Basic Information:

  VIRBase ID:  

VHID00466990

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5908

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-3-5p:  MIMAT0002193          S1PR1:  NM_001400     

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Interactor Information:

	Interactor1	Interactor2
Symbol	kshv-miR-K12-3-5p	S1PR1
miRBase Accession/Entrez ID	MIMAT0002193	1901
Organism	Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	CD363//CHEDG1//D1S3362//ECGF1//EDG-1//EDG1//S1P1

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	S1PR1	chr1:101702480-101702481(+) m6A 5'UTR       - chr1:101702499-101702500(+) m6A 5'UTR//exon       - chr1:101702535-101702536(+) m6A 5'UTR//exon       - chr1:101704658-101704659(+) m6A CDS//exon       22608085 chr1:101704667-101704668(+) m6A CDS//exon       24981863//22608085 chr1:101704677-101704678(+) m6A CDS//exon       24981863//22608085 chr1:101704727-101704728(+) m6A CDS//exon       24981863//22608085 chr1:101704756-101704757(+) m6A CDS//exon       24981863//22608085 chr1:101704811-101704812(+) m6A CDS//exon       24981863//22608085 chr1:101704989-101704990(+) m6A CDS//exon       24981863//22608085 chr1:101705087-101705088(+) m6A CDS       24981863//22608085 chr1:101705227-101705228(+) m6A CDS       24981863 chr1:101705258-101705259(+) m6A CDS       24981863 chr1:101705308-101705309(+) m6A CDS       - chr1:101705395-101705396(+) m6A CDS       - chr1:101705543-101705544(+) m6A CDS       25456834//24981863//22575960//22608085 chr1:101705606-101705607(+) m6A CDS       25456834//24981863//22575960//22608085 chr1:101705639-101705640(+) m6A CDS       25456834//24981863//22575960//22608085 chr1:101705650-101705651(+) m6A CDS       25456834//24981863//22608085 chr1:101705690-101705691(+) m6A 3'UTR       25456834//24981863//22608085 chr1:101705828-101705829(+) m6A 3'UTR       25456834//24981863//22608085 chr1:101705875-101705876(+) m6A 3'UTR       25456834//24981863//22608085 chr1:101706012-101706013(+) m6A 3'UTR       24981863 chr1:101706085-101706086(+) m6A 3'UTR       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	kshv-miR-K12-3-5p	Exosome B cell line (Raji)|Primary dendritic cells|T cell line (J77)     21505438 Exosome KSHV-infected lymphoma cell lines (BCBL-1|TY-1)     27611973 Exosome K562 cells     24460325
	S1PR1	Cytosol HeLa-S3 cells     - Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     -

Interaction Network (The top 100 interactions):

Interactor1: kshv-miR-K12-3-5p
Interactor2: S1PR1

Evidence Support:

Weak-Evidence	Microarray
Prediction-Evidence	miRanda//Targetscan
Support Database	ViRBase//VmiReg

References:

PMID	22174674	Target region	None
Source	ViRBase//VmiReg	Interactor1 expression	None
Tissue or cell line	EA.hy926 cells	Interactor2 expression	Downregulation
Description	As KSHV putative direct targets we extracted transcripts that were significantly down-regulated significantly in the replicate experiments, and which contained at least one seed-match to one of the KSHV miRNAs. We identified 704 putative direct targets in DG-75 cells (Figure 3B), and 980 putative direct targets in EA.hy926 cells (Figure 3C). A complete list of putative direct targets can be found in Dataset S2 for DG-75 cells and in Dataset S3 for EA.hy926 cells. The overlap between the two datasets contained 153 putative direct targets (Dataset S4).