Basic Information:

  VIRBase ID:  

VHID00470305

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-3-5p:  MIMAT0002193          GIMAP7:  NM_153236     

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Interactor Information:

	Interactor1	Interactor2
Symbol	kshv-miR-K12-3-5p	GIMAP7
miRBase Accession/Entrez ID	MIMAT0002193	168537
Organism	Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	hIAN7//IAN7

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	GIMAP7	chr7:150212004-150212005(+) m6A 5'UTR       - chr7:150217078-150217079(+) m6A CDS       - chr7:150217110-150217111(+) m6A CDS       - chr7:150217138-150217139(+) m6A CDS       - chr7:150217198-150217199(+) m6A CDS       - chr7:150217234-150217235(+) m6A CDS       26404942 chr7:150217249-150217250(+) m6A CDS       26404942 chr7:150217285-150217286(+) m6A CDS       26404942 chr7:150217392-150217393(+) m6A CDS       - chr7:150217546-150217547(+) m6A CDS       - chr7:150217578-150217579(+) m6A CDS       - chr7:150217684-150217685(+) m6A CDS       - chr7:150217703-150217704(+) m6A CDS       - chr7:150217760-150217761(+) m6A CDS       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	kshv-miR-K12-3-5p	Exosome B cell line (Raji)|Primary dendritic cells|T cell line (J77)     21505438 Exosome KSHV-infected lymphoma cell lines (BCBL-1|TY-1)     27611973 Exosome K562 cells     24460325
	GIMAP7	Exosome Blood     -

Interaction Network (The top 100 interactions):

Interactor1: kshv-miR-K12-3-5p
Interactor2: GIMAP7

Evidence Support:

Weak-Evidence	Microarray
Support Database	ViRBase

References:

PMID	22174674	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EA.hy926 cells	Interactor2 expression	Downregulation
Description	As KSHV putative direct targets we extracted transcripts that were significantly down-regulated significantly in the replicate experiments, and which contained at least one seed-match to one of the KSHV miRNAs. We identified 704 putative direct targets in DG-75 cells (Figure 3B), and 980 putative direct targets in EA.hy926 cells (Figure 3C). A complete list of putative direct targets can be found in Dataset S2 for DG-75 cells and in Dataset S3 for EA.hy926 cells. The overlap between the two datasets contained 153 putative direct targets (Dataset S4).