Basic Information:

  VIRBase ID:  

VHID00467292

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5908

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-3-5p:  MIMAT0002193          MBNL1:  NR_164865     

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Interactor Information:

	Interactor1	Interactor2
Symbol	kshv-miR-K12-3-5p	MBNL1
miRBase Accession/Entrez ID	MIMAT0002193	4154
Organism	Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	EXP//MBNL

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	MBNL1	chr3:151993347(+) A-I      intronic chr3:151993333(+) A-I      intronic chr3:152124159(+) A-I      intronic chr3:152107269(+) A-I      intronic chr3:151993244(+) A-I      intronic chr3:151993311(+) A-I      intronic chr3:151993322(+) A-I      intronic chr3:152107014(+) A-I      intronic chr3:152107138(+) A-I      intronic chr3:152119771(+) A-I      intronic chr3:152136537(+) A-I      intronic chr3:152155692(+) A-I      intronic chr3:152107143(+) A-I      intronic chr3:152117376(+) A-I      intronic chr3:152119753(+) A-I      intronic chr3:152119690(+) A-I      intronic chr3:151993351(+) A-I      intronic chr3:151993341(+) A-I      intronic chr3:152096695(+) A-I      intronic chr3:152096525(+) A-I      intronic chr3:152181376(+) A-I      3'UTR chr3:152096075(+) A-I      intronic chr3:152117554(+) A-I      intronic chr3:152155728(+) A-I      intronic chr3:151993399(+) A-I      intronic chr3:152136215(+) A-I      intronic chr3:151993442(+) A-I      intronic chr3:151993483(+) A-I      intronic chr3:152117557(+) A-I      intronic chr3:152096064(+) A-I      intronic chr3:152009590(+) A-I      intronic chr3:152009762(+) A-I      intronic chr3:152095970(+) A-I      intronic chr3:152095955(+) A-I      intronic chr3:152095916(+) A-I      intronic chr3:152095871(+) A-I      intronic chr3:152049724(+) A-I      intronic chr3:152049716(+) A-I      intronic chr3:152049670(+) A-I      intronic chr3:152049661(+) A-I      intronic chr3:152136266(+) A-I      intronic chr3:152117430(+) A-I      intronic chr3:152117496(+) A-I      intronic chr3:152155643(+) A-I      intronic chr3:152136305(+) A-I      intronic chr3:152117506(+) A-I      intronic chr3:152117512(+) A-I      intronic chr3:152117553(+) A-I      intronic chr3:152136635(+) A-I      intronic chr3:152136704(+) A-I      intronic chr3:152049642(+) A-I      intronic chr3:152049609(+) A-I      intronic chr3:152049597(+) A-I      intronic chr3:152009764(+) A-I      intronic chr3:152047291(+) A-I      intronic chr3:152096788(+) A-I      intronic chr3:152096781(+) A-I      intronic chr3:152096774(+) A-I      intronic chr3:152096725(+) A-I      intronic chr3:152096705(+) A-I      intronic chr3:152004855(+) A-I      intronic chr3:152004820(+) A-I      intronic chr3:152095901(+) A-I      intronic chr3:152117429(+) A-I      intronic chr3:152004961(+) A-I      intronic chr3:152004954(+) A-I      intronic chr3:152029067(+) A-I      intronic chr3:152096606(+) A-I      intronic chr3:152004829(+) A-I      intronic chr3:152143408(+) A-I      intronic chr3:152003516(+) A-I      intronic chr3:152004892(+) A-I      intronic chr3:152072007(+) A-I      intronic chr3:152136712(+) A-I      intronic chr3:152157583(+) A-I      intronic chr3:152003487(+) A-I      intronic chr3:152049605(+) A-I      intronic chr3:152096562(+) A-I      intronic chr3:152074359(+) A-I      intronic chr3:152074355(+) A-I      intronic chr3:152035294(+) A-I      intronic chr3:152096530(+) A-I      intronic chr3:152004754(+) A-I      intronic chr3:152167783(+) A-I      intronic chr3:152004932(+) A-I      intronic chr3:152096559(+) A-I      intronic chr3:152004823(+) A-I      intronic chr3:152136206(+) A-I      intronic chr3:152136360(+) A-I      intronic chr3:152004886(+) A-I      intronic chr3:152049532(+) A-I      intronic chr3:151993417(+) A-I      intronic chr3:152047367(+) A-I      intronic chr3:152096702(+) A-I      intronic chr3:152119664(+) A-I      intronic chr3:152092849(+) A-I      intronic chr3:152145193(+) A-I      intronic chr3:152049619(+) A-I      intronic chr3:152159682(+) A-I      intronic chr3:152030997(+) A-I      intronic chr3:152049606(+) A-I      intronic chr3:152136252(+) A-I      intronic chr3:152131838(+) A-I      intronic chr3:152145194(+) A-I      intronic chr3:152119669(+) A-I      intronic chr3:152096690(+) A-I      intronic chr3:152095944(+) A-I      intronic chr3:152049580(+) A-I      intronic chr3:152136600(+) A-I      intronic chr3:152119665(+) A-I      intronic chr3:152047331(+) A-I      intronic chr3:152096605(+) A-I      intronic chr3:152009614(+) A-I      intronic chr3:152136200(+) A-I      intronic chr3:152155697(+) A-I      intronic chr3:152093527(+) A-I      intronic chr3:152095885(+) A-I      intronic chr3:152136532(+) A-I      intronic chr3:152003479(+) A-I      intronic chr3:152117418(+) A-I      intronic chr3:152004830(+) A-I      intronic chr3:151993403(+) A-I      intronic chr3:152096038(+) A-I      intronic chr3:151993245(+) A-I      intronic chr3:152155743(+) A-I      intronic chr3:152093336(+) A-I      intronic chr3:152136599(+) A-I      intronic chr3:152035292(+) A-I      intronic chr3:152119700(+) A-I      intronic chr3:152136207(+) A-I      intronic chr3:152003586(+) A-I      intronic chr3:152136255(+) A-I      intronic chr3:152004900(+) A-I      intronic chr3:152096740(+) A-I      intronic chr3:152004928(+) A-I      intronic chr3:152074358(+) A-I      intronic chr3:152004854(+) A-I      intronic chr3:152136328(+) A-I      intronic chr3:151993377(+) A-I      intronic chr3:152167723(+) A-I      intronic chr3:152095888(+) A-I      intronic chr3:152072042(+) A-I      intronic chr3:152136388(+) A-I      intronic chr3:152004860(+) A-I      intronic chr3:152117475(+) A-I      intronic chr3:152095870(+) A-I      intronic chr3:152117360(+) A-I      intronic chr3:152055242(+) A-I      intronic chr3:152096779(+) A-I      intronic chr3:152096688(+) A-I      intronic chr3:152136300(+) A-I      intronic chr3:152092903(+) A-I      intronic chr3:152096609(+) A-I      intronic chr3:152030912(+) A-I      intronic chr3:152004821(+) A-I      intronic chr3:151993418(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	MBNL1	chr3:152048030(+) A-I intron -    21960545   //22327324 chr3:152136207(+) A-I intron -    22327324 chr3:152004754(+) A-I intron -    22028664 chr3:152004820(+) A-I intron -    22028664 chr3:152004821(+) A-I intron -    22028664 chr3:152004823(+) A-I intron -    22028664 chr3:152004829(+) A-I intron -    22028664 chr3:152004830(+) A-I intron -    22028664 chr3:152004854(+) A-I intron -    22028664 chr3:152004855(+) A-I intron -    22028664 chr3:152004860(+) A-I intron -    22028664 chr3:152004886(+) A-I intron -    22028664 chr3:152004892(+) A-I intron -    22028664 chr3:152004896(+) A-I intron -    22028664 chr3:152004900(+) A-I intron -    22028664 chr3:152004928(+) A-I intron -    22028664 chr3:152004932(+) A-I intron -    22028664 chr3:152004954(+) A-I intron -    22028664 chr3:152004961(+) A-I intron -    22028664 chr3:152047317(+) A-I intron -    21960545 chr3:152048029(+) A-I intron -    21960545 chr3:151993238(+) A-G intron -    22484847 chr3:152003436(+) G-T intron -    22484847 chr3:152003441(+) A-G intron -    22484847 chr3:152003479(+) A-G intron -    22484847 chr3:152003487(+) A-G intron -    22484847 chr3:152003512(+) A-G intron -    22484847 chr3:152004754(+) A-G intron -    22484847 chr3:152004830(+) A-G intron -    22484847 chr3:152004854(+) A-G intron -    22484847 chr3:152004860(+) A-G intron -    22484847 chr3:152004896(+) A-G intron -    22484847 chr3:152004900(+) A-G intron -    22484847 chr3:152009614(+) A-G intron -    22484847 chr3:152010589(+) A-G intron -    22484847 chr3:152012079(+) T-C intron -    22484847 chr3:152015515(+) A-G intron -    22484847 chr3:152024827(+) T-G intron -    22484847 chr3:152030830(+) G-T intron -    22484847 chr3:152030832(+) G-A intron -    22484847 chr3:152030912(+) A-G intron -    22484847 chr3:152031003(+) A-G intron -    22484847 chr3:152032181(+) G-T intron -    22484847 chr3:152035292(+) A-G intron -    22484847 chr3:152035294(+) A-G intron -    22484847 chr3:152044717(+) G-A intron -    22484847 chr3:152045235(+) T-C intron -    22484847 chr3:152045317(+) G-A intron -    22484847 chr3:152047295(+) A-G intron -    22484847 chr3:152047317(+) A-G intron -    22484847 chr3:152047331(+) A-G intron -    22484847 chr3:152047994(+) T-C intron -    22484847 chr3:152048029(+) A-G intron -    22484847 chr3:152048030(+) A-G intron -    22484847 chr3:152049532(+) A-G intron -    22484847 chr3:152049580(+) A-G intron -    22484847 chr3:152049605(+) A-G intron -    22484847 chr3:152049606(+) A-G intron -    22484847 chr3:152072007(+) A-G intron -    22484847 chr3:152072100(+) T-C intron -    22484847 chr3:152092903(+) A-G intron -    22484847 chr3:152093336(+) A-G intron -    22484847 chr3:152093517(+) G-A intron -    22484847 chr3:152095870(+) A-G intron -    22484847 chr3:152095885(+) A-G intron -    22484847 chr3:152095888(+) A-G intron -    22484847 chr3:152095901(+) A-G intron -    22484847 chr3:152095944(+) A-G intron -    22484847 chr3:152095947(+) A-G intron -    22484847 chr3:152096028(+) T-C intron -    22484847 chr3:152096038(+) A-G intron -    22484847 chr3:152096529(+) A-G intron -    22484847 chr3:152096530(+) A-G intron -    22484847 chr3:152096559(+) A-G intron -    22484847 chr3:152096562(+) A-G intron -    22484847 chr3:152096605(+) A-G intron -    22484847 chr3:152096606(+) A-G intron -    22484847 chr3:152096609(+) A-G intron -    22484847 chr3:152096688(+) A-G intron -    22484847 chr3:152096690(+) A-G intron -    22484847 chr3:152096702(+) A-G intron -    22484847 chr3:152096739(+) A-G intron -    22484847 chr3:152096740(+) A-G intron -    22484847 chr3:152096779(+) A-G intron -    22484847 chr3:152112680(+) A-G intron -    22484847 chr3:152117360(+) A-G intron -    22484847 chr3:152117365(+) A-G intron -    22484847 chr3:152117418(+) A-G intron -    22484847 chr3:152117444(+) A-G intron -    22484847 chr3:152117465(+) A-G intron -    22484847 chr3:152119665(+) A-G intron -    22484847 chr3:152136200(+) A-G intron -    22484847 chr3:152136206(+) A-G intron -    22484847 chr3:152136207(+) A-G intron -    22484847 chr3:152136252(+) A-G intron -    22484847 chr3:152136261(+) A-G intron -    22484847 chr3:152136300(+) A-G intron -    22484847 chr3:152136304(+) A-G intron -    22484847 chr3:152136532(+) A-G intron -    22484847 chr3:152136586(+) A-G intron -    22484847 chr3:152136599(+) A-G intron -    22484847 chr3:152136600(+) A-G intron -    22484847 chr3:152136712(+) A-G intron -    22484847 chr3:152143321(+) T-C intron -    22484847 chr3:152155697(+) A-G intron -    22484847 chr3:152159682(+) A-G intron -    22484847 chr3:152167723(+) A-G intron -    22484847 chr3:152167783(+) A-G intron -    22484847 chr3:152167793(+) T-C intron -    22484847 chr3:152174297(+) T-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	MBNL1	chr3:151986029-151986030(+) m6A 5'UTR//intron       24284625//24981863//27773535//22608085 chr3:151986090-151986091(+) m6A 5'UTR//intron       24284625//24981863//27773535//22608085 chr3:151986176-151986177(+) m6A 5'UTR//intron       24284625//24981863//27773535//22575960//22608085 chr3:151986305-151986306(+) m6A 5'UTR//intron       24284625//22608085 chr3:151986681-151986682(+) m6A 5'UTR//intron       24284625//24981863 chr3:151986927-151986928(+) m6A 5'UTR//intron       24284625 chr3:151987192-151987193(+) m6A 5'UTR//intron       24981863 chr3:152017237-152017238(+) m6A 5'UTR//exon//intron       24284625//24981863//22608085 chr3:152017285-152017286(+) m6A 5'UTR//exon//intron       24284625//24981863//26404942//22608085 chr3:152017325-152017326(+) m6A 5'UTR//exon//intron       24284625//24981863//26404942//27773535//22608085 chr3:152017485-152017486(+) m6A 5'UTR//exon//intron       24284625//24981863//26404942//27773535//22575960//22608085 chr3:152017508-152017509(+) m6A 5'UTR//exon//intron       24284625//24981863//26404942//27773535//22575960//22608085 chr3:152017535-152017536(+) m6A 5'UTR//exon//intron       24284625//24981863//26404942//27773535//22575960//22608085 chr3:152017575-152017576(+) m6A 5'UTR//exon//intron       24284625//24981863//26404942//27773535//22575960//22608085 chr3:152017748-152017749(+) m6A 5'UTR//exon//intron       24284625//24209618//24981863//26404942//27773535//22608085 chr3:152017754-152017755(+) m6A 5'UTR//exon//intron       24284625//24209618//24981863//26404942//27773535//22608085 chr3:152017875-152017876(+) m6A 5'UTR//exon//intron       24209618//24981863//26404942//27773535//22608085 chr3:152017955-152017956(+) m6A 5'UTR//exon//intron       24209618//24981863//26404942//27773535//22608085 chr3:152017980-152017981(+) m6A 5'UTR//exon//intron       24209618//24981863//26404942//27773535//22608085 chr3:152018010-152018011(+) m6A CDS//exon//intron       24209618//24981863//26404942//27773535//22608085 chr3:152018057-152018058(+) m6A CDS//exon//intron       24981863//26404942//27773535//22608085 chr3:152018073-152018074(+) m6A CDS//exon//intron       24981863//26404942//27773535//22608085 chr3:152019743-152019744(+) m6A exon//intron       26404942 chr3:152019783-152019784(+) m6A exon//intron       26404942 chr3:152019806-152019807(+) m6A exon//intron       26404942 chr3:152019816-152019817(+) m6A exon//intron       26404942 chr3:152019889-152019890(+) m6A exon//intron       26404942 chr3:152019969-152019970(+) m6A exon//intron       24981863//26404942 chr3:152020011-152020012(+) m6A exon//intron       24981863//26404942//27773535 chr3:152020038-152020039(+) m6A exon//intron       24981863//26404942//27773535 chr3:152020071-152020072(+) m6A exon//intron       24981863//26404942 chr3:152020108-152020109(+) m6A exon//intron       26404942 chr3:152052929-152052930(+) m6A 5'UTR//intron       - chr3:152113960-152113961(+) m6A 5'UTR//intron       24209618 chr3:152113979-152113980(+) m6A 5'UTR//intron       24209618 chr3:152132748-152132749(+) m6A 5'UTR//CDS       24209618 chr3:152132829-152132830(+) m6A 5'UTR//CDS       - chr3:152175491-152175492(+) m6A exon//intron       27773535 chr3:152175545-152175546(+) m6A exon//intron       24284625//27773535 chr3:152175595-152175596(+) m6A exon//intron       24284625 chr3:152177079-152177080(+) m6A CDS//exon       24284625//24981863//27773535//22608085 chr3:152177131-152177132(+) m6A 3'UTR//exon       24284625//24981863//26404942//27773535//22608085 chr3:152180193-152180194(+) m6A 3'UTR//exon       24284625//24981863//26404942//27773535//22608085 chr3:152180283-152180284(+) m6A 3'UTR//exon       24284625//24981863//26404942//27773535//22608085 chr3:152180317-152180318(+) m6A 3'UTR//exon       24284625//24981863//26404942//27773535//22608085 chr3:152180411-152180412(+) m6A 3'UTR//exon       26404942 chr3:152180501-152180502(+) m6A 3'UTR//exon       26404942 chr3:152180550-152180551(+) m6A 3'UTR//exon       26404942 chr3:152180750-152180751(+) m6A 3'UTR//exon       26404942//27773535 chr3:152180827-152180828(+) m6A 3'UTR//exon       27773535 chr3:152180946-152180947(+) m6A 3'UTR//exon       24981863//27773535 chr3:152180994-152180995(+) m6A 3'UTR//exon       24981863//26404942//27773535 chr3:152181008-152181009(+) m6A 3'UTR//exon       24981863//26404942//27773535 chr3:152181027-152181028(+) m6A 3'UTR//exon       24981863//26404942//27773535 chr3:152181296-152181297(+) m6A 3'UTR//exon       26404942//27773535 chr3:152181335-152181336(+) m6A 3'UTR//exon       26404942//27773535 chr3:152182466-152182467(+) m6A 3'UTR//exon       26404942 chr3:152182473-152182474(+) m6A 3'UTR//exon       26404942 chr3:152182535-152182536(+) m6A 3'UTR//exon       26404942//27773535 chr3:152182630-152182631(+) m6A 3'UTR//exon       26404942//27773535 chr3:152182711-152182712(+) m6A 3'UTR//exon       24284625//24981863//26404942//27773535//22608085 chr3:152182767-152182768(+) m6A 3'UTR//exon       24284625//24981863//26404942//27773535//22608085 chr3:152182791-152182792(+) m6A 3'UTR//exon       24284625//24981863//26404942//27773535//22608085 chr3:152182846-152182847(+) m6A 3'UTR//exon       24284625//24981863//26404942//27773535//22608085 chr3:152182865-152182866(+) m6A 3'UTR//exon       24284625//24981863//26404942//27773535//22608085 chr3:152182967-152182968(+) m6A 3'UTR//exon       24981863//26404942//27773535//22608085 chr3:152182984-152182985(+) m6A 3'UTR//exon       24981863//26404942//27773535//22608085 chr3:152183009-152183010(+) m6A 3'UTR//exon       24981863//26404942//27773535//22608085 chr3:152183021-152183022(+) m6A 3'UTR//exon       24981863//26404942//27773535//22608085 chr3:152183087-152183088(+) m6A 3'UTR//exon       24981863//26404942//27773535 chr3:152183121-152183122(+) m6A 3'UTR//exon       26404942//27773535 chr3:152183129-152183130(+) m6A 3'UTR//exon       26404942//27773535 chr3:152183134-152183135(+) m6A 3'UTR//exon       26404942//27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	kshv-miR-K12-3-5p	Exosome B cell line (Raji)|Primary dendritic cells|T cell line (J77)     21505438 Exosome KSHV-infected lymphoma cell lines (BCBL-1|TY-1)     27611973 Exosome K562 cells     24460325
	MBNL1	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     - Exosome Blood     - Membrane HCC cell line (HepG2)|K562 cells     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: kshv-miR-K12-3-5p
Interactor2: MBNL1

Evidence Support:

Weak-Evidence	Microarray
Prediction-Evidence	miRanda//Targetscan
Support Database	ViRBase//VmiReg

References:

PMID	22174674	Target region	None
Source	ViRBase//VmiReg	Interactor1 expression	None
Tissue or cell line	EA.hy926 cells	Interactor2 expression	Downregulation
Description	As KSHV putative direct targets we extracted transcripts that were significantly down-regulated significantly in the replicate experiments, and which contained at least one seed-match to one of the KSHV miRNAs. We identified 704 putative direct targets in DG-75 cells (Figure 3B), and 980 putative direct targets in EA.hy926 cells (Figure 3C). A complete list of putative direct targets can be found in Dataset S2 for DG-75 cells and in Dataset S3 for EA.hy926 cells. The overlap between the two datasets contained 153 putative direct targets (Dataset S4).