Detail Information

Basic Information:


  VIRBase ID:  

VHID00464545

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6775

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-4-3p:           BICD2:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol kshv-miR-K12-4-3p BICD2
miRBase
Accession/Entrez ID		 MIMAT0002192 23299
Organism Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV) Homo sapiens
Category miRNA mRNA
Alias - bA526D8.1//SMALED2//SMALED2A//SMALED2B

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR BICD2
chr9:95505527(-) A-I      intronic
chr9:95505529(-) A-I      intronic
chr9:95505763(-) A-I      intronic
chr9:95515989(-) A-I      intronic
chr9:95515990(-) A-I      intronic
chr9:95515991(-) A-I      intronic
chr9:95516315(-) A-I      intronic
chr9:95518692(-) A-I      intronic
chr9:95519001(-) A-I      intronic
chr9:95504902(-) A-I      intronic
chr9:95515917(-) A-I      intronic
chr9:95514266(-) A-I      intronic
chr9:95519950(-) A-I      intronic
chr9:95519496(-) A-I      intronic
chr9:95504676(-) A-I      intronic
chr9:95519501(-) A-I      intronic
chr9:95519135(-) A-I      intronic
chr9:95520798(-) A-I      intronic
chr9:95516192(-) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase BICD2
chr9:95473653-95473654(-) m6A 3'UTR       24981863//27773535//22608085
chr9:95473675-95473676(-) m6A 3'UTR       24981863//27773535//22608085
chr9:95473709-95473710(-) m6A 3'UTR       24981863//27773535//22608085
chr9:95473749-95473750(-) m6A 3'UTR       24981863//27773535//22608085
chr9:95473755-95473756(-) m6A 3'UTR       24981863//27773535//22608085
chr9:95474445-95474446(-) m6A 3'UTR       24284625
chr9:95474455-95474456(-) m6A 3'UTR       24284625
chr9:95474464-95474465(-) m6A 3'UTR       24284625
chr9:95474484-95474485(-) m6A 3'UTR       24284625
chr9:95474491-95474492(-) m6A 3'UTR       24284625
chr9:95475624-95475625(-) m6A 3'UTR       24284625//24981863
chr9:95475720-95475721(-) m6A 3'UTR       24284625//24981863
chr9:95475795-95475796(-) m6A 3'UTR//intron       24284625
chr9:95477282-95477283(-) m6A 3'UTR//intron       24284625//25456834//24981863//27371828
chr9:95477554-95477555(-) m6A CDS       24284625//25456834//24981863//27371828//27773536//22575960//22608085
chr9:95477587-95477588(-) m6A CDS       24284625//25456834//24981863//27371828//27773536//22575960//22608085
chr9:95477598-95477599(-) m6A CDS       24284625//25456834//24981863//27371828//27773536//22575960//22608085
chr9:95477667-95477668(-) m6A CDS       24284625//25456834//24981863//27371828//27773536//22575960//22608085
chr9:95480163-95480164(-) m6A CDS       24284625
chr9:95480923-95480924(-) m6A CDS       24284625//27773536
chr9:95480929-95480930(-) m6A CDS       24284625//27773536
chr9:95480989-95480990(-) m6A CDS       24284625//27371828//27773536
chr9:95481049-95481050(-) m6A CDS       24284625//24981863//27371828//27773536
chr9:95481115-95481116(-) m6A CDS       24284625//27371828//27773536//22575960
chr9:95481262-95481263(-) m6A CDS       24284625//24209618//24981863//26404942//27773535//27371828//27773536//22575960
chr9:95481284-95481285(-) m6A CDS       24284625//24209618//24981863//26404942//27773535//27371828//27773536//22575960
chr9:95481380-95481381(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085
chr9:95481442-95481443(-) m6A CDS       24284625//24209618//25456834//24981863//27371828//27773536//22575960//22608085
chr9:95481643-95481644(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//27371828//27773536//22575960//22608085
chr9:95481658-95481659(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//27371828//27773536//22575960//22608085
chr9:95481682-95481683(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//27371828//27773536//22575960//22608085
chr9:95481694-95481695(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//27371828//27773536//22575960//22608085
chr9:95481704-95481705(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//27371828//27773536//22575960//22608085
chr9:95481780-95481781(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085
chr9:95481823-95481824(-) m6A CDS       24284625//24209618//25456834//24981863//27371828//27773536//22575960//22608085
chr9:95482694-95482695(-) m6A CDS       24284625//24981863//27371828//27773536
chr9:95482702-95482703(-) m6A CDS       24284625//24981863//27371828//27773536
chr9:95482879-95482880(-) m6A CDS       24284625//24981863//27773535//27371828//27773536
chr9:95482887-95482888(-) m6A CDS       24284625//24981863//27773535//27371828//27773536
chr9:95482907-95482908(-) m6A CDS       24284625//24981863//27773535//27371828//27773536//22575960
chr9:95482988-95482989(-) m6A CDS       24284625//24981863//27773535//27371828//27773536//22575960
chr9:95484941-95484942(-) m6A CDS       24284625//27773535//27371828//27773536//22575960
chr9:95484946-95484947(-) m6A CDS       24284625//27773535//27371828//27773536//22575960
chr9:95484980-95484981(-) m6A CDS       24284625//27773535//27371828//27773536//22575960
chr9:95484994-95484995(-) m6A CDS       24284625//27773535//27371828//27773536//22575960
chr9:95485004-95485005(-) m6A CDS       24284625//27773535//27371828//27773536//22575960
chr9:95491495-95491496(-) m6A CDS       24284625//24209618//24981863//27773535//27371828//27773536//22575960
chr9:95491509-95491510(-) m6A CDS       24284625//24209618//24981863//27773535//27371828//27773536//22575960
chr9:95526826-95526827(-) m6A CDS       24284625//24209618//24981863//27773535//27371828//27773536//22575960
chr9:95526920-95526921(-) m6A CDS       24284625//24209618//27371828//27773536//22575960

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate BICD2
Centrosome Cells (HeLa-Kyoto|HeLa)     33649340
Chromatin K562 cells     -
Cytosol K562 cells     -
Exosome Blood     -
Nucleoplasm K562 cells     -
Nucleus HeLa-S3 cells     -
Ribosome Colon cancer cells     24393600

Related Drug Information:


Resource Symbol Drug Name PubChem ID
RNAactDrug kshv-miR-K12-4-3p
Panobinostat       6918837
Nilotinib       644241
Irinotecan       60838
Topotecan       60700
l-685,458       5479543
Palbociclib       5330286
Dovitinib       135398510
Crizotinib       11626560
Nvp-aew541       11476171
Pha-665752       10461815

Interaction Network (The top 100 interactions):


Interactor1: kshv-miR-K12-4-3p
Interactor2: BICD2

Evidence Support:


Weak-Evidence Microarray//PAR-CLIP
Prediction-Evidence cRep//miRanda//PARalyzer//Targetscan
Support Database RepTar//ViRBase//VIRmiRNA//VmiReg

References:


[1]PMID 22100165 Target region 3'UTR
Source RepTar//ViRBase//VIRmiRNA//VmiReg Interactor1 expression None
Tissue or cell line BC-1 cells//BJAB cells Interactor2 expression Downregulation
Description Table S10B Genes that contribute to the enrichments of PAR-CLIP targets of miR-K4-3p from BC-1 libraries in downregulated mRNAs in BJAB/miR-K4-3p cells.Table S10E Genes that contribute to the enrichments of PAR-CLIP targets of miR-K4-3p from BC-3 libraries in downregulated mRNAs in BJAB/miR-K4-3p cells.
[2]PMID 22174674 Target region None
Source RepTar//ViRBase//VIRmiRNA//VmiReg Interactor1 expression None
Tissue or cell line EA.hy926 cells Interactor2 expression Downregulation
Description As KSHV putative direct targets we extracted transcripts that were significantly down-regulated significantly in the replicate experiments, and which contained at least one seed-match to one of the KSHV miRNAs. We identified 704 putative direct targets in DG-75 cells (Figure 3B), and 980 putative direct targets in EA.hy926 cells (Figure 3C). A complete list of putative direct targets can be found in Dataset S2 for DG-75 cells and in Dataset S3 for EA.hy926 cells. The overlap between the two datasets contained 153 putative direct targets (Dataset S4).

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