Basic Information:

  VIRBase ID:  

VHID00467818

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5908

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-3-5p:  MIMAT0002193          ZNF207:  NM_001032293     

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Interactor Information:

	Interactor1	Interactor2
Symbol	kshv-miR-K12-3-5p	ZNF207
miRBase Accession/Entrez ID	MIMAT0002193	7756
Organism	Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	BuGZ//hBuGZ

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	ZNF207	chr17:30710852(+) A-I      intronic chr17:30688296(+) A-I      intronic chr17:30710085(+) A-I      intronic chr17:30677481(+) A-I      intronic chr17:30710666(+) A-I      intronic chr17:30710697(+) A-I      intronic chr17:30710710(+) A-I      intronic chr17:30710718(+) A-I      intronic chr17:30710841(+) A-I      intronic chr17:30710800(+) A-I      intronic chr17:30710764(+) A-I      intronic chr17:30710744(+) A-I      intronic chr17:30710733(+) A-I      intronic chr17:30710704(+) A-I      intronic chr17:30710660(+) A-I      intronic chr17:30686777(+) A-I      intronic chr17:30714463(+) A-I      intronic chr17:30680072(+) A-I      intronic chr17:30680125(+) A-I      intronic chr17:30682278(+) A-I      intronic chr17:30682314(+) A-I      intronic chr17:30684038(+) A-I      intronic chr17:30710847(+) A-I      intronic chr17:30711977(+) A-I      intronic chr17:30712694(+) A-I      intronic chr17:30712836(+) A-I      intronic chr17:30712922(+) A-I      intronic chr17:30712933(+) A-I      intronic chr17:30680031(+) A-I      intronic chr17:30713005(+) A-I      intronic chr17:30684147(+) A-I      intronic chr17:30679993(+) A-I      intronic chr17:30679984(+) A-I      intronic chr17:30684862(+) A-I      intronic chr17:30679128(+) A-I      intronic chr17:30684989(+) A-I      intronic chr17:30686235(+) A-I      intronic chr17:30686765(+) A-I      intronic chr17:30686770(+) A-I      intronic chr17:30679116(+) A-I      intronic chr17:30680545(+) A-I      intronic chr17:30680630(+) A-I      intronic chr17:30680033(+) A-I      intronic chr17:30714477(+) A-I      intronic chr17:30714483(+) A-I      intronic chr17:30714487(+) A-I      intronic chr17:30714512(+) A-I      intronic chr17:30714558(+) A-I      intronic chr17:30714569(+) A-I      intronic chr17:30714575(+) A-I      intronic chr17:30714631(+) A-I      intronic chr17:30680028(+) A-I      intronic chr17:30686773(+) A-I      intronic chr17:30686776(+) A-I      intronic chr17:30707985(+) A-I      3'UTR chr17:30707991(+) A-I      3'UTR chr17:30701276(+) A-I      3'UTR chr17:30701314(+) A-I      3'UTR chr17:30701295(+) A-I      3'UTR chr17:30701285(+) A-I      3'UTR chr17:30701421(+) A-I      3'UTR chr17:30701435(+) A-I      3'UTR chr17:30710680(+) A-I      intronic chr17:30710681(+) A-I      intronic chr17:30686225(+) A-I      intronic chr17:30712737(+) A-I      intronic chr17:30711888(+) A-I      intronic chr17:30684049(+) A-I      intronic chr17:30680624(+) A-I      intronic chr17:30710769(+) A-I      intronic chr17:30712946(+) A-I      intronic chr17:30681107(+) A-I      intronic chr17:30684146(+) A-I      intronic chr17:30714471(+) A-I      intronic chr17:30714472(+) A-I      intronic chr17:30714524(+) A-I      intronic chr17:30682379(+) A-I      intronic chr17:30710773(+) A-I      intronic chr17:30680073(+) A-I      intronic chr17:30681152(+) A-I      intronic chr17:30681733(+) A-I      intronic chr17:30680615(+) A-I      intronic chr17:30681463(+) A-I      intronic chr17:30713028(+) A-I      intronic chr17:30680605(+) A-I      intronic chr17:30713055(+) A-I      intronic chr17:30679171(+) A-I      intronic chr17:30710000(+) A-I      intronic chr17:30710010(+) A-I      intronic chr17:30714418(+) A-I      intronic chr17:30681134(+) A-I      intronic chr17:30681025(+) A-I      intronic chr17:30684980(+) A-I      intronic chr17:30679087(+) A-I      intronic chr17:30679104(+) A-I      intronic chr17:30710667(+) A-I      intronic chr17:30710758(+) A-I      intronic chr17:30695517(+) A-I      intronic chr17:30710077(+) A-I      intronic chr17:30681591(+) A-I      intronic chr17:30712980(+) A-I      intronic chr17:30682138(+) A-I      intronic chr17:30701443(+) A-I      3'UTR chr17:30684054(+) A-I      intronic chr17:30680652(+) A-I      intronic chr17:30680586(+) A-I      intronic chr17:30710861(+) A-I      intronic chr17:30714417(+) A-I      intronic chr17:30681798(+) A-I      intronic chr17:30684024(+) A-I      intronic chr17:30682233(+) A-I      intronic chr17:30679186(+) A-I      intronic chr17:30679091(+) A-I      intronic chr17:30686716(+) A-I      intronic chr17:30682205(+) A-I      intronic chr17:30681732(+) A-I      intronic chr17:30712926(+) A-I      intronic chr17:30682293(+) A-I      intronic chr17:30682175(+) A-I      intronic chr17:30685864(+) A-I      intronic chr17:30683959(+) A-I      intronic chr17:30710816(+) A-I      intronic chr17:30707986(+) A-I      3'UTR chr17:30698614(+) A-I      3'UTR chr17:30681182(+) A-I      intronic chr17:30714528(+) A-I      intronic chr17:30682204(+) A-I      intronic chr17:30686438(+) A-I      intronic chr17:30682301(+) A-I      intronic chr17:30686732(+) A-I      intronic chr17:30714423(+) A-I      intronic chr17:30712829(+) A-I      intronic chr17:30684022(+) A-I      intronic chr17:30712706(+) A-I      intronic chr17:30712898(+) A-I      intronic chr17:30710734(+) A-I      intronic chr17:30681736(+) A-I      intronic chr17:30701497(+) A-I      3'UTR chr17:30713042(+) A-I      intronic chr17:30711887(+) A-I      intronic chr17:30712685(+) A-I      intronic chr17:30681572(+) A-I      intronic chr17:30712955(+) A-I      intronic chr17:30712963(+) A-I      intronic chr17:30686271(+) A-I      intronic chr17:30698662(+) A-I      3'UTR chr17:30695463(+) A-I      intronic chr17:30712701(+) A-I      intronic chr17:30682297(+) A-I      intronic chr17:30714395(+) A-I      intronic chr17:30710768(+) A-I      intronic chr17:30714514(+) A-I      intronic chr17:30682328(+) A-I      intronic chr17:30710870(+) A-I      intronic chr17:30680114(+) A-I      intronic chr17:30685958(+) A-I      intronic chr17:30682362(+) A-I      intronic chr17:30712881(+) A-I      intronic chr17:30714522(+) A-I      intronic chr17:30712920(+) A-I      intronic chr17:30682232(+) A-I      intronic chr17:30712966(+) A-I      intronic chr17:30714562(+) A-I      intronic chr17:30711971(+) A-I      intronic chr17:30714548(+) A-I      intronic chr17:30710869(+) A-I      intronic chr17:30681096(+) A-I      intronic chr17:30686698(+) A-I      intronic chr17:30710840(+) A-I      intronic chr17:30712992(+) A-I      intronic chr17:30712747(+) A-I      intronic chr17:30685009(+) A-I      intronic chr17:30710760(+) A-I      intronic chr17:30679086(+) A-I      intronic chr17:30711993(+) A-I      intronic chr17:30679051(+) A-I      intronic chr17:30684000(+) A-I      intronic chr17:30714511(+) A-I      intronic chr17:30680100(+) A-I      intronic chr17:30685872(+) A-I      intronic chr17:30689444(+) A-I      intronic chr17:30681609(+) A-I      intronic chr17:30712749(+) A-I      intronic chr17:30714576(+) A-I      intronic chr17:30714519(+) A-I      intronic chr17:30714688(+) A-I      intronic chr17:30714680(+) A-I      intronic chr17:30679126(+) A-I      intronic chr17:30714474(+) A-I      intronic chr17:30711962(+) A-I      intronic chr17:30684121(+) A-I      intronic chr17:30710082(+) A-I      intronic chr17:30713041(+) A-I      intronic chr17:30685061(+) A-I      intronic chr17:30681188(+) A-I      intronic chr17:30684045(+) A-I      intronic chr17:30689314(+) A-I      intronic chr17:30714536(+) A-I      intronic chr17:30710019(+) A-I      intronic chr17:30712885(+) A-I      intronic chr17:30699676(+) A-I      3'UTR chr17:30699182(+) A-I      3'UTR chr17:30699205(+) A-I      3'UTR chr17:30699274(+) A-I      3'UTR chr17:30701306(+) A-I      3'UTR chr17:30701378(+) A-I      3'UTR chr17:30699825(+) A-I      3'UTR chr17:30701376(+) A-I      3'UTR

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	ZNF207	chr17:30681096(+) A-I intron -    21960545 chr17:30682293(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	ZNF207	chr17:30677296-30677297(+) m6A 5'UTR//exon       24284625//24981863//27773535 chr17:30677319-30677320(+) m1A 5'UTR//CDS//exon       26863196//26863410 chr17:30678903-30678904(+) m6A 5'UTR//CDS//exon       24981863//27773535 chr17:30685533-30685534(+) m6A CDS//exon       24981863//27773535//22575960 chr17:30685569-30685570(+) m6A CDS//exon       24981863//27773535//22575960 chr17:30685618-30685619(+) m6A CDS//exon       24981863//27773535//22575960 chr17:30685646-30685647(+) m6A CDS//exon       24981863//27773535//22575960 chr17:30685653-30685654(+) m6A CDS//exon       24981863//27773535//22575960 chr17:30687720-30687721(+) Y CDS//exon//intron       26075521 chr17:30687746-30687747(+) m6A CDS//exon       26404942 chr17:30694810-30694811(+) m6A CDS//exon       24981863//26404942 chr17:30694831-30694832(+) m6A CDS//exon       24981863//26404942 chr17:30694864-30694865(+) m6A CDS//exon       24981863//26404942//27773535 chr17:30694942-30694943(+) m6A CDS//exon       24981863//26404942//27773535 chr17:30696687-30696688(+) m6A CDS//exon       24284625 chr17:30696744-30696745(+) m6A CDS//exon       24284625//22608085 chr17:30696814-30696815(+) m6A 3'UTR//intron       24284625//24981863//27773535//22575960//22608085 chr17:30696884-30696885(+) m6A 3'UTR//intron       24284625//24981863//27773535//22575960//22608085 chr17:30696908-30696909(+) m6A 3'UTR//intron       24284625//24981863//27773535//22575960//22608085 chr17:30696916-30696917(+) m6A 3'UTR//intron       24284625//24981863//27773535//22575960//22608085 chr17:30696962-30696963(+) m6A 3'UTR//intron       24284625//24981863//27773535//22575960//22608085 chr17:30697082-30697083(+) m6A 3'UTR//intron       - chr17:30699118-30699119(+) m6A 3'UTR//intron       - chr17:30699141-30699142(+) m6A 3'UTR//intron       - chr17:30699216-30699217(+) m6A 3'UTR//intron       - chr17:30699239-30699240(+) m6A 3'UTR//intron       - chr17:30707965-30707966(+) m6A 3'UTR       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	kshv-miR-K12-3-5p	Exosome B cell line (Raji)|Primary dendritic cells|T cell line (J77)     21505438 Exosome KSHV-infected lymphoma cell lines (BCBL-1|TY-1)     27611973 Exosome K562 cells     24460325
	ZNF207	Chromatin K562 cells     - Cytosol HCC cell line (HepG2)|K562 cells     - Exosome Blood     - Insoluble cytoplasm HCC cell line (HepG2)     - Membrane HCC cell line (HepG2)|K562 cells     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: kshv-miR-K12-3-5p
Interactor2: ZNF207

Evidence Support:

Weak-Evidence	Microarray
Prediction-Evidence	miRanda//Targetscan
Support Database	ViRBase//VmiReg

References:

PMID	22174674	Target region	None
Source	ViRBase//VmiReg	Interactor1 expression	None
Tissue or cell line	EA.hy926 cells	Interactor2 expression	Downregulation
Description	As KSHV putative direct targets we extracted transcripts that were significantly down-regulated significantly in the replicate experiments, and which contained at least one seed-match to one of the KSHV miRNAs. We identified 704 putative direct targets in DG-75 cells (Figure 3B), and 980 putative direct targets in EA.hy926 cells (Figure 3C). A complete list of putative direct targets can be found in Dataset S2 for DG-75 cells and in Dataset S3 for EA.hy926 cells. The overlap between the two datasets contained 153 putative direct targets (Dataset S4).