Basic Information:

  VIRBase ID:  

VHID00466320

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5908

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-4-3p:  MIMAT0002192          ARL13B:  NM_144996     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	kshv-miR-K12-4-3p	ARL13B
miRBase Accession/Entrez ID	MIMAT0002192	200894
Organism	Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	ARL2L1//JBTS8

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	ARL13B	chr3:93744993(+) A-I      intronic chr3:93745029(+) A-I      intronic chr3:93745045(+) A-I      intronic chr3:93745048(+) A-I      intronic chr3:93749102(+) A-I      intronic chr3:93749110(+) A-I      intronic chr3:93749151(+) A-I      intronic chr3:93749170(+) A-I      intronic chr3:93749181(+) A-I      intronic chr3:93749188(+) A-I      intronic chr3:93749279(+) A-I      intronic chr3:93749288(+) A-I      intronic chr3:93705558(+) A-I      intronic chr3:93700494(+) A-I      intronic chr3:93703050(+) A-I      intronic chr3:93744981(+) A-I      intronic chr3:93705660(+) A-I      intronic chr3:93705662(+) A-I      intronic chr3:93705664(+) A-I      intronic chr3:93706075(+) A-I      intronic chr3:93706593(+) A-I      intronic chr3:93706699(+) A-I      intronic chr3:93706710(+) A-I      intronic chr3:93706737(+) A-I      intronic chr3:93710412(+) A-I      intronic chr3:93718186(+) A-I      intronic chr3:93724968(+) A-I      intronic chr3:93732692(+) A-I      intronic chr3:93741047(+) A-I      intronic chr3:93743461(+) A-I      intronic chr3:93743466(+) A-I      intronic chr3:93743483(+) A-I      intronic chr3:93743547(+) A-I      intronic chr3:93749289(+) A-I      intronic chr3:93749749(+) A-I      intronic chr3:93749830(+) A-I      intronic chr3:93749834(+) A-I      intronic chr3:93753934(+) A-I      intronic chr3:93753960(+) A-I      intronic chr3:93700530(+) A-I      intronic chr3:93700539(+) A-I      intronic chr3:93767535(+) A-I      intronic chr3:93767536(+) A-I      intronic chr3:93767553(+) A-I      intronic chr3:93767565(+) A-I      intronic chr3:93700476(+) A-I      intronic chr3:93700470(+) A-I      intronic chr3:93710348(+) A-I      intronic chr3:93754038(+) A-I      intronic chr3:93710319(+) A-I      intronic chr3:93749915(+) A-I      intronic chr3:93706629(+) A-I      intronic chr3:93757534(+) A-I      intronic chr3:93712368(+) A-I      intronic chr3:93749766(+) A-I      intronic chr3:93705617(+) A-I      intronic chr3:93706623(+) A-I      intronic chr3:93703837(+) A-I      intronic chr3:93716812(+) A-I      intronic chr3:93749899(+) A-I      intronic chr3:93749345(+) A-I      intronic chr3:93705703(+) A-I      intronic chr3:93706605(+) A-I      intronic chr3:93705557(+) A-I      intronic chr3:93753824(+) A-I      intronic chr3:93706039(+) A-I      intronic chr3:93749955(+) A-I      intronic chr3:93706515(+) A-I      intronic chr3:93757461(+) A-I      intronic chr3:93705629(+) A-I      intronic chr3:93706680(+) A-I      intronic chr3:93706619(+) A-I      intronic chr3:93749210(+) A-I      intronic chr3:93757497(+) A-I      intronic chr3:93700607(+) A-I      intronic chr3:93700471(+) A-I      intronic chr3:93749778(+) A-I      intronic chr3:93716800(+) A-I      intronic chr3:93764644(+) A-I      intronic chr3:93764590(+) A-I      intronic chr3:93700602(+) A-I      intronic chr3:93753904(+) A-I      intronic chr3:93703780(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	ARL13B	chr3:93722690-93722691(+) m6A 3'UTR//CDS//exon//intron       24981863 chr3:93722719-93722720(+) m6A 3'UTR//CDS//exon//intron       24981863 chr3:93754186-93754187(+) m6A 3'UTR//CDS//exon//intron       24981863 chr3:93755486-93755487(+) m6A 3'UTR//CDS//exon       24981863//27773535//22608085 chr3:93755521-93755522(+) m6A 3'UTR//CDS//exon       24981863//27773535//22608085 chr3:93755547-93755548(+) m6A 3'UTR//CDS//exon       24981863//27773535//22608085 chr3:93755556-93755557(+) m6A 3'UTR//CDS//exon       24981863//27773535//22608085 chr3:93758726-93758727(+) m6A 3'UTR//CDS//exon       24981863//27773535//22608085 chr3:93758735-93758736(+) m6A 3'UTR//CDS//exon       24981863//27773535//22608085 chr3:93758750-93758751(+) m6A 3'UTR//CDS//exon       24981863//27773535//22608085 chr3:93758760-93758761(+) m6A 3'UTR//CDS       24981863//27773535//22608085 chr3:93758782-93758783(+) m6A 3'UTR//CDS       24981863//27773535//22608085 chr3:93758789-93758790(+) m6A 3'UTR//CDS       24981863//27773535//22608085 chr3:93761869-93761870(+) m6A 3'UTR//CDS       24981863//27773535//22608085 chr3:93761889-93761890(+) m6A 3'UTR//CDS       24981863//27773535//22608085 chr3:93761907-93761908(+) m6A 3'UTR//CDS       24981863//27773535//22608085 chr3:93761929-93761930(+) m6A 3'UTR//CDS       24981863//27773535//22608085 chr3:93761957-93761958(+) m6A 3'UTR//CDS       24981863//27773535//22608085 chr3:93762004-93762005(+) m6A 3'UTR//CDS       24981863//27773535//22608085 chr3:93762059-93762060(+) m6A 3'UTR//CDS       24981863//27773535//22608085 chr3:93762063-93762064(+) m6A 3'UTR//CDS       24981863 chr3:93768266-93768267(+) m6A 3'UTR//CDS       24981863//27773535//22608085 chr3:93768274-93768275(+) m6A 3'UTR//CDS       24981863//27773535//22608085 chr3:93768291-93768292(+) m6A 3'UTR//CDS       24981863//27773535//22608085 chr3:93768304-93768305(+) m6A 3'UTR//CDS       24981863//27773535//22608085 chr3:93769678-93769679(+) m6A 3'UTR//CDS       24981863//27773535 chr3:93769695-93769696(+) m6A 3'UTR//CDS       24981863//27773535 chr3:93769704-93769705(+) m6A 3'UTR//CDS       24981863 chr3:93769723-93769724(+) m6A 3'UTR//CDS       24284625//24981863 chr3:93772107-93772108(+) m6A 3'UTR       24284625//24209618//24981863//22608085 chr3:93772148-93772149(+) m6A 3'UTR//intron       24284625//24209618//24981863//27773535//22608085 chr3:93772154-93772155(+) m6A 3'UTR//intron       24284625//24209618//24981863//27773535//22608085 chr3:93772179-93772180(+) m6A 3'UTR//intron       24284625//24209618//24981863//27773535//22608085 chr3:93772248-93772249(+) m6A 3'UTR//intron       24284625//24209618//24981863//27773535//22608085 chr3:93772335-93772336(+) m6A 3'UTR       24284625//24209618//24981863//27773535//22575960//22608085 chr3:93772406-93772407(+) m6A 3'UTR       24284625//24209618//24981863//22608085 chr3:93772428-93772429(+) m6A 3'UTR       24284625//24981863//22608085 chr3:93772515-93772516(+) m6A 3'UTR       24284625//24981863//22608085 chr3:93772546-93772547(+) m6A 3'UTR       22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	ARL13B	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Membrane K562 cells     - Nucleolus K562 cells     - Nucleoplasm K562 cells     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	kshv-miR-K12-4-3p	Panobinostat       6918837 Nilotinib       644241 Irinotecan       60838 Topotecan       60700 l-685,458       5479543 Palbociclib       5330286 Dovitinib       135398510 Crizotinib       11626560 Nvp-aew541       11476171 Pha-665752       10461815

Interaction Network (The top 100 interactions):

Interactor1: kshv-miR-K12-4-3p
Interactor2: ARL13B

Evidence Support:

Weak-Evidence	Microarray
Prediction-Evidence	miRanda//Targetscan
Support Database	ViRBase//VmiReg

References:

PMID	22174674	Target region	None
Source	ViRBase//VmiReg	Interactor1 expression	None
Tissue or cell line	EA.hy926 cells	Interactor2 expression	Downregulation
Description	As KSHV putative direct targets we extracted transcripts that were significantly down-regulated significantly in the replicate experiments, and which contained at least one seed-match to one of the KSHV miRNAs. We identified 704 putative direct targets in DG-75 cells (Figure 3B), and 980 putative direct targets in EA.hy926 cells (Figure 3C). A complete list of putative direct targets can be found in Dataset S2 for DG-75 cells and in Dataset S3 for EA.hy926 cells. The overlap between the two datasets contained 153 putative direct targets (Dataset S4).