Detail Information

Basic Information:


  VIRBase ID:  

VHID00465341

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5908

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-4-3p:           ZBTB2:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol kshv-miR-K12-4-3p ZBTB2
miRBase
Accession/Entrez ID		 MIMAT0002192 57621
Organism Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV) Homo sapiens
Category miRNA mRNA
Alias - ZNF437

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR ZBTB2
chr6:151707502(-) A-I      intronic
chr6:151709719(-) A-I      intronic
chr6:151703963(-) A-I      intronic
chr6:151691427(-) A-I      intronic
chr6:151691344(-) A-I      intronic
chr6:151689563(-) A-I      intronic
chr6:151690610(-) A-I      intronic
chr6:151700694(-) A-I      intronic
chr6:151707638(-) A-I      intronic
chr6:151704384(-) A-I      intronic
chr6:151690748(-) A-I      intronic
chr6:151690637(-) A-I      intronic
chr6:151690896(-) A-I      intronic
chr6:151690102(-) A-I      intronic
chr6:151703519(-) A-I      intronic
chr6:151709775(-) A-I      intronic
chr6:151690117(-) A-I      intronic
chr6:151689995(-) A-I      intronic
chr6:151696983(-) A-I      intronic
chr6:151704191(-) A-I      intronic
chr6:151690032(-) A-I      intronic
chr6:151709774(-) A-I      intronic
chr6:151700519(-) A-I      intronic
chr6:151709791(-) A-I      intronic
chr6:151700742(-) A-I      intronic
chr6:151690063(-) A-I      intronic
chr6:151690059(-) A-I      intronic
chr6:151710312(-) A-I      intronic
chr6:151690070(-) A-I      intronic
chr6:151689928(-) A-I      intronic
chr6:151698941(-) A-I      intronic
chr6:151704198(-) A-I      intronic
chr6:151709777(-) A-I      intronic
chr6:151696898(-) A-I      intronic
chr6:151700525(-) A-I      intronic
chr6:151690039(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED ZBTB2
chr6:151689928(-) A-I intron -    15342557
chr6:151689995(-) A-I intron -    15342557
chr6:151689996(-) A-I intron -    15342557
chr6:151690032(-) A-I intron -    15342557
chr6:151690039(-) A-I intron -    15342557
chr6:151690059(-) A-I intron -    15342557
chr6:151690063(-) A-I intron -    15342557
chr6:151690068(-) A-I intron -    15342557
chr6:151690070(-) A-I intron -    15342557
chr6:151690101(-) A-I intron -    15342557
chr6:151690102(-) A-I intron -    15342557
chr6:151690117(-) A-I intron -    15342557
chr6:151690829(-) A-I intron -    15342557
chr6:151690896(-) A-I intron -    15342557
chr6:151690891(-) A-G intron -    22484847
chr6:151696983(-) A-G intron -    22484847
chr6:151707583(-) A-G intron -    22484847
chr6:151707655(-) A-G intron -    22484847
chr6:151709774(-) A-G intron -    22484847
chr6:151709775(-) A-G intron -    22484847
chr6:151709777(-) A-G intron -    22484847
chr6:151709791(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase ZBTB2
chr6:151685347-151685348(-) m6A 3'UTR       24981863//27773535//22608085
chr6:151685401-151685402(-) m6A 3'UTR       24981863//27773535//22608085
chr6:151685420-151685421(-) m6A 3'UTR       24981863//27773535//22608085
chr6:151685425-151685426(-) m6A 3'UTR       24981863//27773535//22608085
chr6:151686195-151686196(-) m6A 3'UTR       27773535//22608085
chr6:151686202-151686203(-) m6A 3'UTR       27773535//22608085
chr6:151686282-151686283(-) m6A 3'UTR       24981863//27773535//22608085
chr6:151686349-151686350(-) m6A 3'UTR       24284625//24981863//27773535//22608085
chr6:151686372-151686373(-) m6A 3'UTR       24284625//24981863//27773535//22608085
chr6:151686417-151686418(-) m6A 3'UTR       24284625//24209618//24981863//27773535//22608085
chr6:151686480-151686481(-) m6A 3'UTR       24284625//24209618//24981863//27773535//22608085
chr6:151686557-151686558(-) m6A 3'UTR       24284625//24209618//24981863//27773535//22575960//22608085
chr6:151686584-151686585(-) m6A 3'UTR       24284625//24209618//24981863//27773535//22575960//22608085
chr6:151686614-151686615(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr6:151686632-151686633(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr6:151686659-151686660(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr6:151686672-151686673(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr6:151686679-151686680(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr6:151686731-151686732(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr6:151686785-151686786(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr6:151686791-151686792(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr6:151686805-151686806(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr6:151686834-151686835(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr6:151686862-151686863(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr6:151686866-151686867(-) m6A CDS       28052920
chr6:151686870-151686871(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr6:151686887-151686888(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr6:151686919-151686920(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr6:151686927-151686928(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr6:151686935-151686936(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr6:151687060-151687061(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr6:151687175-151687176(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr6:151687191-151687192(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr6:151687387-151687388(-) m6A CDS       24284625//27773535//27371828//22608085
chr6:151687542-151687543(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr6:151687585-151687586(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr6:151687602-151687603(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr6:151687613-151687614(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr6:151687632-151687633(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr6:151687713-151687714(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr6:151687738-151687739(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr6:151687771-151687772(-) m6A CDS       24284625//24981863//27773535//22608085
chr6:151712620-151712621(-) m6A 5'UTR       24981863//27371828//27773536

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate ZBTB2
Exosome Blood     -
Nucleolus K562 cells     -
Nucleus HeLa-S3 cells|K562 cells     -
Ribosome-free cytosol Colon cancer cells     24393600

Related Drug Information:


Resource Symbol Drug Name PubChem ID
RNAactDrug kshv-miR-K12-4-3p
Panobinostat       6918837
Nilotinib       644241
Irinotecan       60838
Topotecan       60700
l-685,458       5479543
Palbociclib       5330286
Dovitinib       135398510
Crizotinib       11626560
Nvp-aew541       11476171
Pha-665752       10461815

Interaction Network (The top 100 interactions):


Interactor1: kshv-miR-K12-4-3p
Interactor2: ZBTB2

Evidence Support:


Weak-Evidence Microarray
Prediction-Evidence miRanda//Targetscan
Support Database ViRBase//VmiReg

References:


PMID 22174674 Target region None
Source ViRBase//VmiReg Interactor1 expression None
Tissue or cell line DG-75 cells Interactor2 expression Downregulation
Description As KSHV putative direct targets we extracted transcripts that were significantly down-regulated significantly in the replicate experiments, and which contained at least one seed-match to one of the KSHV miRNAs. We identified 704 putative direct targets in DG-75 cells (Figure 3B), and 980 putative direct targets in EA.hy926 cells (Figure 3C). A complete list of putative direct targets can be found in Dataset S2 for DG-75 cells and in Dataset S3 for EA.hy926 cells. The overlap between the two datasets contained 153 putative direct targets (Dataset S4).

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