Basic Information:

  VIRBase ID:  

VHID00464437

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-4-3p:  MIMAT0002192          CILK1:  NR_164684     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	kshv-miR-K12-4-3p	CILK1
miRBase Accession/Entrez ID	MIMAT0002192	22858
Organism	Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	ECO//EJM10//hICK//ICK//LCK2//MRK

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	CILK1	chr6:52892577(-) A-I      intronic chr6:52914791(-) A-I      intronic chr6:52892573(-) A-I      intronic chr6:52886001(-) A-I      intronic chr6:52914785(-) A-I      intronic chr6:52892611(-) A-I      intronic chr6:52892585(-) A-I      intronic chr6:52886041(-) A-I      intronic chr6:52886037(-) A-I      intronic chr6:52886036(-) A-I      intronic chr6:52886028(-) A-I      intronic chr6:52872694(-) A-I      intronic chr6:52914731(-) A-I      intronic chr6:52868290(-) A-I      3'UTR chr6:52868293(-) A-I      3'UTR chr6:52868316(-) A-I      3'UTR chr6:52868348(-) A-I      3'UTR chr6:52868294(-) A-I      3'UTR chr6:52873399(-) A-I      intronic chr6:52873502(-) A-I      intronic chr6:52889898(-) A-I      intronic chr6:52868457(-) A-I      3'UTR chr6:52896881(-) A-I      intronic chr6:52873361(-) A-I      intronic chr6:52873406(-) A-I      intronic chr6:52873470(-) A-I      intronic chr6:52914792(-) A-I      intronic chr6:52872655(-) A-I      intronic chr6:52887860(-) A-I      intronic chr6:52885862(-) A-I      intronic chr6:52893038(-) A-I      intronic chr6:52873525(-) A-I      intronic

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	CILK1	Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytoplasm Nasopharyngeal carcinoma cells     20498841 Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Insoluble cytoplasm HCC cell line (HepG2)     - Membrane HCC cell line (HepG2)     - Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus Nasopharyngeal carcinoma cells     20498841 Ribosome HEK-293 cells     22199352

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	kshv-miR-K12-4-3p	Panobinostat       6918837 Nilotinib       644241 Irinotecan       60838 Topotecan       60700 l-685,458       5479543 Palbociclib       5330286 Dovitinib       135398510 Crizotinib       11626560 Nvp-aew541       11476171 Pha-665752       10461815

Interaction Network (The top 100 interactions):

Interactor1: kshv-miR-K12-4-3p
Interactor2: CILK1

Evidence Support:

Weak-Evidence	Microarray
Prediction-Evidence	cRep//miRanda//Targetscan
Support Database	RepTar//ViRBase//VmiReg

References:

PMID	22174674	Target region	None
Source	RepTar//ViRBase//VmiReg	Interactor1 expression	None
Tissue or cell line	DG-75 cells	Interactor2 expression	Downregulation
Description	As KSHV putative direct targets we extracted transcripts that were significantly down-regulated significantly in the replicate experiments, and which contained at least one seed-match to one of the KSHV miRNAs. We identified 704 putative direct targets in DG-75 cells (Figure 3B), and 980 putative direct targets in EA.hy926 cells (Figure 3C). A complete list of putative direct targets can be found in Dataset S2 for DG-75 cells and in Dataset S3 for EA.hy926 cells. The overlap between the two datasets contained 153 putative direct targets (Dataset S4).