Basic Information:

  VIRBase ID:  

VHID00467692

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-3-5p:  MIMAT0002193          ZEB1:  NM_001323677     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	kshv-miR-K12-3-5p	ZEB1
miRBase Accession/Entrez ID	MIMAT0002193	6935
Organism	Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	AREB6//BZP//DELTAEF1//FECD6//NIL2A//PPCD3//TCF8//ZFHEP//ZFHX1A

RNA Editing:

Resource	Symbol	Editing Position
Lncediting	ZEB1	chr10: 31676192

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	ZEB1	chr10:31673005(+) A-I      intronic chr10:31628501(+) A-I      intronic chr10:31673088(+) A-I      intronic chr10:31628541(+) A-I      intronic chr10:31673085(+) A-I      intronic chr10:31673050(+) A-I      intronic chr10:31670846(+) A-I      intronic chr10:31628552(+) A-I      intronic chr10:31738888(+) A-I      intronic chr10:31636330(+) A-I      intronic chr10:31672928(+) A-I      intronic chr10:31674657(+) A-I      intronic chr10:31636419(+) A-I      intronic chr10:31673071(+) A-I      intronic chr10:31651736(+) A-I      intronic chr10:31628631(+) A-I      intronic chr10:31626793(+) A-I      intronic chr10:31674556(+) A-I      intronic chr10:31672972(+) A-I      intronic chr10:31628611(+) A-I      intronic chr10:31674678(+) A-I      intronic chr10:31718736(+) A-I      intronic chr10:31628511(+) A-I      intronic chr10:31628605(+) A-I      intronic chr10:31721254(+) A-I      intronic chr10:31626848(+) A-I      intronic chr10:31628592(+) A-I      intronic chr10:31718944(+) A-I      intronic chr10:31670865(+) A-I      intronic chr10:31636399(+) A-I      intronic chr10:31670885(+) A-I      intronic chr10:31674640(+) A-I      intronic chr10:31626671(+) A-I      intronic chr10:31674549(+) A-I      intronic chr10:31721353(+) A-I      intronic chr10:31670842(+) A-I      intronic chr10:31637278(+) A-I      intronic chr10:31628507(+) A-I      intronic chr10:31721340(+) A-I      intronic chr10:31670676(+) A-I      intronic chr10:31721460(+) A-I      intronic chr10:31721371(+) A-I      intronic chr10:31673031(+) A-I      intronic chr10:31616214(+) A-I      intronic chr10:31721470(+) A-I      intronic chr10:31721263(+) A-I      intronic chr10:31628588(+) A-I      intronic chr10:31721339(+) A-I      intronic chr10:31674619(+) A-I      intronic chr10:31770485(+) A-I      intronic chr10:31655351(+) A-I      intronic chr10:31628572(+) A-I      intronic chr10:31673022(+) A-I      intronic chr10:31670836(+) A-I      intronic chr10:31670790(+) A-I      intronic chr10:31788618(+) A-I      intronic chr10:31670793(+) A-I      intronic chr10:31673044(+) A-I      intronic chr10:31670922(+) A-I      intronic chr10:31670900(+) A-I      intronic chr10:31626826(+) A-I      intronic chr10:31670784(+) A-I      intronic chr10:31718932(+) A-I      intronic chr10:31673179(+) A-I      intronic chr10:31754567(+) A-I      intronic chr10:31673030(+) A-I      intronic chr10:31628578(+) A-I      intronic chr10:31753270(+) A-I      intronic chr10:31670769(+) A-I      intronic chr10:31628521(+) A-I      intronic chr10:31620155(+) A-I      intronic chr10:31628510(+) A-I      intronic chr10:31628481(+) A-I      intronic chr10:31721438(+) A-I      intronic chr10:31753202(+) A-I      intronic chr10:31721289(+) A-I      intronic chr10:31628539(+) A-I      intronic chr10:31657224(+) A-I      intronic chr10:31626713(+) A-I      intronic chr10:31626743(+) A-I      intronic chr10:31721424(+) A-I      intronic chr10:31637231(+) A-I      intronic chr10:31672961(+) A-I      intronic chr10:31628421(+) A-I      intronic chr10:31670782(+) A-I      intronic chr10:31626714(+) A-I      intronic chr10:31753203(+) A-I      intronic chr10:31670744(+) A-I      intronic chr10:31670890(+) A-I      intronic chr10:31670762(+) A-I      intronic chr10:31626886(+) A-I      intronic chr10:31670684(+) A-I      intronic chr10:31626740(+) A-I      intronic chr10:31670685(+) A-I      intronic chr10:31626796(+) A-I      intronic chr10:31637238(+) A-I      intronic chr10:31628579(+) A-I      intronic chr10:31670739(+) A-I      intronic chr10:31626731(+) A-I      intronic chr10:31626778(+) A-I      intronic chr10:31721473(+) A-I      intronic chr10:31628482(+) A-I      intronic chr10:31721407(+) A-I      intronic chr10:31670872(+) A-I      intronic chr10:31673114(+) A-I      intronic chr10:31670754(+) A-I      intronic chr10:31616301(+) A-I      intronic chr10:31673143(+) A-I      intronic chr10:31636362(+) A-I      intronic chr10:31670829(+) A-I      intronic chr10:31718790(+) A-I      intronic chr10:31628443(+) A-I      intronic chr10:31620222(+) A-I      intronic chr10:31718870(+) A-I      intronic chr10:31626802(+) A-I      intronic chr10:31636349(+) A-I      intronic chr10:31674667(+) A-I      intronic chr10:31626810(+) A-I      intronic chr10:31673034(+) A-I      intronic chr10:31626822(+) A-I      intronic chr10:31721256(+) A-I      intronic chr10:31718737(+) A-I      intronic chr10:31721271(+) A-I      intronic chr10:31718773(+) A-I      intronic chr10:31670881(+) A-I      intronic chr10:31718772(+) A-I      intronic chr10:31628538(+) A-I      intronic chr10:31626679(+) A-I      intronic chr10:31670819(+) A-I      intronic chr10:31673141(+) A-I      intronic chr10:31628645(+) A-I      intronic chr10:31718867(+) A-I      intronic chr10:31670725(+) A-I      intronic chr10:31670841(+) A-I      intronic chr10:31620096(+) A-I      intronic chr10:31636413(+) A-I      intronic chr10:31673173(+) A-I      intronic chr10:31754612(+) A-I      intronic chr10:31754591(+) A-I      intronic chr10:31672681(+) A-I      intronic chr10:31672152(+) A-I      intronic chr10:31754676(+) A-I      intronic chr10:31672146(+) A-I      intronic chr10:31680084(+) A-I      intronic chr10:31670761(+) A-I      intronic chr10:31801985(+) A-I      intronic chr10:31672168(+) A-I      intronic chr10:31626753(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	ZEB1	chr10:31626713(+) A-G intron -    22484847 chr10:31628645(+) A-G intron -    22484847 chr10:31637231(+) A-G intron -    22484847 chr10:31672961(+) A-G intron -    22484847 chr10:31718772(+) A-G intron -    22484847 chr10:31718773(+) A-G intron -    22484847 chr10:31718790(+) A-G intron -    22484847 chr10:31754567(+) A-G intron -    22484847 chr10:31754713(+) A-T intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	ZEB1	chr10:31607458-31607459(+) m6A exon       24284625//24209618//25456834//24981863//27371828//27773536 chr10:31607914-31607915(+) m6A exon       24284625//24209618//25456834//24981863//27371828//22608085 chr10:31607966-31607967(+) m6A exon       24284625//24209618//25456834//24981863 chr10:31608146-31608147(+) m6A 5'UTR//exon//intron       24981863 chr10:31608203-31608204(+) m6A CDS//exon//intron       24981863 chr10:31609058-31609059(+) m6A 5'UTR//exon//intron       24981863 chr10:31609122-31609123(+) m6A 5'UTR//exon//intron       - chr10:31749991-31749992(+) m6A 3'UTR//5'UTR//CDS//exon//intron       24209618//24981863 chr10:31750016-31750017(+) m6A 3'UTR//5'UTR//CDS//exon//intron       24209618//24981863 chr10:31750037-31750038(+) m1A 3'UTR//5'UTR//CDS//exon//intron       26863196 chr10:31750097-31750098(+) m6A 3'UTR//5'UTR//CDS//exon//intron       24284625//24209618//24981863 chr10:31750102-31750103(+) m6A 3'UTR//5'UTR//CDS//exon//intron       24284625//24209618//24981863 chr10:31750148-31750149(+) m6A 3'UTR//5'UTR//CDS//exon//intron       24284625//24209618//24981863 chr10:31750164-31750165(+) Cm 3'UTR//5'UTR//CDS//exon//intron       - chr10:31791317-31791318(+) m6A 3'UTR//5'UTR//CDS//exon//intron       24284625 chr10:31791356-31791357(+) m6A 3'UTR//5'UTR//CDS//exon//intron       24284625 chr10:31809172-31809173(+) m6A 3'UTR//CDS//exon       24284625//24981863//22608085 chr10:31809177-31809178(+) m6A 3'UTR//CDS//exon       24284625//24981863//22608085 chr10:31809184-31809185(+) m6A 3'UTR//CDS//exon       24284625//24981863//22608085 chr10:31809267-31809268(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//22608085 chr10:31809279-31809280(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//22608085 chr10:31809304-31809305(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//22608085 chr10:31809309-31809310(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//22608085 chr10:31809330-31809331(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//22608085 chr10:31809582-31809583(+) m6A 3'UTR//CDS//exon       24981863 chr10:31809589-31809590(+) m6A 3'UTR//CDS//exon       24981863 chr10:31809670-31809671(+) m6A 3'UTR//CDS//exon       22608085 chr10:31809764-31809765(+) m6A 3'UTR//CDS//exon       24981863//22608085 chr10:31809818-31809819(+) m6A 3'UTR//CDS//exon       24209618//24981863//22608085 chr10:31810034-31810035(+) m6A 3'UTR//CDS//exon       24284625//24981863 chr10:31810118-31810119(+) m6A 3'UTR//CDS//exon       24284625//24981863//22608085 chr10:31810167-31810168(+) m6A 3'UTR//CDS//exon       24284625//24981863//22608085 chr10:31810191-31810192(+) m6A 3'UTR//CDS//exon       24284625//24981863//22608085 chr10:31810206-31810207(+) m6A 3'UTR//CDS//exon       24284625//24981863//22608085 chr10:31810235-31810236(+) m6A 3'UTR//CDS//exon       24284625//24981863//22608085 chr10:31810269-31810270(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//26404942//22608085 chr10:31810277-31810278(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//26404942//22608085 chr10:31810388-31810389(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//22608085 chr10:31810461-31810462(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//27773535//22608085 chr10:31810535-31810536(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//27773535//22608085 chr10:31810560-31810561(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//27773535//22575960//22608085 chr10:31810568-31810569(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//27773535//22575960//22608085 chr10:31810601-31810602(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//27773535//22575960//22608085 chr10:31810616-31810617(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//27773535//22575960//22608085 chr10:31810623-31810624(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//27773535//22575960//22608085 chr10:31810724-31810725(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//27773535//22608085 chr10:31810827-31810828(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//22608085 chr10:31812868-31812869(+) m6A 3'UTR//CDS//exon       22608085 chr10:31812953-31812954(+) m6A 3'UTR//CDS//exon       27773535 chr10:31813021-31813022(+) m6A 3'UTR//CDS//exon       24284625//24981863//27773535 chr10:31813033-31813034(+) m6A 3'UTR//CDS//exon       24284625//24981863//27773535 chr10:31815606-31815607(+) m6A 3'UTR//CDS//exon       24284625//24981863//27773535 chr10:31815642-31815643(+) m6A 3'UTR//CDS//exon       24284625//24981863//27773535//22608085 chr10:31815648-31815649(+) m6A 3'UTR//CDS//exon       24284625//24981863//27773535//22608085 chr10:31815663-31815664(+) m6A 3'UTR//CDS//exon       24284625//24981863//27773535//22608085 chr10:31815803-31815804(+) Cm 3'UTR//CDS//exon       - chr10:31815920-31815921(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//27773535//27371828//22608085 chr10:31815990-31815991(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//27773535//27371828//22608085 chr10:31816028-31816029(+) m1A 3'UTR//CDS//exon       26863196 chr10:31816037-31816038(+) m1A 3'UTR//CDS//exon       26863196 chr10:31816073-31816074(+) m1A 3'UTR//CDS//exon       26863196 chr10:31816081-31816082(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//28052920//27773535//27371828//22608085 chr10:31816134-31816135(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//27773535//22608085 chr10:31816177-31816178(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//27773535//22608085 chr10:31816266-31816267(+) m6A 3'UTR//exon       22608085 chr10:31816317-31816318(+) m6A 3'UTR//exon       22608085 chr10:31816340-31816341(+) m6A 3'UTR//exon       24981863//22608085 chr10:31816403-31816404(+) m6A 3'UTR//exon       24981863//27773535//22608085 chr10:31816410-31816411(+) m6A 3'UTR//exon       24981863//27773535//22608085 chr10:31816446-31816447(+) m6A 3'UTR//exon       24981863//22608085 chr10:31816476-31816477(+) m6A 3'UTR//exon       24981863//22608085 chr10:31817180-31817181(+) m6A 3'UTR//exon       24981863 chr10:31817187-31817188(+) m6A 3'UTR//exon       24981863 chr10:31817208-31817209(+) m6A 3'UTR//exon       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	kshv-miR-K12-3-5p	Exosome B cell line (Raji)|Primary dendritic cells|T cell line (J77)     21505438 Exosome KSHV-infected lymphoma cell lines (BCBL-1|TY-1)     27611973 Exosome K562 cells     24460325
	ZEB1	Chromatin K562 cells     - Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)     -

Interaction Network (The top 100 interactions):

Interactor1: kshv-miR-K12-3-5p
Interactor2: ZEB1

Evidence Support:

Weak-Evidence	Microarray
Support Database	ViRBase

References:

PMID	22174674	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EA.hy926 cells	Interactor2 expression	Downregulation
Description	As KSHV putative direct targets we extracted transcripts that were significantly down-regulated significantly in the replicate experiments, and which contained at least one seed-match to one of the KSHV miRNAs. We identified 704 putative direct targets in DG-75 cells (Figure 3B), and 980 putative direct targets in EA.hy926 cells (Figure 3C). A complete list of putative direct targets can be found in Dataset S2 for DG-75 cells and in Dataset S3 for EA.hy926 cells. The overlap between the two datasets contained 153 putative direct targets (Dataset S4).