Basic Information:

  VIRBase ID:  

VHID00470461

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5908

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-3-5p:  MIMAT0002193          FAM177A1:  NM_001079519     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	kshv-miR-K12-3-5p	FAM177A1
miRBase Accession/Entrez ID	MIMAT0002193	283635
Organism	Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	C14orf24

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	FAM177A1	chr14:35532568(+) A-I      intronic chr14:35518263(+) A-I      intronic chr14:35518249(+) A-I      intronic chr14:35518244(+) A-I      intronic chr14:35532571(+) A-I      intronic chr14:35519492(+) A-I      intronic chr14:35518923(+) A-I      intronic chr14:35518306(+) A-I      intronic chr14:35519467(+) A-I      intronic chr14:35519495(+) A-I      intronic chr14:35519489(+) A-I      intronic chr14:35532602(+) A-I      intronic chr14:35532633(+) A-I      intronic chr14:35535328(+) A-I      intronic chr14:35535710(+) A-I      intronic chr14:35535714(+) A-I      intronic chr14:35539635(+) A-I      intronic chr14:35536139(+) A-I      intronic chr14:35519330(+) A-I      intronic chr14:35536212(+) A-I      intronic chr14:35538548(+) A-I      intronic chr14:35538609(+) A-I      intronic chr14:35538665(+) A-I      intronic chr14:35518978(+) A-I      intronic chr14:35539653(+) A-I      intronic chr14:35518979(+) A-I      intronic chr14:35520893(+) A-I      intronic chr14:35522021(+) A-I      intronic chr14:35528271(+) A-I      intronic chr14:35540410(+) A-I      intronic chr14:35539490(+) A-I      intronic chr14:35532704(+) A-I      intronic chr14:35528353(+) A-I      intronic chr14:35519398(+) A-I      intronic chr14:35518200(+) A-I      intronic chr14:35518262(+) A-I      intronic chr14:35518294(+) A-I      intronic chr14:35518750(+) A-I      intronic chr14:35519424(+) A-I      intronic chr14:35518780(+) A-I      intronic chr14:35518826(+) A-I      intronic chr14:35518897(+) A-I      intronic chr14:35518903(+) A-I      intronic chr14:35521689(+) A-I      intronic chr14:35521949(+) A-I      intronic chr14:35543468(+) A-I      intronic chr14:35518814(+) A-I      intronic chr14:35527900(+) A-I      intronic chr14:35518948(+) A-I      intronic chr14:35528091(+) A-I      intronic chr14:35518726(+) A-I      intronic chr14:35539510(+) A-I      intronic chr14:35524787(+) A-I      intronic chr14:35518277(+) A-I      intronic chr14:35527438(+) A-I      intronic chr14:35522037(+) A-I      intronic chr14:35527349(+) A-I      intronic chr14:35544175(+) A-I      intronic chr14:35528009(+) A-I      intronic chr14:35521859(+) A-I      intronic chr14:35524898(+) A-I      intronic chr14:35516844(+) A-I      intronic chr14:35524795(+) A-I      intronic chr14:35524766(+) A-I      intronic chr14:35519342(+) A-I      intronic chr14:35524826(+) A-I      intronic chr14:35524062(+) A-I      intronic chr14:35528039(+) A-I      intronic chr14:35521884(+) A-I      intronic chr14:35524063(+) A-I      intronic chr14:35521899(+) A-I      intronic chr14:35516808(+) A-I      intronic chr14:35521977(+) A-I      intronic chr14:35533179(+) A-I      intronic chr14:35544188(+) A-I      intronic chr14:35522936(+) A-I      intronic chr14:35528259(+) A-I      intronic chr14:35533505(+) A-I      intronic chr14:35532592(+) A-I      intronic chr14:35524378(+) A-I      intronic chr14:35538657(+) A-I      intronic chr14:35544151(+) A-I      intronic chr14:35528028(+) A-I      intronic chr14:35518359(+) A-I      intronic chr14:35523039(+) A-I      intronic chr14:35518971(+) A-I      intronic chr14:35538658(+) A-I      intronic chr14:35516793(+) A-I      intronic chr14:35544164(+) A-I      intronic chr14:35524765(+) A-I      intronic chr14:35533186(+) A-I      intronic chr14:35543649(+) A-I      intronic chr14:35516779(+) A-I      intronic chr14:35524744(+) A-I      intronic chr14:35528222(+) A-I      intronic chr14:35539745(+) A-I      intronic chr14:35527826(+) A-I      intronic chr14:35539207(+) A-I      intronic chr14:35524714(+) A-I      intronic chr14:35519245(+) A-I      intronic chr14:35541387(+) A-I      intronic chr14:35520467(+) A-I      intronic chr14:35524250(+) A-I      intronic chr14:35528281(+) A-I      intronic chr14:35539639(+) A-I      intronic chr14:35523149(+) A-I      intronic chr14:35524703(+) A-I      intronic chr14:35528206(+) A-I      intronic chr14:35533927(+) A-I      intronic chr14:35528087(+) A-I      intronic chr14:35539242(+) A-I      intronic chr14:35519237(+) A-I      intronic chr14:35543625(+) A-I      intronic chr14:35528203(+) A-I      intronic chr14:35539795(+) A-I      intronic chr14:35543993(+) A-I      intronic chr14:35523919(+) A-I      intronic chr14:35533937(+) A-I      intronic chr14:35539616(+) A-I      intronic chr14:35539046(+) A-I      intronic chr14:35519358(+) A-I      intronic chr14:35533958(+) A-I      intronic chr14:35539223(+) A-I      intronic chr14:35534034(+) A-I      intronic chr14:35534040(+) A-I      intronic chr14:35534049(+) A-I      intronic chr14:35534065(+) A-I      intronic chr14:35521975(+) A-I      intronic chr14:35518158(+) A-I      intronic chr14:35528197(+) A-I      intronic chr14:35535037(+) A-I      intronic chr14:35524389(+) A-I      intronic chr14:35535043(+) A-I      intronic chr14:35544149(+) A-I      intronic chr14:35523925(+) A-I      intronic chr14:35535064(+) A-I      intronic chr14:35535316(+) A-I      intronic chr14:35528307(+) A-I      intronic chr14:35539640(+) A-I      intronic chr14:35523148(+) A-I      intronic chr14:35551534(+) A-I      3'UTR chr14:35551676(+) A-I      3'UTR chr14:35551640(+) A-I      3'UTR chr14:35551679(+) A-I      3'UTR chr14:35551669(+) A-I      3'UTR chr14:35551660(+) A-I      3'UTR chr14:35551634(+) A-I      3'UTR chr14:35551598(+) A-I      3'UTR chr14:35551568(+) A-I      3'UTR chr14:35551563(+) A-I      3'UTR chr14:35551555(+) A-I      3'UTR chr14:35551538(+) A-I      3'UTR chr14:35551533(+) A-I      3'UTR chr14:35551488(+) A-I      3'UTR chr14:35551470(+) A-I      3'UTR chr14:35551500(+) A-I      3'UTR chr14:35551443(+) A-I      3'UTR chr14:35521986(+) A-I      intronic chr14:35544122(+) A-I      intronic chr14:35522007(+) A-I      intronic chr14:35544152(+) A-I      intronic chr14:35533883(+) A-I      intronic chr14:35522085(+) A-I      intronic chr14:35523926(+) A-I      intronic chr14:35544158(+) A-I      intronic chr14:35528045(+) A-I      intronic chr14:35533067(+) A-I      intronic chr14:35544071(+) A-I      intronic chr14:35518128(+) A-I      intronic chr14:35518751(+) A-I      intronic chr14:35528057(+) A-I      intronic chr14:35539146(+) A-I      intronic chr14:35542473(+) A-I      intronic chr14:35520669(+) A-I      intronic chr14:35521882(+) A-I      intronic chr14:35535170(+) A-I      intronic chr14:35532258(+) A-I      intronic chr14:35539120(+) A-I      intronic chr14:35524876(+) A-I      intronic chr14:35532287(+) A-I      intronic chr14:35525727(+) A-I      intronic chr14:35527544(+) A-I      intronic chr14:35528393(+) A-I      intronic chr14:35537105(+) A-I      intronic chr14:35539164(+) A-I      intronic chr14:35524133(+) A-I      intronic chr14:35527848(+) A-I      intronic chr14:35518813(+) A-I      intronic chr14:35524853(+) A-I      intronic chr14:35518995(+) A-I      intronic chr14:35521997(+) A-I      intronic chr14:35518230(+) A-I      intronic chr14:35532591(+) A-I      intronic chr14:35538753(+) A-I      intronic chr14:35528010(+) A-I      intronic chr14:35535087(+) A-I      intronic chr14:35533549(+) A-I      intronic chr14:35521981(+) A-I      intronic chr14:35521875(+) A-I      intronic chr14:35516716(+) A-I      intronic chr14:35544168(+) A-I      intronic chr14:35536044(+) A-I      intronic chr14:35522053(+) A-I      intronic chr14:35535464(+) A-I      intronic chr14:35519387(+) A-I      intronic chr14:35518870(+) A-I      intronic chr14:35519420(+) A-I      intronic chr14:35541266(+) A-I      intronic chr14:35543992(+) A-I      intronic chr14:35532231(+) A-I      intronic chr14:35519450(+) A-I      intronic chr14:35522005(+) A-I      intronic chr14:35524683(+) A-I      intronic chr14:35539636(+) A-I      intronic chr14:35544132(+) A-I      intronic chr14:35535169(+) A-I      intronic chr14:35518732(+) A-I      intronic chr14:35539781(+) A-I      intronic chr14:35536056(+) A-I      intronic chr14:35521916(+) A-I      intronic chr14:35532637(+) A-I      intronic chr14:35521876(+) A-I      intronic chr14:35522103(+) A-I      intronic chr14:35535326(+) A-I      intronic chr14:35539069(+) A-I      intronic chr14:35518115(+) A-I      intronic chr14:35524237(+) A-I      intronic chr14:35527935(+) A-I      intronic chr14:35528185(+) A-I      intronic chr14:35520780(+) A-I      intronic chr14:35544123(+) A-I      intronic chr14:35539224(+) A-I      intronic chr14:35518226(+) A-I      intronic chr14:35539710(+) A-I      intronic chr14:35520744(+) A-I      intronic chr14:35533514(+) A-I      intronic chr14:35535151(+) A-I      intronic chr14:35518812(+) A-I      intronic chr14:35518728(+) A-I      intronic chr14:35533089(+) A-I      intronic chr14:35539725(+) A-I      intronic chr14:35518280(+) A-I      intronic chr14:35518360(+) A-I      intronic chr14:35539062(+) A-I      intronic chr14:35518876(+) A-I      intronic chr14:35521857(+) A-I      intronic chr14:35532664(+) A-I      intronic chr14:35521921(+) A-I      intronic chr14:35527971(+) A-I      intronic chr14:35518809(+) A-I      intronic chr14:35528338(+) A-I      intronic chr14:35518214(+) A-I      intronic chr14:35519235(+) A-I      intronic chr14:35524332(+) A-I      intronic chr14:35541228(+) A-I      intronic chr14:35535373(+) A-I      intronic chr14:35524904(+) A-I      intronic chr14:35519233(+) A-I      intronic chr14:35518201(+) A-I      intronic chr14:35519277(+) A-I      intronic chr14:35524757(+) A-I      intronic chr14:35528069(+) A-I      intronic chr14:35518941(+) A-I      intronic chr14:35521915(+) A-I      intronic chr14:35522920(+) A-I      intronic chr14:35551456(+) A-I      3'UTR chr14:35551458(+) A-I      3'UTR chr14:35551572(+) A-I      3'UTR chr14:35551465(+) A-I      3'UTR chr14:35551510(+) A-I      3'UTR chr14:35551576(+) A-I      3'UTR chr14:35551599(+) A-I      3'UTR chr14:35551668(+) A-I      3'UTR chr14:35551495(+) A-I      3'UTR chr14:35551447(+) A-I      3'UTR chr14:35551604(+) A-I      3'UTR

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	FAM177A1	chr14:35521882(+) A-I intron -    15545495 chr14:35521921(+) A-I intron -    15545495 chr14:35521949(+) A-I intron -    15545495 chr14:35521977(+) A-I intron -    15545495 chr14:35521986(+) A-I intron -    15545495 chr14:35522021(+) A-I intron -    15545495 chr14:35522103(+) A-I intron -    15545495 chr14:35518814(+) A-G intron -    22484847 chr14:35519235(+) A-G intron -    22484847 chr14:35519450(+) A-G intron -    22484847 chr14:35544071(+) A-G intron -    22484847 chr14:35551447(+) A-G intron -    22484847 chr14:35551456(+) A-G intron -    22484847 chr14:35551458(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	FAM177A1	chr14:35515662-35515663(+) m6A 5'UTR//intron       24284625//24981863 chr14:35515742-35515743(+) m6A CDS       24284625//24209618//24981863 chr14:35515987-35515988(+) m6A 3'UTR//intron       24981863 chr14:35516051-35516052(+) m6A 3'UTR//intron       24981863 chr14:35522453-35522454(+) m6A 5'UTR//intron       24981863 chr14:35522515-35522516(+) m6A 3'UTR//CDS       24209618//24981863 chr14:35522579-35522580(+) m6A 3'UTR//CDS       24209618//24981863//27773535 chr14:35550249-35550250(+) m6A CDS       24284625//24209618//24981863//27773535//22608085 chr14:35550274-35550275(+) m6A CDS       24284625//24209618//24981863//27773535//22608085 chr14:35550299-35550300(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr14:35550317-35550318(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr14:35550332-35550333(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr14:35550381-35550382(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22608085 chr14:35550458-35550459(+) m6A 3'UTR       24284625//24981863//27773535//22608085 chr14:35550488-35550489(+) m6A 3'UTR       24284625//24981863//22608085 chr14:35550513-35550514(+) m6A 3'UTR       24284625//24981863 chr14:35551639-35551640(+) m6A 3'UTR//intron       - chr14:35551708-35551709(+) m6A 3'UTR//intron       - chr14:35551754-35551755(+) m6A 3'UTR//intron       - chr14:35571794-35571795(+) m6A exon//intron       27773535 chr14:35579127-35579128(+) m6A exon//intron       27773535 chr14:35579779-35579780(+) m6A 3'UTR//exon       27773535 chr14:35579815-35579816(+) m6A 3'UTR//exon       27773535 chr14:35579873-35579874(+) m6A exon//intron       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	kshv-miR-K12-3-5p	Exosome B cell line (Raji)|Primary dendritic cells|T cell line (J77)     21505438 Exosome KSHV-infected lymphoma cell lines (BCBL-1|TY-1)     27611973 Exosome K562 cells     24460325
	FAM177A1	Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: kshv-miR-K12-3-5p
Interactor2: FAM177A1

Evidence Support:

Weak-Evidence	Microarray
Prediction-Evidence	miRanda//Targetscan
Support Database	ViRBase//VmiReg

References:

PMID	22174674	Target region	None
Source	ViRBase//VmiReg	Interactor1 expression	None
Tissue or cell line	DG-75 cells	Interactor2 expression	Downregulation
Description	As KSHV putative direct targets we extracted transcripts that were significantly down-regulated significantly in the replicate experiments, and which contained at least one seed-match to one of the KSHV miRNAs. We identified 704 putative direct targets in DG-75 cells (Figure 3B), and 980 putative direct targets in EA.hy926 cells (Figure 3C). A complete list of putative direct targets can be found in Dataset S2 for DG-75 cells and in Dataset S3 for EA.hy926 cells. The overlap between the two datasets contained 153 putative direct targets (Dataset S4).