Basic Information:

  VIRBase ID:  

VHID00463425

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5908

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-4-3p:  MIMAT0002192          P2RX5:  NM_001204520     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	kshv-miR-K12-4-3p	P2RX5
miRBase Accession/Entrez ID	MIMAT0002192	5026
Organism	Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	LRH-1//P2X5//P2X5R

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	P2RX5	chr17:3588307(-) A-I      intronic chr17:3588229(-) A-I      intronic chr17:3588169(-) A-I      intronic chr17:3588167(-) A-I      intronic chr17:3578502(-) A-I      intronic chr17:3579151(-) A-I      intronic chr17:3579156(-) A-I      intronic chr17:3588358(-) A-I      intronic chr17:3580113(-) A-I      intronic chr17:3580221(-) A-I      intronic chr17:3586074(-) A-I      intronic chr17:3586076(-) A-I      intronic chr17:3586243(-) A-I      intronic chr17:3586263(-) A-I      intronic chr17:3586808(-) A-I      intronic chr17:3586820(-) A-I      intronic chr17:3586985(-) A-I      intronic chr17:3587016(-) A-I      intronic chr17:3587718(-) A-I      intronic chr17:3587728(-) A-I      intronic chr17:3587849(-) A-I      intronic chr17:3588131(-) A-I      intronic chr17:3588132(-) A-I      intronic chr17:3588133(-) A-I      intronic chr17:3588134(-) A-I      intronic chr17:3588135(-) A-I      intronic chr17:3588161(-) A-I      intronic chr17:3588200(-) A-I      intronic chr17:3588205(-) A-I      intronic chr17:3588237(-) A-I      intronic chr17:3588248(-) A-I      intronic chr17:3578478(-) A-I      intronic chr17:3588261(-) A-I      intronic chr17:3588264(-) A-I      intronic chr17:3588272(-) A-I      intronic chr17:3588347(-) A-I      intronic chr17:3588278(-) A-I      intronic chr17:3588288(-) A-I      intronic chr17:3588300(-) A-I      intronic chr17:3588304(-) A-I      intronic chr17:3588308(-) A-I      intronic chr17:3588310(-) A-I      intronic chr17:3588311(-) A-I      intronic chr17:3588317(-) A-I      intronic chr17:3588322(-) A-I      intronic chr17:3588372(-) A-I      intronic chr17:3596041(-) A-I      intronic chr17:3596785(-) A-I      intronic chr17:3596864(-) A-I      intronic chr17:3588226(-) A-I      intronic chr17:3597775(-) A-I      intronic chr17:3597732(-) A-I      intronic chr17:3577591(-) A-I      intronic chr17:3578399(-) A-I      intronic chr17:3578410(-) A-I      intronic chr17:3578423(-) A-I      intronic chr17:3578430(-) A-I      intronic chr17:3578439(-) A-I      intronic chr17:3578442(-) A-I      intronic chr17:3578449(-) A-I      intronic chr17:3578462(-) A-I      intronic chr17:3578466(-) A-I      intronic chr17:3587834(-) A-I      intronic chr17:3578498(-) A-I      intronic chr17:3578501(-) A-I      intronic chr17:3578601(-) A-I      intronic chr17:3578853(-) A-I      intronic chr17:3578922(-) A-I      intronic chr17:3578929(-) A-I      intronic chr17:3579035(-) A-I      intronic chr17:3579040(-) A-I      intronic chr17:3580208(-) A-I      intronic chr17:3586902(-) A-I      intronic chr17:3577444(-) A-I      intronic chr17:3597278(-) A-I      intronic chr17:3580348(-) A-I      intronic chr17:3578881(-) A-I      intronic chr17:3597649(-) A-I      intronic chr17:3579011(-) A-I      intronic chr17:3579079(-) A-I      intronic chr17:3586156(-) A-I      intronic chr17:3580248(-) A-I      intronic chr17:3586220(-) A-I      intronic chr17:3577548(-) A-I      intronic chr17:3588418(-) A-I      intronic chr17:3595885(-) A-I      intronic chr17:3580111(-) A-I      intronic chr17:3579050(-) A-I      intronic chr17:3580190(-) A-I      intronic chr17:3578984(-) A-I      intronic chr17:3578472(-) A-I      intronic chr17:3577505(-) A-I      intronic chr17:3580193(-) A-I      intronic chr17:3587801(-) A-I      intronic chr17:3577606(-) A-I      intronic chr17:3577558(-) A-I      intronic chr17:3579026(-) A-I      intronic chr17:3578511(-) A-I      intronic chr17:3580330(-) A-I      intronic chr17:3578513(-) A-I      intronic chr17:3588356(-) A-I      intronic chr17:3580353(-) A-I      intronic chr17:3577483(-) A-I      intronic chr17:3578607(-) A-I      intronic chr17:3578952(-) A-I      intronic chr17:3595891(-) A-I      intronic chr17:3578606(-) A-I      intronic chr17:3588236(-) A-I      intronic chr17:3578877(-) A-I      intronic chr17:3578527(-) A-I      intronic chr17:3579117(-) A-I      intronic chr17:3580244(-) A-I      intronic chr17:3577542(-) A-I      intronic chr17:3586948(-) A-I      intronic chr17:3580173(-) A-I      intronic chr17:3588197(-) A-I      intronic chr17:3580256(-) A-I      intronic chr17:3596910(-) A-I      intronic chr17:3588313(-) A-I      intronic chr17:3586857(-) A-I      intronic chr17:3588411(-) A-I      intronic chr17:3578978(-) A-I      intronic chr17:3587891(-) A-I      intronic chr17:3587852(-) A-I      intronic chr17:3588255(-) A-I      intronic chr17:3580199(-) A-I      intronic chr17:3586062(-) A-I      intronic chr17:3578942(-) A-I      intronic chr17:3586833(-) A-I      intronic chr17:3597627(-) A-I      intronic chr17:3587813(-) A-I      intronic chr17:3587706(-) A-I      intronic chr17:3587743(-) A-I      intronic chr17:3580164(-) A-I      intronic chr17:3578402(-) A-I      intronic chr17:3579014(-) A-I      intronic chr17:3587653(-) A-I      intronic chr17:3577419(-) A-I      intronic chr17:3577352(-) A-I      intronic chr17:3579015(-) A-I      intronic chr17:3587814(-) A-I      intronic chr17:3580247(-) A-I      intronic chr17:3595892(-) A-I      intronic chr17:3580280(-) A-I      intronic chr17:3579082(-) A-I      intronic chr17:3588202(-) A-I      intronic chr17:3577379(-) A-I      intronic chr17:3597148(-) A-I      intronic chr17:3577608(-) A-I      intronic chr17:3595357(-) A-I      intronic chr17:3578951(-) A-I      intronic chr17:3586924(-) A-I      intronic chr17:3595597(-) A-I      intronic chr17:3580207(-) A-I      intronic chr17:3587732(-) A-I      intronic chr17:3586257(-) A-I      intronic chr17:3578974(-) A-I      intronic chr17:3580294(-) A-I      intronic chr17:3577459(-) A-I      intronic chr17:3586153(-) A-I      intronic chr17:3578508(-) A-I      intronic chr17:3578935(-) A-I      intronic chr17:3597704(-) A-I      intronic chr17:3578931(-) A-I      intronic chr17:3580232(-) A-I      intronic chr17:3596867(-) A-I      intronic chr17:3588318(-) A-I      intronic chr17:3588412(-) A-I      intronic chr17:3578512(-) A-I      intronic chr17:3587729(-) A-I      intronic chr17:3586938(-) A-I      intronic chr17:3587863(-) A-I      intronic chr17:3588428(-) A-I      intronic chr17:3578445(-) A-I      intronic chr17:3597345(-) A-I      intronic chr17:3577427(-) A-I      intronic chr17:3578503(-) A-I      intronic chr17:3586196(-) A-I      intronic chr17:3580112(-) A-I      intronic chr17:3579118(-) A-I      intronic chr17:3578954(-) A-I      intronic chr17:3588364(-) A-I      intronic chr17:3588334(-) A-I      intronic chr17:3579016(-) A-I      intronic chr17:3597353(-) A-I      intronic chr17:3579124(-) A-I      intronic chr17:3577441(-) A-I      intronic chr17:3577481(-) A-I      intronic chr17:3586859(-) A-I      intronic chr17:3579025(-) A-I      intronic chr17:3578943(-) A-I      intronic chr17:3587780(-) A-I      intronic chr17:3580176(-) A-I      intronic chr17:3588168(-) A-I      intronic chr17:3580234(-) A-I      intronic chr17:3578908(-) A-I      intronic chr17:3586198(-) A-I      intronic chr17:3586127(-) A-I      intronic chr17:3577365(-) A-I      intronic chr17:3597196(-) A-I      intronic chr17:3579880(-) A-I      intronic chr17:3586097(-) A-I      intronic chr17:3577778(-) A-I      intronic chr17:3579043(-) A-I      intronic chr17:3578576(-) A-I      intronic chr17:3579042(-) A-I      intronic chr17:3586176(-) A-I      intronic chr17:3580334(-) A-I      intronic chr17:3579160(-) A-I      intronic chr17:3588424(-) A-I      intronic chr17:3588251(-) A-I      intronic chr17:3587641(-) A-I      intronic chr17:3577450(-) A-I      intronic chr17:3588377(-) A-I      intronic chr17:3586770(-) A-I      intronic chr17:3578537(-) A-I      intronic chr17:3578957(-) A-I      intronic chr17:3578505(-) A-I      intronic chr17:3586163(-) A-I      intronic chr17:3577364(-) A-I      intronic chr17:3597636(-) A-I      intronic chr17:3578615(-) A-I      intronic chr17:3588277(-) A-I      intronic chr17:3579023(-) A-I      intronic chr17:3579029(-) A-I      intronic chr17:3578906(-) A-I      intronic chr17:3586114(-) A-I      intronic chr17:3577460(-) A-I      intronic chr17:3577387(-) A-I      intronic chr17:3580099(-) A-I      intronic chr17:3587677(-) A-I      intronic chr17:3586238(-) A-I      intronic chr17:3578516(-) A-I      intronic chr17:3578401(-) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	P2RX5	chr17:3575779-3575780(-) m6A CDS       27371828 chr17:3576589-3576590(-) m6A 3'UTR//exon//intron       24981863 chr17:3576668-3576669(-) m6A 3'UTR//exon//intron       24981863 chr17:3576829-3576830(-) m6A 3'UTR//exon//intron       24284625//24981863 chr17:3576870-3576871(-) m6A 3'UTR//exon//intron       24284625//25456834//24981863//27371828//22575960 chr17:3576967-3576968(-) m6A 3'UTR//exon//intron       24284625//25456834//24981863//28052920//27371828//22575960 chr17:3577024-3577025(-) m6A 3'UTR//exon//intron       24284625//25456834//24981863//27371828//22575960 chr17:3577127-3577128(-) m6A 3'UTR//exon//intron       24284625 chr17:3579478-3579479(-) m6A exon//intron       24284625 chr17:3579612-3579613(-) m6A exon//intron       27371828 chr17:3583066-3583067(-) m6A CDS//exon       27371828 chr17:3585286-3585287(-) m6A exon//intron       - chr17:3585322-3585323(-) m6A exon//intron       - chr17:3585580-3585581(-) m6A exon//intron       - chr17:3592861-3592862(-) m6A CDS//intron       24284625 chr17:3592900-3592901(-) m6A CDS//intron       24284625 chr17:3599222-3599223(-) m6A CDS//exon       27371828 chr17:3599247-3599248(-) m6A CDS//exon       27371828 chr17:3599361-3599362(-) m6A 5'UTR//exon       27371828 chr17:3599369-3599370(-) m6A 5'UTR//exon       27371828 chr17:3599430-3599431(-) m6A 5'UTR//exon       27371828 chr17:3599559-3599560(-) m1A 5'UTR       26863196 chr17:3599626-3599627(-) m6A 5'UTR       27371828

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	P2RX5	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	kshv-miR-K12-4-3p	Panobinostat       6918837 Nilotinib       644241 Irinotecan       60838 Topotecan       60700 l-685,458       5479543 Palbociclib       5330286 Dovitinib       135398510 Crizotinib       11626560 Nvp-aew541       11476171 Pha-665752       10461815

Interaction Network (The top 100 interactions):

Interactor1: kshv-miR-K12-4-3p
Interactor2: P2RX5

Evidence Support:

Weak-Evidence	Microarray
Prediction-Evidence	miRanda//Targetscan
Support Database	ViRBase//VmiReg

References:

PMID	22174674	Target region	None
Source	ViRBase//VmiReg	Interactor1 expression	None
Tissue or cell line	DG-75 cells	Interactor2 expression	Downregulation
Description	As KSHV putative direct targets we extracted transcripts that were significantly down-regulated significantly in the replicate experiments, and which contained at least one seed-match to one of the KSHV miRNAs. We identified 704 putative direct targets in DG-75 cells (Figure 3B), and 980 putative direct targets in EA.hy926 cells (Figure 3C). A complete list of putative direct targets can be found in Dataset S2 for DG-75 cells and in Dataset S3 for EA.hy926 cells. The overlap between the two datasets contained 153 putative direct targets (Dataset S4).