Basic Information:

  VIRBase ID:  

VHID00464314

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6040

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-4-3p:  MIMAT0002192          GNA13:  NM_006572     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	kshv-miR-K12-4-3p	GNA13
miRBase Accession/Entrez ID	MIMAT0002192	10672
Organism	Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	G13

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	GNA13	chr17:63045485(-) A-I      intronic chr17:63049088(-) A-I      intronic chr17:63034603(-) A-I      intronic chr17:63034588(-) A-I      intronic chr17:63034579(-) A-I      intronic chr17:63034578(-) A-I      intronic chr17:63034564(-) A-I      intronic chr17:63034558(-) A-I      intronic chr17:63020236(-) A-I      intronic chr17:63020231(-) A-I      intronic chr17:63034566(-) A-I      intronic chr17:63040250(-) A-I      intronic chr17:63042469(-) A-I      intronic chr17:63042485(-) A-I      intronic chr17:63042519(-) A-I      intronic chr17:63043387(-) A-I      intronic chr17:63043406(-) A-I      intronic chr17:63045333(-) A-I      intronic chr17:63045356(-) A-I      intronic chr17:63045455(-) A-I      intronic chr17:63045466(-) A-I      intronic chr17:63012752(-) A-I      intronic chr17:63045489(-) A-I      intronic chr17:63048368(-) A-I      intronic chr17:63048396(-) A-I      intronic chr17:63048447(-) A-I      intronic chr17:63048449(-) A-I      intronic chr17:63048450(-) A-I      intronic chr17:63048451(-) A-I      intronic chr17:63048545(-) A-I      intronic chr17:63048964(-) A-I      intronic chr17:63049005(-) A-I      intronic chr17:63049045(-) A-I      intronic chr17:63049098(-) A-I      intronic chr17:63012753(-) A-I      intronic chr17:63020205(-) A-I      intronic chr17:63020259(-) A-I      intronic chr17:63020276(-) A-I      intronic chr17:63020308(-) A-I      intronic chr17:63021166(-) A-I      intronic chr17:63021171(-) A-I      intronic chr17:63021980(-) A-I      intronic chr17:63021992(-) A-I      intronic chr17:63022009(-) A-I      intronic chr17:63023006(-) A-I      intronic chr17:63023018(-) A-I      intronic chr17:63023090(-) A-I      intronic chr17:63030555(-) A-I      intronic chr17:63029080(-) A-I      intronic chr17:63039678(-) A-I      intronic chr17:63029129(-) A-I      intronic chr17:63029143(-) A-I      intronic chr17:63029146(-) A-I      intronic chr17:63029147(-) A-I      intronic chr17:63029172(-) A-I      intronic chr17:63029193(-) A-I      intronic chr17:63029198(-) A-I      intronic chr17:63029982(-) A-I      intronic chr17:63030048(-) A-I      intronic chr17:63030049(-) A-I      intronic chr17:63011599(-) A-I      intronic chr17:63030581(-) A-I      intronic chr17:63031076(-) A-I      intronic chr17:63031085(-) A-I      intronic chr17:63031169(-) A-I      intronic chr17:63032607(-) A-I      intronic chr17:63032632(-) A-I      intronic chr17:63032652(-) A-I      intronic chr17:63032660(-) A-I      intronic chr17:63032742(-) A-I      intronic chr17:63034278(-) A-I      intronic chr17:63034316(-) A-I      intronic chr17:63034412(-) A-I      intronic chr17:63034474(-) A-I      intronic chr17:63034693(-) A-I      intronic chr17:63034772(-) A-I      intronic chr17:63039436(-) A-I      intronic chr17:63039466(-) A-I      intronic chr17:63011536(-) A-I      intronic chr17:63011622(-) A-I      intronic chr17:63011659(-) A-I      intronic chr17:63011673(-) A-I      intronic chr17:63011780(-) A-I      intronic chr17:63012518(-) A-I      intronic chr17:63012643(-) A-I      intronic chr17:63039632(-) A-I      intronic chr17:63039677(-) A-I      intronic chr17:63012684(-) A-I      intronic chr17:63040154(-) A-I      intronic chr17:63045476(-) A-I      intronic chr17:63022021(-) A-I      intronic chr17:63029928(-) A-I      intronic chr17:63039561(-) A-I      intronic chr17:63012673(-) A-I      intronic chr17:63030129(-) A-I      intronic chr17:63024401(-) A-I      intronic chr17:63029968(-) A-I      intronic chr17:63048400(-) A-I      intronic chr17:63029959(-) A-I      intronic chr17:63032741(-) A-I      intronic chr17:63034771(-) A-I      intronic chr17:63021117(-) A-I      intronic chr17:63034628(-) A-I      intronic chr17:63029987(-) A-I      intronic chr17:63039684(-) A-I      intronic chr17:63030591(-) A-I      intronic chr17:63030123(-) A-I      intronic chr17:63029066(-) A-I      intronic chr17:63038817(-) A-I      intronic chr17:63034795(-) A-I      intronic chr17:63030127(-) A-I      intronic chr17:63030009(-) A-I      intronic chr17:63023035(-) A-I      intronic chr17:63027905(-) A-I      intronic chr17:63039569(-) A-I      intronic chr17:63029888(-) A-I      intronic chr17:63049059(-) A-I      intronic chr17:63034593(-) A-I      intronic chr17:63011122(-) A-I      intronic chr17:63029946(-) A-I      intronic chr17:63012755(-) A-I      intronic chr17:63045456(-) A-I      intronic chr17:63030695(-) A-I      intronic chr17:63029889(-) A-I      intronic chr17:63029032(-) A-I      intronic chr17:63029965(-) A-I      intronic chr17:63039533(-) A-I      intronic chr17:63045325(-) A-I      intronic chr17:63049033(-) A-I      intronic chr17:63048982(-) A-I      intronic chr17:63030054(-) A-I      intronic chr17:63029974(-) A-I      intronic chr17:63012769(-) A-I      intronic chr17:63032621(-) A-I      intronic chr17:63011126(-) A-I      intronic chr17:63023075(-) A-I      intronic chr17:63048344(-) A-I      intronic chr17:63021175(-) A-I      intronic chr17:63011128(-) A-I      intronic chr17:63021234(-) A-I      intronic chr17:63021129(-) A-I      intronic chr17:63045343(-) A-I      intronic chr17:63023512(-) A-I      intronic chr17:63039572(-) A-I      intronic chr17:63040153(-) A-I      intronic chr17:63024177(-) A-I      intronic chr17:63049062(-) A-I      intronic chr17:63042547(-) A-I      intronic chr17:63045352(-) A-I      intronic chr17:63023539(-) A-I      intronic chr17:63011167(-) A-I      intronic chr17:63042557(-) A-I      intronic chr17:63034413(-) A-I      intronic chr17:63020151(-) A-I      intronic chr17:63012616(-) A-I      intronic chr17:63029107(-) A-I      intronic chr17:63021863(-) A-I      intronic chr17:63045366(-) A-I      intronic chr17:63031041(-) A-I      intronic chr17:63047633(-) A-I      intronic chr17:63032606(-) A-I      intronic chr17:63031176(-) A-I      intronic chr17:63034458(-) A-I      intronic chr17:63049001(-) A-I      intronic chr17:63029063(-) A-I      intronic chr17:63040200(-) A-I      intronic chr17:63023522(-) A-I      intronic chr17:63021982(-) A-I      intronic chr17:63024411(-) A-I      intronic chr17:63034572(-) A-I      intronic chr17:63029105(-) A-I      intronic chr17:63048345(-) A-I      intronic chr17:63024445(-) A-I      intronic chr17:63023095(-) A-I      intronic chr17:63011140(-) A-I      intronic chr17:63040128(-) A-I      intronic chr17:63012617(-) A-I      intronic chr17:63045452(-) A-I      intronic chr17:63031042(-) A-I      intronic chr17:63011202(-) A-I      intronic chr17:63028994(-) A-I      intronic chr17:63024426(-) A-I      intronic chr17:63021893(-) A-I      intronic chr17:63048979(-) A-I      intronic chr17:63040108(-) A-I      intronic chr17:63049023(-) A-I      intronic chr17:63021305(-) A-I      intronic chr17:63023061(-) A-I      intronic chr17:63021112(-) A-I      intronic chr17:63011163(-) A-I      intronic chr17:63020168(-) A-I      intronic chr17:63011591(-) A-I      intronic chr17:63022028(-) A-I      intronic chr17:63021215(-) A-I      intronic chr17:63022004(-) A-I      intronic chr17:63042636(-) A-I      intronic chr17:63021956(-) A-I      intronic chr17:63032810(-) A-I      intronic chr17:63011613(-) A-I      intronic chr17:63020227(-) A-I      intronic chr17:63034836(-) A-I      intronic chr17:63012577(-) A-I      intronic chr17:63011184(-) A-I      intronic chr17:63045324(-) A-I      intronic chr17:63034811(-) A-I      intronic chr17:63021289(-) A-I      intronic chr17:63034336(-) A-I      intronic chr17:63040139(-) A-I      intronic chr17:63023069(-) A-I      intronic chr17:63024444(-) A-I      intronic chr17:63021265(-) A-I      intronic chr17:63012576(-) A-I      intronic chr17:63034796(-) A-I      intronic chr17:63024055(-) A-I      intronic chr17:63034409(-) A-I      intronic chr17:63033845(-) A-I      intronic chr17:63023109(-) A-I      intronic chr17:63023064(-) A-I      intronic chr17:63034565(-) A-I      intronic chr17:63038798(-) A-I      intronic chr17:63049480(-) A-I      intronic chr17:63045388(-) A-I      intronic chr17:63036043(-) A-I      intronic chr17:63023538(-) A-I      intronic chr17:63034438(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	GNA13	chr17:63029888(-) A-I intron -    22028664 chr17:63029889(-) A-I intron -    22028664 chr17:63029928(-) A-I intron -    22028664 chr17:63029946(-) A-I intron -    22028664 chr17:63029959(-) A-I intron -    22028664 chr17:63029965(-) A-I intron -    22028664 chr17:63029968(-) A-I intron -    22028664 chr17:63029974(-) A-I intron -    22028664 chr17:63029987(-) A-I intron -    22028664 chr17:63030009(-) A-I intron -    22028664 chr17:63030054(-) A-I intron -    22028664 chr17:63030123(-) A-I intron -    22028664 chr17:63030127(-) A-I intron -    22028664 chr17:63030129(-) A-I intron -    22028664 chr17:63021129(-) A-G intron -    22484847 chr17:63021305(-) A-G intron -    22484847 chr17:63031041(-) A-G intron -    22484847 chr17:63031042(-) A-G intron -    22484847 chr17:63040128(-) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	GNA13	chr17:63009884-63009885(-) Y 3'UTR       26075521 chr17:63010062-63010063(-) m6A 3'UTR       24284625 chr17:63010102-63010103(-) m6A 3'UTR       24284625 chr17:63010121-63010122(-) m6A 3'UTR       24284625 chr17:63010278-63010279(-) m6A 3'UTR       24284625//24981863//26404942//27773535//22608085 chr17:63010363-63010364(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22608085 chr17:63010447-63010448(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr17:63010501-63010502(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr17:63010513-63010514(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr17:63010588-63010589(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr17:63010631-63010632(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr17:63010636-63010637(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr17:63010688-63010689(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr17:63010699-63010700(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr17:63010905-63010906(-) m6A CDS       24284625//24209618//24981863//26404942//27773535//27371828//22575960//22608085 chr17:63014373-63014374(-) m6A CDS       24284625//24209618//24981863//26404942//22608085 chr17:63014382-63014383(-) m6A CDS       24284625//24209618//24981863//26404942//22608085 chr17:63049665-63049666(-) m6A CDS       24209618 chr17:63052487-63052488(-) m6A CDS       27371828//27773536 chr17:63052584-63052585(-) m6A CDS       27371828//27773536//22575960 chr17:63052703-63052704(-) m6A CDS       24209618//27371828//27773536//22575960 chr17:63052842-63052843(-) Y 5'UTR       26075521 chr17:63052855-63052856(-) Y 5'UTR       26075521

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	GNA13	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Membrane HCC cell line (HepG2)     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|K562 cells     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	kshv-miR-K12-4-3p	Panobinostat       6918837 Nilotinib       644241 Irinotecan       60838 Topotecan       60700 l-685,458       5479543 Palbociclib       5330286 Dovitinib       135398510 Crizotinib       11626560 Nvp-aew541       11476171 Pha-665752       10461815

Interaction Network (The top 100 interactions):

Interactor1: kshv-miR-K12-4-3p
Interactor2: GNA13

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	cRep//miRanda//PARalyzer//Targetscan
Support Database	RepTar//ViRBase//VIRmiRNA//VmiReg

References:

PMID	22100165	Target region	3'UTR
Source	RepTar//ViRBase//VIRmiRNA//VmiReg	Interactor1 expression	None
Tissue or cell line	BC-1 cells//BC-3 cells//BJAB cells	Interactor2 expression	None
Description	Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.