Basic Information:

  VIRBase ID:  

VHID00466409

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-4-3p:  MIMAT0002192          ZDHHC23:  NM_173570     

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Interactor Information:

	Interactor1	Interactor2
Symbol	kshv-miR-K12-4-3p	ZDHHC23
miRBase Accession/Entrez ID	MIMAT0002192	254887
Organism	Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	DHHC-23//NIDD

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	ZDHHC23	chr3:113667734-113667735(+) Tm CDS       - chr3:113667755-113667756(+) m6A CDS       24284625//24981863//22608085 chr3:113672577-113672578(+) m6A CDS       24284625//24209618//24981863//22608085 chr3:113672650-113672651(+) m6A CDS       24284625//24209618//25456834//24981863//22608085 chr3:113672792-113672793(+) m6A CDS       24284625//24209618//25456834//24981863//22608085 chr3:113672819-113672820(+) m6A CDS       24284625//24209618//25456834//24981863//22608085 chr3:113673045-113673046(+) m6A CDS       24284625//25456834//24981863//22608085 chr3:113673067-113673068(+) m6A CDS       24284625//25456834//24981863//22608085 chr3:113673160-113673161(+) m6A CDS       24284625//25456834//24981863//22608085 chr3:113677345-113677346(+) m6A CDS//exon       24284625//22608085 chr3:113677379-113677380(+) m6A CDS//exon       24284625//25456834//24981863//22608085 chr3:113677412-113677413(+) m6A exon//intron       24284625//25456834//24981863//22608085 chr3:113677466-113677467(+) m6A exon//intron       24284625 chr3:113677605-113677606(+) m6A exon//intron       24284625//24981863//22608085 chr3:113677651-113677652(+) m6A exon//intron       24284625//24981863//22608085 chr3:113677723-113677724(+) m6A exon//intron       24284625//24981863//22608085 chr3:113678409-113678410(+) m6A 3'UTR//exon//intron       24981863 chr3:113679614-113679615(+) m6A 3'UTR//exon//intron       22608085 chr3:113679672-113679673(+) m6A 3'UTR//exon//intron       24284625//24981863//22608085 chr3:113679683-113679684(+) m6A 3'UTR//exon//intron       24284625//24981863//22608085 chr3:113679703-113679704(+) m6A 3'UTR//exon//intron       24284625//24981863//22608085 chr3:113679773-113679774(+) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//22608085 chr3:113679857-113679858(+) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//22608085 chr3:113679933-113679934(+) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//27773535//22608085 chr3:113680005-113680006(+) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//27773535//22608085 chr3:113680050-113680051(+) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//27773535//22608085 chr3:113680062-113680063(+) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//27773535//22608085 chr3:113680111-113680112(+) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//27773535//22608085 chr3:113680184-113680185(+) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//27773535//22608085 chr3:113680205-113680206(+) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//27773535//22608085 chr3:113680345-113680346(+) m6A 3'UTR//exon//intron       24284625//24209618//24981863//22608085 chr3:113680419-113680420(+) m6A 3'UTR//exon//intron       24284625//24209618//24981863//22608085 chr3:113681551-113681552(+) m6A 3'UTR//exon//intron       - chr3:113681561-113681562(+) m6A 3'UTR//exon//intron       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	ZDHHC23	Chromatin K562 cells     - Exosome Blood     - Nucleus Colon cancer cells     24393600 Nucleus HeLa-S3 cells     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	kshv-miR-K12-4-3p	Panobinostat       6918837 Nilotinib       644241 Irinotecan       60838 Topotecan       60700 l-685,458       5479543 Palbociclib       5330286 Dovitinib       135398510 Crizotinib       11626560 Nvp-aew541       11476171 Pha-665752       10461815

Interaction Network (The top 100 interactions):

Interactor1: kshv-miR-K12-4-3p
Interactor2: ZDHHC23

Evidence Support:

Weak-Evidence	Microarray
Prediction-Evidence	cRep//miRanda//Targetscan
Support Database	RepTar//ViRBase//VmiReg

References:

PMID	22174674	Target region	None
Source	RepTar//ViRBase//VmiReg	Interactor1 expression	None
Tissue or cell line	DG-75 cells	Interactor2 expression	Downregulation
Description	As KSHV putative direct targets we extracted transcripts that were significantly down-regulated significantly in the replicate experiments, and which contained at least one seed-match to one of the KSHV miRNAs. We identified 704 putative direct targets in DG-75 cells (Figure 3B), and 980 putative direct targets in EA.hy926 cells (Figure 3C). A complete list of putative direct targets can be found in Dataset S2 for DG-75 cells and in Dataset S3 for EA.hy926 cells. The overlap between the two datasets contained 153 putative direct targets (Dataset S4).