Basic Information:

  VIRBase ID:  

VHID00465750

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-4-3p:  MIMAT0002192          KBTBD8:  NM_032505     

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Interactor Information:

	Interactor1	Interactor2
Symbol	kshv-miR-K12-4-3p	KBTBD8
miRBase Accession/Entrez ID	MIMAT0002192	84541
Organism	Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	TA-KRP//TAKRP

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	KBTBD8	chr3:67056267(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	KBTBD8	chr3:67049449-67049450(+) m6A 5'UTR//CDS//exon//intron       24981863//22608085 chr3:67049470-67049471(+) m6A CDS//exon//intron       24981863//22608085 chr3:67049508-67049509(+) m6A CDS//exon//intron       22608085 chr3:67053707-67053708(+) m6A CDS//intron       22608085 chr3:67053800-67053801(+) m6A CDS//intron       22608085 chr3:67053833-67053834(+) m6A CDS//intron       24981863//22608085 chr3:67053888-67053889(+) m6A CDS//intron       24981863//22608085 chr3:67053945-67053946(+) m6A CDS//intron       24981863//22608085 chr3:67053971-67053972(+) m6A CDS//exon//intron       24981863//22608085 chr3:67053992-67053993(+) m6A CDS//exon//intron       24981863//22608085 chr3:67054013-67054014(+) m6A CDS//exon//intron       24981863//22608085 chr3:67054062-67054063(+) m6A CDS//exon//intron       24981863//22608085 chr3:67054197-67054198(+) m6A CDS//exon//intron       25456834//24981863//22608085 chr3:67054278-67054279(+) m6A CDS//intron       25456834//24981863//22608085 chr3:67054297-67054298(+) m6A CDS//intron       25456834//24981863//22608085 chr3:67054338-67054339(+) m6A CDS//intron       25456834//24981863//22608085 chr3:67054347-67054348(+) m6A CDS//intron       25456834//24981863//22608085 chr3:67054509-67054510(+) m6A CDS//intron       24981863//22608085 chr3:67054542-67054543(+) m6A CDS//intron       24981863//22608085 chr3:67054607-67054608(+) m6A CDS//intron       24981863//22608085 chr3:67058378-67058379(+) m6A CDS       24981863//22608085 chr3:67058444-67058445(+) m6A CDS       24981863//22608085 chr3:67058467-67058468(+) m6A CDS       24981863//22608085 chr3:67058530-67058531(+) m6A CDS       24981863//22608085 chr3:67058543-67058544(+) m6A CDS       24981863//22608085 chr3:67058580-67058581(+) m6A CDS       24981863//22608085 chr3:67058597-67058598(+) m6A CDS       24981863//22608085 chr3:67058643-67058644(+) m6A CDS       24981863//22608085 chr3:67058656-67058657(+) m6A CDS       24981863//22608085 chr3:67058722-67058723(+) m6A CDS       24981863//22608085 chr3:67058741-67058742(+) m6A CDS       24981863//22608085 chr3:67058775-67058776(+) m6A CDS       22608085 chr3:67058855-67058856(+) m6A 3'UTR       22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	KBTBD8	Cytosol HCC cell line (HepG2)     - Exosome Blood     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	kshv-miR-K12-4-3p	Panobinostat       6918837 Nilotinib       644241 Irinotecan       60838 Topotecan       60700 l-685,458       5479543 Palbociclib       5330286 Dovitinib       135398510 Crizotinib       11626560 Nvp-aew541       11476171 Pha-665752       10461815

Interaction Network (The top 100 interactions):

Interactor1: kshv-miR-K12-4-3p
Interactor2: KBTBD8

Evidence Support:

Weak-Evidence	Microarray
Prediction-Evidence	cRep//miRanda//Targetscan
Support Database	RepTar//ViRBase//VmiReg

References:

PMID	22174674	Target region	None
Source	RepTar//ViRBase//VmiReg	Interactor1 expression	None
Tissue or cell line	DG-75 cells	Interactor2 expression	Downregulation
Description	As KSHV putative direct targets we extracted transcripts that were significantly down-regulated significantly in the replicate experiments, and which contained at least one seed-match to one of the KSHV miRNAs. We identified 704 putative direct targets in DG-75 cells (Figure 3B), and 980 putative direct targets in EA.hy926 cells (Figure 3C). A complete list of putative direct targets can be found in Dataset S2 for DG-75 cells and in Dataset S3 for EA.hy926 cells. The overlap between the two datasets contained 153 putative direct targets (Dataset S4).