Basic Information:

  VIRBase ID:  

VHID00463760

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.9136

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-4-3p:  MIMAT0002192          TPD52:  NR_105034     

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Interactor Information:

	Interactor1	Interactor2
Symbol	kshv-miR-K12-4-3p	TPD52
miRBase Accession/Entrez ID	MIMAT0002192	7163
Organism	Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	D52//hD52//N8L//PC-1//PrLZ

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	TPD52	chr8:81018146(-) A-I      intronic chr8:81018155(-) A-I      intronic chr8:81019225(-) A-I      intronic chr8:81019261(-) A-I      intronic chr8:81019264(-) A-I      intronic chr8:81019270(-) A-I      intronic chr8:81019291(-) A-I      intronic chr8:81019359(-) A-I      intronic chr8:81021738(-) A-I      intronic chr8:81037601(-) A-I      intronic chr8:81023268(-) A-I      intronic chr8:81023325(-) A-I      intronic chr8:81023339(-) A-I      intronic chr8:81023364(-) A-I      intronic chr8:81026312(-) A-I      intronic chr8:81026314(-) A-I      intronic chr8:81036664(-) A-I      intronic chr8:81037563(-) A-I      intronic chr8:81037573(-) A-I      intronic chr8:81037645(-) A-I      intronic chr8:81038813(-) A-I      intronic chr8:81038991(-) A-I      intronic chr8:81039139(-) A-I      intronic chr8:81039225(-) A-I      intronic chr8:81039232(-) A-I      intronic chr8:81039310(-) A-I      intronic chr8:81060693(-) A-I      intronic chr8:81072163(-) A-I      intronic chr8:81072278(-) A-I      intronic chr8:81072326(-) A-I      intronic chr8:81073058(-) A-I      intronic chr8:81073185(-) A-I      intronic chr8:81021855(-) A-I      intronic chr8:81073211(-) A-I      intronic chr8:81074027(-) A-I      intronic chr8:81074057(-) A-I      intronic chr8:81074062(-) A-I      intronic chr8:81074075(-) A-I      intronic chr8:81074093(-) A-I      intronic chr8:81074140(-) A-I      intronic chr8:81074144(-) A-I      intronic chr8:81074165(-) A-I      intronic chr8:81074168(-) A-I      intronic chr8:81074236(-) A-I      intronic chr8:81074259(-) A-I      intronic chr8:81074830(-) A-I      intronic chr8:81078366(-) A-I      intronic chr8:81078588(-) A-I      intronic chr8:80998478(-) A-I      intronic chr8:80998436(-) A-I      intronic chr8:81078308(-) A-I      intronic chr8:80952698(-) A-I      intronic chr8:80952671(-) A-I      intronic chr8:81078660(-) A-I      intronic chr8:80987484(-) A-I      intronic chr8:80952675(-) A-I      intronic chr8:80952692(-) A-I      intronic chr8:80952697(-) A-I      intronic chr8:80954081(-) A-I      intronic chr8:80954143(-) A-I      intronic chr8:80954241(-) A-I      intronic chr8:80984456(-) A-I      intronic chr8:80984491(-) A-I      intronic chr8:80985172(-) A-I      intronic chr8:81082630(-) A-I      intronic chr8:81082568(-) A-I      intronic chr8:80985256(-) A-I      intronic chr8:80985263(-) A-I      intronic chr8:80985270(-) A-I      intronic chr8:80987300(-) A-I      intronic chr8:81082501(-) A-I      intronic chr8:80987375(-) A-I      intronic chr8:81081458(-) A-I      intronic chr8:81081423(-) A-I      intronic chr8:81081398(-) A-I      intronic chr8:81079078(-) A-I      intronic chr8:81079033(-) A-I      intronic chr8:81079032(-) A-I      intronic chr8:81078959(-) A-I      intronic chr8:81078947(-) A-I      intronic chr8:81078935(-) A-I      intronic chr8:81078917(-) A-I      intronic chr8:81078671(-) A-I      intronic chr8:81039111(-) A-I      intronic chr8:80998420(-) A-I      intronic chr8:80987507(-) A-I      intronic chr8:80988942(-) A-I      intronic chr8:80988945(-) A-I      intronic chr8:80989100(-) A-I      intronic chr8:80989175(-) A-I      intronic chr8:80989255(-) A-I      intronic chr8:80994042(-) A-I      intronic chr8:80998533(-) A-I      intronic chr8:80998555(-) A-I      intronic chr8:80998997(-) A-I      intronic chr8:80998482(-) A-I      intronic chr8:80998486(-) A-I      intronic chr8:80998492(-) A-I      intronic chr8:80999009(-) A-I      intronic chr8:80999022(-) A-I      intronic chr8:80999027(-) A-I      intronic chr8:80999096(-) A-I      intronic chr8:80999104(-) A-I      intronic chr8:81001156(-) A-I      intronic chr8:81001159(-) A-I      intronic chr8:81003471(-) A-I      intronic chr8:81003509(-) A-I      intronic chr8:81003514(-) A-I      intronic chr8:81008396(-) A-I      intronic chr8:81008447(-) A-I      intronic chr8:81016727(-) A-I      intronic chr8:81016731(-) A-I      intronic chr8:81016732(-) A-I      intronic chr8:81018034(-) A-I      intronic chr8:81081462(-) A-I      intronic chr8:81079029(-) A-I      intronic chr8:81073221(-) A-I      intronic chr8:81067321(-) A-I      intronic chr8:81082543(-) A-I      intronic chr8:81081420(-) A-I      intronic chr8:81067344(-) A-I      intronic chr8:80998547(-) A-I      intronic chr8:81081282(-) A-I      intronic chr8:80998865(-) A-I      intronic chr8:81050090(-) A-I      intronic chr8:81064894(-) A-I      intronic chr8:81044385(-) A-I      intronic chr8:81017132(-) A-I      intronic chr8:80998624(-) A-I      intronic chr8:81017381(-) A-I      intronic chr8:81081495(-) A-I      intronic chr8:80998946(-) A-I      intronic chr8:81078349(-) A-I      intronic chr8:81013517(-) A-I      intronic chr8:81082542(-) A-I      intronic chr8:80998960(-) A-I      intronic chr8:81081471(-) A-I      intronic chr8:81050290(-) A-I      intronic chr8:81021739(-) A-I      intronic chr8:81072331(-) A-I      intronic chr8:81081358(-) A-I      intronic chr8:80989009(-) A-I      intronic chr8:81073028(-) A-I      intronic chr8:81074191(-) A-I      intronic chr8:81017183(-) A-I      intronic chr8:81017195(-) A-I      intronic chr8:81073215(-) A-I      intronic chr8:81078976(-) A-I      intronic chr8:81017944(-) A-I      intronic chr8:81072304(-) A-I      intronic chr8:81068087(-) A-I      intronic chr8:81078973(-) A-I      intronic chr8:80952621(-) A-I      intronic chr8:81037609(-) A-I      intronic chr8:81039313(-) A-I      intronic chr8:80998858(-) A-I      intronic chr8:81039292(-) A-I      intronic chr8:80998450(-) A-I      intronic chr8:81023244(-) A-I      intronic chr8:81079059(-) A-I      intronic chr8:81018081(-) A-I      intronic chr8:81035780(-) A-I      intronic chr8:81078564(-) A-I      intronic chr8:81050132(-) A-I      intronic chr8:81042129(-) A-I      intronic chr8:81050140(-) A-I      intronic chr8:81017361(-) A-I      intronic chr8:81078436(-) A-I      intronic chr8:81017050(-) A-I      intronic chr8:80952530(-) A-I      intronic chr8:81018064(-) A-I      intronic chr8:81039344(-) A-I      intronic chr8:80998929(-) A-I      intronic chr8:81008455(-) A-I      intronic chr8:81074146(-) A-I      intronic chr8:81030246(-) A-I      intronic chr8:81082393(-) A-I      intronic chr8:81050169(-) A-I      intronic chr8:81078335(-) A-I      intronic chr8:81038855(-) A-I      intronic chr8:81017219(-) A-I      intronic chr8:81018065(-) A-I      intronic chr8:80998981(-) A-I      intronic chr8:80952586(-) A-I      intronic chr8:81064765(-) A-I      intronic chr8:80989361(-) A-I      intronic chr8:81017052(-) A-I      intronic chr8:80954202(-) A-I      intronic chr8:80989362(-) A-I      intronic chr8:81017038(-) A-I      intronic chr8:81017147(-) A-I      intronic chr8:80952589(-) A-I      intronic chr8:81081368(-) A-I      intronic chr8:81078318(-) A-I      intronic chr8:81023411(-) A-I      intronic chr8:81001203(-) A-I      intronic chr8:81074167(-) A-I      intronic chr8:81017285(-) A-I      intronic chr8:80998924(-) A-I      intronic chr8:81018724(-) A-I      intronic chr8:81074245(-) A-I      intronic chr8:81067300(-) A-I      intronic chr8:81074157(-) A-I      intronic chr8:81074213(-) A-I      intronic chr8:80998421(-) A-I      intronic chr8:81082485(-) A-I      intronic chr8:80999026(-) A-I      intronic chr8:81073053(-) A-I      intronic chr8:81078485(-) A-I      intronic chr8:81074163(-) A-I      intronic chr8:81075159(-) A-I      intronic chr8:81008168(-) A-I      intronic chr8:81019296(-) A-I      intronic chr8:81018730(-) A-I      intronic chr8:81072327(-) A-I      intronic chr8:80999023(-) A-I      intronic chr8:81078605(-) A-I      intronic chr8:80994145(-) A-I      intronic chr8:81078596(-) A-I      intronic chr8:81078670(-) A-I      intronic chr8:81081399(-) A-I      intronic chr8:80989400(-) A-I      intronic chr8:80998961(-) A-I      intronic chr8:80952551(-) A-I      intronic chr8:81074243(-) A-I      intronic chr8:81072221(-) A-I      intronic chr8:81082569(-) A-I      intronic chr8:80954160(-) A-I      intronic chr8:80952569(-) A-I      intronic chr8:80998943(-) A-I      intronic chr8:80998852(-) A-I      intronic chr8:81079055(-) A-I      intronic chr8:80998415(-) A-I      intronic chr8:80998619(-) A-I      intronic chr8:81042063(-) A-I      intronic chr8:80998864(-) A-I      intronic chr8:81072253(-) A-I      intronic chr8:80989053(-) A-I      intronic chr8:80998562(-) A-I      intronic chr8:81037557(-) A-I      intronic chr8:81017200(-) A-I      intronic chr8:81018107(-) A-I      intronic chr8:81017103(-) A-I      intronic chr8:80989144(-) A-I      intronic chr8:81018035(-) A-I      intronic chr8:81017049(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	TPD52	chr8:80952667(-) A-I intron -    22327324 chr8:81038855(-) A-I intron -    22327324 chr8:81039177(-) A-I intron -    22327324 chr8:81039292(-) A-I intron -    22327324 chr8:80952530(-) A-G intron -    22484847 chr8:80952551(-) A-G intron -    22484847 chr8:80952561(-) A-G intron -    22484847 chr8:80952586(-) A-G intron -    22484847 chr8:80952667(-) A-G intron -    22484847 chr8:80954160(-) A-G intron -    22484847 chr8:80988999(-) A-G intron -    22484847 chr8:80989009(-) A-G intron -    22484847 chr8:80989039(-) A-G intron -    22484847 chr8:80989053(-) A-G intron -    22484847 chr8:80989144(-) A-G intron -    22484847 chr8:80989268(-) A-G intron -    22484847 chr8:80989347(-) A-G intron -    22484847 chr8:80989361(-) A-G intron -    22484847 chr8:80989400(-) A-G intron -    22484847 chr8:80998450(-) A-G intron -    22484847 chr8:80998451(-) A-G intron -    22484847 chr8:80998455(-) A-G intron -    22484847 chr8:80998458(-) A-G intron -    22484847 chr8:80998547(-) A-G intron -    22484847 chr8:80998548(-) A-G intron -    22484847 chr8:80998562(-) A-G intron -    22484847 chr8:80998619(-) A-G intron -    22484847 chr8:80998624(-) A-G intron -    22484847 chr8:80998852(-) A-G intron -    22484847 chr8:80998858(-) A-G intron -    22484847 chr8:80998864(-) A-G intron -    22484847 chr8:80998865(-) A-G intron -    22484847 chr8:80998924(-) A-G intron -    22484847 chr8:80998926(-) A-G intron -    22484847 chr8:80998929(-) A-G intron -    22484847 chr8:80998943(-) A-G intron -    22484847 chr8:80998961(-) A-G intron -    22484847 chr8:80998981(-) A-G intron -    22484847 chr8:80999023(-) A-G intron -    22484847 chr8:80999026(-) A-G intron -    22484847 chr8:81001202(-) A-G intron -    22484847 chr8:81001203(-) A-G intron -    22484847 chr8:81008043(-) A-G intron -    22484847 chr8:81008100(-) A-G intron -    22484847 chr8:81008467(-) T-C intron -    22484847 chr8:81013512(-) C-T intron -    22484847 chr8:81013517(-) A-G intron -    22484847 chr8:81013542(-) T-C intron -    22484847 chr8:81013700(-) T-G intron -    22484847 chr8:81017049(-) A-G intron -    22484847 chr8:81017103(-) A-G intron -    22484847 chr8:81017200(-) A-G intron -    22484847 chr8:81017219(-) A-G intron -    22484847 chr8:81017243(-) A-G intron -    22484847 chr8:81017280(-) A-G intron -    22484847 chr8:81017285(-) A-G intron -    22484847 chr8:81017361(-) A-G intron -    22484847 chr8:81017381(-) A-G intron -    22484847 chr8:81018035(-) A-G intron -    22484847 chr8:81018064(-) A-G intron -    22484847 chr8:81018065(-) A-G intron -    22484847 chr8:81018081(-) A-G intron -    22484847 chr8:81018107(-) A-G intron -    22484847 chr8:81018730(-) A-G intron -    22484847 chr8:81018756(-) A-G intron -    22484847 chr8:81018815(-) A-T intron -    22484847 chr8:81019289(-) A-G intron -    22484847 chr8:81019296(-) A-G intron -    22484847 chr8:81021739(-) A-G intron -    22484847 chr8:81023223(-) A-G intron -    22484847 chr8:81023244(-) A-G intron -    22484847 chr8:81023275(-) A-G intron -    22484847 chr8:81029965(-) G-A intron -    22484847 chr8:81029969(-) G-A intron -    22484847 chr8:81030093(-) C-T intron -    22484847 chr8:81030246(-) A-G intron -    22484847 chr8:81040726(-) G-T intron -    22484847 chr8:81040727(-) A-T intron -    22484847 chr8:81040729(-) G-T intron -    22484847 chr8:81042232(-) G-C intron -    22484847 chr8:81044385(-) A-G intron -    22484847 chr8:81044388(-) A-G intron -    22484847 chr8:81054167(-) A-T intron -    22484847 chr8:81060551(-) T-C intron -    22484847 chr8:81060552(-) T-A intron -    22484847 chr8:81060581(-) T-C intron -    22484847 chr8:81060644(-) A-G intron -    22484847 chr8:81064765(-) A-G intron -    22484847 chr8:81067251(-) C-A intron -    22484847 chr8:81067260(-) A-G intron -    22484847 chr8:81067344(-) A-G intron -    22484847 chr8:81068042(-) G-A intron -    22484847 chr8:81068087(-) A-G intron -    22484847 chr8:81070850(-) C-G intron -    22484847 chr8:81072253(-) A-G intron -    22484847 chr8:81072425(-) G-T intron -    22484847 chr8:81073028(-) A-G intron -    22484847 chr8:81073041(-) C-T intron -    22484847 chr8:81073053(-) A-G intron -    22484847 chr8:81073175(-) A-G intron -    22484847 chr8:81073189(-) A-G intron -    22484847 chr8:81073215(-) A-G intron -    22484847 chr8:81073221(-) A-G intron -    22484847 chr8:81074103(-) A-G intron -    22484847 chr8:81074157(-) A-G intron -    22484847 chr8:81074163(-) A-G intron -    22484847 chr8:81074167(-) A-G intron -    22484847 chr8:81074191(-) A-G intron -    22484847 chr8:81074201(-) A-G intron -    22484847 chr8:81074213(-) A-G intron -    22484847 chr8:81074243(-) A-G intron -    22484847 chr8:81074245(-) A-G intron -    22484847 chr8:81077031(-) G-C intron -    22484847 chr8:81077032(-) A-T intron -    22484847 chr8:81077033(-) C-T intron -    22484847 chr8:81078318(-) A-G intron -    22484847 chr8:81078335(-) A-G intron -    22484847 chr8:81078336(-) A-G intron -    22484847 chr8:81078436(-) A-G intron -    22484847 chr8:81078564(-) A-G intron -    22484847 chr8:81078596(-) A-G intron -    22484847 chr8:81078605(-) A-G intron -    22484847 chr8:81078661(-) A-G intron -    22484847 chr8:81078670(-) A-G intron -    22484847 chr8:81078973(-) A-G intron -    22484847 chr8:81078976(-) A-G intron -    22484847 chr8:81078997(-) A-G intron -    22484847 chr8:81079019(-) A-G intron -    22484847 chr8:81079029(-) A-G intron -    22484847 chr8:81079055(-) A-G intron -    22484847 chr8:81079058(-) A-G intron -    22484847 chr8:81079059(-) A-G intron -    22484847 chr8:81081282(-) A-G intron -    22484847 chr8:81081319(-) A-G intron -    22484847 chr8:81081344(-) A-G intron -    22484847 chr8:81081358(-) A-G intron -    22484847 chr8:81081368(-) A-G intron -    22484847 chr8:81081420(-) A-G intron -    22484847 chr8:81081462(-) A-G intron -    22484847 chr8:81081471(-) A-G intron -    22484847 chr8:81082485(-) A-G intron -    22484847 chr8:81082542(-) A-G intron -    22484847 chr8:81082543(-) A-G intron -    22484847 chr8:81082569(-) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	TPD52	chr8:80948202-80948203(-) m6A 3'UTR       27773535 chr8:80948277-80948278(-) m6A 3'UTR       24981863 chr8:80948303-80948304(-) m6A 3'UTR       24981863 chr8:80949702-80949703(-) m6A 3'UTR       26404942 chr8:80949726-80949727(-) m6A 3'UTR       26404942 chr8:80949778-80949779(-) m6A 3'UTR       26404942 chr8:80949788-80949789(-) m6A 3'UTR       26404942 chr8:80949795-80949796(-) m6A 3'UTR       26404942 chr8:80950094-80950095(-) m6A 3'UTR//exon       26404942 chr8:80950113-80950114(-) m6A 3'UTR//exon       26404942 chr8:80950127-80950128(-) m6A 3'UTR//exon       26404942 chr8:80950166-80950167(-) m6A 3'UTR//exon       26404942 chr8:80963826-80963827(-) m6A 3'UTR//5'UTR//CDS//exon       27773535//27371828 chr8:80963843-80963844(-) m6A 3'UTR//5'UTR//CDS//exon       27773535//27371828 chr8:80963852-80963853(-) m6A 3'UTR//5'UTR//CDS//exon       27773535//27371828 chr8:80963927-80963928(-) m6A exon//intron       27773535//27371828 chr8:80965473-80965474(-) m6A exon//intron       24981863 chr8:80965555-80965556(-) m6A 3'UTR//5'UTR//CDS//exon       24209618//24981863//28052920//27773535//27371828 chr8:80965560-80965561(-) m6A 3'UTR//5'UTR//CDS//exon       24209618//24981863//28052920//27773535//27371828 chr8:80965566-80965567(-) m6A 3'UTR//5'UTR//CDS//exon       24209618//24981863//28052920//27773535//27371828 chr8:80965590-80965591(-) m6A 3'UTR//5'UTR//CDS//exon       24209618//24981863//28052920//27773535//27371828 chr8:80965646-80965647(-) m6A 3'UTR//5'UTR//CDS//exon       24209618//24981863//28052920//27773535//27371828//27773536 chr8:80965657-80965658(-) m1A 3'UTR//5'UTR//CDS//exon       26863196 chr8:80976704-80976705(-) m6A exon//intron       24209618//24981863//28052920//27773535//27371828//27773536 chr8:80976721-80976722(-) m6A 3'UTR//5'UTR//CDS//exon//intron       24209618//24981863//28052920//27773535//27371828//27773536 chr8:80976759-80976760(-) m6A 3'UTR//5'UTR//CDS//exon//intron       24284625//24209618//24981863//28052920//27773535//27371828//27773536//22575960 chr8:80976816-80976817(-) m6A 5'UTR//CDS//exon//intron       24284625//24209618//24981863//28052920//27773535//27371828//27773536//22575960 chr8:80976899-80976900(-) m6A exon//intron       24284625//24209618//24981863//27371828//27773536//22575960 chr8:80979156-80979157(-) m6A exon//intron       27371828 chr8:80979176-80979177(-) m6A exon//intron       27371828 chr8:80992620-80992621(-) m6A CDS//exon//intron       - chr8:80992656-80992657(-) m6A CDS//exon//intron       - chr8:80992668-80992669(-) m6A CDS//exon//intron       - chr8:81083294-81083295(-) m6A 5'UTR//intron       24981863 chr8:81083455-81083456(-) m6A CDS//intron       27773536 chr8:81083607-81083608(-) m6A CDS//intron       24209618//24981863//27371828//27773536//22575960 chr8:81083673-81083674(-) m6A CDS//intron       24209618//25456834//24981863//27371828//27773536//22575960 chr8:81083679-81083680(-) m6A 5'UTR//intron       24209618//25456834//24981863//27371828//27773536//22575960 chr8:81083700-81083701(-) m6A 5'UTR//intron       24209618//25456834//24981863//27371828//27773536//22575960 chr8:81083797-81083798(-) m6A 5'UTR//intron       24209618//25456834//24981863//27371828//27773536

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	TPD52	Cytosol HCC cell line (HepG2)     - Exosome Blood     - Membrane HCC cell line (HepG2)     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells     - Ribosome Colon cancer cells     24393600

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	kshv-miR-K12-4-3p	Panobinostat       6918837 Nilotinib       644241 Irinotecan       60838 Topotecan       60700 l-685,458       5479543 Palbociclib       5330286 Dovitinib       135398510 Crizotinib       11626560 Nvp-aew541       11476171 Pha-665752       10461815

Interaction Network (The top 100 interactions):

Interactor1: kshv-miR-K12-4-3p
Interactor2: TPD52

Evidence Support:

Strong-Evidence	3'UTR indicator assay
Weak-Evidence	Microarray//PAR-CLIP
Prediction-Evidence	cRep//miRanda//PARalyzer//Rep//Targetscan
Support Database	RepTar//ViRBase//VmiReg

References:

[1]PMID	22100165	Target region	3'UTR
Source	RepTar//ViRBase//VmiReg	Interactor1 expression	None
Tissue or cell line	BC-1 cells//BJAB cells	Interactor2 expression	Downregulation
Description	We focused this analysis mostly on 3'UTRs of mRNAs encoding proteins with functions of potential relevance to KSHV biology and pathogenesis (Table S11). Thirty-six combinations of 3'UTR indicators and KSHV miRNAs with PAR-CLIP interactions were tested for regulation. Nine of these interactions were independently also predicted by microarray analysis of the BJAB cell pools expressing miR-K1, miR-K4-3p, or miR-K11 described above (i.e. for miR-K1: NMI, RAD21, BCL11A, RFXAP; for miR-K4-3p: TPD52, GRB2, MCC, YWHAB; for miR-K11: WEE1). Targets were representative of the full range of seed match types observed in the libraries (Tables S6 and S11).

[2]PMID	22174674	Target region	None
Source	RepTar//ViRBase//VmiReg	Interactor1 expression	None
Tissue or cell line	DG-75 cells	Interactor2 expression	Downregulation
Description	As KSHV putative direct targets we extracted transcripts that were significantly down-regulated significantly in the replicate experiments, and which contained at least one seed-match to one of the KSHV miRNAs. We identified 704 putative direct targets in DG-75 cells (Figure 3B), and 980 putative direct targets in EA.hy926 cells (Figure 3C). A complete list of putative direct targets can be found in Dataset S2 for DG-75 cells and in Dataset S3 for EA.hy926 cells. The overlap between the two datasets contained 153 putative direct targets (Dataset S4).