Basic Information:

  VIRBase ID:  

VHID00464332

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-4-3p:  MIMAT0002192          ZBTB6:  NM_006626     

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Interactor Information:

	Interactor1	Interactor2
Symbol	kshv-miR-K12-4-3p	ZBTB6
miRBase Accession/Entrez ID	MIMAT0002192	10773
Organism	Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	ZID//ZNF482

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	ZBTB6	chr9:125670800-125670801(-) m6A 3'UTR       27773535 chr9:125673063-125673064(-) m6A 3'UTR       24981863//27773535//22608085 chr9:125673115-125673116(-) m6A CDS       24284625//25456834//24981863//27773535//27371828//22608085 chr9:125673230-125673231(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr9:125673239-125673240(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr9:125673267-125673268(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr9:125673310-125673311(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr9:125673351-125673352(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr9:125673379-125673380(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr9:125673407-125673408(-) m6A CDS       24284625//24209618//24981863//27773535//27371828//22575960//22608085 chr9:125673600-125673601(-) m6A CDS       24981863//27773535//22608085 chr9:125673710-125673711(-) m6A CDS       24284625//24981863//27773535//22608085 chr9:125673725-125673726(-) m6A CDS       24284625//24981863//27773535//22608085 chr9:125673833-125673834(-) m6A CDS       24284625//24981863//27773535//22608085 chr9:125673872-125673873(-) m6A CDS       24284625//24981863//27773535//22608085 chr9:125673947-125673948(-) m6A CDS       24981863//27773535//22608085 chr9:125674147-125674148(-) m6A CDS       24284625//24981863//27773535//22608085 chr9:125674270-125674271(-) m6A CDS       24284625//24981863//27773535//22608085 chr9:125674312-125674313(-) m6A CDS       24284625//24981863//27773535//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	ZBTB6	Exosome Blood     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	kshv-miR-K12-4-3p	Panobinostat       6918837 Nilotinib       644241 Irinotecan       60838 Topotecan       60700 l-685,458       5479543 Palbociclib       5330286 Dovitinib       135398510 Crizotinib       11626560 Nvp-aew541       11476171 Pha-665752       10461815

Interaction Network (The top 100 interactions):

Interactor1: kshv-miR-K12-4-3p
Interactor2: ZBTB6

Evidence Support:

Weak-Evidence	Microarray
Prediction-Evidence	cRep//miRanda//Targetscan
Support Database	RepTar//ViRBase//VmiReg

References:

PMID	22174674	Target region	None
Source	RepTar//ViRBase//VmiReg	Interactor1 expression	None
Tissue or cell line	EA.hy926 cells	Interactor2 expression	Downregulation
Description	As KSHV putative direct targets we extracted transcripts that were significantly down-regulated significantly in the replicate experiments, and which contained at least one seed-match to one of the KSHV miRNAs. We identified 704 putative direct targets in DG-75 cells (Figure 3B), and 980 putative direct targets in EA.hy926 cells (Figure 3C). A complete list of putative direct targets can be found in Dataset S2 for DG-75 cells and in Dataset S3 for EA.hy926 cells. The overlap between the two datasets contained 153 putative direct targets (Dataset S4).