Basic Information:

  VIRBase ID:  

VHID00469807

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-3-5p:  MIMAT0002193          UNC119B:  NM_001080533     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	kshv-miR-K12-3-5p	UNC119B
miRBase Accession/Entrez ID	MIMAT0002193	84747
Organism	Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	POC7B

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	UNC119B	chr12:121152813(+) A-I      intronic chr12:121152833(+) A-I      intronic chr12:121152836(+) A-I      intronic chr12:121152879(+) A-I      intronic chr12:121152249(+) A-I      intronic chr12:121152203(+) A-I      intronic chr12:121153596(+) A-I      intronic chr12:121152883(+) A-I      intronic chr12:121152298(+) A-I      intronic chr12:121152397(+) A-I      intronic chr12:121152735(+) A-I      intronic chr12:121152793(+) A-I      intronic chr12:121152796(+) A-I      intronic chr12:121152395(+) A-I      intronic chr12:121152989(+) A-I      intronic chr12:121152204(+) A-I      intronic chr12:121152736(+) A-I      intronic chr12:121152806(+) A-I      intronic chr12:121152321(+) A-I      intronic chr12:121152265(+) A-I      intronic chr12:121152914(+) A-I      intronic chr12:121152398(+) A-I      intronic chr12:121152847(+) A-I      intronic chr12:121152887(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	UNC119B	chr12:121148358-121148359(+) m1A CDS//exon       26863196//26863410 chr12:121148383-121148384(+) m6A CDS//exon       24209618//25456834//24981863 chr12:121148473-121148474(+) m6A CDS//exon       24209618 chr12:121151089-121151090(+) m6A CDS//exon       - chr12:121151097-121151098(+) m6A CDS//exon       - chr12:121154469-121154470(+) m6A CDS       24981863 chr12:121154528-121154529(+) m6A CDS       24981863 chr12:121154692-121154693(+) m6A CDS       24981863 chr12:121154707-121154708(+) m6A CDS       24284625//24981863 chr12:121154741-121154742(+) m6A CDS       24284625//24981863 chr12:121154755-121154756(+) m6A CDS       24284625//24981863 chr12:121154797-121154798(+) m6A CDS       24284625//24981863 chr12:121154807-121154808(+) m6A CDS       24284625//24981863 chr12:121157751-121157752(+) m6A CDS       24284625//24981863 chr12:121158453-121158454(+) Y 3'UTR       26075521 chr12:121160707-121160708(+) m6A 3'UTR       24981863 chr12:121160779-121160780(+) m6A 3'UTR       24981863 chr12:121160843-121160844(+) m6A 3'UTR       24981863 chr12:121160887-121160888(+) m6A 3'UTR       24981863 chr12:121161120-121161121(+) m6A 3'UTR       24981863 chr12:121161152-121161153(+) m6A 3'UTR       24981863 chr12:121161210-121161211(+) m6A 3'UTR       24981863 chr12:121161283-121161284(+) m6A 3'UTR       24981863//27773535 chr12:121161371-121161372(+) m6A 3'UTR       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	kshv-miR-K12-3-5p	Exosome B cell line (Raji)|Primary dendritic cells|T cell line (J77)     21505438 Exosome KSHV-infected lymphoma cell lines (BCBL-1|TY-1)     27611973 Exosome K562 cells     24460325
	UNC119B	Chromatin K562 cells     - Exosome Blood     - Nucleoplasm K562 cells     - Nucleus HeLa-S3 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: kshv-miR-K12-3-5p
Interactor2: UNC119B

Evidence Support:

Weak-Evidence	Microarray
Prediction-Evidence	miRanda//Rep//Targetscan
Support Database	RepTar//ViRBase//VmiReg

References:

PMID	22174674	Target region	None
Source	RepTar//ViRBase//VmiReg	Interactor1 expression	None
Tissue or cell line	EA.hy926 cells	Interactor2 expression	Downregulation
Description	As KSHV putative direct targets we extracted transcripts that were significantly down-regulated significantly in the replicate experiments, and which contained at least one seed-match to one of the KSHV miRNAs. We identified 704 putative direct targets in DG-75 cells (Figure 3B), and 980 putative direct targets in EA.hy926 cells (Figure 3C). A complete list of putative direct targets can be found in Dataset S2 for DG-75 cells and in Dataset S3 for EA.hy926 cells. The overlap between the two datasets contained 153 putative direct targets (Dataset S4).