Basic Information:

  VIRBase ID:  

VHID00463689

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.1828

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-4-3p:  MIMAT0002192          SPP1:  NM_000582     

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Interactor Information:

	Interactor1	Interactor2
Symbol	kshv-miR-K12-4-3p	SPP1
miRBase Accession/Entrez ID	MIMAT0002192	6696
Organism	Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	BNSP//BSPI//ETA-1//OPN

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	SPP1	chr4:88896900-88896901(+) m6A 5'UTR//exon       25456834//24981863//27773535 chr4:88896905-88896906(+) m6A 5'UTR//exon       25456834//24981863//27773535 chr4:88898037-88898038(+) m6A 5'UTR//exon       24981863//26404942//27773535 chr4:88898215-88898216(+) m6A CDS//exon       24981863//27773535 chr4:88898849-88898850(+) m6A exon//intron       27773535 chr4:88898863-88898864(+) m6A exon//intron       27773535 chr4:88898895-88898896(+) m6A exon//intron       27773535 chr4:88898928-88898929(+) m6A exon//intron       27773535 chr4:88901237-88901238(+) m6A CDS//exon//intron       27773535 chr4:88901288-88901289(+) m6A exon//intron       27773535 chr4:88901303-88901304(+) m6A exon//intron       27773535 chr4:88901565-88901566(+) m6A CDS//exon//intron       27773535 chr4:88901579-88901580(+) m6A CDS//exon//intron       27773535 chr4:88901811-88901812(+) m6A exon//intron       26404942//27773535 chr4:88902702-88902703(+) m6A CDS//exon//intron       24981863//26404942//27773535 chr4:88902711-88902712(+) m6A CDS//exon//intron       24981863//26404942//27773535 chr4:88902802-88902803(+) m6A CDS//exon       25456834//24981863//26404942//27773535 chr4:88902825-88902826(+) m6A CDS//exon       25456834//24981863//26404942//27773535 chr4:88902870-88902871(+) m6A CDS//exon       25456834//24981863//26404942//27773535 chr4:88902907-88902908(+) m6A CDS//exon       25456834//24981863//26404942//27773535 chr4:88902937-88902938(+) m6A CDS//exon       25456834//24981863//26404942//27773535 chr4:88903665-88903666(+) m6A CDS//exon       25456834//24981863//26404942//27773535 chr4:88903731-88903732(+) m6A CDS//exon       24209618//25456834//24981863//26404942//27773535 chr4:88903755-88903756(+) m6A CDS//exon       24209618//25456834//24981863//26404942//27773535 chr4:88903770-88903771(+) m6A CDS//exon       24209618//25456834//24981863//26404942//27773535 chr4:88903811-88903812(+) m6A CDS//exon       24209618//25456834//24981863//26404942//27773535 chr4:88903897-88903898(+) m6A CDS//exon       24209618//24981863//26404942//27773535 chr4:88903965-88903966(+) m6A CDS//exon       24209618//24981863//26404942//27773535 chr4:88903990-88903991(+) m6A CDS//exon       24209618//24981863//26404942//27773535 chr4:88904121-88904122(+) m6A 3'UTR//exon       26404942//27773535 chr4:88904225-88904226(+) m6A 3'UTR//exon       26404942//27773535 chr4:88904236-88904237(+) m6A 3'UTR//exon       26404942//27773535 chr4:88904286-88904287(+) m6A 3'UTR//exon       26404942//27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	SPP1	Exosome Blood     - Insoluble cytoplasm HCC cell line (HepG2)     - Nucleus HCC cell line (HepG2)     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	kshv-miR-K12-4-3p	Panobinostat       6918837 Nilotinib       644241 Irinotecan       60838 Topotecan       60700 l-685,458       5479543 Palbociclib       5330286 Dovitinib       135398510 Crizotinib       11626560 Nvp-aew541       11476171 Pha-665752       10461815

Interaction Network (The top 100 interactions):

Interactor1: kshv-miR-K12-4-3p
Interactor2: SPP1

Evidence Support:

Prediction-Evidence	miRanda
Support Database	ViRBase

References:

PMID	17500590	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	293 cells//BJAB cells	Interactor2 expression	None
Description	3'UTRs of SPP1, PRG1, ITM2A, S100A2, RAB27A, and THBS1 were also scanned by miRanda, which predicted high probability miRNA binding sites (scores above 190 and/or free energy values below 20 kcal/mol) within their 3'UTRs (Figure S3).