Basic Information:

  VIRBase ID:  

VHID00470766

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-3-3p:  MIMAT0002194          GNAL:  NM_001261443     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	kshv-miR-K12-3-3p	GNAL
miRBase Accession/Entrez ID	MIMAT0002194	2774
Organism	Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	DYT25

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	GNAL	chr18:11883942(+) A-I      3'UTR chr18:11878638(+) A-I      intronic chr18:11882499(+) A-I      3'UTR chr18:11883951(+) A-I      3'UTR chr18:11883952(+) A-I      3'UTR chr18:11833290(+) A-I      intronic chr18:11833265(+) A-I      intronic chr18:11715030(+) A-I      intronic chr18:11882527(+) A-I      3'UTR chr18:11840947(+) A-I      intronic chr18:11882524(+) A-I      3'UTR chr18:11882523(+) A-I      3'UTR chr18:11882509(+) A-I      3'UTR chr18:11882508(+) A-I      3'UTR chr18:11882501(+) A-I      3'UTR chr18:11882483(+) A-I      3'UTR chr18:11882458(+) A-I      3'UTR chr18:11883796(+) A-I      3'UTR chr18:11846611(+) A-I      intronic chr18:11846613(+) A-I      intronic chr18:11883795(+) A-I      3'UTR chr18:11833303(+) A-I      intronic chr18:11883835(+) A-I      3'UTR chr18:11715023(+) A-I      intronic chr18:11715005(+) A-I      intronic chr18:11833291(+) A-I      intronic chr18:11846627(+) A-I      intronic chr18:11883966(+) A-I      3'UTR chr18:11833309(+) A-I      intronic chr18:11846607(+) A-I      intronic chr18:11846568(+) A-I      intronic chr18:11882529(+) A-I      3'UTR chr18:11714995(+) A-I      intronic chr18:11714998(+) A-I      intronic chr18:11882534(+) A-I      3'UTR chr18:11846605(+) A-I      intronic chr18:11846592(+) A-I      intronic chr18:11883887(+) A-I      3'UTR chr18:11854556(+) A-I      intronic chr18:11835882(+) A-I      intronic chr18:11849324(+) A-I      intronic chr18:11849330(+) A-I      intronic chr18:11855782(+) A-I      intronic chr18:11855786(+) A-I      intronic chr18:11855791(+) A-I      intronic chr18:11855792(+) A-I      intronic chr18:11859862(+) A-I      intronic chr18:11864106(+) A-I      intronic chr18:11864118(+) A-I      intronic chr18:11817985(+) A-I      intronic chr18:11880296(+) A-I      intronic chr18:11849345(+) A-I      intronic chr18:11849354(+) A-I      intronic chr18:11721545(+) A-I      intronic chr18:11790894(+) A-I      intronic chr18:11793791(+) A-I      intronic chr18:11796322(+) A-I      intronic chr18:11796338(+) A-I      intronic chr18:11796379(+) A-I      intronic chr18:11825466(+) A-I      intronic chr18:11825468(+) A-I      intronic chr18:11835880(+) A-I      intronic chr18:11849458(+) A-I      intronic chr18:11693791(+) A-I      intronic chr18:11840934(+) A-I      intronic chr18:11837878(+) A-I      intronic chr18:11764344(+) A-I      intronic chr18:11795204(+) A-I      intronic chr18:11880011(+) A-I      intronic chr18:11880453(+) A-I      intronic chr18:11770999(+) A-I      intronic chr18:11849294(+) A-I      intronic chr18:11878286(+) A-I      intronic chr18:11837033(+) A-I      intronic chr18:11843243(+) A-I      intronic chr18:11846595(+) A-I      intronic chr18:11846850(+) A-I      intronic chr18:11764341(+) A-I      intronic chr18:11841444(+) A-I      intronic chr18:11841387(+) A-I      intronic chr18:11854943(+) A-I      intronic chr18:11868191(+) A-I      intronic chr18:11882432(+) A-I      3'UTR chr18:11878311(+) A-I      intronic chr18:11846536(+) A-I      intronic chr18:11882538(+) A-I      3'UTR chr18:11822515(+) A-I      intronic chr18:11846838(+) A-I      intronic chr18:11882431(+) A-I      3'UTR chr18:11882597(+) A-I      3'UTR chr18:11869787(+) A-I      intronic chr18:11764694(+) A-I      intronic chr18:11878686(+) A-I      intronic chr18:11882409(+) A-I      3'UTR chr18:11882613(+) A-I      3'UTR chr18:11796389(+) A-I      intronic chr18:11809024(+) A-I      intronic chr18:11698236(+) A-I      intronic chr18:11878708(+) A-I      intronic chr18:11878802(+) A-I      intronic chr18:11837083(+) A-I      intronic chr18:11878258(+) A-I      intronic chr18:11843363(+) A-I      intronic chr18:11878631(+) A-I      intronic chr18:11878284(+) A-I      intronic chr18:11834666(+) A-I      intronic chr18:11878750(+) A-I      intronic chr18:11817979(+) A-I      intronic chr18:11796357(+) A-I      intronic chr18:11839478(+) A-I      intronic chr18:11880454(+) A-I      intronic chr18:11849276(+) A-I      intronic chr18:11856787(+) A-I      intronic chr18:11849450(+) A-I      intronic chr18:11841631(+) A-I      intronic chr18:11735699(+) A-I      intronic chr18:11693767(+) A-I      intronic chr18:11846591(+) A-I      intronic chr18:11827492(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	GNAL	chr18:11689701-11689702(+) m6A CDS//exon       24209618 chr18:11689712-11689713(+) m6A CDS//exon       24209618 chr18:11689767-11689768(+) m6A CDS//exon       24209618 chr18:11851397-11851398(+) m6A intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr18:11851409-11851410(+) m6A intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr18:11851415-11851416(+) m6A intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr18:11851440-11851441(+) m6A intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr18:11851527-11851528(+) m6A intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr18:11851560-11851561(+) m6A intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr18:11851688-11851689(+) m6A intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr18:11851822-11851823(+) m6A intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr18:11851856-11851857(+) m6A intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr18:11851879-11851880(+) m6A intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr18:11851900-11851901(+) Cm intron       - chr18:11851910-11851911(+) m6A intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr18:11851949-11851950(+) m6A intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr18:11852026-11852027(+) m6A intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr18:11852070-11852071(+) m6A intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr18:11852082-11852083(+) m6A intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr18:11852117-11852118(+) m6A intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr18:11852194-11852195(+) m6A intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr18:11852201-11852202(+) m6A intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr18:11852352-11852353(+) m6A intron       24209618 chr18:11852399-11852400(+) m6A intron       24209618//27773535 chr18:11852549-11852550(+) m6A intron       24981863//26404942//22608085 chr18:11852572-11852573(+) m6A intron       24981863//22608085 chr18:11852640-11852641(+) m6A intron       24981863//22608085 chr18:11853025-11853026(+) m6A intron       24981863//22608085 chr18:11853047-11853048(+) m6A intron       24981863//22608085 chr18:11853055-11853056(+) m6A intron       24981863//22608085 chr18:11853114-11853115(+) m6A intron       24981863 chr18:11857445-11857446(+) m6A 5'UTR//intron       24284625 chr18:11857457-11857458(+) m6A 5'UTR//intron       24284625 chr18:11857462-11857463(+) m6A 5'UTR//intron       24284625 chr18:11857501-11857502(+) m6A 5'UTR//intron       24284625 chr18:11857647-11857648(+) m6A 5'UTR//intron       24981863 chr18:11881016-11881017(+) m6A CDS       24284625 chr18:11881051-11881052(+) m6A CDS       24284625//25456834//24981863//22575960 chr18:11881060-11881061(+) m6A CDS       24284625//25456834//24981863//22575960 chr18:11881172-11881173(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960 chr18:11881349-11881350(+) m6A 3'UTR       24284625//24209618//24981863//22608085 chr18:11881439-11881440(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22608085 chr18:11881459-11881460(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22608085 chr18:11881604-11881605(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22608085 chr18:11881640-11881641(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22608085 chr18:11881720-11881721(+) m6A 3'UTR       24284625 chr18:11882776-11882777(+) m6A 3'UTR       24981863 chr18:11882786-11882787(+) m6A 3'UTR       24981863 chr18:11883439-11883440(+) m6A 3'UTR       27773535 chr18:11883455-11883456(+) m6A 3'UTR       27773535 chr18:11884038-11884039(+) m6A 3'UTR       27773535 chr18:11884060-11884061(+) m6A 3'UTR       27773535 chr18:11884133-11884134(+) m6A 3'UTR       27773535 chr18:11884139-11884140(+) m6A 3'UTR       27773535 chr18:11884231-11884232(+) m6A 3'UTR       24981863//27773535 chr18:11884274-11884275(+) m6A 3'UTR       24981863//27773535 chr18:11884476-11884477(+) m6A 3'UTR       24284625//24981863//28052920//27773535//22608085 chr18:11884525-11884526(+) m6A 3'UTR       24284625//24981863//27773535//22608085 chr18:11884564-11884565(+) m6A 3'UTR       24284625//24981863//27773535//22608085 chr18:11884869-11884870(+) m6A 3'UTR       27773535 chr18:11884885-11884886(+) m6A 3'UTR       27773535 chr18:11885387-11885388(+) m6A 3'UTR       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	GNAL	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleoplasm K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: kshv-miR-K12-3-3p
Interactor2: GNAL

Evidence Support:

Weak-Evidence	Microarray
Support Database	ViRBase

References:

PMID	29550353	Target region	None
Source	ViRBase	Interactor1 expression	Upregulation
Tissue or cell line	HOK cells	Interactor2 expression	Downregulation
Description	GPCR signaling is among the miR-K12-3-3p targeted pathways affected with downregulation of multiple genes in this network (Figure 3B, highlighted in green).