Basic Information:

  VIRBase ID:  

VHID00466080

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-4-3p:  MIMAT0002192          STXBP5:  NM_001127715     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	kshv-miR-K12-4-3p	STXBP5
miRBase Accession/Entrez ID	MIMAT0002192	134957
Organism	Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	LGL3//LLGL3//Nbla04300

RNA Editing:

Resource	Symbol	Editing Position
Lncediting	STXBP5	chr6: 147710839

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	STXBP5	chr6:147694413(+) A-I      intronic chr6:147642630(+) A-I      intronic chr6:147568227(+) A-I      intronic chr6:147568232(+) A-I      intronic chr6:147568861(+) A-I      intronic chr6:147663643(+) A-I      intronic chr6:147642638(+) A-I      intronic chr6:147532377(+) A-I      intronic chr6:147536629(+) A-I      intronic chr6:147536646(+) A-I      intronic chr6:147537363(+) A-I      intronic chr6:147537370(+) A-I      intronic chr6:147654384(+) A-I      intronic chr6:147537376(+) A-I      intronic chr6:147537408(+) A-I      intronic chr6:147654517(+) A-I      intronic chr6:147654394(+) A-I      intronic chr6:147537434(+) A-I      intronic chr6:147537449(+) A-I      intronic chr6:147569282(+) A-I      intronic chr6:147693754(+) A-I      intronic chr6:147694342(+) A-I      intronic chr6:147537372(+) A-I      intronic chr6:147576865(+) A-I      intronic chr6:147642644(+) A-I      intronic chr6:147539720(+) A-I      intronic chr6:147642643(+) A-I      intronic chr6:147569161(+) A-I      intronic chr6:147569160(+) A-I      intronic chr6:147534443(+) A-I      intronic chr6:147532822(+) A-I      intronic chr6:147532792(+) A-I      intronic chr6:147694355(+) A-I      intronic chr6:147694422(+) A-I      intronic chr6:147532852(+) A-I      intronic chr6:147547308(+) A-I      intronic chr6:147694433(+) A-I      intronic chr6:147596713(+) A-I      intronic chr6:147694421(+) A-I      intronic chr6:147674149(+) A-I      intronic chr6:147642673(+) A-I      intronic chr6:147694349(+) A-I      intronic chr6:147532809(+) A-I      intronic chr6:147545509(+) A-I      intronic chr6:147642659(+) A-I      intronic chr6:147532835(+) A-I      intronic chr6:147693635(+) A-I      intronic chr6:147648695(+) A-I      intronic chr6:147532973(+) A-I      intronic chr6:147532960(+) A-I      intronic chr6:147547388(+) A-I      intronic chr6:147532849(+) A-I      intronic chr6:147694251(+) A-I      intronic chr6:147644632(+) A-I      intronic chr6:147694518(+) A-I      intronic chr6:147532758(+) A-I      intronic chr6:147694293(+) A-I      intronic chr6:147644645(+) A-I      intronic chr6:147547309(+) A-I      intronic chr6:147532961(+) A-I      intronic chr6:147645611(+) A-I      intronic chr6:147694416(+) A-I      intronic chr6:147642635(+) A-I      intronic chr6:147579609(+) A-I      intronic chr6:147694348(+) A-I      intronic chr6:147694359(+) A-I      intronic chr6:147532325(+) A-I      intronic chr6:147648735(+) A-I      intronic chr6:147532906(+) A-I      intronic chr6:147532848(+) A-I      intronic chr6:147532826(+) A-I      intronic chr6:147648814(+) A-I      intronic chr6:147694447(+) A-I      intronic chr6:147641031(+) A-I      intronic chr6:147547345(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	STXBP5	chr6:147546347(+) A-I intron -    15342557 chr6:147547185(+) A-I intron -    15342557 chr6:147547250(+) A-I intron -    15342557 chr6:147547308(+) A-I intron -    15342557 chr6:147547309(+) A-I intron -    15342557 chr6:147547318(+) A-I intron -    15342557 chr6:147547345(+) A-I intron -    15342557 chr6:147547388(+) A-I intron -    15342557 chr6:147570855(+) T-G intron -    22484847 chr6:147532325(+) A-G intron -    22484847 chr6:147532758(+) A-G intron -    22484847 chr6:147532826(+) A-G intron -    22484847 chr6:147532835(+) A-G intron -    22484847 chr6:147532960(+) A-G intron -    22484847 chr6:147532961(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	STXBP5	chr6:147525620-147525621(+) m6A 5'UTR       24284625 chr6:147525665-147525666(+) m6A 5'UTR       24284625 chr6:147525762-147525763(+) m6A CDS       24284625 chr6:147684659-147684660(+) m6A CDS       24981863//22608085 chr6:147684719-147684720(+) m6A CDS       24981863//22608085 chr6:147684748-147684749(+) m6A CDS       24981863//22608085 chr6:147684822-147684823(+) m6A CDS       24981863 chr6:147706126-147706127(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr6:147706152-147706153(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr6:147706173-147706174(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr6:147706186-147706187(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr6:147706213-147706214(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22608085 chr6:147706331-147706332(+) m6A 3'UTR       24209618//24981863//22608085 chr6:147706343-147706344(+) m6A 3'UTR       24209618//24981863//22608085 chr6:147706356-147706357(+) m6A 3'UTR       24209618//24981863//22608085 chr6:147706408-147706409(+) m6A 3'UTR       24981863//22608085 chr6:147706435-147706436(+) m6A 3'UTR       24981863//22608085 chr6:147706471-147706472(+) m6A 3'UTR       24981863//22608085 chr6:147706525-147706526(+) m6A 3'UTR       24981863//22608085 chr6:147706559-147706560(+) m6A 3'UTR       24981863//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	STXBP5	Chromatin K562 cells     - Cytosol HCC cell line (HepG2)|K562 cells     - Exosome Blood     - Insoluble cytoplasm HCC cell line (HepG2)|K562 cells     - Membrane HCC cell line (HepG2)|K562 cells     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HeLa-S3 cells|K562 cells     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	kshv-miR-K12-4-3p	Panobinostat       6918837 Nilotinib       644241 Irinotecan       60838 Topotecan       60700 l-685,458       5479543 Palbociclib       5330286 Dovitinib       135398510 Crizotinib       11626560 Nvp-aew541       11476171 Pha-665752       10461815

Interaction Network (The top 100 interactions):

Interactor1: kshv-miR-K12-4-3p
Interactor2: STXBP5

Evidence Support:

Weak-Evidence	Microarray
Support Database	ViRBase

References:

PMID	22174674	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EA.hy926 cells	Interactor2 expression	Downregulation
Description	As KSHV putative direct targets we extracted transcripts that were significantly down-regulated significantly in the replicate experiments, and which contained at least one seed-match to one of the KSHV miRNAs. We identified 704 putative direct targets in DG-75 cells (Figure 3B), and 980 putative direct targets in EA.hy926 cells (Figure 3C). A complete list of putative direct targets can be found in Dataset S2 for DG-75 cells and in Dataset S3 for EA.hy926 cells. The overlap between the two datasets contained 153 putative direct targets (Dataset S4).