7:5568162-5568163(-) m6A 3'UTR//CDS//exon       24284625//27773535//27773536//22575960 chr7:5568177-5568178(-) m6A 3'UTR//CDS//exon       24284625//27773535//27773536//22575960 chr7:5568252-5568253(-) m6A 3'UTR//CDS//exon       24284625//27773535//27773536//22575960 chr7:5568337-5568338(-) m6A 3'UTR//CDS//exon       24284625//27773535//27773536//22575960 chr7:5568457-5568458(-) m6A exon//intron       24284625//27773535//27773536//22575960 chr7:5568472-5568473(-) m6A exon//intron       24284625//27773535//27773536//22575960 chr7:5568822-5568823(-) m6A CDS//exon//intron       24284625//27773535//27371828//27773536//22575960 chr7:5569536-5569537(-) m6A 5'UTR//intron       24284625//25456834//24981863//26404942//22575960//22608085 chr7:5570222-5570223(-) m6A 5'UTR//exon//intron       24284625//25456834//24981863//28052920//26404942//27371828//27773536//22575960//22608085 chr7:5570254-5570255(-) m6A 5'UTR//intron       24284625//25456834//24981863//28052920//26404942//27371828//27773536//22575960 chr7:5602325-5602326(-) m6A 5'UTR//intron       24981863 chr7:5602377-5602378(-) m6A 5'UTR//intron       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	kshv-miR-K12-12-5p	Exosome Primary dendritic cells     21505438
	ACTB	Cell leading edge Human T lymphocytes (Jurkat E6-1)     12923260 Cell leading edge CRC cell line (SW480)     18535985 Chromatin K562 cells     - Cytoplasm HEK-293T cells     27471035 Cytoplasm Human umbilical vein endothelial cells     29408197 Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytoplasm Embryonic stem cells     22193719 Cytoplasm U2OS cells     22679391 Cytosol Multidrug resistant cell line (NCI/ADR-RES)     20453113 Cytosol HeLa-S3 cells|K562 cells     - Endoplasmic reticulum HeLa cells     15081402 Exosome Colorectal cancer cell lines (HCT-15|SW480|WiDr)     22895844 Exosome Plasma|Serum     - Inner nuclear membrane HeLa cells     15081402 Lamellipodium Lung fibroblasts     23452202 Mitochondrion Human cervical cancer cell line (HeLa)     26195734 Nucleolus K562 cells     - Nucleoplasm HeLa cells     15081402 Nucleoplasm K562 cells     - Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus HeLa-S3 cells|K562 cells     - Outer nuclear membrane HeLa cells     15081402 Perinuclear Human T lymphocytes (Jurkat E6-1)     12923260 Ribosome Human lung fibroblasts (MRC5)     23452202 Ribosome Colon cancer cells     24393600 Ribosome HEK-293 cells     26239904 RNA-rich region WI-38 cells     29133588

Interaction Network (The top 100 interactions):

Interactor1: kshv-miR-K12-12-5p
Interactor2: ACTB

Evidence Support:

Prediction-Evidence	miRanda//RNAHybrid//Targetscan
Support Database	VmiReg