Basic Information:

  VIRBase ID:  

VHID00463808

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.9124

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-4-3p:  MIMAT0002192          YWHAB:  NM_139323     

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Interactor Information:

	Interactor1	Interactor2
Symbol	kshv-miR-K12-4-3p	YWHAB
miRBase Accession/Entrez ID	MIMAT0002192	7529
Organism	Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	GW128//HEL-S-1//HS1//KCIP-1//YWHAA

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	YWHAB	chr20:43528793(+) A-I      intronic chr20:43527336(+) A-I      intronic chr20:43527229(+) A-I      intronic chr20:43528746(+) A-I      intronic chr20:43528027(+) A-I      intronic chr20:43528023(+) A-I      intronic chr20:43528022(+) A-I      intronic chr20:43528001(+) A-I      intronic chr20:43527970(+) A-I      intronic chr20:43527960(+) A-I      intronic chr20:43527959(+) A-I      intronic chr20:43527599(+) A-I      intronic chr20:43527600(+) A-I      intronic chr20:43528828(+) A-I      intronic chr20:43527685(+) A-I      intronic chr20:43527230(+) A-I      intronic chr20:43535970(+) A-I      3'UTR chr20:43527278(+) A-I      intronic chr20:43524330(+) A-I      intronic chr20:43527718(+) A-I      intronic chr20:43528066(+) A-I      intronic chr20:43527169(+) A-I      intronic chr20:43519986(+) A-I      intronic chr20:43527956(+) A-I      intronic chr20:43527288(+) A-I      intronic chr20:43527250(+) A-I      intronic chr20:43528741(+) A-I      intronic chr20:43527615(+) A-I      intronic chr20:43528801(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	YWHAB	chr20:43528067(+) A-G intron -    22484847 chr20:43528741(+) A-G intron -    22484847 chr20:43536067(+) G-A intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	YWHAB	chr20:43514319-43514320(+) m6A 5'UTR       24209618//25456834//24981863 chr20:43514570-43514571(+) m6A exon//intron       - chr20:43516350-43516351(+) Gm 5'UTR//exon//intron       - chr20:43516371-43516372(+) m6A 5'UTR//exon//intron       24981863 chr20:43530212-43530213(+) m6A CDS//exon       24981863//26404942 chr20:43530272-43530273(+) m6A CDS//exon       24981863//26404942//27773535//22575960 chr20:43530284-43530285(+) m6A CDS//exon       24981863//26404942//27773535//22575960 chr20:43530384-43530385(+) m6A CDS//exon       24981863//26404942//27773535//22575960 chr20:43530408-43530409(+) Cm CDS//exon       - chr20:43530446-43530447(+) m6A CDS//exon       24981863//27773535 chr20:43530454-43530455(+) m6A CDS//exon       24981863//27773535 chr20:43530500-43530501(+) m6A exon//intron       - chr20:43531700-43531701(+) m6A 3'UTR//CDS//exon//intron       24981863//27773535 chr20:43531739-43531740(+) m6A 3'UTR//CDS//exon//intron       - chr20:43531750-43531751(+) m6A 3'UTR//CDS//exon//intron       - chr20:43532576-43532577(+) m6A exon//intron       24981863 chr20:43532745-43532746(+) m6A 3'UTR//CDS//exon       26404942 chr20:43532752-43532753(+) m6A 3'UTR//CDS//exon       26404942 chr20:43533737-43533738(+) m6A 3'UTR//CDS//exon       27773535 chr20:43534278-43534279(+) m6A exon//intron       27773535 chr20:43534591-43534592(+) m6A exon//intron       - chr20:43534605-43534606(+) m6A exon//intron       - chr20:43534696-43534697(+) m6A 3'UTR//CDS//exon       27773535 chr20:43534726-43534727(+) m6A 3'UTR//CDS//exon       26404942//27773535 chr20:43535028-43535029(+) m6A 3'UTR//CDS//exon       26404942//27773535 chr20:43535038-43535039(+) m6A 3'UTR//CDS//exon       26404942//27773535 chr20:43535074-43535075(+) m6A 3'UTR//CDS//exon       26404942//27773535 chr20:43535384-43535385(+) m6A 3'UTR       27773535 chr20:43535407-43535408(+) m6A 3'UTR       27773535 chr20:43535523-43535524(+) m6A 3'UTR       27773535 chr20:43535535-43535536(+) m6A 3'UTR       27773535 chr20:43535596-43535597(+) m6A 3'UTR       24284625//27773535 chr20:43535604-43535605(+) m6A 3'UTR       24284625//27773535 chr20:43535679-43535680(+) m6A 3'UTR       24284625//27773535 chr20:43535770-43535771(+) m6A 3'UTR       24284625//27773535 chr20:43536617-43536618(+) m6A 3'UTR       26404942//27773535 chr20:43536643-43536644(+) m6A 3'UTR       26404942//27773535 chr20:43536790-43536791(+) m6A 3'UTR       27773535 chr20:43536813-43536814(+) m6A 3'UTR       27773535 chr20:43536844-43536845(+) m6A 3'UTR       27773535 chr20:43536897-43536898(+) m6A 3'UTR       27773535 chr20:43537082-43537083(+) m6A 3'UTR       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	YWHAB	Chromatin K562 cells     - Cytosol K562 cells     - Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells     - Ribosome Colon cancer cells     24393600

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	kshv-miR-K12-4-3p	Panobinostat       6918837 Nilotinib       644241 Irinotecan       60838 Topotecan       60700 l-685,458       5479543 Palbociclib       5330286 Dovitinib       135398510 Crizotinib       11626560 Nvp-aew541       11476171 Pha-665752       10461815

Interaction Network (The top 100 interactions):

Interactor1: kshv-miR-K12-4-3p
Interactor2: YWHAB

Evidence Support:

Strong-Evidence	3'UTR indicator assay
Weak-Evidence	Microarray//PAR-CLIP
Prediction-Evidence	miRanda//PARalyzer//Targetscan
Support Database	RepTar//ViRBase//VIRmiRNA//VmiReg

References:

PMID	22100165	Target region	3'UTR
Source	RepTar//ViRBase//VIRmiRNA//VmiReg	Interactor1 expression	None
Tissue or cell line	BC-1 cells//BJAB cells	Interactor2 expression	None
Description	We focused this analysis mostly on 3'UTRs of mRNAs encoding proteins with functions of potential relevance to KSHV biology and pathogenesis (Table S11). Thirty-six combinations of 3'UTR indicators and KSHV miRNAs with PAR-CLIP interactions were tested for regulation. Nine of these interactions were independently also predicted by microarray analysis of the BJAB cell pools expressing miR-K1, miR-K4-3p, or miR-K11 described above (i.e. for miR-K1: NMI, RAD21, BCL11A, RFXAP; for miR-K4-3p: TPD52, GRB2, MCC, YWHAB; for miR-K11: WEE1). Targets were representative of the full range of seed match types observed in the libraries (Tables S6 and S11).