Basic Information:

  VIRBase ID:  

VHID00463643

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5908

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-4-3p:  MIMAT0002192          SRSF3:  NR_036610     

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Interactor Information:

	Interactor1	Interactor2
Symbol	kshv-miR-K12-4-3p	SRSF3
miRBase Accession/Entrez ID	MIMAT0002192	6428
Organism	Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	SFRS3//SRp20

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	SRSF3	chr6:36563776(+) A-I      intronic chr6:36565707(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	SRSF3	chr6:36564896(+) G-T intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	SRSF3	chr6:36562205-36562206(+) m6A 5'UTR//exon       24284625//25456834//24981863//27773535 chr6:36564564-36564565(+) m6A CDS//exon       27773535 chr6:36564594-36564595(+) m6A CDS//exon       27773535 chr6:36564640-36564641(+) m6A CDS//exon       22575960 chr6:36564669-36564670(+) m6A CDS//exon       22575960 chr6:36564735-36564736(+) Tm CDS//exon       - chr6:36566655-36566656(+) m6A 3'UTR//CDS//exon       22575960 chr6:36567974-36567975(+) m6A 3'UTR//exon//intron       24284625//24981863//27773535 chr6:36569769-36569770(+) m6A 3'UTR//exon       27773535 chr6:36569849-36569850(+) m6A 3'UTR//exon       27773535 chr6:36569911-36569912(+) m6A 3'UTR//exon       27773535 chr6:36570024-36570025(+) m6A 3'UTR//exon       27773535 chr6:36570042-36570043(+) m6A 3'UTR//exon       27773535 chr6:36570053-36570054(+) m6A 3'UTR//exon       27773535 chr6:36570061-36570062(+) m6A 3'UTR//exon       27773535 chr6:36570178-36570179(+) m6A 3'UTR//exon       26404942 chr6:36570195-36570196(+) m6A 3'UTR//exon       26404942 chr6:36570206-36570207(+) m6A 3'UTR//exon       26404942 chr6:36570943-36570944(+) m6A 3'UTR       26404942

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	SRSF3	Chromatin K562 cells     - Cytosol HCC cell line (HepG2)     - Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|K562 cells     - Ribosome Colon cancer cells     24393600

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	kshv-miR-K12-4-3p	Panobinostat       6918837 Nilotinib       644241 Irinotecan       60838 Topotecan       60700 l-685,458       5479543 Palbociclib       5330286 Dovitinib       135398510 Crizotinib       11626560 Nvp-aew541       11476171 Pha-665752       10461815

Interaction Network (The top 100 interactions):

Interactor1: kshv-miR-K12-4-3p
Interactor2: SRSF3

Evidence Support:

Weak-Evidence	Microarray
Prediction-Evidence	miRanda//Targetscan
Support Database	ViRBase//VmiReg

References:

PMID	22174674	Target region	None
Source	ViRBase//VmiReg	Interactor1 expression	None
Tissue or cell line	EA.hy926 cells	Interactor2 expression	Downregulation
Description	As KSHV putative direct targets we extracted transcripts that were significantly down-regulated significantly in the replicate experiments, and which contained at least one seed-match to one of the KSHV miRNAs. We identified 704 putative direct targets in DG-75 cells (Figure 3B), and 980 putative direct targets in EA.hy926 cells (Figure 3C). A complete list of putative direct targets can be found in Dataset S2 for DG-75 cells and in Dataset S3 for EA.hy926 cells. The overlap between the two datasets contained 153 putative direct targets (Dataset S4).