Basic Information:

  VIRBase ID:  

VHID00468722

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.2381

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-3-5p:  MIMAT0002193          GHITM:  NM_014394     

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Interactor Information:

	Interactor1	Interactor2
Symbol	kshv-miR-K12-3-5p	GHITM
miRBase Accession/Entrez ID	MIMAT0002193	27069
Organism	Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	DERP2//HSPC282//MICS1//My021//PTD010//TMBIM5

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	GHITM	chr10:85908286(+) A-I      intronic chr10:85908313(+) A-I      intronic chr10:85905727(+) A-I      intronic chr10:85905723(+) A-I      intronic chr10:85905696(+) A-I      intronic chr10:85905690(+) A-I      intronic chr10:85908314(+) A-I      intronic chr10:85907081(+) A-I      intronic chr10:85905710(+) A-I      intronic chr10:85905742(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	GHITM	chr10:85899278-85899279(+) m6A 5'UTR       24284625//25456834//24981863 chr10:85899319-85899320(+) m6A 5'UTR       24284625//24981863//22575960 chr10:85899343-85899344(+) m6A 5'UTR       24284625//24981863//22575960 chr10:85901238-85901239(+) m6A 5'UTR       24981863//22575960 chr10:85901286-85901287(+) m6A CDS       24981863//22575960 chr10:85901297-85901298(+) Y CDS       26075521 chr10:85902425-85902426(+) m6A CDS       24981863//27773535 chr10:85902452-85902453(+) m6A CDS       24981863//26404942//27773535 chr10:85902463-85902464(+) m6A CDS       24981863//26404942//27773535 chr10:85902484-85902485(+) m6A CDS       24981863//26404942//27773535 chr10:85903836-85903837(+) Gm CDS       - chr10:85912214-85912215(+) m6A 3'UTR       27773535 chr10:85912366-85912367(+) m6A 3'UTR       27773535 chr10:85912858-85912859(+) m6A 3'UTR       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	kshv-miR-K12-3-5p	Exosome B cell line (Raji)|Primary dendritic cells|T cell line (J77)     21505438 Exosome KSHV-infected lymphoma cell lines (BCBL-1|TY-1)     27611973 Exosome K562 cells     24460325
	GHITM	Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: kshv-miR-K12-3-5p
Interactor2: GHITM

Evidence Support:

Prediction-Evidence	cRep//miRanda//Targetscan
Support Database	RepTar//VmiReg