Basic Information:

  VIRBase ID:  

VHID00463743

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.1828

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-4-3p:  MIMAT0002192          THBS1:  NM_003246     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	kshv-miR-K12-4-3p	THBS1
miRBase Accession/Entrez ID	MIMAT0002192	7057
Organism	Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	THBS//THBS-1//TSP//TSP-1//TSP1

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	THBS1	chr15:39874657-39874658(+) m6A CDS       22575960 chr15:39874711-39874712(+) m6A CDS       22575960 chr15:39874813-39874814(+) m6A CDS       24284625//22575960 chr15:39874894-39874895(+) m6A CDS       24284625 chr15:39874913-39874914(+) m6A CDS       24284625 chr15:39875850-39875851(+) m6A CDS       24284625 chr15:39875863-39875864(+) m6A CDS       24284625 chr15:39875875-39875876(+) m6A CDS       24284625 chr15:39876271-39876272(+) m6A CDS       24284625 chr15:39876278-39876279(+) m6A CDS       24284625 chr15:39876333-39876334(+) m6A CDS       24284625 chr15:39876371-39876372(+) m6A CDS       24284625 chr15:39876510-39876511(+) m6A CDS       24284625 chr15:39876590-39876591(+) m6A CDS       24284625 chr15:39878867-39878868(+) m6A intron       - chr15:39878944-39878945(+) m6A intron       - chr15:39878986-39878987(+) m6A intron       - chr15:39879684-39879685(+) m6A CDS//exon       22575960 chr15:39879690-39879691(+) m6A CDS//exon       22575960 chr15:39880246-39880247(+) m6A CDS//exon       22575960 chr15:39881457-39881458(+) m6A CDS//exon       24284625 chr15:39881463-39881464(+) m6A CDS//exon       24284625 chr15:39881533-39881534(+) m6A CDS//exon       24284625 chr15:39881551-39881552(+) m6A CDS//exon       24284625 chr15:39882038-39882039(+) m6A CDS//exon       24284625 chr15:39882153-39882154(+) m6A CDS       24284625//22575960 chr15:39882159-39882160(+) m6A CDS       24284625//22575960 chr15:39882183-39882184(+) m6A CDS       24284625 chr15:39882753-39882754(+) m6A CDS       24284625 chr15:39883150-39883151(+) m6A exon//intron       24284625 chr15:39883354-39883355(+) m6A exon//intron       24284625 chr15:39883392-39883393(+) m6A CDS//exon       24284625 chr15:39883452-39883453(+) m6A CDS//exon       24284625//22575960 chr15:39883497-39883498(+) m6A CDS//exon       24284625//22575960 chr15:39883503-39883504(+) m6A CDS//exon       24284625//22575960 chr15:39883536-39883537(+) m6A CDS//exon       24284625//26404942//22575960 chr15:39883723-39883724(+) m6A CDS//exon       24284625//26404942//22575960 chr15:39883750-39883751(+) m6A CDS//exon       24284625//22575960 chr15:39883759-39883760(+) m6A CDS//exon       24284625//22575960 chr15:39883808-39883809(+) m6A CDS//exon       24284625//22575960 chr15:39884772-39884773(+) m6A CDS       24284625//22575960 chr15:39884784-39884785(+) m6A CDS       24284625 chr15:39884841-39884842(+) m6A CDS       24284625//24981863 chr15:39884850-39884851(+) m6A CDS       24284625//24981863//26404942 chr15:39884958-39884959(+) m6A CDS       26404942 chr15:39884968-39884969(+) m6A CDS       26404942 chr15:39884994-39884995(+) m6A CDS       26404942 chr15:39886543-39886544(+) m6A CDS//exon       24209618 chr15:39886559-39886560(+) m6A CDS//exon       24284625//24209618//24981863 chr15:39886576-39886577(+) m6A CDS//exon       24284625//24209618//24981863 chr15:39887592-39887593(+) m6A 3'UTR//exon       24284625//24209618//24981863//26404942//22575960 chr15:39887603-39887604(+) m6A 3'UTR//exon       24284625//24209618//24981863//26404942//22575960 chr15:39887630-39887631(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//22575960 chr15:39887647-39887648(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//22575960 chr15:39887703-39887704(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22575960 chr15:39887749-39887750(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22575960 chr15:39887781-39887782(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960 chr15:39887800-39887801(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960 chr15:39887919-39887920(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960 chr15:39887956-39887957(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960 chr15:39887974-39887975(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960 chr15:39887979-39887980(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960 chr15:39888004-39888005(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960 chr15:39888079-39888080(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960 chr15:39888123-39888124(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22575960 chr15:39888207-39888208(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22575960 chr15:39888213-39888214(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22575960 chr15:39888225-39888226(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22575960 chr15:39888291-39888292(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22575960 chr15:39888391-39888392(+) m6A 3'UTR       24284625//24209618 chr15:39888638-39888639(+) m6A 3'UTR       24981863 chr15:39888656-39888657(+) m6A 3'UTR       24981863 chr15:39890382-39890383(+) m6A 3'UTR       24981863 chr15:39890750-39890751(+) m6A 3'UTR       24981863 chr15:39890774-39890775(+) m6A 3'UTR       24981863 chr15:39890835-39890836(+) m6A 3'UTR       24981863 chr15:39890873-39890874(+) m6A 3'UTR       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	THBS1	Cytosol HeLa-S3 cells     - Exosome Blood     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	kshv-miR-K12-4-3p	Panobinostat       6918837 Nilotinib       644241 Irinotecan       60838 Topotecan       60700 l-685,458       5479543 Palbociclib       5330286 Dovitinib       135398510 Crizotinib       11626560 Nvp-aew541       11476171 Pha-665752       10461815

Interaction Network (The top 100 interactions):

Interactor1: kshv-miR-K12-4-3p
Interactor2: THBS1

Evidence Support:

Prediction-Evidence	miRanda
Support Database	ViRBase

References:

PMID	17500590	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	293 cells//BJAB cells	Interactor2 expression	Downregulation
Description	3'UTRs of SPP1, PRG1, ITM2A, S100A2, RAB27A, and THBS1 were also scanned by miRanda, which predicted high probability miRNA binding sites (scores above 190 and/or free energy values below 20 kcal/mol) within their 3'UTRs (Figure S3).