Detail Information

Basic Information:


  VIRBase ID:  

VHID00465390

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-4-3p:           SAV1:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol kshv-miR-K12-4-3p SAV1
miRBase
Accession/Entrez ID		 MIMAT0002192 60485
Organism Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV) Homo sapiens
Category miRNA mRNA
Alias - SAV//WW45//WWP4

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR SAV1
chr14:51101242(-) A-I      3'UTR
chr14:51122601(-) A-I      intronic
chr14:51117664(-) A-I      intronic
chr14:51122281(-) A-I      intronic
chr14:51122241(-) A-I      intronic
chr14:51101264(-) A-I      3'UTR
chr14:51101247(-) A-I      3'UTR
chr14:51122174(-) A-I      intronic
chr14:51101244(-) A-I      3'UTR
chr14:51101239(-) A-I      3'UTR
chr14:51127438(-) A-I      intronic
chr14:51120504(-) A-I      intronic
chr14:51101235(-) A-I      3'UTR
chr14:51123946(-) A-I      intronic
chr14:51123954(-) A-I      intronic
chr14:51123956(-) A-I      intronic
chr14:51123957(-) A-I      intronic
chr14:51123972(-) A-I      intronic
chr14:51123868(-) A-I      intronic
chr14:51123885(-) A-I      intronic
chr14:51123864(-) A-I      intronic
chr14:51120475(-) A-I      intronic
chr14:51123980(-) A-I      intronic
chr14:51129122(-) A-I      intronic
chr14:51122719(-) A-I      intronic
chr14:51129114(-) A-I      intronic
chr14:51123985(-) A-I      intronic
chr14:51126469(-) A-I      intronic
chr14:51120511(-) A-I      intronic
chr14:51122750(-) A-I      intronic
chr14:51118485(-) A-I      intronic
chr14:51118639(-) A-I      intronic
chr14:51126356(-) A-I      intronic
chr14:51129090(-) A-I      intronic
chr14:51123433(-) A-I      intronic
chr14:51122615(-) A-I      intronic
chr14:51126481(-) A-I      intronic
chr14:51118380(-) A-I      intronic
chr14:51102363(-) A-I      intronic
chr14:51122304(-) A-I      intronic
chr14:51122311(-) A-I      intronic
chr14:51122317(-) A-I      intronic
chr14:51118417(-) A-I      intronic
chr14:51122322(-) A-I      intronic
chr14:51123237(-) A-I      intronic
chr14:51122323(-) A-I      intronic
chr14:51126424(-) A-I      intronic
chr14:51123276(-) A-I      intronic
chr14:51122272(-) A-I      intronic
chr14:51123321(-) A-I      intronic
chr14:51122760(-) A-I      intronic
chr14:51102697(-) A-I      intronic
chr14:51122663(-) A-I      intronic
chr14:51123325(-) A-I      intronic
chr14:51122337(-) A-I      intronic
chr14:51126442(-) A-I      intronic
chr14:51122435(-) A-I      intronic
chr14:51123891(-) A-I      intronic
chr14:51126452(-) A-I      intronic
chr14:51122737(-) A-I      intronic
chr14:51123917(-) A-I      intronic
chr14:51101336(-) A-I      3'UTR
chr14:51101177(-) A-I      3'UTR
chr14:51101341(-) A-I      3'UTR
chr14:51101152(-) A-I      3'UTR
chr14:51101257(-) A-I      3'UTR
chr14:51101251(-) A-I      3'UTR
chr14:51101158(-) A-I      3'UTR
chr14:51101205(-) A-I      3'UTR
chr14:51101287(-) A-I      3'UTR
chr14:51118548(-) A-I      intronic
chr14:51102289(-) A-I      intronic
chr14:51126560(-) A-I      intronic
chr14:51122680(-) A-I      intronic
chr14:51122703(-) A-I      intronic
chr14:51122282(-) A-I      intronic
chr14:51122509(-) A-I      intronic
chr14:51122300(-) A-I      intronic
chr14:51122651(-) A-I      intronic
chr14:51126400(-) A-I      intronic
chr14:51122390(-) A-I      intronic
chr14:51122433(-) A-I      intronic
chr14:51122724(-) A-I      intronic
chr14:51105624(-) A-I      intronic
chr14:51118622(-) A-I      intronic
chr14:51122491(-) A-I      intronic
chr14:51126406(-) A-I      intronic
chr14:51122394(-) A-I      intronic
chr14:51122598(-) A-I      intronic
chr14:51126521(-) A-I      intronic
chr14:51119639(-) A-I      intronic
chr14:51119666(-) A-I      intronic
chr14:51126556(-) A-I      intronic
chr14:51126478(-) A-I      intronic
chr14:51123802(-) A-I      intronic
chr14:51122641(-) A-I      intronic
chr14:51122762(-) A-I      intronic
chr14:51122240(-) A-I      intronic
chr14:51122395(-) A-I      intronic
chr14:51123813(-) A-I      intronic
chr14:51107110(-) A-I      intronic
chr14:51123890(-) A-I      intronic
chr14:51122220(-) A-I      intronic
chr14:51122347(-) A-I      intronic
chr14:51101263(-) A-I      3'UTR
chr14:51101231(-) A-I      3'UTR
chr14:51101288(-) A-I      3'UTR
chr14:51101136(-) A-I      3'UTR
chr14:51101272(-) A-I      3'UTR
chr14:51101223(-) A-I      3'UTR
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED SAV1
chr14:51101272(-) A-G exon 3'UTR    22484847
chr14:51118639(-) A-G intron -    22484847
chr14:51126424(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase SAV1
chr14:51100810-51100811(-) m6A 3'UTR       27773535
chr14:51100927-51100928(-) m6A 3'UTR//intron       27773535
chr14:51101056-51101057(-) m6A 3'UTR//intron       24981863
chr14:51101092-51101093(-) m6A 3'UTR//intron       24981863
chr14:51101833-51101834(-) m6A 3'UTR//intron       24981863//27773535//22608085
chr14:51101939-51101940(-) m6A 3'UTR//CDS       24981863//27773535//22608085
chr14:51101952-51101953(-) m6A 3'UTR//CDS       24981863//27773535//22608085
chr14:51101978-51101979(-) m6A 3'UTR//CDS       24981863//27773535//22608085
chr14:51107561-51107562(-) m6A CDS//intron       27773535
chr14:51111519-51111520(-) m6A CDS//intron       24981863//27773535//22608085
chr14:51111562-51111563(-) m6A CDS//intron       24981863//22608085
chr14:51111639-51111640(-) m6A CDS//intron       27773535//22608085
chr14:51111644-51111645(-) m6A CDS//intron       27773535//22608085
chr14:51129285-51129286(-) m6A intron       27773535
chr14:51129345-51129346(-) m6A intron       27773535
chr14:51129695-51129696(-) m6A intron       25456834//24981863//27773535//27371828//22608085
chr14:51129721-51129722(-) m6A intron       25456834//24981863//27773535//27371828//22608085
chr14:51129740-51129741(-) m6A intron       25456834//24981863//27773535//27371828//22608085
chr14:51129782-51129783(-) m6A intron       27773535
chr14:51131483-51131484(-) m6A exon//intron       24981863
chr14:51131509-51131510(-) m6A exon//intron       24981863
chr14:51131520-51131521(-) m6A exon//intron       24981863
chr14:51131542-51131543(-) m6A exon//intron       24981863
chr14:51131805-51131806(-) m6A exon//intron       24981863
chr14:51131811-51131812(-) m6A exon//intron       24981863
chr14:51131967-51131968(-) m6A CDS       24284625//24209618//24981863//27773535//22608085
chr14:51132021-51132022(-) m6A CDS       24284625//24209618//24981863//27773535//22608085
chr14:51132048-51132049(-) m6A CDS       24284625//24981863//27773535//22608085
chr14:51132190-51132191(-) m6A CDS       24284625//24981863//27773535//22608085
chr14:51132205-51132206(-) m6A CDS       24284625//24209618//24981863//27773535//22608085
chr14:51132222-51132223(-) m6A CDS       24284625//24209618//24981863//27773535//22608085
chr14:51132289-51132290(-) m6A CDS       24284625//24209618//24981863//27773535//22608085
chr14:51134108-51134109(-) m6A CDS//intron       24284625//24209618//24981863//27773535//22608085
chr14:51134148-51134149(-) m6A CDS//intron       24284625//24209618//24981863//27773535//22608085
chr14:51134188-51134189(-) m6A CDS//intron       24209618//27773535
chr14:51134615-51134616(-) m1A CDS       26863196
chr14:51134666-51134667(-) m6A CDS       24209618//24981863//27773536
chr14:51134820-51134821(-) m6A 5'UTR       24209618//27371828//27773536
chr14:51134857-51134858(-) m6A 5'UTR       24209618//27371828//27773536
chr14:51134901-51134902(-) m6A 5'UTR       24209618//24981863//27371828//27773536
chr14:51134991-51134992(-) m6A 5'UTR       24209618//24981863//27371828//27773536

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate SAV1
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -

Related Drug Information:


Resource Symbol Drug Name PubChem ID
RNAactDrug kshv-miR-K12-4-3p
Panobinostat       6918837
Nilotinib       644241
Irinotecan       60838
Topotecan       60700
l-685,458       5479543
Palbociclib       5330286
Dovitinib       135398510
Crizotinib       11626560
Nvp-aew541       11476171
Pha-665752       10461815

Interaction Network (The top 100 interactions):


Interactor1: kshv-miR-K12-4-3p
Interactor2: SAV1

Evidence Support:


Weak-Evidence Microarray
Prediction-Evidence miRanda//Rep//Targetscan
Support Database RepTar//ViRBase//VmiReg

References:


PMID 22174674 Target region None
Source RepTar//ViRBase//VmiReg Interactor1 expression None
Tissue or cell line EA.hy926 cells Interactor2 expression Downregulation
Description As KSHV putative direct targets we extracted transcripts that were significantly down-regulated significantly in the replicate experiments, and which contained at least one seed-match to one of the KSHV miRNAs. We identified 704 putative direct targets in DG-75 cells (Figure 3B), and 980 putative direct targets in EA.hy926 cells (Figure 3C). A complete list of putative direct targets can be found in Dataset S2 for DG-75 cells and in Dataset S3 for EA.hy926 cells. The overlap between the two datasets contained 153 putative direct targets (Dataset S4).

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