Basic Information:

  VIRBase ID:  

VHID00469341

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-3-5p:  MIMAT0002193          PDP2:  NM_001329934     

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Interactor Information:

	Interactor1	Interactor2
Symbol	kshv-miR-K12-3-5p	PDP2
miRBase Accession/Entrez ID	MIMAT0002193	57546
Organism	Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	PDPC 2//PPM2B//PPM2C2

RNA Editing:

Resource	Symbol	Editing Position
Lncediting	PDP2	chr16: 66922010     chr16: 66922204     chr16: 66922205     chr16: 66922213     chr16: 66922201     chr16: 66921997     chr16: 66922227     chr16: 66922240     chr16: 66922200     chr16: 66922186     chr16: 66922386     chr16: 66922432     chr16: 66922443     chr16: 66922242     chr16: 66922246     chr16: 66922484

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	PDP2	chr16:66923434(+) A-I      3'UTR chr16:66923358(+) A-I      3'UTR chr16:66924025(+) A-I      3'UTR chr16:66923283(+) A-I      3'UTR chr16:66924024(+) A-I      3'UTR chr16:66924054(+) A-I      3'UTR chr16:66924062(+) A-I      3'UTR chr16:66924031(+) A-I      3'UTR chr16:66923299(+) A-I      3'UTR chr16:66923474(+) A-I      3'UTR chr16:66923999(+) A-I      3'UTR chr16:66923996(+) A-I      3'UTR chr16:66923944(+) A-I      3'UTR chr16:66923713(+) A-I      3'UTR chr16:66923701(+) A-I      3'UTR chr16:66923647(+) A-I      3'UTR chr16:66923439(+) A-I      3'UTR chr16:66923997(+) A-I      3'UTR chr16:66923344(+) A-I      3'UTR chr16:66917565(+) A-I      intronic chr16:66917551(+) A-I      intronic chr16:66916748(+) A-I      intronic chr16:66916296(+) A-I      intronic chr16:66916264(+) A-I      intronic chr16:66915786(+) A-I      intronic chr16:66917916(+) A-I      intronic chr16:66917915(+) A-I      intronic chr16:66923206(+) A-I      3'UTR chr16:66923278(+) A-I      3'UTR chr16:66923339(+) A-I      3'UTR chr16:66923368(+) A-I      3'UTR chr16:66923460(+) A-I      3'UTR chr16:66923480(+) A-I      3'UTR chr16:66923623(+) A-I      3'UTR chr16:66923716(+) A-I      3'UTR chr16:66923845(+) A-I      3'UTR chr16:66923897(+) A-I      3'UTR chr16:66923973(+) A-I      3'UTR chr16:66921694(+) A-I      3'UTR chr16:66921704(+) A-I      3'UTR chr16:66921735(+) A-I      3'UTR chr16:66921740(+) A-I      3'UTR chr16:66921744(+) A-I      3'UTR chr16:66921761(+) A-I      3'UTR chr16:66921765(+) A-I      3'UTR chr16:66924023(+) A-I      3'UTR chr16:66924110(+) A-I      3'UTR chr16:66924027(+) A-I      3'UTR chr16:66924044(+) A-I      3'UTR chr16:66924115(+) A-I      3'UTR chr16:66924117(+) A-I      3'UTR chr16:66924128(+) A-I      3'UTR chr16:66924179(+) A-I      3'UTR chr16:66924085(+) A-I      3'UTR chr16:66921766(+) A-I      3'UTR chr16:66921800(+) A-I      3'UTR chr16:66921807(+) A-I      3'UTR chr16:66922026(+) A-I      3'UTR chr16:66922153(+) A-I      3'UTR chr16:66922166(+) A-I      3'UTR chr16:66922175(+) A-I      3'UTR chr16:66916087(+) A-I      intronic chr16:66917242(+) A-I      intronic chr16:66915651(+) A-I      intronic chr16:66917390(+) A-I      intronic chr16:66922205(+) A-I      3'UTR chr16:66923611(+) A-I      3'UTR chr16:66922201(+) A-I      3'UTR chr16:66922070(+) A-I      3'UTR chr16:66923369(+) A-I      3'UTR chr16:66922027(+) A-I      3'UTR chr16:66924004(+) A-I      3'UTR chr16:66924033(+) A-I      3'UTR chr16:66924089(+) A-I      3'UTR chr16:66924012(+) A-I      3'UTR chr16:66923851(+) A-I      3'UTR chr16:66921680(+) A-I      3'UTR chr16:66922213(+) A-I      3'UTR chr16:66923759(+) A-I      3'UTR chr16:66922200(+) A-I      3'UTR chr16:66922443(+) A-I      3'UTR chr16:66924007(+) A-I      3'UTR chr16:66921609(+) A-I      3'UTR chr16:66923384(+) A-I      3'UTR chr16:66922072(+) A-I      3'UTR chr16:66923389(+) A-I      3'UTR chr16:66924103(+) A-I      3'UTR chr16:66921636(+) A-I      3'UTR chr16:66921705(+) A-I      3'UTR chr16:66923273(+) A-I      3'UTR chr16:66922432(+) A-I      3'UTR chr16:66923297(+) A-I      3'UTR chr16:66923429(+) A-I      3'UTR chr16:66923870(+) A-I      3'UTR chr16:66922242(+) A-I      3'UTR chr16:66921685(+) A-I      3'UTR chr16:66916146(+) A-I      intronic chr16:66917973(+) A-I      intronic chr16:66915653(+) A-I      intronic chr16:66916123(+) A-I      intronic chr16:66917983(+) A-I      intronic chr16:66917934(+) A-I      intronic chr16:66917920(+) A-I      intronic chr16:66917175(+) A-I      intronic chr16:66917900(+) A-I      intronic chr16:66917966(+) A-I      intronic chr16:66916919(+) A-I      intronic chr16:66915813(+) A-I      intronic chr16:66917619(+) A-I      intronic chr16:66915696(+) A-I      intronic chr16:66916131(+) A-I      intronic chr16:66916333(+) A-I      intronic chr16:66917197(+) A-I      intronic chr16:66915684(+) A-I      intronic chr16:66916273(+) A-I      intronic chr16:66915639(+) A-I      intronic chr16:66916798(+) A-I      intronic chr16:66916790(+) A-I      intronic chr16:66922149(+) A-I      3'UTR chr16:66923239(+) A-I      3'UTR chr16:66924094(+) A-I      3'UTR chr16:66921584(+) A-I      3'UTR chr16:66923618(+) A-I      3'UTR chr16:66924111(+) A-I      3'UTR chr16:66922151(+) A-I      3'UTR chr16:66923461(+) A-I      3'UTR chr16:66923263(+) A-I      3'UTR chr16:66922186(+) A-I      3'UTR chr16:66924005(+) A-I      3'UTR chr16:66923688(+) A-I      3'UTR chr16:66922155(+) A-I      3'UTR chr16:66923717(+) A-I      3'UTR chr16:66923714(+) A-I      3'UTR chr16:66924032(+) A-I      3'UTR chr16:66923229(+) A-I      3'UTR chr16:66922064(+) A-I      3'UTR chr16:66922100(+) A-I      3'UTR chr16:66924022(+) A-I      3'UTR chr16:66923352(+) A-I      3'UTR chr16:66923483(+) A-I      3'UTR chr16:66923327(+) A-I      3'UTR chr16:66923393(+) A-I      3'UTR chr16:66921708(+) A-I      3'UTR chr16:66923963(+) A-I      3'UTR chr16:66923265(+) A-I      3'UTR chr16:66924072(+) A-I      3'UTR chr16:66923254(+) A-I      3'UTR chr16:66923284(+) A-I      3'UTR chr16:66923765(+) A-I      3'UTR chr16:66923658(+) A-I      3'UTR chr16:66923644(+) A-I      3'UTR chr16:66924162(+) A-I      3'UTR chr16:66922032(+) A-I      3'UTR chr16:66923387(+) A-I      3'UTR chr16:66923304(+) A-I      3'UTR chr16:66921600(+) A-I      3'UTR chr16:66921805(+) A-I      3'UTR chr16:66923595(+) A-I      3'UTR chr16:66923435(+) A-I      3'UTR chr16:66923225(+) A-I      3'UTR chr16:66923709(+) A-I      3'UTR chr16:66922240(+) A-I      3'UTR chr16:66921695(+) A-I      3'UTR chr16:66924046(+) A-I      3'UTR chr16:66923766(+) A-I      3'UTR chr16:66923788(+) A-I      3'UTR chr16:66922051(+) A-I      3'UTR chr16:66924063(+) A-I      3'UTR chr16:66921670(+) A-I      3'UTR chr16:66922227(+) A-I      3'UTR chr16:66922484(+) A-I      3'UTR chr16:66923342(+) A-I      3'UTR chr16:66922071(+) A-I      3'UTR chr16:66923253(+) A-I      3'UTR chr16:66921776(+) A-I      3'UTR chr16:66922075(+) A-I      3'UTR chr16:66924079(+) A-I      3'UTR chr16:66923378(+) A-I      3'UTR chr16:66923950(+) A-I      3'UTR chr16:66923303(+) A-I      3'UTR chr16:66923413(+) A-I      3'UTR chr16:66921672(+) A-I      3'UTR chr16:66923235(+) A-I      3'UTR chr16:66923325(+) A-I      3'UTR chr16:66923767(+) A-I      3'UTR chr16:66924108(+) A-I      3'UTR chr16:66923601(+) A-I      3'UTR chr16:66924173(+) A-I      3'UTR chr16:66921697(+) A-I      3'UTR chr16:66924124(+) A-I      3'UTR chr16:66923332(+) A-I      3'UTR chr16:66921587(+) A-I      3'UTR chr16:66923770(+) A-I      3'UTR chr16:66923715(+) A-I      3'UTR chr16:66923452(+) A-I      3'UTR chr16:66924006(+) A-I      3'UTR chr16:66923936(+) A-I      3'UTR chr16:66923719(+) A-I      3'UTR chr16:66922204(+) A-I      3'UTR chr16:66921655(+) A-I      3'UTR chr16:66922386(+) A-I      3'UTR chr16:66923447(+) A-I      3'UTR chr16:66921650(+) A-I      3'UTR chr16:66923401(+) A-I      3'UTR chr16:66923462(+) A-I      3'UTR chr16:66923742(+) A-I      3'UTR chr16:66924133(+) A-I      3'UTR chr16:66923951(+) A-I      3'UTR chr16:66923267(+) A-I      3'UTR chr16:66923329(+) A-I      3'UTR chr16:66921775(+) A-I      3'UTR chr16:66922246(+) A-I      3'UTR chr16:66921997(+) A-I      3'UTR chr16:66923259(+) A-I      3'UTR chr16:66924036(+) A-I      3'UTR chr16:66923639(+) A-I      3'UTR chr16:66923949(+) A-I      3'UTR chr16:66921641(+) A-I      3'UTR chr16:66924068(+) A-I      3'UTR chr16:66924095(+) A-I      3'UTR chr16:66923933(+) A-I      3'UTR chr16:66921698(+) A-I      3'UTR chr16:66922010(+) A-I      3'UTR chr16:66921601(+) A-I      3'UTR chr16:66923468(+) A-I      3'UTR

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	PDP2	chr16:66922201(+) A-I exon 3'UTR    15258596 chr16:66922205(+) A-I exon 3'UTR    15258596 chr16:66922240(+) A-I exon 3'UTR    15258596 chr16:66922246(+) A-I exon 3'UTR    15258596 chr16:66923254(+) A-I exon 3'UTR    15342557 chr16:66923284(+) A-I exon 3'UTR    15258596 chr16:66923297(+) A-I exon 3'UTR    15258596 chr16:66923303(+) A-I exon 3'UTR    15258596 chr16:66923332(+) A-I exon 3'UTR    15342557   //15258596 chr16:66923384(+) A-I exon 3'UTR    15342557   //15258596   //22327324 chr16:66923387(+) A-I exon 3'UTR    15258596 chr16:66923393(+) A-I exon 3'UTR    15258596   //22327324 chr16:66923435(+) A-I exon 3'UTR    15342557   //15258596 chr16:66923468(+) A-I exon 3'UTR    15258596 chr16:66924004(+) A-I exon 3'UTR    15342557   //15258596 chr16:66924032(+) A-I exon 3'UTR    15342557   //15258596 chr16:66921587(+) A-I intron -    21960545   //22327324 chr16:66921601(+) A-I intron -    21960545   //22327324 chr16:66923235(+) A-I intron -    22327324 chr16:66921765(+) A-G intron -    21725310 chr16:66916919(+) A-G intron -    22484847 chr16:66921587(+) A-G intron -    22484847 chr16:66921601(+) A-G intron -    22484847 chr16:66921609(+) A-G intron -    22484847 chr16:66921708(+) A-G intron -    22484847 chr16:66921776(+) A-G intron -    22484847 chr16:66922071(+) A-G intron -    22484847 chr16:66922072(+) A-G intron -    22484847 chr16:66922155(+) A-G intron -    22484847 chr16:66922186(+) A-G intron -    22484847 chr16:66922201(+) A-G intron -    22484847 chr16:66922204(+) A-G intron -    22484847 chr16:66922227(+) A-G intron -    22484847 chr16:66922246(+) A-G intron -    22484847 chr16:66922386(+) A-G intron -    22484847 chr16:66923229(+) A-G intron -    22484847 chr16:66923235(+) A-G intron -    22484847 chr16:66923253(+) A-G intron -    22484847 chr16:66923259(+) A-G intron -    22484847 chr16:66923263(+) A-G intron -    22484847 chr16:66923265(+) A-G intron -    22484847 chr16:66923267(+) A-G intron -    22484847 chr16:66923297(+) A-G intron -    22484847 chr16:66923303(+) A-G intron -    22484847 chr16:66923327(+) A-G intron -    22484847 chr16:66923332(+) A-G intron -    22484847 chr16:66923369(+) A-G intron -    22484847 chr16:66923384(+) A-G intron -    22484847 chr16:66923387(+) A-G intron -    22484847 chr16:66923393(+) A-G intron -    22484847 chr16:66923401(+) A-G intron -    22484847 chr16:66923413(+) A-G intron -    22484847 chr16:66923429(+) A-G intron -    22484847 chr16:66923435(+) A-G intron -    22484847 chr16:66923447(+) A-G intron -    22484847 chr16:66923452(+) A-G intron -    22484847 chr16:66923468(+) A-G intron -    22484847 chr16:66923715(+) A-G intron -    22484847 chr16:66923759(+) A-G intron -    22484847 chr16:66923766(+) A-G intron -    22484847 chr16:66923767(+) A-G intron -    22484847 chr16:66923770(+) A-G intron -    22484847 chr16:66923788(+) A-G intron -    22484847 chr16:66923950(+) A-G intron -    22484847 chr16:66924004(+) A-G intron -    22484847 chr16:66924005(+) A-G intron -    22484847 chr16:66924012(+) A-G intron -    22484847 chr16:66924072(+) A-G intron -    22484847 chr16:66924095(+) A-G intron -    22484847 chr16:66924103(+) A-G intron -    22484847 chr16:66924108(+) A-G intron -    22484847 chr16:66924111(+) A-G intron -    22484847 chr16:66924133(+) A-G intron -    22484847 chr16:66924162(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	PDP2	chr16:66914463-66914464(+) m6A 5'UTR//exon//intron       24981863 chr16:66914503-66914504(+) m6A 5'UTR//exon//intron       24981863 chr16:66914596-66914597(+) m6A 5'UTR//intron       24284625 chr16:66918162-66918163(+) m6A 5'UTR//exon//intron       24284625//24981863//22608085 chr16:66918230-66918231(+) m6A CDS//exon//intron       24284625//24981863//22608085 chr16:66918335-66918336(+) m6A CDS//intron       24284625//24209618//24981863//22608085 chr16:66918378-66918379(+) m6A CDS//intron       24284625//24209618//24981863//22608085 chr16:66918457-66918458(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22608085 chr16:66918551-66918552(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr16:66918580-66918581(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr16:66918588-66918589(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr16:66918612-66918613(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr16:66918691-66918692(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr16:66918729-66918730(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr16:66918770-66918771(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr16:66918831-66918832(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr16:66918858-66918859(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr16:66918897-66918898(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr16:66918956-66918957(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr16:66919073-66919074(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr16:66919124-66919125(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr16:66919172-66919173(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr16:66919193-66919194(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr16:66919433-66919434(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr16:66919501-66919502(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr16:66919518-66919519(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr16:66919614-66919615(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr16:66919628-66919629(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr16:66919688-66919689(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr16:66919842-66919843(+) m6A 3'UTR//intron       24284625//22608085 chr16:66919855-66919856(+) m6A 3'UTR//intron       24284625//22608085 chr16:66919898-66919899(+) m6A 3'UTR//intron       24284625//22608085 chr16:66919916-66919917(+) m6A 3'UTR//intron       24284625 chr16:66919938-66919939(+) m6A 3'UTR//intron       24284625 chr16:66920001-66920002(+) m6A 3'UTR//intron       24284625//24981863//22608085 chr16:66920071-66920072(+) m6A 3'UTR//intron       24284625//24981863//22608085 chr16:66920128-66920129(+) m6A 3'UTR//intron       24284625//24981863//22608085 chr16:66920200-66920201(+) m6A 3'UTR//intron       24284625//24981863//22608085 chr16:66920208-66920209(+) m6A 3'UTR//intron       24981863//22608085 chr16:66920283-66920284(+) m6A 3'UTR//intron       22608085 chr16:66920990-66920991(+) m6A 3'UTR//intron       - chr16:66921018-66921019(+) m6A 3'UTR//intron       - chr16:66921030-66921031(+) m6A 3'UTR//intron       - chr16:66924586-66924587(+) m6A 3'UTR//intron       24284625 chr16:66924602-66924603(+) m6A 3'UTR//intron       24284625 chr16:66924649-66924650(+) m6A 3'UTR//intron       24284625 chr16:66924767-66924768(+) m6A 3'UTR//intron       24284625

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	kshv-miR-K12-3-5p	Exosome B cell line (Raji)|Primary dendritic cells|T cell line (J77)     21505438 Exosome KSHV-infected lymphoma cell lines (BCBL-1|TY-1)     27611973 Exosome K562 cells     24460325
	PDP2	Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: kshv-miR-K12-3-5p
Interactor2: PDP2

Evidence Support:

Weak-Evidence	Microarray
Support Database	ViRBase

References:

PMID	22174674	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EA.hy926 cells	Interactor2 expression	Downregulation
Description	As KSHV putative direct targets we extracted transcripts that were significantly down-regulated significantly in the replicate experiments, and which contained at least one seed-match to one of the KSHV miRNAs. We identified 704 putative direct targets in DG-75 cells (Figure 3B), and 980 putative direct targets in EA.hy926 cells (Figure 3C). A complete list of putative direct targets can be found in Dataset S2 for DG-75 cells and in Dataset S3 for EA.hy926 cells. The overlap between the two datasets contained 153 putative direct targets (Dataset S4).