Basic Information:

  VIRBase ID:  

VHID00469686

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5908

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-3-5p:  MIMAT0002193          TSPAN14:  NM_030927     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	kshv-miR-K12-3-5p	TSPAN14
miRBase Accession/Entrez ID	MIMAT0002193	81619
Organism	Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	DC-TM4F2//TM4SF14//tspan-14

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	TSPAN14	chr10:82235171(+) A-I      intronic chr10:82235170(+) A-I      intronic chr10:82243488(+) A-I      intronic chr10:82217086(+) A-I      intronic chr10:82217084(+) A-I      intronic chr10:82243838(+) A-I      intronic chr10:82217074(+) A-I      intronic chr10:82243850(+) A-I      intronic chr10:82215570(+) A-I      intronic chr10:82216663(+) A-I      intronic chr10:82243858(+) A-I      intronic chr10:82243951(+) A-I      intronic chr10:82235138(+) A-I      intronic chr10:82243445(+) A-I      intronic chr10:82226252(+) A-I      5'UTR chr10:82235175(+) A-I      intronic chr10:82243925(+) A-I      intronic chr10:82281995(+) A-I      3'UTR chr10:82243836(+) A-I      intronic chr10:82243508(+) A-I      intronic chr10:82235162(+) A-I      intronic chr10:82282223(+) A-I      3'UTR chr10:82282249(+) A-I      3'UTR chr10:82282120(+) A-I      3'UTR chr10:82282111(+) A-I      3'UTR chr10:82282095(+) A-I      3'UTR chr10:82282071(+) A-I      3'UTR chr10:82282057(+) A-I      3'UTR chr10:82282034(+) A-I      3'UTR chr10:82282017(+) A-I      3'UTR chr10:82242324(+) A-I      intronic chr10:82244188(+) A-I      intronic chr10:82242179(+) A-I      intronic chr10:82243839(+) A-I      intronic chr10:82242172(+) A-I      intronic chr10:82243581(+) A-I      intronic chr10:82243843(+) A-I      intronic chr10:82242136(+) A-I      intronic chr10:82238528(+) A-I      intronic chr10:82243559(+) A-I      intronic chr10:82243450(+) A-I      intronic chr10:82217071(+) A-I      intronic chr10:82235617(+) A-I      intronic chr10:82243478(+) A-I      intronic chr10:82243479(+) A-I      intronic chr10:82241691(+) A-I      intronic chr10:82243607(+) A-I      intronic chr10:82243618(+) A-I      intronic chr10:82241716(+) A-I      intronic chr10:82243750(+) A-I      intronic chr10:82235211(+) A-I      intronic chr10:82243760(+) A-I      intronic chr10:82243455(+) A-I      intronic chr10:82243745(+) A-I      intronic chr10:82243801(+) A-I      intronic chr10:82243842(+) A-I      intronic chr10:82243577(+) A-I      intronic chr10:82243481(+) A-I      intronic chr10:82243890(+) A-I      intronic chr10:82244174(+) A-I      intronic chr10:82235059(+) A-I      intronic chr10:82240755(+) A-I      intronic chr10:82244181(+) A-I      intronic chr10:82235163(+) A-I      intronic chr10:82243912(+) A-I      intronic chr10:82243921(+) A-I      intronic chr10:82244158(+) A-I      intronic chr10:82244240(+) A-I      intronic chr10:82243840(+) A-I      intronic chr10:82271643(+) A-I      intronic chr10:82240773(+) A-I      intronic chr10:82243410(+) A-I      intronic chr10:82243507(+) A-I      intronic chr10:82243407(+) A-I      intronic chr10:82243449(+) A-I      intronic chr10:82241649(+) A-I      intronic chr10:82243578(+) A-I      intronic chr10:82243519(+) A-I      intronic chr10:82282152(+) A-I      3'UTR chr10:82282216(+) A-I      3'UTR chr10:82282033(+) A-I      3'UTR chr10:82282128(+) A-I      3'UTR chr10:82282091(+) A-I      3'UTR chr10:82282038(+) A-I      3'UTR chr10:82282028(+) A-I      3'UTR chr10:82281669(+) A-I      3'UTR chr10:82282179(+) A-I      3'UTR chr10:82282188(+) A-I      3'UTR chr10:82282209(+) A-I      3'UTR chr10:82282173(+) A-I      3'UTR chr10:82282199(+) A-I      3'UTR chr10:82235970(+) A-I      intronic chr10:82243654(+) A-I      intronic chr10:82235195(+) A-I      intronic chr10:82271654(+) A-I      intronic chr10:82244210(+) A-I      intronic chr10:82243572(+) A-I      intronic chr10:82244257(+) A-I      intronic chr10:82241521(+) A-I      intronic chr10:82243854(+) A-I      intronic chr10:82240750(+) A-I      intronic chr10:82243942(+) A-I      intronic chr10:82235049(+) A-I      intronic chr10:82243415(+) A-I      intronic chr10:82243766(+) A-I      intronic chr10:82243527(+) A-I      intronic chr10:82270551(+) A-I      intronic chr10:82243851(+) A-I      intronic chr10:82243908(+) A-I      intronic chr10:82240767(+) A-I      intronic chr10:82215549(+) A-I      intronic chr10:82235967(+) A-I      intronic chr10:82246762(+) A-I      intronic chr10:82243744(+) A-I      intronic chr10:82252385(+) A-I      intronic chr10:82235476(+) A-I      intronic chr10:82240793(+) A-I      intronic chr10:82236008(+) A-I      intronic chr10:82244180(+) A-I      intronic chr10:82231749(+) A-I      intronic chr10:82235942(+) A-I      intronic chr10:82216564(+) A-I      intronic chr10:82243440(+) A-I      intronic chr10:82228542(+) A-I      intronic chr10:82235365(+) A-I      intronic chr10:82235557(+) A-I      intronic chr10:82243841(+) A-I      intronic chr10:82241627(+) A-I      intronic chr10:82244235(+) A-I      intronic chr10:82243825(+) A-I      intronic chr10:82243815(+) A-I      intronic chr10:82243848(+) A-I      intronic chr10:82235995(+) A-I      intronic chr10:82241675(+) A-I      intronic chr10:82243501(+) A-I      intronic chr10:82243903(+) A-I      intronic chr10:82235946(+) A-I      intronic chr10:82241639(+) A-I      intronic chr10:82235140(+) A-I      intronic chr10:82243516(+) A-I      intronic chr10:82240741(+) A-I      intronic chr10:82243916(+) A-I      intronic chr10:82235164(+) A-I      intronic chr10:82244185(+) A-I      intronic chr10:82243489(+) A-I      intronic chr10:82240715(+) A-I      intronic chr10:82235126(+) A-I      intronic chr10:82243546(+) A-I      intronic chr10:82244217(+) A-I      intronic chr10:82243545(+) A-I      intronic chr10:82228526(+) A-I      intronic chr10:82235065(+) A-I      intronic chr10:82274988(+) A-I      intronic chr10:82282102(+) A-I      3'UTR chr10:82282105(+) A-I      3'UTR chr10:82282146(+) A-I      3'UTR chr10:82282081(+) A-I      3'UTR chr10:82282011(+) A-I      3'UTR chr10:82275015(+) A-I      intronic chr10:82282042(+) A-I      3'UTR chr10:82275009(+) A-I      intronic chr10:82282163(+) A-I      3'UTR chr10:82281533(+) A-I      3'UTR chr10:82281989(+) A-I      3'UTR chr10:82281559(+) A-I      3'UTR chr10:82275092(+) A-I      intronic chr10:82226285(+) A-I      5'UTR chr10:82274682(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	TSPAN14	chr10:82214067-82214068(+) m6A 5'UTR       24209618//24981863 chr10:82219075-82219076(+) m6A 5'UTR//intron       24209618//24981863 chr10:82277697-82277698(+) m6A CDS//exon       24284625//26404942 chr10:82277898-82277899(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr10:82277927-82277928(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr10:82277962-82277963(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr10:82278003-82278004(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr10:82278044-82278045(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr10:82278073-82278074(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr10:82278104-82278105(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr10:82278153-82278154(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr10:82278167-82278168(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr10:82278271-82278272(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr10:82278345-82278346(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr10:82278412-82278413(+) m6A 3'UTR//exon       24209618//25456834//24981863//22575960//22608085 chr10:82278651-82278652(+) m6A 3'UTR//exon       24284625//24209618//24981863//27773535 chr10:82278852-82278853(+) m6A 3'UTR//exon       - chr10:82279175-82279176(+) m6A 3'UTR//exon       26404942 chr10:82279466-82279467(+) m6A 3'UTR       - chr10:82279487-82279488(+) m6A 3'UTR       - chr10:82280428-82280429(+) m6A 3'UTR       24981863 chr10:82280588-82280589(+) m6A 3'UTR       24981863 chr10:82280967-82280968(+) m6A 3'UTR       24284625 chr10:82281005-82281006(+) m6A 3'UTR       24284625 chr10:82281736-82281737(+) m6A 3'UTR       24981863//26404942//27773535 chr10:82281757-82281758(+) m6A 3'UTR       24209618//24981863//26404942//27773535 chr10:82281892-82281893(+) m6A 3'UTR       24209618//24981863//26404942 chr10:82281981-82281982(+) m6A 3'UTR       25456834//24981863 chr10:82282019-82282020(+) m6A 3'UTR       24284625//25456834//24981863 chr10:82282035-82282036(+) m6A 3'UTR       24284625//25456834//24981863 chr10:82282067-82282068(+) m6A 3'UTR       24284625//25456834//24981863 chr10:82282077-82282078(+) m6A 3'UTR       24284625//25456834//24981863 chr10:82282187-82282188(+) m6A 3'UTR       24981863//27773535 chr10:82282196-82282197(+) m6A 3'UTR       24981863//27773535 chr10:82282253-82282254(+) m6A 3'UTR       24981863//27773535 chr10:82282284-82282285(+) m6A 3'UTR       24981863//27773535 chr10:82282310-82282311(+) m6A 3'UTR       24981863//27773535 chr10:82282320-82282321(+) m6A 3'UTR       24981863//27773535 chr10:82282331-82282332(+) m6A 3'UTR       24981863//27773535 chr10:82282370-82282371(+) m6A 3'UTR       24981863//27773535 chr10:82285742-82285743(+) m6A 3'UTR       24981863 chr10:82285750-82285751(+) m6A 3'UTR       24981863 chr10:82285795-82285796(+) m6A 3'UTR       24981863 chr10:82287822-82287823(+) m6A 3'UTR       24981863 chr10:82287863-82287864(+) m6A 3'UTR       24981863 chr10:82288340-82288341(+) m6A 3'UTR       - chr10:82288443-82288444(+) m6A 3'UTR       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	kshv-miR-K12-3-5p	Exosome B cell line (Raji)|Primary dendritic cells|T cell line (J77)     21505438 Exosome KSHV-infected lymphoma cell lines (BCBL-1|TY-1)     27611973 Exosome K562 cells     24460325
	TSPAN14	Chromatin K562 cells     - Cytosol HCC cell line (HepG2)     - Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Membrane K562 cells     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: kshv-miR-K12-3-5p
Interactor2: TSPAN14

Evidence Support:

Weak-Evidence	Microarray
Prediction-Evidence	miRanda//Targetscan
Support Database	ViRBase//VmiReg

References:

PMID	22174674	Target region	None
Source	ViRBase//VmiReg	Interactor1 expression	None
Tissue or cell line	EA.hy926 cells	Interactor2 expression	Downregulation
Description	As KSHV putative direct targets we extracted transcripts that were significantly down-regulated significantly in the replicate experiments, and which contained at least one seed-match to one of the KSHV miRNAs. We identified 704 putative direct targets in DG-75 cells (Figure 3B), and 980 putative direct targets in EA.hy926 cells (Figure 3C). A complete list of putative direct targets can be found in Dataset S2 for DG-75 cells and in Dataset S3 for EA.hy926 cells. The overlap between the two datasets contained 153 putative direct targets (Dataset S4).