Basic Information:

  VIRBase ID:  

VHID00470839

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-3-3p:  MIMAT0002194          KDELR1:  NM_006801     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	kshv-miR-K12-3-3p	KDELR1
miRBase Accession/Entrez ID	MIMAT0002194	10945
Organism	Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	ERD2//ERD2.1//HDEL//PM23

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	KDELR1	chr19:48889469(-) A-I      intronic chr19:48889487(-) A-I      intronic chr19:48892392(-) A-I      intronic chr19:48892403(-) A-I      intronic chr19:48892407(-) A-I      intronic chr19:48892415(-) A-I      intronic chr19:48892427(-) A-I      intronic chr19:48892437(-) A-I      intronic chr19:48892440(-) A-I      intronic chr19:48892441(-) A-I      intronic chr19:48892444(-) A-I      intronic chr19:48892451(-) A-I      intronic chr19:48889483(-) A-I      intronic chr19:48889474(-) A-I      intronic chr19:48888196(-) A-I      intronic chr19:48888229(-) A-I      intronic chr19:48891886(-) A-I      intronic chr19:48891896(-) A-I      intronic chr19:48890891(-) A-I      intronic chr19:48890080(-) A-I      intronic chr19:48890209(-) A-I      intronic chr19:48890241(-) A-I      intronic chr19:48890246(-) A-I      intronic chr19:48890759(-) A-I      intronic chr19:48888235(-) A-I      intronic chr19:48888236(-) A-I      intronic chr19:48888282(-) A-I      intronic chr19:48891795(-) A-I      intronic chr19:48889577(-) A-I      intronic chr19:48889790(-) A-I      intronic chr19:48889810(-) A-I      intronic chr19:48889875(-) A-I      intronic chr19:48889883(-) A-I      intronic chr19:48889575(-) A-I      intronic chr19:48889825(-) A-I      intronic chr19:48890216(-) A-I      intronic chr19:48889500(-) A-I      intronic chr19:48889443(-) A-I      intronic chr19:48889843(-) A-I      intronic chr19:48890689(-) A-I      intronic chr19:48889977(-) A-I      intronic chr19:48890719(-) A-I      intronic chr19:48890790(-) A-I      intronic chr19:48890242(-) A-I      intronic chr19:48890135(-) A-I      intronic chr19:48889542(-) A-I      intronic chr19:48890827(-) A-I      intronic chr19:48889509(-) A-I      intronic chr19:48889982(-) A-I      intronic chr19:48888272(-) A-I      intronic chr19:48890718(-) A-I      intronic chr19:48889540(-) A-I      intronic chr19:48890817(-) A-I      intronic chr19:48890862(-) A-I      intronic chr19:48889488(-) A-I      intronic chr19:48890206(-) A-I      intronic chr19:48888181(-) A-I      intronic chr19:48890167(-) A-I      intronic chr19:48889567(-) A-I      intronic chr19:48890228(-) A-I      intronic chr19:48889974(-) A-I      intronic chr19:48889990(-) A-I      intronic chr19:48889878(-) A-I      intronic chr19:48890776(-) A-I      intronic chr19:48890161(-) A-I      intronic chr19:48889842(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	KDELR1	chr19:48889842(-) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	KDELR1	chr19:48885831-48885832(-) m6A 3'UTR       27773535 chr19:48885846-48885847(-) m6A 3'UTR       27773535 chr19:48885879-48885880(-) m6A 3'UTR       27773535 chr19:48886096-48886097(-) m6A 3'UTR       24981863//26404942//27773535 chr19:48886146-48886147(-) m6A 3'UTR       24981863//26404942//27773535 chr19:48886337-48886338(-) m6A 3'UTR       27773535 chr19:48886369-48886370(-) m6A 3'UTR       27773535 chr19:48886402-48886403(-) m6A 3'UTR       27773535 chr19:48886491-48886492(-) Am 3'UTR       - chr19:48893723-48893724(-) m6A 5'UTR//CDS//exon       27773535 chr19:48893787-48893788(-) m6A 5'UTR//intron       27773535 chr19:48894098-48894099(-) m6A 5'UTR//intron       - chr19:48894109-48894110(-) m6A 5'UTR//intron       24284625//25456834 chr19:48894589-48894590(-) m6A CDS//exon       24284625//25456834//24981863//28052920//27773535 chr19:48894687-48894688(-) m6A 5'UTR//exon       24284625//25456834//24981863//28052920//27773535//27773536//22575960

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	KDELR1	Chromatin K562 cells     - Cytosol HCC cell line (HepG2)|K562 cells     - Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleolus HCC cell line (HepG2)|K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     - Ribosome HEK-293 cells     22199352 Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: kshv-miR-K12-3-3p
Interactor2: KDELR1

Evidence Support:

Weak-Evidence	Microarray
Support Database	ViRBase

References:

PMID	22174674	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EA.hy926 cells	Interactor2 expression	Downregulation
Description	As KSHV putative direct targets we extracted transcripts that were significantly down-regulated significantly in the replicate experiments, and which contained at least one seed-match to one of the KSHV miRNAs. We identified 704 putative direct targets in DG-75 cells (Figure 3B), and 980 putative direct targets in EA.hy926 cells (Figure 3C). A complete list of putative direct targets can be found in Dataset S2 for DG-75 cells and in Dataset S3 for EA.hy926 cells. The overlap between the two datasets contained 153 putative direct targets (Dataset S4).